COMMD6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	44 studies	66% ± 19%	Explore
natural killer cell	38 studies	61% ± 14%	Explore
macrophage	37 studies	53% ± 18%	Explore
endothelial cell	37 studies	52% ± 21%	Explore
fibroblast	36 studies	58% ± 19%	Explore
CD8-positive, alpha-beta T cell	36 studies	64% ± 17%	Explore
T cell	35 studies	59% ± 20%	Explore
CD4-positive, alpha-beta T cell	34 studies	67% ± 20%	Explore
pericyte	29 studies	57% ± 21%	Explore
conventional dendritic cell	29 studies	77% ± 13%	Explore
classical monocyte	27 studies	63% ± 16%	Explore
regulatory T cell	27 studies	73% ± 15%	Explore
dendritic cell	26 studies	60% ± 24%	Explore
smooth muscle cell	25 studies	64% ± 18%	Explore
plasmacytoid dendritic cell	25 studies	81% ± 16%	Explore
non-classical monocyte	24 studies	65% ± 16%	Explore
mast cell	21 studies	57% ± 18%	Explore
monocyte	21 studies	61% ± 16%	Explore
mature NK T cell	21 studies	61% ± 14%	Explore
epithelial cell	21 studies	61% ± 21%	Explore
endothelial cell of lymphatic vessel	20 studies	68% ± 13%	Explore
memory B cell	20 studies	76% ± 11%	Explore
naive B cell	20 studies	66% ± 15%	Explore
basal cell	20 studies	68% ± 18%	Explore
gamma-delta T cell	19 studies	64% ± 16%	Explore
connective tissue cell	19 studies	63% ± 20%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	73% ± 17%	Explore
mucosal invariant T cell	16 studies	62% ± 17%	Explore
plasma cell	16 studies	44% ± 18%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	60% ± 21%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	62% ± 15%	Explore
ciliated cell	15 studies	66% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	79% ± 9%	Explore
myeloid cell	14 studies	59% ± 17%	Explore
myofibroblast cell	13 studies	69% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	60% ± 23%	Explore
innate lymphoid cell	12 studies	63% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	67% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	67% ± 14%	Explore
capillary endothelial cell	12 studies	40% ± 17%	Explore
vein endothelial cell	12 studies	56% ± 19%	Explore
secretory cell	11 studies	67% ± 17%	Explore
endothelial cell of artery	11 studies	54% ± 16%	Explore
goblet cell	11 studies	49% ± 24%	Explore
endothelial cell of vascular tree	11 studies	61% ± 13%	Explore
plasmablast	10 studies	49% ± 23%	Explore
progenitor cell	10 studies	69% ± 20%	Explore
abnormal cell	10 studies	58% ± 22%	Explore
mesothelial cell	10 studies	75% ± 21%	Explore
type II pneumocyte	9 studies	51% ± 25%	Explore
leukocyte	9 studies	61% ± 17%	Explore
T follicular helper cell	9 studies	77% ± 11%	Explore
type I pneumocyte	8 studies	42% ± 22%	Explore
club cell	8 studies	61% ± 18%	Explore
hematopoietic stem cell	8 studies	77% ± 19%	Explore
erythrocyte	8 studies	39% ± 16%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	67% ± 13%	Explore
epithelial cell of proximal tubule	7 studies	55% ± 18%	Explore
neutrophil	7 studies	42% ± 12%	Explore
microglial cell	7 studies	51% ± 25%	Explore
neuron	7 studies	57% ± 24%	Explore
astrocyte	7 studies	29% ± 18%	Explore
hematopoietic precursor cell	6 studies	68% ± 27%	Explore
platelet	6 studies	36% ± 17%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	72% ± 12%	Explore
kidney loop of Henle epithelial cell	6 studies	56% ± 6%	Explore
renal alpha-intercalated cell	6 studies	83% ± 4%	Explore
enterocyte	6 studies	44% ± 16%	Explore
intestinal crypt stem cell	6 studies	54% ± 27%	Explore
transit amplifying cell	6 studies	47% ± 25%	Explore
precursor B cell	6 studies	68% ± 11%	Explore
immature B cell	6 studies	72% ± 15%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	74% ± 13%	Explore
oligodendrocyte precursor cell	6 studies	34% ± 21%	Explore
alveolar macrophage	5 studies	63% ± 15%	Explore
CD4-positive helper T cell	5 studies	62% ± 9%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	66% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	61% ± 14%	Explore
exhausted T cell	5 studies	77% ± 5%	Explore
ionocyte	5 studies	53% ± 15%	Explore
respiratory goblet cell	5 studies	45% ± 20%	Explore
mononuclear phagocyte	5 studies	74% ± 16%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	76% ± 10%	Explore
enteroendocrine cell	5 studies	63% ± 27%	Explore
IgG plasma cell	5 studies	25% ± 6%	Explore
pro-B cell	5 studies	55% ± 20%	Explore
T-helper 17 cell	5 studies	71% ± 10%	Explore
double negative thymocyte	5 studies	80% ± 6%	Explore
intermediate monocyte	5 studies	74% ± 20%	Explore
granulocyte	5 studies	66% ± 16%	Explore
glutamatergic neuron	5 studies	34% ± 9%	Explore
interneuron	5 studies	37% ± 20%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	53% ± 26%	Explore
duct epithelial cell	4 studies	55% ± 6%	Explore
pancreatic A cell	4 studies	58% ± 15%	Explore
type B pancreatic cell	4 studies	61% ± 19%	Explore
glomerular endothelial cell	4 studies	37% ± 13%	Explore
retinal ganglion cell	4 studies	50% ± 29%	Explore
erythroblast	4 studies	51% ± 14%	Explore
brush cell	4 studies	38% ± 28%	Explore
adventitial cell	4 studies	46% ± 7%	Explore
mucus secreting cell	4 studies	57% ± 18%	Explore
oligodendrocyte	4 studies	21% ± 4%	Explore
germinal center B cell	4 studies	65% ± 21%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	73% ± 13%	Explore
GABAergic neuron	4 studies	29% ± 7%	Explore
group 3 innate lymphoid cell	4 studies	70% ± 9%	Explore
T-helper 1 cell	4 studies	76% ± 9%	Explore
deuterosomal cell	3 studies	56% ± 1%	Explore
precursor cell	3 studies	65% ± 17%	Explore
monocyte-derived dendritic cell	3 studies	81% ± 16%	Explore
podocyte	3 studies	57% ± 15%	Explore
renal beta-intercalated cell	3 studies	88% ± 3%	Explore
neural crest cell	3 studies	75% ± 7%	Explore
IgA plasma cell	3 studies	26% ± 7%	Explore
renal principal cell	3 studies	67% ± 5%	Explore
thymocyte	3 studies	63% ± 15%	Explore
extravillous trophoblast	3 studies	77% ± 4%	Explore
placental villous trophoblast	3 studies	54% ± 20%	Explore
lymphocyte	3 studies	72% ± 10%	Explore
neuroendocrine cell	3 studies	70% ± 23%	Explore
amacrine cell	3 studies	44% ± 14%	Explore
retina horizontal cell	3 studies	37% ± 17%	Explore
retinal cone cell	3 studies	56% ± 19%	Explore
retinal rod cell	3 studies	31% ± 12%	Explore
serous secreting cell	3 studies	62% ± 4%	Explore
intraepithelial lymphocyte	3 studies	66% ± 10%	Explore
Mueller cell	3 studies	43% ± 5%	Explore
acinar cell	3 studies	44% ± 11%	Explore
endothelial cell of sinusoid	3 studies	36% ± 10%	Explore
muscle cell	3 studies	58% ± 19%	Explore
myoepithelial cell	3 studies	80% ± 1%	Explore
inflammatory macrophage	3 studies	45% ± 12%	Explore
luminal cell of prostate epithelium	3 studies	61% ± 10%	Explore
IgM plasma cell	3 studies	36% ± 12%	Explore
pancreatic ductal cell	3 studies	60% ± 13%	Explore
granulocyte monocyte progenitor cell	3 studies	59% ± 25%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	84% ± 10%	Explore
glial cell	3 studies	58% ± 23%	Explore
hepatocyte	3 studies	63% ± 26%	Explore
keratinocyte	3 studies	67% ± 7%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	83% ± 1%	Explore
double-positive, alpha-beta thymocyte	3 studies	79% ± 7%	Explore
progenitor cell of mammary luminal epithelium	3 studies	84% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	68% ± 14%	Explore
lung	18 studies	61% ± 17%	Explore
intestine	14 studies	48% ± 23%	Explore
brain	10 studies	34% ± 14%	Explore
kidney	9 studies	58% ± 15%	Explore
eye	8 studies	36% ± 16%	Explore
bone marrow	6 studies	50% ± 19%	Explore
lymph node	6 studies	67% ± 12%	Explore
liver	6 studies	52% ± 21%	Explore
pancreas	5 studies	53% ± 17%	Explore
placenta	5 studies	50% ± 18%	Explore
uterus	5 studies	67% ± 19%	Explore
prostate	4 studies	55% ± 16%	Explore
breast	4 studies	69% ± 11%	Explore
adrenal gland	3 studies	61% ± 8%	Explore
esophagus	3 studies	60% ± 24%	Explore
skin	3 studies	56% ± 15%	Explore
thymus	3 studies	72% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3523.82	1445 / 1445	100%	53.17	183 / 183
ovary	100%	6228.82	180 / 180	100%	87.53	430 / 430
stomach	100%	3074.67	359 / 359	100%	79.98	286 / 286
uterus	100%	4625.43	170 / 170	100%	86.78	459 / 459
kidney	100%	3269.93	89 / 89	100%	65.48	900 / 901
thymus	100%	3891.05	653 / 653	100%	100.27	604 / 605
brain	100%	1894.27	2632 / 2642	100%	65.42	705 / 705
intestine	100%	4385.33	966 / 966	100%	85.70	525 / 527
skin	100%	3027.28	1806 / 1809	100%	57.24	470 / 472
bladder	100%	4697.71	21 / 21	99%	82.13	501 / 504
prostate	100%	3718.18	245 / 245	99%	75.63	499 / 502
lung	99%	2534.32	574 / 578	100%	61.06	1155 / 1155
breast	100%	3822.13	459 / 459	99%	73.01	1109 / 1118
adrenal gland	100%	5192.95	258 / 258	99%	63.07	228 / 230
liver	100%	1326.35	225 / 226	99%	48.52	402 / 406
pancreas	98%	1500.48	323 / 328	100%	78.61	178 / 178
adipose	100%	3600.27	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4370.32	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	60.85	80 / 80
lymph node	0%	0	0 / 0	100%	152.34	29 / 29
spleen	100%	3044.80	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	56.46	45 / 45
ureter	0%	0	0 / 0	100%	24.26	1 / 1
heart	99%	2139.41	851 / 861	0%	0	0 / 0
muscle	87%	890.63	696 / 803	0%	0	0 / 0
peripheral blood	41%	1208.09	379 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0032088	Biological process	negative regulation of NF-kappaB transcription factor activity
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding
GO_0051059	Molecular function	NF-kappaB binding

Gene name	COMMD6
Protein name	COMM domain containing 6 COMM domain-containing protein 6
Synonyms	MSTP076
Description	FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes . Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation. .
Accessions	ENST00000626103.1 ENST00000377615.7 [Q7Z4G1-1] ENST00000377612.8 ENST00000682242.1 [Q7Z4G1-1] ENST00000377619.9 Q7Z4G1 B0QZ40 ENST00000355801.4 [Q7Z4G1-2] H7C607

COMMD6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review