DBI | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	39 studies	40% ± 13%	Explore
natural killer cell	39 studies	55% ± 17%	Explore
macrophage	38 studies	55% ± 19%	Explore
fibroblast	35 studies	39% ± 15%	Explore
CD8-positive, alpha-beta T cell	34 studies	46% ± 20%	Explore
endothelial cell	32 studies	38% ± 11%	Explore
T cell	31 studies	42% ± 16%	Explore
conventional dendritic cell	29 studies	67% ± 15%	Explore
CD4-positive, alpha-beta T cell	29 studies	39% ± 19%	Explore
pericyte	28 studies	38% ± 15%	Explore
dendritic cell	26 studies	64% ± 21%	Explore
classical monocyte	26 studies	53% ± 14%	Explore
plasmacytoid dendritic cell	25 studies	66% ± 15%	Explore
smooth muscle cell	24 studies	35% ± 13%	Explore
regulatory T cell	24 studies	45% ± 17%	Explore
mature NK T cell	23 studies	44% ± 14%	Explore
non-classical monocyte	23 studies	52% ± 14%	Explore
epithelial cell	22 studies	56% ± 21%	Explore
mast cell	21 studies	54% ± 20%	Explore
monocyte	20 studies	51% ± 15%	Explore
memory B cell	20 studies	36% ± 11%	Explore
naive B cell	20 studies	38% ± 10%	Explore
basal cell	20 studies	47% ± 20%	Explore
endothelial cell of lymphatic vessel	18 studies	49% ± 13%	Explore
connective tissue cell	17 studies	39% ± 12%	Explore
gamma-delta T cell	17 studies	48% ± 12%	Explore
plasma cell	16 studies	43% ± 14%	Explore
ciliated cell	16 studies	58% ± 12%	Explore
astrocyte	16 studies	36% ± 19%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	42% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	55% ± 15%	Explore
myeloid cell	15 studies	58% ± 24%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	28% ± 7%	Explore
mucosal invariant T cell	13 studies	35% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	45% ± 19%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	38% ± 15%	Explore
myofibroblast cell	12 studies	33% ± 13%	Explore
plasmablast	11 studies	52% ± 19%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	41% ± 19%	Explore
secretory cell	11 studies	42% ± 16%	Explore
capillary endothelial cell	11 studies	36% ± 9%	Explore
vein endothelial cell	11 studies	33% ± 11%	Explore
endothelial cell of vascular tree	11 studies	33% ± 10%	Explore
progenitor cell	10 studies	60% ± 20%	Explore
abnormal cell	10 studies	52% ± 19%	Explore
oligodendrocyte precursor cell	10 studies	42% ± 23%	Explore
endothelial cell of artery	10 studies	35% ± 11%	Explore
type II pneumocyte	9 studies	74% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	43% ± 12%	Explore
goblet cell	9 studies	49% ± 10%	Explore
type I pneumocyte	8 studies	39% ± 14%	Explore
leukocyte	8 studies	52% ± 6%	Explore
T follicular helper cell	8 studies	38% ± 12%	Explore
club cell	7 studies	58% ± 12%	Explore
ionocyte	7 studies	67% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	60% ± 22%	Explore
oligodendrocyte	7 studies	30% ± 9%	Explore
epithelial cell of proximal tubule	7 studies	72% ± 11%	Explore
enterocyte	7 studies	63% ± 14%	Explore
innate lymphoid cell	7 studies	42% ± 10%	Explore
alveolar macrophage	6 studies	65% ± 23%	Explore
hematopoietic precursor cell	6 studies	46% ± 22%	Explore
respiratory goblet cell	6 studies	46% ± 16%	Explore
mononuclear phagocyte	6 studies	55% ± 16%	Explore
kidney loop of Henle epithelial cell	6 studies	56% ± 7%	Explore
renal alpha-intercalated cell	6 studies	71% ± 11%	Explore
transit amplifying cell	6 studies	58% ± 28%	Explore
microglial cell	6 studies	56% ± 22%	Explore
precursor B cell	6 studies	53% ± 10%	Explore
neuron	6 studies	41% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	47% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	41% ± 13%	Explore
exhausted T cell	5 studies	58% ± 13%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	67% ± 11%	Explore
intestinal crypt stem cell	5 studies	59% ± 22%	Explore
mesothelial cell	5 studies	29% ± 6%	Explore
immature B cell	5 studies	45% ± 16%	Explore
double negative thymocyte	5 studies	55% ± 14%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	59% ± 18%	Explore
intermediate monocyte	5 studies	67% ± 14%	Explore
hepatocyte	5 studies	54% ± 33%	Explore
granulocyte	5 studies	54% ± 28%	Explore
deuterosomal cell	4 studies	44% ± 12%	Explore
pancreatic A cell	4 studies	73% ± 12%	Explore
type B pancreatic cell	4 studies	71% ± 13%	Explore
enteroendocrine cell	4 studies	62% ± 12%	Explore
IgA plasma cell	4 studies	22% ± 8%	Explore
retinal ganglion cell	4 studies	51% ± 28%	Explore
hematopoietic stem cell	4 studies	41% ± 11%	Explore
pro-B cell	4 studies	39% ± 4%	Explore
adventitial cell	4 studies	39% ± 4%	Explore
mucus secreting cell	4 studies	51% ± 27%	Explore
Mueller cell	4 studies	61% ± 25%	Explore
inflammatory macrophage	4 studies	44% ± 14%	Explore
neutrophil	4 studies	40% ± 17%	Explore
germinal center B cell	4 studies	59% ± 17%	Explore
CD4-positive helper T cell	4 studies	31% ± 8%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	71% ± 11%	Explore
luminal cell of prostate epithelium	4 studies	58% ± 23%	Explore
T-helper 17 cell	4 studies	51% ± 26%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	54% ± 25%	Explore
duct epithelial cell	3 studies	59% ± 0%	Explore
precursor cell	3 studies	61% ± 22%	Explore
squamous epithelial cell	3 studies	37% ± 27%	Explore
pancreatic D cell	3 studies	57% ± 21%	Explore
monocyte-derived dendritic cell	3 studies	78% ± 22%	Explore
podocyte	3 studies	30% ± 6%	Explore
neural crest cell	3 studies	65% ± 16%	Explore
renal principal cell	3 studies	62% ± 6%	Explore
extravillous trophoblast	3 studies	56% ± 17%	Explore
placental villous trophoblast	3 studies	79% ± 23%	Explore
common myeloid progenitor	3 studies	46% ± 19%	Explore
erythroblast	3 studies	21% ± 1%	Explore
lymphocyte	3 studies	65% ± 11%	Explore
brush cell	3 studies	42% ± 31%	Explore
neuroendocrine cell	3 studies	70% ± 19%	Explore
retinal pigment epithelial cell	3 studies	45% ± 21%	Explore
retinal rod cell	3 studies	20% ± 3%	Explore
serous secreting cell	3 studies	69% ± 14%	Explore
tissue-resident macrophage	3 studies	42% ± 19%	Explore
intraepithelial lymphocyte	3 studies	52% ± 11%	Explore
acinar cell	3 studies	43% ± 25%	Explore
cardiac muscle cell	3 studies	27% ± 10%	Explore
endothelial cell of sinusoid	3 studies	22% ± 5%	Explore
adipocyte	3 studies	22% ± 7%	Explore
myoepithelial cell	3 studies	33% ± 3%	Explore
pancreatic ductal cell	3 studies	74% ± 6%	Explore
glial cell	3 studies	56% ± 22%	Explore
group 3 innate lymphoid cell	3 studies	47% ± 17%	Explore
keratinocyte	3 studies	68% ± 13%	Explore
melanocyte	3 studies	51% ± 25%	Explore
T-helper 1 cell	3 studies	55% ± 23%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	34% ± 8%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	33% ± 11%	Explore
progenitor cell of mammary luminal epithelium	3 studies	77% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	45% ± 12%	Explore
lung	18 studies	48% ± 15%	Explore
intestine	13 studies	40% ± 17%	Explore
brain	9 studies	31% ± 15%	Explore
kidney	9 studies	50% ± 11%	Explore
eye	8 studies	32% ± 9%	Explore
liver	7 studies	37% ± 13%	Explore
bone marrow	6 studies	32% ± 17%	Explore
pancreas	5 studies	58% ± 21%	Explore
placenta	5 studies	46% ± 27%	Explore
lymph node	5 studies	46% ± 16%	Explore
uterus	4 studies	52% ± 15%	Explore
prostate	4 studies	33% ± 6%	Explore
breast	4 studies	57% ± 11%	Explore
adipose	3 studies	31% ± 7%	Explore
adrenal gland	3 studies	41% ± 5%	Explore
esophagus	3 studies	57% ± 22%	Explore
skin	3 studies	51% ± 16%	Explore
thymus	3 studies	60% ± 18%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	9152.92	226 / 226	100%	214.80	406 / 406
brain	100%	6737.00	2639 / 2642	100%	629.36	705 / 705
bladder	100%	3137.95	21 / 21	100%	205.03	502 / 504
prostate	100%	6895.56	244 / 245	100%	380.67	501 / 502
skin	100%	8475.64	1809 / 1809	99%	178.25	469 / 472
breast	100%	7758.51	459 / 459	99%	239.77	1107 / 1118
stomach	99%	3181.97	356 / 359	100%	163.74	285 / 286
thymus	98%	3288.29	642 / 653	100%	169.96	604 / 605
kidney	100%	10479.61	89 / 89	97%	126.79	878 / 901
lung	98%	4609.74	569 / 578	99%	162.94	1143 / 1155
intestine	98%	4381.99	945 / 966	99%	180.74	524 / 527
esophagus	97%	6229.98	1402 / 1445	99%	127.19	182 / 183
ovary	89%	1762.36	161 / 180	91%	78.33	391 / 430
uterus	81%	1648.72	137 / 170	99%	190.51	455 / 459
pancreas	81%	1583.05	265 / 328	98%	137.75	175 / 178
adrenal gland	100%	3417.50	257 / 258	73%	57.33	168 / 230
adipose	100%	7444.72	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	276.08	29 / 29
tonsil	0%	0	0 / 0	100%	254.55	45 / 45
ureter	0%	0	0 / 0	100%	105.79	1 / 1
spleen	100%	2612.40	240 / 241	0%	0	0 / 0
heart	97%	6240.50	835 / 861	0%	0	0 / 0
blood vessel	97%	2676.33	1290 / 1335	0%	0	0 / 0
muscle	81%	2066.73	653 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	81%	57.82	65 / 80
peripheral blood	37%	3416.99	345 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_2001140	Biological process	positive regulation of phospholipid transport
GO_0036151	Biological process	phosphatidylcholine acyl-chain remodeling
GO_1903060	Biological process	negative regulation of protein lipidation
GO_0006631	Biological process	fatty acid metabolic process
GO_1905920	Biological process	positive regulation of CoA-transferase activity
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0005783	Cellular component	endoplasmic reticulum
GO_0070062	Cellular component	extracellular exosome
GO_0032994	Cellular component	protein-lipid complex
GO_0005794	Cellular component	Golgi apparatus
GO_0030156	Molecular function	benzodiazepine receptor binding
GO_0036042	Molecular function	long-chain fatty acyl-CoA binding
GO_0000062	Molecular function	fatty-acyl-CoA binding
GO_0042802	Molecular function	identical protein binding

IV. Literature review

[source]

Gene name	DBI
Protein name	Acyl-CoA-binding protein Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP)
Synonyms
Description	FUNCTION: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
Accessions	P07108 ENST00000355857.8 [P07108-1] ENST00000409094.5 [P07108-2] ENST00000535757.5 [P07108-2] B8ZWD8 ENST00000393103.2 [P07108-3] ENST00000627305.2 [P07108-5] B8ZWD1 ENST00000311521.8 [P07108-2] B8ZWD9 ENST00000627093.2 [P07108-4] ENST00000535617.5

DBI report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review