COX4I1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	50 studies	75% ± 22%	Explore
macrophage	46 studies	68% ± 27%	Explore
endothelial cell	44 studies	61% ± 24%	Explore
natural killer cell	43 studies	73% ± 20%	Explore
T cell	39 studies	69% ± 25%	Explore
fibroblast	38 studies	67% ± 20%	Explore
CD8-positive, alpha-beta T cell	38 studies	73% ± 22%	Explore
pericyte	34 studies	67% ± 24%	Explore
CD4-positive, alpha-beta T cell	34 studies	79% ± 21%	Explore
conventional dendritic cell	31 studies	87% ± 16%	Explore
dendritic cell	29 studies	74% ± 26%	Explore
classical monocyte	29 studies	81% ± 18%	Explore
plasmacytoid dendritic cell	27 studies	88% ± 9%	Explore
regulatory T cell	27 studies	83% ± 14%	Explore
smooth muscle cell	26 studies	72% ± 20%	Explore
monocyte	25 studies	73% ± 24%	Explore
non-classical monocyte	25 studies	86% ± 16%	Explore
epithelial cell	25 studies	80% ± 20%	Explore
plasma cell	24 studies	71% ± 20%	Explore
mast cell	22 studies	68% ± 20%	Explore
mature NK T cell	22 studies	70% ± 21%	Explore
basal cell	22 studies	78% ± 22%	Explore
endothelial cell of lymphatic vessel	21 studies	79% ± 14%	Explore
gamma-delta T cell	20 studies	78% ± 18%	Explore
memory B cell	20 studies	88% ± 10%	Explore
naive B cell	19 studies	83% ± 12%	Explore
ciliated cell	18 studies	74% ± 19%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	82% ± 17%	Explore
connective tissue cell	18 studies	75% ± 15%	Explore
mucosal invariant T cell	16 studies	79% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	87% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	78% ± 15%	Explore
astrocyte	15 studies	36% ± 21%	Explore
capillary endothelial cell	15 studies	53% ± 22%	Explore
myeloid cell	15 studies	73% ± 26%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	77% ± 18%	Explore
endothelial cell of artery	14 studies	61% ± 22%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	75% ± 22%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	75% ± 21%	Explore
myofibroblast cell	13 studies	79% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	70% ± 22%	Explore
innate lymphoid cell	12 studies	78% ± 14%	Explore
plasmablast	12 studies	82% ± 13%	Explore
secretory cell	12 studies	85% ± 13%	Explore
vein endothelial cell	12 studies	67% ± 20%	Explore
endothelial cell of vascular tree	12 studies	70% ± 20%	Explore
neutrophil	11 studies	57% ± 24%	Explore
mesothelial cell	11 studies	76% ± 25%	Explore
T follicular helper cell	10 studies	83% ± 11%	Explore
leukocyte	10 studies	74% ± 24%	Explore
glutamatergic neuron	10 studies	32% ± 17%	Explore
progenitor cell	10 studies	88% ± 15%	Explore
goblet cell	10 studies	81% ± 16%	Explore
microglial cell	10 studies	53% ± 28%	Explore
type I pneumocyte	9 studies	60% ± 20%	Explore
type II pneumocyte	9 studies	71% ± 27%	Explore
abnormal cell	9 studies	77% ± 17%	Explore
neuron	9 studies	57% ± 27%	Explore
oligodendrocyte	9 studies	30% ± 14%	Explore
IgG plasma cell	9 studies	54% ± 20%	Explore
club cell	8 studies	79% ± 22%	Explore
platelet	8 studies	55% ± 19%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	78% ± 23%	Explore
enterocyte	8 studies	82% ± 19%	Explore
IgA plasma cell	8 studies	56% ± 23%	Explore
hematopoietic stem cell	8 studies	84% ± 22%	Explore
erythrocyte	8 studies	64% ± 20%	Explore
ionocyte	7 studies	82% ± 14%	Explore
respiratory goblet cell	7 studies	75% ± 18%	Explore
mononuclear phagocyte	7 studies	74% ± 24%	Explore
epithelial cell of proximal tubule	7 studies	77% ± 15%	Explore
enteroendocrine cell	7 studies	81% ± 27%	Explore
retinal rod cell	7 studies	55% ± 24%	Explore
oligodendrocyte precursor cell	7 studies	42% ± 25%	Explore
alveolar macrophage	6 studies	78% ± 22%	Explore
hematopoietic precursor cell	6 studies	75% ± 23%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	87% ± 14%	Explore
kidney loop of Henle epithelial cell	6 studies	80% ± 10%	Explore
renal alpha-intercalated cell	6 studies	95% ± 3%	Explore
erythroblast	6 studies	59% ± 26%	Explore
transit amplifying cell	6 studies	72% ± 32%	Explore
amacrine cell	6 studies	62% ± 23%	Explore
retinal ganglion cell	6 studies	77% ± 25%	Explore
retinal cone cell	6 studies	68% ± 28%	Explore
precursor B cell	6 studies	82% ± 8%	Explore
brush cell	6 studies	78% ± 18%	Explore
immature B cell	6 studies	83% ± 19%	Explore
intermediate monocyte	6 studies	82% ± 23%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	86% ± 10%	Explore
GABAergic neuron	6 studies	32% ± 12%	Explore
interneuron	6 studies	39% ± 23%	Explore
CD4-positive helper T cell	5 studies	73% ± 12%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	77% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	77% ± 9%	Explore
exhausted T cell	5 studies	89% ± 5%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	90% ± 4%	Explore
megakaryocyte	5 studies	76% ± 13%	Explore
neuroendocrine cell	5 studies	85% ± 17%	Explore
T-helper 17 cell	5 studies	85% ± 12%	Explore
group 3 innate lymphoid cell	5 studies	87% ± 5%	Explore
mucus secreting cell	5 studies	67% ± 28%	Explore
cardiac muscle cell	5 studies	38% ± 16%	Explore
double negative thymocyte	5 studies	90% ± 3%	Explore
hepatocyte	5 studies	56% ± 29%	Explore
granulocyte	5 studies	80% ± 10%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	69% ± 29%	Explore
deuterosomal cell	4 studies	70% ± 19%	Explore
duct epithelial cell	4 studies	90% ± 1%	Explore
squamous epithelial cell	4 studies	51% ± 23%	Explore
pancreatic A cell	4 studies	88% ± 10%	Explore
type B pancreatic cell	4 studies	89% ± 8%	Explore
glomerular endothelial cell	4 studies	57% ± 19%	Explore
podocyte	4 studies	75% ± 16%	Explore
intestinal crypt stem cell	4 studies	97% ± 3%	Explore
OFF-bipolar cell	4 studies	68% ± 24%	Explore
ON-bipolar cell	4 studies	70% ± 23%	Explore
lymphocyte	4 studies	88% ± 5%	Explore
pro-B cell	4 studies	81% ± 9%	Explore
retina horizontal cell	4 studies	71% ± 16%	Explore
retinal pigment epithelial cell	4 studies	54% ± 30%	Explore
adventitial cell	4 studies	64% ± 9%	Explore
Mueller cell	4 studies	55% ± 19%	Explore
inflammatory macrophage	4 studies	68% ± 17%	Explore
acinar cell	4 studies	69% ± 17%	Explore
muscle cell	4 studies	49% ± 16%	Explore
germinal center B cell	4 studies	79% ± 15%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	90% ± 8%	Explore
luminal cell of prostate epithelium	4 studies	72% ± 29%	Explore
glial cell	4 studies	56% ± 26%	Explore
melanocyte	4 studies	74% ± 17%	Explore
T-helper 1 cell	4 studies	91% ± 5%	Explore
hillock cell	3 studies	68% ± 33%	Explore
precursor cell	3 studies	93% ± 3%	Explore
pancreatic D cell	3 studies	88% ± 9%	Explore
monocyte-derived dendritic cell	3 studies	90% ± 12%	Explore
kidney connecting tubule epithelial cell	3 studies	86% ± 8%	Explore
renal beta-intercalated cell	3 studies	95% ± 4%	Explore
renal intercalated cell	3 studies	84% ± 8%	Explore
neural crest cell	3 studies	90% ± 6%	Explore
paneth cell	3 studies	79% ± 15%	Explore
retinal bipolar neuron	3 studies	74% ± 26%	Explore
GABAergic amacrine cell	3 studies	58% ± 16%	Explore
glycinergic amacrine cell	3 studies	54% ± 18%	Explore
renal principal cell	3 studies	84% ± 9%	Explore
thymocyte	3 studies	83% ± 11%	Explore
extravillous trophoblast	3 studies	93% ± 5%	Explore
placental villous trophoblast	3 studies	98% ± 1%	Explore
serous secreting cell	3 studies	77% ± 5%	Explore
tissue-resident macrophage	3 studies	63% ± 28%	Explore
follicular B cell	3 studies	76% ± 9%	Explore
intraepithelial lymphocyte	3 studies	81% ± 7%	Explore
rod bipolar cell	3 studies	74% ± 17%	Explore
endothelial cell of sinusoid	3 studies	42% ± 23%	Explore
adipocyte	3 studies	24% ± 6%	Explore
myoepithelial cell	3 studies	86% ± 5%	Explore
cholangiocyte	3 studies	44% ± 31%	Explore
IgM plasma cell	3 studies	71% ± 14%	Explore
pancreatic ductal cell	3 studies	91% ± 1%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	90% ± 11%	Explore
keratinocyte	3 studies	86% ± 10%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	92% ± 1%	Explore
double-positive, alpha-beta thymocyte	3 studies	94% ± 2%	Explore
progenitor cell of mammary luminal epithelium	3 studies	94% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	21 studies	83% ± 16%	Explore
lung	19 studies	71% ± 19%	Explore
brain	15 studies	38% ± 18%	Explore
intestine	13 studies	72% ± 19%	Explore
eye	10 studies	56% ± 22%	Explore
kidney	9 studies	74% ± 17%	Explore
liver	7 studies	61% ± 24%	Explore
bone marrow	6 studies	64% ± 21%	Explore
lymph node	6 studies	86% ± 6%	Explore
pancreas	5 studies	77% ± 19%	Explore
uterus	5 studies	76% ± 23%	Explore
prostate	5 studies	63% ± 30%	Explore
placenta	4 studies	81% ± 19%	Explore
heart	4 studies	35% ± 18%	Explore
esophagus	4 studies	57% ± 31%	Explore
breast	4 studies	83% ± 7%	Explore
adipose	3 studies	46% ± 27%	Explore
adrenal gland	3 studies	70% ± 14%	Explore
skin	3 studies	67% ± 21%	Explore
thymus	3 studies	80% ± 23%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	10844.54	258 / 258	100%	255.34	230 / 230
brain	100%	20285.98	2642 / 2642	100%	223.63	705 / 705
esophagus	100%	13692.11	1445 / 1445	100%	156.25	183 / 183
ovary	100%	10094.08	180 / 180	100%	160.73	430 / 430
skin	100%	13544.47	1809 / 1809	100%	197.69	472 / 472
uterus	100%	9179.97	170 / 170	100%	234.87	459 / 459
thymus	100%	11412.11	652 / 653	100%	250.36	605 / 605
kidney	100%	15678.39	89 / 89	100%	242.90	899 / 901
pancreas	100%	7621.40	327 / 328	100%	203.86	178 / 178
stomach	100%	13949.54	359 / 359	100%	230.07	285 / 286
liver	100%	9195.64	225 / 226	100%	196.69	406 / 406
intestine	100%	17251.26	966 / 966	99%	284.30	524 / 527
bladder	100%	11540.67	21 / 21	99%	255.30	501 / 504
prostate	100%	11453.67	245 / 245	99%	204.15	499 / 502
lung	99%	9665.91	575 / 578	99%	167.88	1146 / 1155
breast	100%	11964.49	459 / 459	98%	150.67	1099 / 1118
adipose	100%	12077.68	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	328.86	80 / 80
lymph node	0%	0	0 / 0	100%	414.98	29 / 29
muscle	100%	20294.60	803 / 803	0%	0	0 / 0
spleen	100%	11965.89	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	207.04	45 / 45
ureter	0%	0	0 / 0	100%	444.08	1 / 1
blood vessel	99%	8664.64	1328 / 1335	0%	0	0 / 0
heart	99%	31808.30	855 / 861	0%	0	0 / 0
peripheral blood	96%	9642.86	891 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	COX4I1
Protein name	Cytochrome c oxidase subunit 4 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) Cytochrome c oxidase subunit 4I1
Synonyms	COX4
Description	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. . FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. . FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. . FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. .
Accessions	H3BN72 ENST00000562336.5 ENST00000566115.5 ENST00000564903.1 H3BNV9 ENST00000253452.8 ENST00000565078.5 ENST00000568794.5 Q86WV2 H3BPG0 ENST00000564544.1 H3BNI5 H3BPR4 P13073 ENST00000566405.5 ENST00000561569.5

GO_1902600	Biological process	proton transmembrane transport
GO_0006091	Biological process	generation of precursor metabolites and energy
GO_0045333	Biological process	cellular respiration
GO_0006123	Biological process	mitochondrial electron transport, cytochrome c to oxygen
GO_0031966	Cellular component	mitochondrial membrane
GO_0005751	Cellular component	mitochondrial respiratory chain complex IV
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0016020	Cellular component	membrane
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0004129	Molecular function	cytochrome-c oxidase activity
GO_0005515	Molecular function	protein binding

COX4I1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review