AP2S1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0098884Biological processpostsynaptic neurotransmitter receptor internalization
GO_0048488Biological processsynaptic vesicle endocytosis
GO_0006886Biological processintracellular protein transport
GO_0016192Biological processvesicle-mediated transport
GO_0048268Biological processclathrin coat assembly
GO_0030100Biological processregulation of endocytosis
GO_0072583Biological processclathrin-dependent endocytosis
GO_0098793Cellular componentpresynapse
GO_0005886Cellular componentplasma membrane
GO_0030122Cellular componentAP-2 adaptor complex
GO_0030666Cellular componentendocytic vesicle membrane
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0098794Cellular componentpostsynapse
GO_0005829Cellular componentcytosol
GO_0045334Cellular componentclathrin-coated endocytic vesicle
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0036020Cellular componentendolysosome membrane
GO_0035615Molecular functionclathrin adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAP2S1
Protein nameAP-2 complex subunit sigma (Clathrin assembly protein 2 sigma small chain) (Sigma2-adaptin)
AP complex subunit sigma
AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)
SynonymsCLAPS2
AP17
DescriptionFUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). May also play a role in extracellular calcium homeostasis. .

AccessionsENST00000263270.11 [P53680-1]
ENST00000601649.1 [P53680-2]
ENST00000597020.5
ENST00000593442.5
ENST00000352203.8
X6R390
M0R0N4
M0QYZ2
M0QZ21
ENST00000599990.5
P53680
M0R1S0
ENST00000601498.5