ANAPC16 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	44 studies	49% ± 16%	Explore
endothelial cell	42 studies	38% ± 16%	Explore
fibroblast	40 studies	32% ± 13%	Explore
natural killer cell	38 studies	45% ± 12%	Explore
CD8-positive, alpha-beta T cell	37 studies	44% ± 14%	Explore
T cell	36 studies	41% ± 17%	Explore
macrophage	36 studies	29% ± 10%	Explore
CD4-positive, alpha-beta T cell	34 studies	48% ± 13%	Explore
pericyte	30 studies	40% ± 15%	Explore
smooth muscle cell	29 studies	41% ± 14%	Explore
regulatory T cell	27 studies	51% ± 14%	Explore
conventional dendritic cell	24 studies	35% ± 16%	Explore
classical monocyte	24 studies	33% ± 12%	Explore
dendritic cell	23 studies	36% ± 20%	Explore
mast cell	23 studies	35% ± 14%	Explore
endothelial cell of lymphatic vessel	23 studies	44% ± 16%	Explore
non-classical monocyte	23 studies	37% ± 15%	Explore
mature NK T cell	22 studies	43% ± 12%	Explore
plasmacytoid dendritic cell	22 studies	51% ± 14%	Explore
basal cell	22 studies	44% ± 18%	Explore
epithelial cell	22 studies	45% ± 19%	Explore
plasma cell	21 studies	41% ± 15%	Explore
monocyte	20 studies	31% ± 10%	Explore
memory B cell	20 studies	54% ± 12%	Explore
naive B cell	20 studies	52% ± 11%	Explore
gamma-delta T cell	19 studies	46% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	19 studies	44% ± 15%	Explore
ciliated cell	19 studies	54% ± 20%	Explore
connective tissue cell	17 studies	35% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	42% ± 16%	Explore
mucosal invariant T cell	16 studies	40% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	43% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	51% ± 12%	Explore
myofibroblast cell	14 studies	37% ± 10%	Explore
astrocyte	14 studies	33% ± 15%	Explore
myeloid cell	13 studies	30% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	45% ± 13%	Explore
capillary endothelial cell	12 studies	37% ± 10%	Explore
vein endothelial cell	12 studies	38% ± 13%	Explore
type I pneumocyte	11 studies	36% ± 14%	Explore
type II pneumocyte	11 studies	46% ± 21%	Explore
plasmablast	11 studies	41% ± 23%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	44% ± 12%	Explore
secretory cell	11 studies	41% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	43% ± 17%	Explore
oligodendrocyte	11 studies	32% ± 15%	Explore
endothelial cell of vascular tree	11 studies	37% ± 11%	Explore
club cell	10 studies	45% ± 15%	Explore
leukocyte	10 studies	34% ± 8%	Explore
progenitor cell	10 studies	38% ± 12%	Explore
abnormal cell	10 studies	41% ± 14%	Explore
endothelial cell of artery	10 studies	39% ± 11%	Explore
mesothelial cell	10 studies	44% ± 18%	Explore
microglial cell	10 studies	33% ± 14%	Explore
innate lymphoid cell	9 studies	40% ± 15%	Explore
goblet cell	9 studies	34% ± 15%	Explore
T follicular helper cell	9 studies	58% ± 13%	Explore
retinal rod cell	8 studies	39% ± 18%	Explore
adipocyte	8 studies	29% ± 12%	Explore
alveolar macrophage	7 studies	26% ± 8%	Explore
respiratory goblet cell	7 studies	41% ± 21%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	41% ± 12%	Explore
epithelial cell of proximal tubule	7 studies	42% ± 12%	Explore
neuron	7 studies	37% ± 19%	Explore
IgG plasma cell	7 studies	29% ± 8%	Explore
glutamatergic neuron	7 studies	40% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	36% ± 16%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	49% ± 13%	Explore
mononuclear phagocyte	6 studies	33% ± 15%	Explore
kidney loop of Henle epithelial cell	6 studies	52% ± 9%	Explore
renal alpha-intercalated cell	6 studies	61% ± 8%	Explore
enterocyte	6 studies	27% ± 5%	Explore
IgA plasma cell	6 studies	27% ± 8%	Explore
transit amplifying cell	6 studies	31% ± 12%	Explore
GABAergic neuron	6 studies	39% ± 22%	Explore
retinal cone cell	6 studies	46% ± 27%	Explore
hematopoietic stem cell	6 studies	32% ± 10%	Explore
lymphocyte	6 studies	39% ± 14%	Explore
precursor B cell	6 studies	47% ± 14%	Explore
immature B cell	6 studies	58% ± 14%	Explore
mucus secreting cell	6 studies	39% ± 16%	Explore
cardiac muscle cell	6 studies	39% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	52% ± 13%	Explore
hepatocyte	6 studies	42% ± 23%	Explore
oligodendrocyte precursor cell	6 studies	36% ± 11%	Explore
CD4-positive helper T cell	5 studies	37% ± 14%	Explore
hematopoietic precursor cell	5 studies	42% ± 20%	Explore
duct epithelial cell	5 studies	51% ± 7%	Explore
exhausted T cell	5 studies	53% ± 10%	Explore
ionocyte	5 studies	45% ± 10%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	59% ± 8%	Explore
enteroendocrine cell	5 studies	43% ± 18%	Explore
intestinal crypt stem cell	5 studies	29% ± 7%	Explore
pro-B cell	5 studies	37% ± 10%	Explore
Mueller cell	5 studies	37% ± 13%	Explore
erythrocyte	5 studies	34% ± 16%	Explore
muscle cell	5 studies	37% ± 20%	Explore
neutrophil	5 studies	20% ± 3%	Explore
granulocyte	5 studies	37% ± 16%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	42% ± 17%	Explore
deuterosomal cell	4 studies	38% ± 11%	Explore
pancreatic A cell	4 studies	57% ± 4%	Explore
type B pancreatic cell	4 studies	65% ± 9%	Explore
glomerular endothelial cell	4 studies	38% ± 7%	Explore
retinal bipolar neuron	4 studies	36% ± 19%	Explore
OFF-bipolar cell	4 studies	30% ± 9%	Explore
retinal ganglion cell	4 studies	49% ± 23%	Explore
brush cell	4 studies	37% ± 16%	Explore
retina horizontal cell	4 studies	29% ± 8%	Explore
retinal pigment epithelial cell	4 studies	38% ± 23%	Explore
adventitial cell	4 studies	27% ± 9%	Explore
glial cell	4 studies	33% ± 16%	Explore
acinar cell	4 studies	41% ± 14%	Explore
endothelial cell of sinusoid	4 studies	20% ± 3%	Explore
intermediate monocyte	4 studies	52% ± 20%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	45% ± 13%	Explore
luminal cell of prostate epithelium	4 studies	34% ± 8%	Explore
group 3 innate lymphoid cell	4 studies	62% ± 6%	Explore
T-helper 17 cell	4 studies	52% ± 12%	Explore
interneuron	4 studies	39% ± 21%	Explore
T-helper 1 cell	4 studies	58% ± 6%	Explore
double negative thymocyte	4 studies	54% ± 16%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	44% ± 16%	Explore
hillock cell	3 studies	27% ± 10%	Explore
squamous epithelial cell	3 studies	37% ± 28%	Explore
pancreatic D cell	3 studies	56% ± 8%	Explore
podocyte	3 studies	67% ± 11%	Explore
neural crest cell	3 studies	38% ± 9%	Explore
renal principal cell	3 studies	55% ± 8%	Explore
thymocyte	3 studies	36% ± 18%	Explore
extravillous trophoblast	3 studies	24% ± 4%	Explore
erythroblast	3 studies	38% ± 16%	Explore
neuroendocrine cell	3 studies	56% ± 19%	Explore
amacrine cell	3 studies	39% ± 5%	Explore
serous secreting cell	3 studies	66% ± 9%	Explore
intraepithelial lymphocyte	3 studies	51% ± 12%	Explore
ON-bipolar cell	3 studies	31% ± 5%	Explore
rod bipolar cell	3 studies	35% ± 7%	Explore
chondrocyte	3 studies	33% ± 16%	Explore
germinal center B cell	3 studies	55% ± 4%	Explore
myoepithelial cell	3 studies	39% ± 10%	Explore
IgM plasma cell	3 studies	36% ± 12%	Explore
pancreatic ductal cell	3 studies	56% ± 4%	Explore
ependymal cell	3 studies	33% ± 17%	Explore
melanocyte	3 studies	25% ± 6%	Explore
keratinocyte	3 studies	27% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	57% ± 9%	Explore
progenitor cell of mammary luminal epithelium	3 studies	37% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	20 studies	43% ± 15%	Explore
peripheral blood	20 studies	43% ± 16%	Explore
brain	14 studies	34% ± 17%	Explore
intestine	12 studies	35% ± 14%	Explore
eye	11 studies	34% ± 16%	Explore
kidney	9 studies	43% ± 6%	Explore
liver	7 studies	39% ± 13%	Explore
bone marrow	6 studies	28% ± 9%	Explore
lymph node	6 studies	46% ± 15%	Explore
heart	6 studies	27% ± 3%	Explore
pancreas	5 studies	50% ± 16%	Explore
placenta	5 studies	25% ± 9%	Explore
adipose	5 studies	28% ± 13%	Explore
prostate	5 studies	27% ± 7%	Explore
uterus	4 studies	49% ± 12%	Explore
esophagus	4 studies	37% ± 25%	Explore
breast	4 studies	38% ± 10%	Explore
adrenal gland	3 studies	41% ± 6%	Explore
stomach	3 studies	35% ± 19%	Explore
thymus	3 studies	55% ± 18%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	7466.43	21 / 21	100%	66.11	504 / 504
esophagus	100%	7248.00	1445 / 1445	100%	52.70	183 / 183
liver	100%	4278.59	226 / 226	100%	51.97	406 / 406
ovary	100%	7918.17	180 / 180	100%	68.19	430 / 430
pancreas	100%	6046.79	328 / 328	100%	72.08	178 / 178
prostate	100%	8087.16	245 / 245	100%	106.91	502 / 502
stomach	100%	6601.07	359 / 359	100%	55.04	286 / 286
thymus	100%	7059.22	653 / 653	100%	105.30	605 / 605
uterus	100%	7507.48	170 / 170	100%	74.03	459 / 459
breast	100%	6632.74	459 / 459	100%	84.20	1117 / 1118
kidney	100%	7269.21	89 / 89	100%	81.06	900 / 901
lung	100%	5759.08	577 / 578	100%	71.68	1155 / 1155
intestine	100%	7473.38	966 / 966	100%	61.83	526 / 527
adrenal gland	100%	8083.51	258 / 258	100%	84.23	229 / 230
brain	99%	3293.76	2615 / 2642	100%	48.47	705 / 705
skin	100%	4680.65	1807 / 1809	98%	44.79	464 / 472
adipose	100%	6381.79	1204 / 1204	0%	0	0 / 0
blood vessel	100%	8686.19	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	91.78	29 / 29
muscle	100%	9576.36	803 / 803	0%	0	0 / 0
spleen	100%	7320.98	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	64.23	45 / 45
ureter	0%	0	0 / 0	100%	31.72	1 / 1
heart	99%	8705.54	850 / 861	0%	0	0 / 0
peripheral blood	98%	4309.40	907 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	95%	42.72	76 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	ANAPC16
Protein name	Anaphase-promoting complex subunit 16 (Cyclosome subunit 16) Anaphase-promoting complex subunit 16 (APC16) (Cyclosome subunit 16)
Synonyms	C10orf104 CENP-27
Description	FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. . FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. .
Accessions	ENST00000299381.5 Q96DE5 ENST00000615507.4 ENST00000621663.4 A0A087WUN5

GO_0016567	Biological process	protein ubiquitination
GO_0031145	Biological process	anaphase-promoting complex-dependent catabolic process
GO_0070936	Biological process	protein K48-linked ubiquitination
GO_0070979	Biological process	protein K11-linked ubiquitination
GO_0051301	Biological process	cell division
GO_0051445	Biological process	regulation of meiotic cell cycle
GO_0007346	Biological process	regulation of mitotic cell cycle
GO_0000776	Cellular component	kinetochore
GO_0005680	Cellular component	anaphase-promoting complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005515	Molecular function	protein binding

ANAPC16 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review