CHCHD2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	46 studies	63% ± 20%	Explore
endothelial cell	42 studies	58% ± 24%	Explore
natural killer cell	40 studies	70% ± 16%	Explore
fibroblast	39 studies	68% ± 23%	Explore
macrophage	38 studies	64% ± 21%	Explore
T cell	35 studies	64% ± 22%	Explore
CD8-positive, alpha-beta T cell	35 studies	68% ± 19%	Explore
pericyte	33 studies	70% ± 23%	Explore
CD4-positive, alpha-beta T cell	32 studies	69% ± 19%	Explore
conventional dendritic cell	29 studies	80% ± 11%	Explore
smooth muscle cell	28 studies	69% ± 25%	Explore
regulatory T cell	27 studies	73% ± 15%	Explore
dendritic cell	26 studies	65% ± 27%	Explore
plasmacytoid dendritic cell	26 studies	82% ± 16%	Explore
classical monocyte	25 studies	72% ± 11%	Explore
non-classical monocyte	24 studies	80% ± 14%	Explore
epithelial cell	24 studies	73% ± 25%	Explore
plasma cell	23 studies	68% ± 21%	Explore
mature NK T cell	22 studies	60% ± 20%	Explore
monocyte	21 studies	64% ± 22%	Explore
endothelial cell of lymphatic vessel	21 studies	74% ± 16%	Explore
basal cell	21 studies	74% ± 21%	Explore
mast cell	20 studies	56% ± 22%	Explore
memory B cell	20 studies	70% ± 13%	Explore
gamma-delta T cell	19 studies	69% ± 17%	Explore
naive B cell	19 studies	63% ± 13%	Explore
ciliated cell	17 studies	77% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	58% ± 17%	Explore
connective tissue cell	17 studies	74% ± 18%	Explore
mucosal invariant T cell	16 studies	64% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	69% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	66% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	68% ± 14%	Explore
capillary endothelial cell	14 studies	55% ± 21%	Explore
myofibroblast cell	14 studies	76% ± 21%	Explore
astrocyte	13 studies	36% ± 20%	Explore
myeloid cell	13 studies	64% ± 26%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	61% ± 23%	Explore
plasmablast	12 studies	80% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	67% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	70% ± 19%	Explore
secretory cell	12 studies	78% ± 20%	Explore
endothelial cell of artery	12 studies	62% ± 17%	Explore
vein endothelial cell	12 studies	64% ± 22%	Explore
endothelial cell of vascular tree	12 studies	70% ± 22%	Explore
innate lymphoid cell	11 studies	64% ± 17%	Explore
goblet cell	11 studies	61% ± 24%	Explore
progenitor cell	10 studies	80% ± 20%	Explore
abnormal cell	10 studies	74% ± 24%	Explore
mesothelial cell	10 studies	76% ± 24%	Explore
type I pneumocyte	9 studies	56% ± 20%	Explore
type II pneumocyte	9 studies	64% ± 27%	Explore
neutrophil	9 studies	42% ± 23%	Explore
platelet	9 studies	37% ± 13%	Explore
leukocyte	9 studies	67% ± 20%	Explore
T follicular helper cell	9 studies	67% ± 16%	Explore
erythrocyte	9 studies	57% ± 25%	Explore
club cell	8 studies	71% ± 21%	Explore
neuron	8 studies	59% ± 26%	Explore
IgG plasma cell	8 studies	53% ± 17%	Explore
microglial cell	8 studies	52% ± 22%	Explore
brush cell	8 studies	54% ± 26%	Explore
ionocyte	7 studies	74% ± 20%	Explore
respiratory goblet cell	7 studies	69% ± 23%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	79% ± 13%	Explore
mononuclear phagocyte	7 studies	60% ± 24%	Explore
epithelial cell of proximal tubule	7 studies	66% ± 22%	Explore
enterocyte	7 studies	68% ± 20%	Explore
IgA plasma cell	7 studies	51% ± 18%	Explore
retinal rod cell	7 studies	48% ± 18%	Explore
hematopoietic stem cell	7 studies	71% ± 28%	Explore
precursor B cell	7 studies	68% ± 23%	Explore
alveolar macrophage	6 studies	69% ± 23%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	80% ± 13%	Explore
glutamatergic neuron	6 studies	36% ± 15%	Explore
kidney loop of Henle epithelial cell	6 studies	74% ± 15%	Explore
renal alpha-intercalated cell	6 studies	92% ± 3%	Explore
oligodendrocyte	6 studies	29% ± 11%	Explore
enteroendocrine cell	6 studies	73% ± 27%	Explore
transit amplifying cell	6 studies	63% ± 30%	Explore
amacrine cell	6 studies	49% ± 21%	Explore
retinal cone cell	6 studies	51% ± 28%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	77% ± 14%	Explore
GABAergic neuron	6 studies	31% ± 9%	Explore
interneuron	6 studies	40% ± 23%	Explore
CD4-positive helper T cell	5 studies	60% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	65% ± 12%	Explore
hematopoietic precursor cell	5 studies	70% ± 29%	Explore
exhausted T cell	5 studies	80% ± 6%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	86% ± 7%	Explore
megakaryocyte	5 studies	60% ± 23%	Explore
erythroblast	5 studies	71% ± 19%	Explore
intestinal crypt stem cell	5 studies	73% ± 27%	Explore
retinal ganglion cell	5 studies	77% ± 24%	Explore
ON-bipolar cell	5 studies	57% ± 29%	Explore
pro-B cell	5 studies	68% ± 26%	Explore
neuroendocrine cell	5 studies	86% ± 19%	Explore
T-helper 17 cell	5 studies	77% ± 16%	Explore
group 3 innate lymphoid cell	5 studies	79% ± 10%	Explore
immature B cell	5 studies	80% ± 9%	Explore
mucus secreting cell	5 studies	63% ± 28%	Explore
double negative thymocyte	5 studies	79% ± 11%	Explore
intermediate monocyte	5 studies	85% ± 12%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	62% ± 30%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	66% ± 13%	Explore
deuterosomal cell	4 studies	76% ± 26%	Explore
duct epithelial cell	4 studies	85% ± 2%	Explore
pancreatic A cell	4 studies	92% ± 8%	Explore
type B pancreatic cell	4 studies	89% ± 11%	Explore
glomerular endothelial cell	4 studies	58% ± 15%	Explore
kidney connecting tubule epithelial cell	4 studies	83% ± 9%	Explore
podocyte	4 studies	82% ± 9%	Explore
retinal bipolar neuron	4 studies	59% ± 29%	Explore
OFF-bipolar cell	4 studies	64% ± 25%	Explore
lymphocyte	4 studies	85% ± 7%	Explore
glial cell	4 studies	61% ± 16%	Explore
retina horizontal cell	4 studies	68% ± 13%	Explore
retinal pigment epithelial cell	4 studies	46% ± 17%	Explore
adventitial cell	4 studies	70% ± 12%	Explore
Mueller cell	4 studies	65% ± 22%	Explore
acinar cell	4 studies	70% ± 26%	Explore
muscle cell	4 studies	49% ± 16%	Explore
germinal center B cell	4 studies	74% ± 16%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	91% ± 7%	Explore
granulocyte	4 studies	71% ± 15%	Explore
luminal cell of prostate epithelium	4 studies	73% ± 31%	Explore
oligodendrocyte precursor cell	4 studies	51% ± 20%	Explore
hepatocyte	4 studies	59% ± 24%	Explore
melanocyte	4 studies	56% ± 23%	Explore
T-helper 1 cell	4 studies	83% ± 11%	Explore
precursor cell	3 studies	90% ± 4%	Explore
squamous epithelial cell	3 studies	53% ± 25%	Explore
pancreatic D cell	3 studies	92% ± 8%	Explore
monocyte-derived dendritic cell	3 studies	80% ± 18%	Explore
renal beta-intercalated cell	3 studies	94% ± 4%	Explore
neural crest cell	3 studies	90% ± 7%	Explore
GABAergic amacrine cell	3 studies	51% ± 12%	Explore
glycinergic amacrine cell	3 studies	46% ± 13%	Explore
renal principal cell	3 studies	81% ± 5%	Explore
thymocyte	3 studies	66% ± 26%	Explore
extravillous trophoblast	3 studies	92% ± 4%	Explore
placental villous trophoblast	3 studies	96% ± 2%	Explore
Schwann cell	3 studies	57% ± 31%	Explore
serous secreting cell	3 studies	73% ± 6%	Explore
tissue-resident macrophage	3 studies	50% ± 24%	Explore
intraepithelial lymphocyte	3 studies	74% ± 12%	Explore
rod bipolar cell	3 studies	73% ± 18%	Explore
cardiac muscle cell	3 studies	31% ± 10%	Explore
myoepithelial cell	3 studies	84% ± 7%	Explore
inflammatory macrophage	3 studies	51% ± 15%	Explore
IgM plasma cell	3 studies	71% ± 9%	Explore
pancreatic ductal cell	3 studies	92% ± 4%	Explore
keratinocyte	3 studies	77% ± 9%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	64% ± 34%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	74% ± 6%	Explore
double-positive, alpha-beta thymocyte	3 studies	86% ± 5%	Explore
progenitor cell of mammary luminal epithelium	3 studies	91% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	69% ± 14%	Explore
lung	18 studies	68% ± 16%	Explore
intestine	13 studies	60% ± 25%	Explore
brain	13 studies	34% ± 14%	Explore
eye	10 studies	52% ± 19%	Explore
kidney	9 studies	66% ± 19%	Explore
lymph node	6 studies	73% ± 15%	Explore
liver	6 studies	63% ± 18%	Explore
pancreas	5 studies	78% ± 25%	Explore
bone marrow	5 studies	44% ± 18%	Explore
uterus	5 studies	73% ± 23%	Explore
placenta	4 studies	76% ± 23%	Explore
prostate	4 studies	76% ± 19%	Explore
breast	4 studies	81% ± 6%	Explore
heart	3 studies	34% ± 16%	Explore
adrenal gland	3 studies	69% ± 9%	Explore
esophagus	3 studies	66% ± 24%	Explore
skin	3 studies	57% ± 25%	Explore
thymus	3 studies	75% ± 28%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	7865.22	1445 / 1445	100%	780.88	183 / 183
ovary	100%	7995.56	180 / 180	100%	1160.61	430 / 430
pancreas	100%	5905.04	328 / 328	100%	536.35	178 / 178
stomach	100%	7511.61	359 / 359	100%	854.53	286 / 286
brain	100%	9187.03	2639 / 2642	100%	1208.21	705 / 705
intestine	100%	8367.55	966 / 966	100%	876.13	526 / 527
uterus	100%	7492.92	170 / 170	100%	762.76	458 / 459
skin	100%	8698.06	1808 / 1809	100%	710.60	471 / 472
thymus	100%	7675.07	652 / 653	100%	616.28	604 / 605
kidney	100%	10168.09	89 / 89	100%	535.08	898 / 901
prostate	100%	8452.43	245 / 245	99%	638.74	499 / 502
breast	100%	8843.98	459 / 459	99%	737.11	1111 / 1118
liver	100%	5795.83	225 / 226	100%	496.25	405 / 406
lung	100%	7463.19	576 / 578	100%	794.31	1151 / 1155
bladder	100%	7507.33	21 / 21	99%	761.04	498 / 504
adrenal gland	100%	21529.66	258 / 258	98%	825.34	226 / 230
adipose	100%	8352.72	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	567.02	80 / 80
lymph node	0%	0	0 / 0	100%	1075.26	29 / 29
muscle	100%	14676.46	803 / 803	0%	0	0 / 0
spleen	100%	7481.78	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	693.50	45 / 45
ureter	0%	0	0 / 0	100%	280.13	1 / 1
blood vessel	100%	9460.21	1332 / 1335	0%	0	0 / 0
heart	97%	9061.67	837 / 861	0%	0	0 / 0
peripheral blood	97%	8063.47	900 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0034599	Biological process	cellular response to oxidative stress
GO_0007005	Biological process	mitochondrion organization
GO_1905448	Biological process	positive regulation of mitochondrial ATP synthesis coupled electron transport
GO_0043467	Biological process	regulation of generation of precursor metabolites and energy
GO_1900037	Biological process	regulation of cellular response to hypoxia
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005758	Cellular component	mitochondrial intermembrane space
GO_0005739	Cellular component	mitochondrion
GO_0005634	Cellular component	nucleus
GO_0140297	Molecular function	DNA-binding transcription factor binding
GO_0005515	Molecular function	protein binding
GO_0043565	Molecular function	sequence-specific DNA binding

Gene name	CHCHD2
Protein name	Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (Aging-associated gene 10 protein) (HCV NS2 trans-regulated protein) (NS2TP)
Synonyms	C7orf17 AAG10
Description	FUNCTION: Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) . .
Accessions	ENST00000395422.4 Q9Y6H1

CHCHD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review