COX5B | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	41 studies	49% ± 15%	Explore
endothelial cell	41 studies	53% ± 22%	Explore
natural killer cell	38 studies	54% ± 15%	Explore
macrophage	37 studies	61% ± 19%	Explore
fibroblast	35 studies	53% ± 17%	Explore
CD8-positive, alpha-beta T cell	35 studies	53% ± 20%	Explore
pericyte	33 studies	60% ± 22%	Explore
T cell	32 studies	52% ± 16%	Explore
CD4-positive, alpha-beta T cell	31 studies	54% ± 18%	Explore
conventional dendritic cell	28 studies	73% ± 15%	Explore
smooth muscle cell	27 studies	59% ± 19%	Explore
classical monocyte	26 studies	67% ± 18%	Explore
regulatory T cell	26 studies	60% ± 16%	Explore
epithelial cell	25 studies	72% ± 20%	Explore
dendritic cell	24 studies	60% ± 25%	Explore
non-classical monocyte	23 studies	80% ± 15%	Explore
plasma cell	22 studies	56% ± 21%	Explore
plasmacytoid dendritic cell	22 studies	59% ± 15%	Explore
basal cell	21 studies	67% ± 20%	Explore
mature NK T cell	20 studies	50% ± 16%	Explore
mast cell	19 studies	50% ± 17%	Explore
monocyte	19 studies	67% ± 16%	Explore
endothelial cell of lymphatic vessel	19 studies	69% ± 12%	Explore
memory B cell	19 studies	53% ± 12%	Explore
gamma-delta T cell	18 studies	53% ± 15%	Explore
naive B cell	18 studies	42% ± 10%	Explore
connective tissue cell	18 studies	57% ± 20%	Explore
mucosal invariant T cell	16 studies	46% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	48% ± 13%	Explore
ciliated cell	16 studies	76% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	56% ± 17%	Explore
capillary endothelial cell	15 studies	47% ± 19%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	53% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	57% ± 14%	Explore
myofibroblast cell	13 studies	61% ± 15%	Explore
myeloid cell	13 studies	63% ± 22%	Explore
plasmablast	12 studies	67% ± 20%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	53% ± 21%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	54% ± 20%	Explore
secretory cell	12 studies	74% ± 14%	Explore
endothelial cell of artery	12 studies	55% ± 17%	Explore
vein endothelial cell	11 studies	58% ± 15%	Explore
endothelial cell of vascular tree	11 studies	58% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	52% ± 18%	Explore
innate lymphoid cell	10 studies	50% ± 15%	Explore
progenitor cell	10 studies	81% ± 18%	Explore
goblet cell	10 studies	75% ± 20%	Explore
mesothelial cell	10 studies	71% ± 21%	Explore
type I pneumocyte	9 studies	54% ± 20%	Explore
type II pneumocyte	9 studies	58% ± 26%	Explore
neutrophil	9 studies	46% ± 19%	Explore
leukocyte	9 studies	51% ± 18%	Explore
abnormal cell	9 studies	68% ± 20%	Explore
astrocyte	9 studies	43% ± 21%	Explore
T follicular helper cell	9 studies	52% ± 15%	Explore
club cell	8 studies	72% ± 21%	Explore
neuron	8 studies	57% ± 25%	Explore
enterocyte	8 studies	76% ± 25%	Explore
ionocyte	7 studies	82% ± 14%	Explore
platelet	7 studies	29% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	63% ± 21%	Explore
epithelial cell of proximal tubule	7 studies	72% ± 18%	Explore
oligodendrocyte	7 studies	34% ± 13%	Explore
erythroblast	7 studies	42% ± 28%	Explore
IgG plasma cell	7 studies	33% ± 18%	Explore
retinal rod cell	7 studies	54% ± 24%	Explore
microglial cell	7 studies	43% ± 18%	Explore
hematopoietic precursor cell	6 studies	55% ± 28%	Explore
respiratory goblet cell	6 studies	68% ± 17%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	64% ± 24%	Explore
mononuclear phagocyte	6 studies	64% ± 24%	Explore
kidney loop of Henle epithelial cell	6 studies	85% ± 13%	Explore
renal alpha-intercalated cell	6 studies	91% ± 6%	Explore
IgA plasma cell	6 studies	36% ± 18%	Explore
amacrine cell	6 studies	56% ± 24%	Explore
retinal ganglion cell	6 studies	71% ± 30%	Explore
retinal cone cell	6 studies	67% ± 30%	Explore
hematopoietic stem cell	6 studies	68% ± 16%	Explore
brush cell	6 studies	73% ± 14%	Explore
erythrocyte	6 studies	57% ± 23%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	61% ± 21%	Explore
alveolar macrophage	5 studies	76% ± 11%	Explore
CD4-positive helper T cell	5 studies	40% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	50% ± 14%	Explore
exhausted T cell	5 studies	72% ± 12%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	93% ± 2%	Explore
enteroendocrine cell	5 studies	88% ± 10%	Explore
transit amplifying cell	5 studies	76% ± 31%	Explore
glutamatergic neuron	5 studies	26% ± 9%	Explore
precursor B cell	5 studies	54% ± 13%	Explore
neuroendocrine cell	5 studies	83% ± 19%	Explore
T-helper 17 cell	5 studies	62% ± 20%	Explore
immature B cell	5 studies	62% ± 12%	Explore
cardiac muscle cell	5 studies	34% ± 15%	Explore
double negative thymocyte	5 studies	66% ± 12%	Explore
intermediate monocyte	5 studies	82% ± 9%	Explore
hepatocyte	5 studies	50% ± 33%	Explore
granulocyte	5 studies	56% ± 17%	Explore
oligodendrocyte precursor cell	5 studies	43% ± 19%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	48% ± 15%	Explore
deuterosomal cell	4 studies	66% ± 18%	Explore
duct epithelial cell	4 studies	87% ± 3%	Explore
pancreatic A cell	4 studies	70% ± 19%	Explore
type B pancreatic cell	4 studies	69% ± 14%	Explore
glomerular endothelial cell	4 studies	62% ± 15%	Explore
kidney connecting tubule epithelial cell	4 studies	93% ± 4%	Explore
podocyte	4 studies	80% ± 11%	Explore
intestinal crypt stem cell	4 studies	93% ± 6%	Explore
OFF-bipolar cell	4 studies	60% ± 28%	Explore
ON-bipolar cell	4 studies	62% ± 27%	Explore
lymphocyte	4 studies	74% ± 13%	Explore
retina horizontal cell	4 studies	58% ± 23%	Explore
retinal pigment epithelial cell	4 studies	46% ± 29%	Explore
adventitial cell	4 studies	52% ± 6%	Explore
mucus secreting cell	4 studies	68% ± 19%	Explore
Mueller cell	4 studies	52% ± 23%	Explore
muscle cell	4 studies	43% ± 23%	Explore
germinal center B cell	4 studies	52% ± 21%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	73% ± 8%	Explore
glial cell	4 studies	50% ± 26%	Explore
group 3 innate lymphoid cell	4 studies	59% ± 14%	Explore
GABAergic neuron	4 studies	21% ± 4%	Explore
interneuron	4 studies	25% ± 6%	Explore
T-helper 1 cell	4 studies	68% ± 15%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	65% ± 21%	Explore
precursor cell	3 studies	79% ± 7%	Explore
squamous epithelial cell	3 studies	57% ± 19%	Explore
monocyte-derived dendritic cell	3 studies	65% ± 30%	Explore
renal beta-intercalated cell	3 studies	90% ± 10%	Explore
neural crest cell	3 studies	69% ± 4%	Explore
retinal bipolar neuron	3 studies	72% ± 27%	Explore
GABAergic amacrine cell	3 studies	44% ± 13%	Explore
glycinergic amacrine cell	3 studies	44% ± 14%	Explore
renal principal cell	3 studies	87% ± 6%	Explore
thymocyte	3 studies	43% ± 29%	Explore
extravillous trophoblast	3 studies	85% ± 7%	Explore
placental villous trophoblast	3 studies	87% ± 13%	Explore
megakaryocyte	3 studies	51% ± 14%	Explore
pro-B cell	3 studies	62% ± 3%	Explore
serous secreting cell	3 studies	70% ± 3%	Explore
tissue-resident macrophage	3 studies	46% ± 22%	Explore
intraepithelial lymphocyte	3 studies	56% ± 13%	Explore
rod bipolar cell	3 studies	65% ± 23%	Explore
acinar cell	3 studies	44% ± 9%	Explore
adipocyte	3 studies	22% ± 4%	Explore
myoepithelial cell	3 studies	57% ± 14%	Explore
inflammatory macrophage	3 studies	48% ± 10%	Explore
luminal cell of prostate epithelium	3 studies	65% ± 9%	Explore
IgM plasma cell	3 studies	47% ± 15%	Explore
pancreatic ductal cell	3 studies	74% ± 14%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	66% ± 36%	Explore
keratinocyte	3 studies	67% ± 1%	Explore
melanocyte	3 studies	58% ± 19%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	60% ± 11%	Explore
progenitor cell of mammary luminal epithelium	3 studies	67% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	60% ± 12%	Explore
lung	18 studies	61% ± 18%	Explore
intestine	14 studies	53% ± 26%	Explore
brain	11 studies	34% ± 13%	Explore
eye	10 studies	49% ± 23%	Explore
kidney	9 studies	64% ± 16%	Explore
liver	7 studies	48% ± 24%	Explore
lymph node	6 studies	58% ± 21%	Explore
pancreas	5 studies	58% ± 23%	Explore
bone marrow	5 studies	40% ± 20%	Explore
placenta	4 studies	66% ± 24%	Explore
uterus	4 studies	73% ± 12%	Explore
prostate	4 studies	55% ± 13%	Explore
breast	4 studies	58% ± 9%	Explore
heart	3 studies	36% ± 12%	Explore
adrenal gland	3 studies	54% ± 6%	Explore
esophagus	3 studies	66% ± 26%	Explore
skin	3 studies	47% ± 18%	Explore
thymus	3 studies	66% ± 22%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	6564.44	258 / 258	100%	300.40	230 / 230
esophagus	100%	6244.61	1445 / 1445	100%	289.46	183 / 183
ovary	100%	3527.41	180 / 180	100%	659.71	430 / 430
uterus	100%	3425.54	170 / 170	100%	307.93	459 / 459
brain	100%	8568.09	2638 / 2642	100%	261.41	705 / 705
skin	100%	5106.77	1807 / 1809	100%	249.15	471 / 472
kidney	100%	9437.71	89 / 89	100%	314.28	898 / 901
liver	100%	5264.05	225 / 226	100%	297.45	406 / 406
thymus	100%	5414.53	650 / 653	100%	265.23	605 / 605
intestine	100%	7467.00	966 / 966	99%	414.37	524 / 527
stomach	100%	5976.32	359 / 359	99%	366.55	284 / 286
bladder	100%	4927.24	21 / 21	99%	340.93	499 / 504
prostate	100%	4497.36	244 / 245	99%	255.02	498 / 502
breast	100%	4846.15	459 / 459	98%	215.35	1100 / 1118
lung	98%	3367.18	566 / 578	99%	244.00	1144 / 1155
pancreas	96%	2439.45	315 / 328	99%	209.18	177 / 178
eye	0%	0	0 / 0	100%	324.99	80 / 80
lymph node	0%	0	0 / 0	100%	312.94	29 / 29
muscle	100%	14846.74	803 / 803	0%	0	0 / 0
spleen	100%	4308.42	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	302.94	45 / 45
ureter	0%	0	0 / 0	100%	239.77	1 / 1
adipose	100%	5007.34	1198 / 1204	0%	0	0 / 0
heart	99%	17293.97	855 / 861	0%	0	0 / 0
blood vessel	99%	4348.25	1321 / 1335	0%	0	0 / 0
peripheral blood	92%	3723.82	852 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	COX5B
Protein name	Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide Vb)
Synonyms
Description	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. .
Accessions	ENST00000708077.1 Q6FHM4 Q6FHJ9 P10606 ENST00000258424.3

GO_1902600	Biological process	proton transmembrane transport
GO_0045333	Biological process	cellular respiration
GO_0006123	Biological process	mitochondrial electron transport, cytochrome c to oxygen
GO_0007585	Biological process	respiratory gaseous exchange by respiratory system
GO_0031966	Cellular component	mitochondrial membrane
GO_0005751	Cellular component	mitochondrial respiratory chain complex IV
GO_0005739	Cellular component	mitochondrion
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0004129	Molecular function	cytochrome-c oxidase activity
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding

COX5B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review