COX7B | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	38 studies	37% ± 13%	Explore
natural killer cell	37 studies	46% ± 12%	Explore
macrophage	36 studies	52% ± 17%	Explore
CD8-positive, alpha-beta T cell	35 studies	43% ± 15%	Explore
fibroblast	34 studies	42% ± 15%	Explore
endothelial cell	33 studies	45% ± 18%	Explore
pericyte	31 studies	52% ± 17%	Explore
CD4-positive, alpha-beta T cell	31 studies	42% ± 13%	Explore
T cell	30 studies	45% ± 15%	Explore
conventional dendritic cell	27 studies	63% ± 15%	Explore
classical monocyte	26 studies	54% ± 16%	Explore
smooth muscle cell	25 studies	54% ± 14%	Explore
non-classical monocyte	24 studies	66% ± 14%	Explore
regulatory T cell	24 studies	42% ± 11%	Explore
dendritic cell	23 studies	53% ± 22%	Explore
epithelial cell	23 studies	59% ± 20%	Explore
monocyte	21 studies	53% ± 20%	Explore
plasmacytoid dendritic cell	21 studies	45% ± 12%	Explore
basal cell	21 studies	55% ± 19%	Explore
mature NK T cell	20 studies	40% ± 12%	Explore
mast cell	19 studies	39% ± 16%	Explore
memory B cell	19 studies	36% ± 10%	Explore
plasma cell	19 studies	49% ± 18%	Explore
naive B cell	17 studies	31% ± 9%	Explore
connective tissue cell	17 studies	47% ± 12%	Explore
gamma-delta T cell	17 studies	46% ± 14%	Explore
endothelial cell of lymphatic vessel	16 studies	55% ± 15%	Explore
ciliated cell	16 studies	64% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	34% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	39% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	44% ± 10%	Explore
mucosal invariant T cell	14 studies	35% ± 10%	Explore
myofibroblast cell	13 studies	49% ± 15%	Explore
myeloid cell	13 studies	55% ± 21%	Explore
plasmablast	12 studies	62% ± 22%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	41% ± 10%	Explore
capillary endothelial cell	12 studies	38% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	40% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	45% ± 15%	Explore
secretory cell	11 studies	58% ± 16%	Explore
endothelial cell of artery	11 studies	42% ± 13%	Explore
goblet cell	11 studies	58% ± 24%	Explore
vein endothelial cell	11 studies	41% ± 13%	Explore
endothelial cell of vascular tree	11 studies	40% ± 7%	Explore
progenitor cell	10 studies	67% ± 18%	Explore
mesothelial cell	10 studies	55% ± 13%	Explore
type II pneumocyte	9 studies	46% ± 24%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	43% ± 12%	Explore
innate lymphoid cell	9 studies	47% ± 13%	Explore
type I pneumocyte	8 studies	41% ± 15%	Explore
leukocyte	8 studies	51% ± 13%	Explore
abnormal cell	8 studies	54% ± 18%	Explore
T follicular helper cell	8 studies	43% ± 9%	Explore
astrocyte	8 studies	36% ± 18%	Explore
club cell	7 studies	63% ± 11%	Explore
ionocyte	7 studies	73% ± 17%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	50% ± 16%	Explore
epithelial cell of proximal tubule	7 studies	71% ± 10%	Explore
neuron	7 studies	54% ± 26%	Explore
enterocyte	7 studies	70% ± 22%	Explore
brush cell	7 studies	51% ± 28%	Explore
erythrocyte	7 studies	51% ± 28%	Explore
respiratory goblet cell	6 studies	55% ± 18%	Explore
platelet	6 studies	23% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	46% ± 13%	Explore
mononuclear phagocyte	6 studies	56% ± 22%	Explore
kidney loop of Henle epithelial cell	6 studies	74% ± 20%	Explore
neutrophil	6 studies	40% ± 8%	Explore
renal alpha-intercalated cell	6 studies	90% ± 9%	Explore
erythroblast	6 studies	47% ± 29%	Explore
retinal rod cell	6 studies	45% ± 21%	Explore
retinal cone cell	6 studies	61% ± 31%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	47% ± 14%	Explore
alveolar macrophage	5 studies	68% ± 14%	Explore
CD4-positive helper T cell	5 studies	32% ± 14%	Explore
hematopoietic precursor cell	5 studies	52% ± 26%	Explore
exhausted T cell	5 studies	48% ± 12%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	82% ± 7%	Explore
enteroendocrine cell	5 studies	79% ± 12%	Explore
intestinal crypt stem cell	5 studies	60% ± 33%	Explore
IgA plasma cell	5 studies	29% ± 15%	Explore
IgG plasma cell	5 studies	35% ± 14%	Explore
transit amplifying cell	5 studies	61% ± 29%	Explore
retinal ganglion cell	5 studies	69% ± 28%	Explore
precursor B cell	5 studies	47% ± 16%	Explore
neuroendocrine cell	5 studies	74% ± 16%	Explore
cardiac muscle cell	5 studies	35% ± 17%	Explore
intermediate monocyte	5 studies	73% ± 11%	Explore
hepatocyte	5 studies	48% ± 34%	Explore
granulocyte	5 studies	43% ± 13%	Explore
deuterosomal cell	4 studies	52% ± 13%	Explore
duct epithelial cell	4 studies	66% ± 5%	Explore
pancreatic A cell	4 studies	75% ± 9%	Explore
type B pancreatic cell	4 studies	73% ± 16%	Explore
glomerular endothelial cell	4 studies	43% ± 16%	Explore
kidney connecting tubule epithelial cell	4 studies	89% ± 5%	Explore
OFF-bipolar cell	4 studies	49% ± 31%	Explore
ON-bipolar cell	4 studies	51% ± 30%	Explore
microglial cell	4 studies	41% ± 18%	Explore
hematopoietic stem cell	4 studies	49% ± 14%	Explore
immature B cell	4 studies	48% ± 15%	Explore
amacrine cell	4 studies	59% ± 16%	Explore
retina horizontal cell	4 studies	43% ± 21%	Explore
retinal pigment epithelial cell	4 studies	45% ± 25%	Explore
adventitial cell	4 studies	32% ± 3%	Explore
mucus secreting cell	4 studies	49% ± 14%	Explore
acinar cell	4 studies	41% ± 15%	Explore
muscle cell	4 studies	43% ± 21%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	55% ± 6%	Explore
GABAergic neuron	4 studies	22% ± 6%	Explore
group 3 innate lymphoid cell	4 studies	53% ± 14%	Explore
T-helper 17 cell	4 studies	51% ± 12%	Explore
T-helper 1 cell	4 studies	55% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	39% ± 9%	Explore
double negative thymocyte	4 studies	53% ± 20%	Explore
precursor cell	3 studies	64% ± 12%	Explore
squamous epithelial cell	3 studies	46% ± 25%	Explore
pancreatic D cell	3 studies	75% ± 18%	Explore
monocyte-derived dendritic cell	3 studies	64% ± 27%	Explore
podocyte	3 studies	63% ± 10%	Explore
renal beta-intercalated cell	3 studies	83% ± 16%	Explore
renal intercalated cell	3 studies	91% ± 4%	Explore
neural crest cell	3 studies	63% ± 8%	Explore
retinal bipolar neuron	3 studies	59% ± 27%	Explore
GABAergic amacrine cell	3 studies	27% ± 10%	Explore
glycinergic amacrine cell	3 studies	29% ± 9%	Explore
renal principal cell	3 studies	81% ± 7%	Explore
thymocyte	3 studies	41% ± 26%	Explore
extravillous trophoblast	3 studies	50% ± 12%	Explore
placental villous trophoblast	3 studies	78% ± 6%	Explore
lymphocyte	3 studies	61% ± 9%	Explore
megakaryocyte	3 studies	43% ± 10%	Explore
pro-B cell	3 studies	52% ± 5%	Explore
serous secreting cell	3 studies	57% ± 4%	Explore
Mueller cell	3 studies	49% ± 14%	Explore
rod bipolar cell	3 studies	53% ± 20%	Explore
germinal center B cell	3 studies	49% ± 4%	Explore
myoepithelial cell	3 studies	43% ± 7%	Explore
inflammatory macrophage	3 studies	47% ± 12%	Explore
luminal cell of prostate epithelium	3 studies	46% ± 9%	Explore
IgM plasma cell	3 studies	44% ± 9%	Explore
glutamatergic neuron	3 studies	29% ± 6%	Explore
pancreatic ductal cell	3 studies	83% ± 5%	Explore
oligodendrocyte precursor cell	3 studies	41% ± 18%	Explore
glial cell	3 studies	50% ± 23%	Explore
keratinocyte	3 studies	59% ± 3%	Explore
interneuron	3 studies	24% ± 6%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	40% ± 7%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	38% ± 10%	Explore
progenitor cell of mammary luminal epithelium	3 studies	45% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	53% ± 15%	Explore
peripheral blood	18 studies	47% ± 10%	Explore
intestine	12 studies	48% ± 21%	Explore
eye	10 studies	41% ± 20%	Explore
kidney	9 studies	55% ± 13%	Explore
brain	8 studies	31% ± 10%	Explore
lymph node	6 studies	43% ± 17%	Explore
liver	6 studies	51% ± 24%	Explore
pancreas	5 studies	63% ± 21%	Explore
uterus	5 studies	55% ± 18%	Explore
bone marrow	4 studies	40% ± 12%	Explore
placenta	4 studies	53% ± 18%	Explore
prostate	4 studies	45% ± 8%	Explore
breast	4 studies	47% ± 3%	Explore
heart	3 studies	32% ± 11%	Explore
adrenal gland	3 studies	47% ± 6%	Explore
esophagus	3 studies	62% ± 26%	Explore
skin	3 studies	39% ± 14%	Explore
thymus	3 studies	65% ± 16%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	3806.16	258 / 258	100%	124.65	230 / 230
kidney	100%	7666.16	89 / 89	100%	121.96	901 / 901
ovary	100%	1992.88	180 / 180	100%	167.39	430 / 430
stomach	100%	4404.96	359 / 359	100%	143.45	286 / 286
uterus	100%	2723.01	170 / 170	100%	144.93	459 / 459
intestine	100%	5511.90	966 / 966	100%	148.17	526 / 527
bladder	100%	3564.19	21 / 21	100%	127.35	503 / 504
prostate	100%	3271.91	245 / 245	100%	100.95	501 / 502
breast	100%	3278.58	459 / 459	100%	97.87	1114 / 1118
liver	100%	3886.76	225 / 226	100%	125.28	406 / 406
thymus	100%	3558.29	651 / 653	100%	94.70	604 / 605
esophagus	100%	5268.82	1445 / 1445	99%	112.52	182 / 183
lung	99%	3102.92	574 / 578	100%	100.39	1153 / 1155
brain	100%	4914.31	2635 / 2642	99%	96.92	699 / 705
skin	100%	3492.42	1802 / 1809	99%	91.66	467 / 472
pancreas	91%	1461.81	297 / 328	99%	87.61	177 / 178
lymph node	0%	0	0 / 0	100%	128.20	29 / 29
muscle	100%	11587.79	803 / 803	0%	0	0 / 0
spleen	100%	2848.20	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	141.50	45 / 45
ureter	0%	0	0 / 0	100%	98.19	1 / 1
adipose	100%	3334.27	1202 / 1204	0%	0	0 / 0
blood vessel	99%	3221.62	1327 / 1335	0%	0	0 / 0
heart	99%	15198.84	852 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	96%	87.63	77 / 80
peripheral blood	35%	1624.80	329 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	COX7B
Protein name	Cytochrome c oxidase subunit 7B Cytochrome c oxidase subunit 7B, mitochondrial (Cytochrome c oxidase polypeptide VIIb)
Synonyms
Description	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (By similarity). Plays a role in proper central nervous system (CNS) development in vertebrates . .
Accessions	P24311 ENST00000475465.1 A0A3B3ITX0 A0A3B3IRN8 ENST00000373335.4 ENST00000647835.1 A0A3B3ISY5 ENST00000650309.2

GO_1902600	Biological process	proton transmembrane transport
GO_0045333	Biological process	cellular respiration
GO_0006123	Biological process	mitochondrial electron transport, cytochrome c to oxygen
GO_0007417	Biological process	central nervous system development
GO_0031966	Cellular component	mitochondrial membrane
GO_0045277	Cellular component	respiratory chain complex IV
GO_0005751	Cellular component	mitochondrial respiratory chain complex IV
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0004129	Molecular function	cytochrome-c oxidase activity
GO_0005515	Molecular function	protein binding

COX7B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review