CBX3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0006338Biological processchromatin remodeling
GO_0031507Biological processheterochromatin formation
GO_0048511Biological processrhythmic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0000775Cellular componentchromosome, centromeric region
GO_0000792Cellular componentheterochromatin
GO_0000791Cellular componenteuchromatin
GO_0005654Cellular componentnucleoplasm
GO_0005637Cellular componentnuclear inner membrane
GO_0005635Cellular componentnuclear envelope
GO_0061793Cellular componentchromatin lock complex
GO_0090734Cellular componentsite of DNA damage
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005721Cellular componentpericentric heterochromatin
GO_0000779Cellular componentcondensed chromosome, centromeric region
GO_0000781Cellular componentchromosome, telomeric region
GO_0000785Cellular componentchromatin
GO_0005819Cellular componentspindle
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0019899Molecular functionenzyme binding
GO_0019904Molecular functionprotein domain specific binding
GO_0003682Molecular functionchromatin binding
GO_0001221Molecular functiontranscription coregulator binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_1990226Molecular functionhistone methyltransferase binding

IV. Literature review

[source]
Gene nameCBX3
Protein nameChromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Chromobox 3
Chromobox homolog 3 (HP1 gamma homolog, Drosophila) (Coiled-coil domain containing 32, isoform CRA_c)
Chromobox 3 (Chromobox homolog 3 (HP1 gamma homolog, Drosophila), isoform CRA_b)
SynonymshCG_1999239
CCDC32
tcag7.173
hCG_1745364
DescriptionFUNCTION: Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) . .

AccessionsA4D177
C9JMM0
ENST00000456948.5
Q13185
ENST00000396386.7
ENST00000409747.5
ENST00000337620.8
B8ZZ43
S4R2Y4
ENST00000462165.2