COX7A2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	43 studies	51% ± 15%	Explore
endothelial cell	40 studies	53% ± 22%	Explore
natural killer cell	39 studies	55% ± 16%	Explore
macrophage	37 studies	56% ± 19%	Explore
fibroblast	37 studies	55% ± 19%	Explore
T cell	35 studies	54% ± 20%	Explore
CD8-positive, alpha-beta T cell	35 studies	59% ± 19%	Explore
pericyte	32 studies	64% ± 20%	Explore
CD4-positive, alpha-beta T cell	32 studies	60% ± 18%	Explore
conventional dendritic cell	28 studies	64% ± 14%	Explore
smooth muscle cell	27 studies	65% ± 19%	Explore
regulatory T cell	27 studies	61% ± 16%	Explore
classical monocyte	25 studies	58% ± 14%	Explore
non-classical monocyte	24 studies	68% ± 15%	Explore
plasmacytoid dendritic cell	24 studies	69% ± 16%	Explore
epithelial cell	24 studies	70% ± 22%	Explore
dendritic cell	23 studies	57% ± 21%	Explore
plasma cell	23 studies	67% ± 19%	Explore
monocyte	22 studies	57% ± 19%	Explore
mature NK T cell	21 studies	51% ± 15%	Explore
basal cell	21 studies	69% ± 20%	Explore
mast cell	20 studies	50% ± 19%	Explore
memory B cell	20 studies	53% ± 12%	Explore
endothelial cell of lymphatic vessel	19 studies	71% ± 11%	Explore
gamma-delta T cell	19 studies	56% ± 17%	Explore
naive B cell	19 studies	45% ± 12%	Explore
connective tissue cell	19 studies	60% ± 21%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	49% ± 15%	Explore
mucosal invariant T cell	16 studies	49% ± 13%	Explore
ciliated cell	16 studies	78% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	55% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	52% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	58% ± 16%	Explore
capillary endothelial cell	14 studies	49% ± 17%	Explore
endothelial cell of artery	14 studies	53% ± 19%	Explore
myeloid cell	14 studies	57% ± 21%	Explore
myofibroblast cell	13 studies	66% ± 15%	Explore
plasmablast	12 studies	75% ± 15%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	56% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	58% ± 18%	Explore
secretory cell	12 studies	73% ± 17%	Explore
vein endothelial cell	12 studies	54% ± 17%	Explore
innate lymphoid cell	11 studies	51% ± 18%	Explore
endothelial cell of vascular tree	11 studies	60% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	55% ± 19%	Explore
progenitor cell	10 studies	81% ± 12%	Explore
astrocyte	10 studies	39% ± 25%	Explore
goblet cell	10 studies	74% ± 18%	Explore
mesothelial cell	10 studies	67% ± 19%	Explore
type I pneumocyte	9 studies	52% ± 16%	Explore
type II pneumocyte	9 studies	66% ± 25%	Explore
leukocyte	9 studies	55% ± 16%	Explore
abnormal cell	9 studies	61% ± 21%	Explore
IgG plasma cell	9 studies	49% ± 22%	Explore
T follicular helper cell	9 studies	56% ± 14%	Explore
club cell	8 studies	72% ± 22%	Explore
platelet	8 studies	26% ± 10%	Explore
neuron	8 studies	61% ± 26%	Explore
brush cell	8 studies	59% ± 30%	Explore
ionocyte	7 studies	81% ± 15%	Explore
neutrophil	7 studies	43% ± 12%	Explore
respiratory goblet cell	7 studies	74% ± 17%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	68% ± 18%	Explore
epithelial cell of proximal tubule	7 studies	67% ± 13%	Explore
enterocyte	7 studies	79% ± 15%	Explore
IgA plasma cell	7 studies	51% ± 19%	Explore
retinal rod cell	7 studies	57% ± 27%	Explore
hematopoietic stem cell	7 studies	60% ± 20%	Explore
erythrocyte	7 studies	53% ± 25%	Explore
hematopoietic precursor cell	6 studies	56% ± 29%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	69% ± 16%	Explore
mononuclear phagocyte	6 studies	60% ± 22%	Explore
kidney loop of Henle epithelial cell	6 studies	75% ± 7%	Explore
renal alpha-intercalated cell	6 studies	91% ± 2%	Explore
megakaryocyte	6 studies	56% ± 21%	Explore
oligodendrocyte	6 studies	31% ± 11%	Explore
erythroblast	6 studies	52% ± 26%	Explore
transit amplifying cell	6 studies	62% ± 34%	Explore
amacrine cell	6 studies	62% ± 24%	Explore
retinal ganglion cell	6 studies	71% ± 30%	Explore
microglial cell	6 studies	47% ± 17%	Explore
retinal cone cell	6 studies	70% ± 30%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	64% ± 19%	Explore
alveolar macrophage	5 studies	74% ± 13%	Explore
CD4-positive helper T cell	5 studies	46% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	49% ± 15%	Explore
exhausted T cell	5 studies	73% ± 10%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	86% ± 5%	Explore
enteroendocrine cell	5 studies	90% ± 9%	Explore
ON-bipolar cell	5 studies	57% ± 31%	Explore
precursor B cell	5 studies	62% ± 11%	Explore
neuroendocrine cell	5 studies	86% ± 19%	Explore
glial cell	5 studies	53% ± 23%	Explore
T-helper 17 cell	5 studies	69% ± 16%	Explore
immature B cell	5 studies	61% ± 16%	Explore
double negative thymocyte	5 studies	73% ± 15%	Explore
intermediate monocyte	5 studies	77% ± 14%	Explore
hepatocyte	5 studies	50% ± 34%	Explore
granulocyte	5 studies	59% ± 16%	Explore
GABAergic neuron	5 studies	32% ± 8%	Explore
glutamatergic neuron	5 studies	44% ± 5%	Explore
interneuron	5 studies	46% ± 20%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	51% ± 31%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	50% ± 17%	Explore
deuterosomal cell	4 studies	77% ± 20%	Explore
duct epithelial cell	4 studies	82% ± 5%	Explore
pancreatic A cell	4 studies	93% ± 6%	Explore
type B pancreatic cell	4 studies	87% ± 10%	Explore
glomerular endothelial cell	4 studies	60% ± 17%	Explore
podocyte	4 studies	78% ± 11%	Explore
intestinal crypt stem cell	4 studies	86% ± 10%	Explore
OFF-bipolar cell	4 studies	65% ± 27%	Explore
pro-B cell	4 studies	59% ± 12%	Explore
retina horizontal cell	4 studies	64% ± 21%	Explore
retinal pigment epithelial cell	4 studies	44% ± 29%	Explore
adventitial cell	4 studies	52% ± 7%	Explore
mucus secreting cell	4 studies	73% ± 23%	Explore
Mueller cell	4 studies	52% ± 21%	Explore
acinar cell	4 studies	58% ± 18%	Explore
muscle cell	4 studies	48% ± 19%	Explore
germinal center B cell	4 studies	57% ± 18%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	80% ± 8%	Explore
oligodendrocyte precursor cell	4 studies	52% ± 15%	Explore
group 3 innate lymphoid cell	4 studies	61% ± 13%	Explore
melanocyte	4 studies	67% ± 21%	Explore
T-helper 1 cell	4 studies	74% ± 10%	Explore
precursor cell	3 studies	80% ± 8%	Explore
squamous epithelial cell	3 studies	63% ± 16%	Explore
pancreatic D cell	3 studies	91% ± 6%	Explore
monocyte-derived dendritic cell	3 studies	64% ± 28%	Explore
kidney connecting tubule epithelial cell	3 studies	84% ± 10%	Explore
renal beta-intercalated cell	3 studies	92% ± 5%	Explore
neural crest cell	3 studies	74% ± 13%	Explore
retinal bipolar neuron	3 studies	74% ± 28%	Explore
GABAergic amacrine cell	3 studies	54% ± 16%	Explore
glycinergic amacrine cell	3 studies	53% ± 17%	Explore
renal principal cell	3 studies	76% ± 8%	Explore
thymocyte	3 studies	55% ± 28%	Explore
extravillous trophoblast	3 studies	79% ± 10%	Explore
placental villous trophoblast	3 studies	87% ± 10%	Explore
lymphocyte	3 studies	72% ± 6%	Explore
serous secreting cell	3 studies	74% ± 6%	Explore
tissue-resident macrophage	3 studies	38% ± 21%	Explore
intraepithelial lymphocyte	3 studies	60% ± 14%	Explore
rod bipolar cell	3 studies	70% ± 22%	Explore
cardiac muscle cell	3 studies	36% ± 12%	Explore
myoepithelial cell	3 studies	54% ± 3%	Explore
inflammatory macrophage	3 studies	47% ± 9%	Explore
luminal cell of prostate epithelium	3 studies	85% ± 8%	Explore
IgM plasma cell	3 studies	67% ± 9%	Explore
pancreatic ductal cell	3 studies	86% ± 4%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	67% ± 36%	Explore
keratinocyte	3 studies	71% ± 4%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	61% ± 8%	Explore
progenitor cell of mammary luminal epithelium	3 studies	72% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	57% ± 13%	Explore
lung	18 studies	65% ± 15%	Explore
intestine	13 studies	58% ± 25%	Explore
brain	11 studies	38% ± 11%	Explore
eye	10 studies	54% ± 23%	Explore
kidney	9 studies	63% ± 15%	Explore
liver	7 studies	52% ± 25%	Explore
bone marrow	6 studies	43% ± 13%	Explore
lymph node	6 studies	59% ± 14%	Explore
pancreas	5 studies	76% ± 21%	Explore
uterus	5 studies	64% ± 20%	Explore
placenta	4 studies	69% ± 19%	Explore
prostate	4 studies	62% ± 21%	Explore
breast	4 studies	64% ± 10%	Explore
heart	3 studies	34% ± 11%	Explore
adrenal gland	3 studies	60% ± 9%	Explore
esophagus	3 studies	67% ± 27%	Explore
skin	3 studies	57% ± 10%	Explore
thymus	3 studies	72% ± 24%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4885.79	1445 / 1445	100%	176.88	183 / 183
kidney	100%	6251.81	89 / 89	100%	139.02	901 / 901
ovary	100%	2359.41	180 / 180	100%	238.42	430 / 430
stomach	100%	4769.53	359 / 359	100%	213.49	286 / 286
brain	100%	5717.08	2641 / 2642	100%	174.49	705 / 705
intestine	100%	5311.64	966 / 966	100%	221.17	526 / 527
prostate	100%	3762.64	245 / 245	100%	198.64	501 / 502
uterus	100%	2941.28	170 / 170	100%	190.01	458 / 459
thymus	100%	3653.65	652 / 653	100%	145.10	604 / 605
skin	100%	3729.12	1807 / 1809	100%	151.64	471 / 472
lung	100%	3524.04	576 / 578	100%	173.29	1155 / 1155
bladder	100%	3605.29	21 / 21	100%	191.67	502 / 504
adrenal gland	100%	4305.86	258 / 258	100%	199.65	229 / 230
liver	100%	3629.85	225 / 226	100%	155.29	406 / 406
breast	100%	3912.80	459 / 459	100%	176.17	1113 / 1118
pancreas	98%	1881.79	323 / 328	100%	135.97	178 / 178
adipose	100%	3851.92	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	144.42	80 / 80
lymph node	0%	0	0 / 0	100%	178.65	29 / 29
spleen	100%	3150.64	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	172.12	45 / 45
ureter	0%	0	0 / 0	100%	77.98	1 / 1
blood vessel	100%	4462.95	1332 / 1335	0%	0	0 / 0
heart	99%	7340.51	852 / 861	0%	0	0 / 0
muscle	98%	2445.86	786 / 803	0%	0	0 / 0
peripheral blood	79%	2164.63	734 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	COX7A2
Protein name	Cytochrome c oxidase subunit 7A2, mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart) Cytochrome c oxidase subunit 7A2, mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart) (Cytochrome c oxidase subunit VIIa-L) (Cytochrome c oxidase subunit VIIaL) Cytochrome c oxidase subunit 7A2
Synonyms	COX7AL hCG_17987
Description	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. .
Accessions	ENST00000377978.3 D6R9C3 ENST00000684430.2 Q496I0 P14406 ENST00000370089.6 ENST00000472311.6 D6RGV5 ENST00000460985.1 ENST00000370081.6 D6RIE3 ENST00000459637.2 D6RA35 H0Y8S6 H0UI06 ENST00000509698.6

GO_0097250	Biological process	mitochondrial respirasome assembly
GO_0045333	Biological process	cellular respiration
GO_0006123	Biological process	mitochondrial electron transport, cytochrome c to oxygen
GO_0002082	Biological process	regulation of oxidative phosphorylation
GO_0031966	Cellular component	mitochondrial membrane
GO_0005751	Cellular component	mitochondrial respiratory chain complex IV
GO_0005746	Cellular component	mitochondrial respirasome
GO_0016491	Molecular function	oxidoreductase activity
GO_0005515	Molecular function	protein binding

COX7A2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review