COX6C | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	43 studies	56% ± 24%	Explore
B cell	42 studies	54% ± 16%	Explore
natural killer cell	40 studies	59% ± 18%	Explore
macrophage	39 studies	57% ± 19%	Explore
fibroblast	37 studies	61% ± 20%	Explore
CD8-positive, alpha-beta T cell	36 studies	60% ± 21%	Explore
T cell	35 studies	57% ± 21%	Explore
CD4-positive, alpha-beta T cell	32 studies	64% ± 19%	Explore
pericyte	31 studies	68% ± 20%	Explore
conventional dendritic cell	29 studies	71% ± 13%	Explore
smooth muscle cell	27 studies	69% ± 21%	Explore
regulatory T cell	27 studies	63% ± 16%	Explore
classical monocyte	26 studies	57% ± 15%	Explore
dendritic cell	25 studies	59% ± 24%	Explore
plasmacytoid dendritic cell	24 studies	68% ± 16%	Explore
epithelial cell	24 studies	71% ± 20%	Explore
plasma cell	23 studies	56% ± 21%	Explore
non-classical monocyte	23 studies	70% ± 14%	Explore
mast cell	21 studies	46% ± 19%	Explore
mature NK T cell	21 studies	54% ± 16%	Explore
basal cell	21 studies	67% ± 20%	Explore
monocyte	20 studies	54% ± 18%	Explore
endothelial cell of lymphatic vessel	20 studies	76% ± 13%	Explore
memory B cell	20 studies	58% ± 12%	Explore
gamma-delta T cell	19 studies	58% ± 18%	Explore
naive B cell	19 studies	47% ± 12%	Explore
connective tissue cell	19 studies	68% ± 20%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	60% ± 17%	Explore
mucosal invariant T cell	16 studies	52% ± 16%	Explore
ciliated cell	16 studies	79% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	54% ± 20%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	65% ± 13%	Explore
capillary endothelial cell	15 studies	52% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	70% ± 12%	Explore
astrocyte	14 studies	36% ± 23%	Explore
endothelial cell of artery	14 studies	56% ± 20%	Explore
myofibroblast cell	13 studies	74% ± 16%	Explore
myeloid cell	13 studies	67% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	54% ± 22%	Explore
plasmablast	12 studies	70% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	64% ± 17%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	63% ± 17%	Explore
secretory cell	12 studies	74% ± 14%	Explore
vein endothelial cell	12 studies	60% ± 19%	Explore
goblet cell	11 studies	68% ± 23%	Explore
endothelial cell of vascular tree	11 studies	63% ± 13%	Explore
innate lymphoid cell	10 studies	55% ± 15%	Explore
progenitor cell	10 studies	81% ± 10%	Explore
mesothelial cell	10 studies	75% ± 22%	Explore
glutamatergic neuron	10 studies	35% ± 20%	Explore
type I pneumocyte	9 studies	56% ± 19%	Explore
type II pneumocyte	9 studies	65% ± 25%	Explore
leukocyte	9 studies	57% ± 17%	Explore
abnormal cell	9 studies	71% ± 20%	Explore
T follicular helper cell	9 studies	63% ± 14%	Explore
club cell	8 studies	72% ± 21%	Explore
platelet	8 studies	29% ± 10%	Explore
neuron	8 studies	62% ± 23%	Explore
oligodendrocyte	8 studies	30% ± 11%	Explore
enterocyte	8 studies	72% ± 24%	Explore
brush cell	8 studies	59% ± 29%	Explore
ionocyte	7 studies	79% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	69% ± 20%	Explore
epithelial cell of proximal tubule	7 studies	72% ± 12%	Explore
IgA plasma cell	7 studies	32% ± 17%	Explore
retinal rod cell	7 studies	53% ± 25%	Explore
microglial cell	7 studies	46% ± 19%	Explore
hematopoietic stem cell	7 studies	72% ± 10%	Explore
precursor B cell	7 studies	64% ± 20%	Explore
interneuron	7 studies	44% ± 21%	Explore
hematopoietic precursor cell	6 studies	65% ± 30%	Explore
respiratory goblet cell	6 studies	71% ± 18%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	68% ± 19%	Explore
mononuclear phagocyte	6 studies	62% ± 23%	Explore
kidney loop of Henle epithelial cell	6 studies	77% ± 12%	Explore
neutrophil	6 studies	37% ± 7%	Explore
renal alpha-intercalated cell	6 studies	94% ± 3%	Explore
enteroendocrine cell	6 studies	79% ± 27%	Explore
erythroblast	6 studies	61% ± 31%	Explore
IgG plasma cell	6 studies	36% ± 17%	Explore
transit amplifying cell	6 studies	64% ± 34%	Explore
amacrine cell	6 studies	59% ± 26%	Explore
retinal ganglion cell	6 studies	70% ± 28%	Explore
retinal cone cell	6 studies	69% ± 29%	Explore
immature B cell	6 studies	64% ± 14%	Explore
erythrocyte	6 studies	59% ± 20%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	69% ± 18%	Explore
GABAergic neuron	6 studies	39% ± 15%	Explore
oligodendrocyte precursor cell	6 studies	45% ± 20%	Explore
alveolar macrophage	5 studies	74% ± 10%	Explore
CD4-positive helper T cell	5 studies	47% ± 11%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	58% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	54% ± 17%	Explore
exhausted T cell	5 studies	74% ± 12%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	89% ± 2%	Explore
intestinal crypt stem cell	5 studies	78% ± 26%	Explore
pro-B cell	5 studies	64% ± 21%	Explore
neuroendocrine cell	5 studies	87% ± 14%	Explore
T-helper 17 cell	5 studies	69% ± 16%	Explore
double negative thymocyte	5 studies	78% ± 9%	Explore
intermediate monocyte	5 studies	77% ± 12%	Explore
hepatocyte	5 studies	54% ± 32%	Explore
granulocyte	5 studies	56% ± 15%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	53% ± 30%	Explore
deuterosomal cell	4 studies	78% ± 19%	Explore
duct epithelial cell	4 studies	81% ± 7%	Explore
pancreatic A cell	4 studies	89% ± 5%	Explore
type B pancreatic cell	4 studies	86% ± 9%	Explore
glomerular endothelial cell	4 studies	64% ± 17%	Explore
kidney connecting tubule epithelial cell	4 studies	86% ± 6%	Explore
podocyte	4 studies	80% ± 8%	Explore
OFF-bipolar cell	4 studies	63% ± 27%	Explore
ON-bipolar cell	4 studies	65% ± 24%	Explore
megakaryocyte	4 studies	42% ± 12%	Explore
retina horizontal cell	4 studies	67% ± 19%	Explore
retinal pigment epithelial cell	4 studies	55% ± 29%	Explore
adventitial cell	4 studies	61% ± 10%	Explore
mucus secreting cell	4 studies	64% ± 18%	Explore
Mueller cell	4 studies	58% ± 21%	Explore
acinar cell	4 studies	60% ± 13%	Explore
muscle cell	4 studies	48% ± 15%	Explore
germinal center B cell	4 studies	64% ± 17%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	83% ± 7%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	71% ± 33%	Explore
glial cell	4 studies	52% ± 26%	Explore
group 3 innate lymphoid cell	4 studies	66% ± 11%	Explore
T-helper 1 cell	4 studies	74% ± 13%	Explore
precursor cell	3 studies	78% ± 8%	Explore
squamous epithelial cell	3 studies	55% ± 22%	Explore
pancreatic D cell	3 studies	88% ± 7%	Explore
monocyte-derived dendritic cell	3 studies	65% ± 29%	Explore
renal beta-intercalated cell	3 studies	95% ± 6%	Explore
renal intercalated cell	3 studies	83% ± 8%	Explore
neural crest cell	3 studies	73% ± 9%	Explore
retinal bipolar neuron	3 studies	73% ± 30%	Explore
GABAergic amacrine cell	3 studies	50% ± 10%	Explore
glycinergic amacrine cell	3 studies	47% ± 12%	Explore
renal principal cell	3 studies	84% ± 7%	Explore
thymocyte	3 studies	51% ± 29%	Explore
extravillous trophoblast	3 studies	87% ± 5%	Explore
placental villous trophoblast	3 studies	96% ± 2%	Explore
lymphocyte	3 studies	79% ± 7%	Explore
serous secreting cell	3 studies	71% ± 5%	Explore
tissue-resident macrophage	3 studies	45% ± 21%	Explore
intraepithelial lymphocyte	3 studies	66% ± 18%	Explore
rod bipolar cell	3 studies	69% ± 21%	Explore
cardiac muscle cell	3 studies	45% ± 16%	Explore
endothelial cell of sinusoid	3 studies	38% ± 14%	Explore
myoepithelial cell	3 studies	59% ± 14%	Explore
inflammatory macrophage	3 studies	47% ± 10%	Explore
luminal cell of prostate epithelium	3 studies	64% ± 8%	Explore
IgM plasma cell	3 studies	53% ± 15%	Explore
pancreatic ductal cell	3 studies	83% ± 6%	Explore
granulocyte monocyte progenitor cell	3 studies	58% ± 34%	Explore
keratinocyte	3 studies	74% ± 5%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	74% ± 4%	Explore
double-positive, alpha-beta thymocyte	3 studies	81% ± 7%	Explore
progenitor cell of mammary luminal epithelium	3 studies	61% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	62% ± 14%	Explore
lung	18 studies	65% ± 16%	Explore
brain	15 studies	37% ± 15%	Explore
intestine	13 studies	58% ± 25%	Explore
eye	10 studies	55% ± 22%	Explore
kidney	9 studies	65% ± 14%	Explore
bone marrow	7 studies	45% ± 20%	Explore
liver	7 studies	54% ± 24%	Explore
lymph node	6 studies	63% ± 15%	Explore
pancreas	5 studies	74% ± 18%	Explore
uterus	5 studies	75% ± 18%	Explore
placenta	4 studies	75% ± 20%	Explore
prostate	4 studies	59% ± 10%	Explore
breast	4 studies	65% ± 8%	Explore
heart	3 studies	39% ± 14%	Explore
adrenal gland	3 studies	63% ± 8%	Explore
esophagus	3 studies	67% ± 24%	Explore
skin	3 studies	59% ± 15%	Explore
thymus	3 studies	78% ± 18%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	4696.72	258 / 258	100%	124.07	230 / 230
esophagus	100%	6072.78	1445 / 1445	100%	98.03	183 / 183
uterus	100%	5440.05	170 / 170	100%	135.83	459 / 459
brain	100%	8188.02	2640 / 2642	100%	104.12	705 / 705
stomach	100%	4686.32	359 / 359	100%	116.54	285 / 286
intestine	100%	7589.01	966 / 966	100%	118.13	525 / 527
bladder	100%	5492.67	21 / 21	100%	143.56	502 / 504
liver	100%	4849.80	225 / 226	100%	177.83	406 / 406
skin	100%	3902.06	1801 / 1809	100%	100.02	471 / 472
breast	100%	4509.56	458 / 459	100%	582.86	1113 / 1118
thymus	100%	4389.87	651 / 653	100%	99.56	602 / 605
kidney	100%	5917.47	89 / 89	99%	88.12	891 / 901
ovary	100%	4827.78	180 / 180	99%	103.31	425 / 430
prostate	100%	4836.26	244 / 245	99%	107.03	498 / 502
lung	99%	3659.87	571 / 578	100%	95.55	1154 / 1155
pancreas	95%	1969.32	310 / 328	99%	88.45	176 / 178
eye	0%	0	0 / 0	100%	128.80	80 / 80
lymph node	0%	0	0 / 0	100%	160.14	29 / 29
muscle	100%	10054.15	803 / 803	0%	0	0 / 0
spleen	100%	3627.21	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	110.39	45 / 45
ureter	0%	0	0 / 0	100%	190.99	1 / 1
adipose	100%	4575.94	1201 / 1204	0%	0	0 / 0
blood vessel	100%	4962.36	1331 / 1335	0%	0	0 / 0
heart	99%	13284.22	851 / 861	0%	0	0 / 0
peripheral blood	22%	1884.71	207 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	COX6C
Protein name	Cytochrome c oxidase subunit 6C (Cytochrome c oxidase polypeptide VIc)
Synonyms
Description	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. .
Accessions	ENST00000523016.1 ENST00000520468.7 ENST00000517682.6 P09669 ENST00000522934.5 ENST00000520517.5 ENST00000524245.5 ENST00000297564.6 ENST00000522940.5 ENST00000520271.5 ENST00000518171.5

GO_0006091	Biological process	generation of precursor metabolites and energy
GO_0045333	Biological process	cellular respiration
GO_0006123	Biological process	mitochondrial electron transport, cytochrome c to oxygen
GO_0031966	Cellular component	mitochondrial membrane
GO_0005751	Cellular component	mitochondrial respiratory chain complex IV
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0005515	Molecular function	protein binding

COX6C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review