ANAPC11 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	34 studies	38% ± 17%	Explore
natural killer cell	31 studies	34% ± 13%	Explore
macrophage	29 studies	40% ± 14%	Explore
endothelial cell	29 studies	38% ± 17%	Explore
CD8-positive, alpha-beta T cell	29 studies	34% ± 17%	Explore
CD4-positive, alpha-beta T cell	27 studies	31% ± 18%	Explore
T cell	26 studies	31% ± 13%	Explore
B cell	25 studies	28% ± 12%	Explore
pericyte	25 studies	40% ± 17%	Explore
classical monocyte	24 studies	38% ± 16%	Explore
conventional dendritic cell	24 studies	40% ± 15%	Explore
smooth muscle cell	23 studies	42% ± 15%	Explore
non-classical monocyte	22 studies	42% ± 16%	Explore
epithelial cell	21 studies	48% ± 21%	Explore
regulatory T cell	20 studies	32% ± 10%	Explore
plasmacytoid dendritic cell	19 studies	42% ± 14%	Explore
monocyte	18 studies	37% ± 13%	Explore
plasma cell	17 studies	44% ± 14%	Explore
basal cell	17 studies	45% ± 17%	Explore
dendritic cell	17 studies	39% ± 20%	Explore
connective tissue cell	17 studies	45% ± 17%	Explore
endothelial cell of lymphatic vessel	16 studies	40% ± 14%	Explore
memory B cell	16 studies	24% ± 8%	Explore
ciliated cell	16 studies	47% ± 19%	Explore
mast cell	14 studies	27% ± 13%	Explore
mature NK T cell	14 studies	29% ± 6%	Explore
gamma-delta T cell	14 studies	34% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	34% ± 9%	Explore
naive B cell	13 studies	22% ± 6%	Explore
myofibroblast cell	13 studies	45% ± 16%	Explore
secretory cell	12 studies	42% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	24% ± 5%	Explore
capillary endothelial cell	12 studies	32% ± 14%	Explore
plasmablast	11 studies	52% ± 23%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	31% ± 7%	Explore
endothelial cell of artery	11 studies	37% ± 16%	Explore
goblet cell	11 studies	34% ± 17%	Explore
vein endothelial cell	11 studies	34% ± 16%	Explore
myeloid cell	11 studies	48% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	32% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	34% ± 8%	Explore
abnormal cell	10 studies	47% ± 21%	Explore
mucosal invariant T cell	10 studies	27% ± 5%	Explore
endothelial cell of vascular tree	10 studies	29% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	31% ± 11%	Explore
progenitor cell	9 studies	48% ± 14%	Explore
type I pneumocyte	8 studies	38% ± 17%	Explore
type II pneumocyte	8 studies	46% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	29% ± 8%	Explore
T follicular helper cell	8 studies	31% ± 10%	Explore
club cell	7 studies	51% ± 8%	Explore
epithelial cell of proximal tubule	7 studies	40% ± 14%	Explore
mesothelial cell	7 studies	46% ± 22%	Explore
hematopoietic precursor cell	6 studies	39% ± 20%	Explore
respiratory goblet cell	6 studies	44% ± 20%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	45% ± 16%	Explore
leukocyte	6 studies	36% ± 15%	Explore
kidney loop of Henle epithelial cell	6 studies	37% ± 9%	Explore
renal alpha-intercalated cell	6 studies	56% ± 6%	Explore
enterocyte	6 studies	30% ± 8%	Explore
transit amplifying cell	6 studies	40% ± 21%	Explore
innate lymphoid cell	6 studies	25% ± 5%	Explore
neuron	6 studies	51% ± 22%	Explore
erythrocyte	6 studies	40% ± 18%	Explore
alveolar macrophage	5 studies	38% ± 9%	Explore
ionocyte	5 studies	38% ± 11%	Explore
mononuclear phagocyte	5 studies	40% ± 18%	Explore
enteroendocrine cell	5 studies	51% ± 20%	Explore
erythroblast	5 studies	40% ± 27%	Explore
intestinal crypt stem cell	5 studies	30% ± 13%	Explore
precursor B cell	5 studies	32% ± 12%	Explore
pro-B cell	5 studies	34% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	33% ± 13%	Explore
platelet	4 studies	22% ± 6%	Explore
pancreatic A cell	4 studies	65% ± 18%	Explore
type B pancreatic cell	4 studies	54% ± 20%	Explore
exhausted T cell	4 studies	41% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	53% ± 13%	Explore
IgA plasma cell	4 studies	23% ± 8%	Explore
retinal ganglion cell	4 studies	61% ± 27%	Explore
retinal cone cell	4 studies	59% ± 26%	Explore
hematopoietic stem cell	4 studies	34% ± 3%	Explore
megakaryocyte	4 studies	31% ± 5%	Explore
brush cell	4 studies	31% ± 14%	Explore
amacrine cell	4 studies	42% ± 19%	Explore
astrocyte	4 studies	37% ± 17%	Explore
adventitial cell	4 studies	33% ± 5%	Explore
mucus secreting cell	4 studies	45% ± 24%	Explore
neutrophil	4 studies	19% ± 2%	Explore
oligodendrocyte	4 studies	22% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	43% ± 3%	Explore
intermediate monocyte	4 studies	56% ± 11%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	53% ± 8%	Explore
glutamatergic neuron	4 studies	26% ± 8%	Explore
oligodendrocyte precursor cell	4 studies	38% ± 13%	Explore
T-helper 17 cell	4 studies	40% ± 25%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	29% ± 6%	Explore
deuterosomal cell	3 studies	56% ± 6%	Explore
duct epithelial cell	3 studies	44% ± 13%	Explore
precursor cell	3 studies	64% ± 16%	Explore
glomerular endothelial cell	3 studies	24% ± 4%	Explore
neural crest cell	3 studies	67% ± 12%	Explore
IgG plasma cell	3 studies	31% ± 8%	Explore
extravillous trophoblast	3 studies	64% ± 15%	Explore
placental villous trophoblast	3 studies	72% ± 13%	Explore
common myeloid progenitor	3 studies	42% ± 19%	Explore
lymphocyte	3 studies	48% ± 17%	Explore
neuroendocrine cell	3 studies	52% ± 18%	Explore
immature B cell	3 studies	28% ± 5%	Explore
retina horizontal cell	3 studies	40% ± 18%	Explore
retinal rod cell	3 studies	36% ± 11%	Explore
microglial cell	3 studies	31% ± 13%	Explore
serous secreting cell	3 studies	59% ± 13%	Explore
intraepithelial lymphocyte	3 studies	31% ± 7%	Explore
Mueller cell	3 studies	36% ± 9%	Explore
acinar cell	3 studies	23% ± 7%	Explore
muscle cell	3 studies	43% ± 19%	Explore
germinal center B cell	3 studies	38% ± 5%	Explore
myoepithelial cell	3 studies	40% ± 13%	Explore
inflammatory macrophage	3 studies	25% ± 6%	Explore
luminal cell of prostate epithelium	3 studies	49% ± 13%	Explore
glial cell	3 studies	45% ± 24%	Explore
hepatocyte	3 studies	56% ± 29%	Explore
group 3 innate lymphoid cell	3 studies	38% ± 13%	Explore
keratinocyte	3 studies	31% ± 3%	Explore
T-helper 1 cell	3 studies	38% ± 14%	Explore
double negative thymocyte	3 studies	44% ± 16%	Explore
progenitor cell of mammary luminal epithelium	3 studies	34% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	17 studies	41% ± 16%	Explore
peripheral blood	16 studies	34% ± 9%	Explore
intestine	12 studies	32% ± 18%	Explore
kidney	8 studies	37% ± 9%	Explore
eye	8 studies	30% ± 14%	Explore
brain	7 studies	27% ± 7%	Explore
liver	7 studies	34% ± 23%	Explore
pancreas	5 studies	46% ± 24%	Explore
lymph node	5 studies	39% ± 17%	Explore
placenta	4 studies	50% ± 24%	Explore
bone marrow	4 studies	32% ± 8%	Explore
uterus	4 studies	45% ± 19%	Explore
breast	4 studies	35% ± 7%	Explore
adrenal gland	3 studies	33% ± 7%	Explore
prostate	3 studies	33% ± 6%	Explore
skin	3 studies	28% ± 2%	Explore
thymus	3 studies	47% ± 21%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2543.46	1445 / 1445	100%	40.40	183 / 183
liver	100%	2113.66	226 / 226	100%	72.33	406 / 406
ovary	100%	1693.15	180 / 180	100%	59.87	430 / 430
pancreas	100%	1362.45	328 / 328	100%	48.23	178 / 178
uterus	100%	1866.06	170 / 170	100%	85.01	459 / 459
brain	100%	2629.19	2638 / 2642	100%	74.76	705 / 705
thymus	100%	2197.96	653 / 653	100%	53.77	603 / 605
intestine	100%	2442.25	966 / 966	99%	68.54	523 / 527
prostate	100%	2456.93	245 / 245	99%	69.03	498 / 502
adrenal gland	100%	2578.99	258 / 258	99%	49.23	228 / 230
stomach	100%	2089.04	359 / 359	99%	56.78	283 / 286
skin	100%	2720.70	1808 / 1809	99%	59.43	467 / 472
kidney	100%	2513.81	89 / 89	99%	37.94	889 / 901
bladder	100%	2200.00	21 / 21	99%	83.13	497 / 504
breast	100%	2386.09	459 / 459	98%	60.52	1101 / 1118
lung	100%	2115.95	576 / 578	99%	61.83	1140 / 1155
adipose	100%	2391.43	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	46.72	80 / 80
lymph node	0%	0	0 / 0	100%	78.94	29 / 29
spleen	100%	1934.13	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	60.76	45 / 45
ureter	0%	0	0 / 0	100%	88.97	1 / 1
muscle	100%	3710.58	802 / 803	0%	0	0 / 0
blood vessel	100%	2469.43	1332 / 1335	0%	0	0 / 0
heart	99%	3067.24	854 / 861	0%	0	0 / 0
peripheral blood	94%	1572.33	870 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0016567	Biological process	protein ubiquitination
GO_0070979	Biological process	protein K11-linked ubiquitination
GO_0051445	Biological process	regulation of meiotic cell cycle
GO_0000278	Biological process	mitotic cell cycle
GO_0045842	Biological process	positive regulation of mitotic metaphase/anaphase transition
GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0051301	Biological process	cell division
GO_0031145	Biological process	anaphase-promoting complex-dependent catabolic process
GO_0070936	Biological process	protein K48-linked ubiquitination
GO_0007346	Biological process	regulation of mitotic cell cycle
GO_0005730	Cellular component	nucleolus
GO_0005680	Cellular component	anaphase-promoting complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005634	Cellular component	nucleus
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0034450	Molecular function	ubiquitin-ubiquitin ligase activity
GO_0097602	Molecular function	cullin family protein binding
GO_0008270	Molecular function	zinc ion binding
GO_0004842	Molecular function	ubiquitin-protein transferase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ANAPC11
Protein name	Anaphase promoting complex subunit 11 Anaphase-promoting complex subunit 11 (APC11) (Cyclosome subunit 11) (Hepatocellular carcinoma-associated RING finger protein)
Synonyms	HSPC214
Description	FUNCTION: Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. .
Accessions	Q9NYG5 A0A087X1B5 ENST00000571570.5 [Q9NYG5-1] ENST00000572639.5 [Q9NYG5-1] ENST00000578544.1 ENST00000392376.7 [Q9NYG5-1] ENST00000578550.5 [Q9NYG5-1] ENST00000571024.6 [Q9NYG5-1] ENST00000357385.7 [Q9NYG5-2] ENST00000585259.1 ENST00000583839.1 [Q9NYG5-1] ENST00000571874.6 [Q9NYG5-1] ENST00000584197.5 ENST00000344877.10 [Q9NYG5-1] J3KSK3 ENST00000575195.2 [Q9NYG5-1] ENST00000577425.5 J3QL35 ENST00000577747.5 [Q9NYG5-1] ENST00000579978.5 [Q9NYG5-1] ENST00000584314.5 ENST00000574924.6 [Q9NYG5-1] J3QS46 ENST00000579133.5 ENST00000572851.6 [Q9NYG5-1] ENST00000612413.4 ENST00000582222.5

ANAPC11 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review