VPS28 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	35 studies	32% ± 10%	Explore
natural killer cell	33 studies	36% ± 10%	Explore
endothelial cell	33 studies	39% ± 16%	Explore
fibroblast	32 studies	39% ± 15%	Explore
macrophage	30 studies	37% ± 12%	Explore
CD4-positive, alpha-beta T cell	29 studies	34% ± 10%	Explore
CD8-positive, alpha-beta T cell	29 studies	34% ± 11%	Explore
pericyte	28 studies	42% ± 15%	Explore
conventional dendritic cell	27 studies	41% ± 15%	Explore
T cell	26 studies	30% ± 8%	Explore
classical monocyte	25 studies	38% ± 15%	Explore
regulatory T cell	24 studies	38% ± 11%	Explore
non-classical monocyte	23 studies	45% ± 16%	Explore
smooth muscle cell	22 studies	42% ± 14%	Explore
memory B cell	20 studies	30% ± 9%	Explore
epithelial cell	19 studies	44% ± 22%	Explore
dendritic cell	18 studies	41% ± 21%	Explore
mast cell	18 studies	41% ± 13%	Explore
monocyte	18 studies	36% ± 9%	Explore
basal cell	18 studies	33% ± 18%	Explore
naive B cell	18 studies	27% ± 8%	Explore
mature NK T cell	17 studies	35% ± 11%	Explore
connective tissue cell	17 studies	42% ± 17%	Explore
endothelial cell of lymphatic vessel	16 studies	49% ± 12%	Explore
ciliated cell	16 studies	45% ± 18%	Explore
plasmacytoid dendritic cell	16 studies	30% ± 12%	Explore
gamma-delta T cell	16 studies	36% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	38% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	37% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	34% ± 9%	Explore
myofibroblast cell	14 studies	46% ± 16%	Explore
plasma cell	12 studies	35% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	38% ± 11%	Explore
capillary endothelial cell	12 studies	36% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	35% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	36% ± 12%	Explore
endothelial cell of artery	11 studies	39% ± 14%	Explore
vein endothelial cell	11 studies	38% ± 14%	Explore
mucosal invariant T cell	11 studies	35% ± 9%	Explore
abnormal cell	10 studies	38% ± 14%	Explore
endothelial cell of vascular tree	10 studies	35% ± 10%	Explore
myeloid cell	10 studies	36% ± 14%	Explore
platelet	9 studies	31% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	37% ± 13%	Explore
goblet cell	9 studies	36% ± 15%	Explore
type I pneumocyte	8 studies	39% ± 12%	Explore
innate lymphoid cell	8 studies	31% ± 10%	Explore
secretory cell	8 studies	41% ± 17%	Explore
progenitor cell	8 studies	35% ± 12%	Explore
type II pneumocyte	7 studies	36% ± 17%	Explore
plasmablast	7 studies	45% ± 23%	Explore
club cell	7 studies	32% ± 8%	Explore
leukocyte	7 studies	35% ± 11%	Explore
enterocyte	7 studies	39% ± 14%	Explore
T follicular helper cell	7 studies	36% ± 7%	Explore
alveolar macrophage	6 studies	33% ± 9%	Explore
hematopoietic precursor cell	6 studies	37% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	41% ± 8%	Explore
epithelial cell of proximal tubule	6 studies	42% ± 11%	Explore
neuron	6 studies	56% ± 25%	Explore
mesothelial cell	6 studies	50% ± 15%	Explore
hematopoietic stem cell	6 studies	36% ± 15%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	38% ± 15%	Explore
CD4-positive helper T cell	5 studies	22% ± 7%	Explore
exhausted T cell	5 studies	50% ± 9%	Explore
ionocyte	5 studies	31% ± 11%	Explore
mononuclear phagocyte	5 studies	44% ± 20%	Explore
kidney loop of Henle epithelial cell	5 studies	38% ± 9%	Explore
renal alpha-intercalated cell	5 studies	45% ± 9%	Explore
enteroendocrine cell	5 studies	45% ± 20%	Explore
precursor B cell	5 studies	36% ± 10%	Explore
brush cell	5 studies	34% ± 9%	Explore
astrocyte	5 studies	27% ± 14%	Explore
granulocyte	5 studies	38% ± 17%	Explore
respiratory goblet cell	4 studies	34% ± 19%	Explore
squamous epithelial cell	4 studies	33% ± 25%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	47% ± 3%	Explore
transit amplifying cell	4 studies	22% ± 4%	Explore
retinal ganglion cell	4 studies	68% ± 22%	Explore
megakaryocyte	4 studies	43% ± 10%	Explore
pro-B cell	4 studies	39% ± 9%	Explore
immature B cell	4 studies	43% ± 14%	Explore
amacrine cell	4 studies	39% ± 15%	Explore
adventitial cell	4 studies	28% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	54% ± 4%	Explore
intermediate monocyte	4 studies	52% ± 20%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	40% ± 9%	Explore
erythrocyte	4 studies	39% ± 19%	Explore
neutrophil	4 studies	25% ± 5%	Explore
group 3 innate lymphoid cell	4 studies	46% ± 12%	Explore
T-helper 17 cell	4 studies	30% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	35% ± 8%	Explore
deuterosomal cell	3 studies	20% ± 6%	Explore
duct epithelial cell	3 studies	27% ± 7%	Explore
precursor cell	3 studies	47% ± 13%	Explore
pancreatic A cell	3 studies	50% ± 19%	Explore
glomerular endothelial cell	3 studies	30% ± 7%	Explore
intestinal crypt stem cell	3 studies	31% ± 7%	Explore
neural crest cell	3 studies	43% ± 1%	Explore
retinal bipolar neuron	3 studies	36% ± 12%	Explore
erythroblast	3 studies	35% ± 22%	Explore
lymphocyte	3 studies	45% ± 7%	Explore
neuroendocrine cell	3 studies	42% ± 14%	Explore
retina horizontal cell	3 studies	34% ± 15%	Explore
retinal cone cell	3 studies	46% ± 8%	Explore
retinal rod cell	3 studies	33% ± 6%	Explore
microglial cell	3 studies	33% ± 14%	Explore
mucus secreting cell	3 studies	34% ± 11%	Explore
serous secreting cell	3 studies	30% ± 5%	Explore
intraepithelial lymphocyte	3 studies	40% ± 14%	Explore
Mueller cell	3 studies	32% ± 9%	Explore
germinal center B cell	3 studies	32% ± 6%	Explore
myoepithelial cell	3 studies	39% ± 17%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	51% ± 29%	Explore
glial cell	3 studies	44% ± 23%	Explore
hepatocyte	3 studies	37% ± 30%	Explore
keratinocyte	3 studies	24% ± 4%	Explore
T-helper 1 cell	3 studies	42% ± 8%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	38% ± 13%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	33% ± 14%	Explore
double negative thymocyte	3 studies	51% ± 16%	Explore
progenitor cell of mammary luminal epithelium	3 studies	30% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	39% ± 11%	Explore
lung	16 studies	40% ± 14%	Explore
intestine	12 studies	34% ± 16%	Explore
kidney	8 studies	39% ± 9%	Explore
eye	7 studies	29% ± 11%	Explore
brain	5 studies	22% ± 6%	Explore
lymph node	5 studies	43% ± 16%	Explore
liver	5 studies	35% ± 18%	Explore
bone marrow	4 studies	28% ± 10%	Explore
uterus	4 studies	50% ± 13%	Explore
breast	4 studies	32% ± 5%	Explore
pancreas	3 studies	42% ± 18%	Explore
placenta	3 studies	24% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	6289.84	258 / 258	100%	106.30	230 / 230
esophagus	100%	6234.85	1445 / 1445	100%	60.93	183 / 183
liver	100%	4120.46	226 / 226	100%	127.82	406 / 406
ovary	100%	9038.63	180 / 180	100%	144.55	430 / 430
pancreas	100%	4159.06	328 / 328	100%	112.51	178 / 178
skin	100%	6388.01	1809 / 1809	100%	116.95	472 / 472
thymus	100%	8918.65	653 / 653	100%	136.72	605 / 605
uterus	100%	8032.48	170 / 170	100%	106.92	459 / 459
brain	100%	5447.65	2637 / 2642	100%	122.63	705 / 705
kidney	100%	7661.53	89 / 89	100%	94.20	897 / 901
intestine	100%	7535.03	966 / 966	99%	99.57	524 / 527
stomach	100%	5920.51	359 / 359	99%	84.17	284 / 286
prostate	100%	8736.75	245 / 245	99%	144.29	498 / 502
breast	100%	7070.94	459 / 459	99%	128.02	1109 / 1118
lung	100%	6897.27	578 / 578	99%	88.27	1142 / 1155
bladder	100%	6800.48	21 / 21	98%	118.12	496 / 504
adipose	100%	6354.38	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	235.90	80 / 80
lymph node	0%	0	0 / 0	100%	133.98	29 / 29
peripheral blood	100%	5812.84	929 / 929	0%	0	0 / 0
spleen	100%	9397.89	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	92.37	45 / 45
ureter	0%	0	0 / 0	100%	288.98	1 / 1
blood vessel	100%	6760.20	1334 / 1335	0%	0	0 / 0
heart	100%	4692.86	859 / 861	0%	0	0 / 0
muscle	100%	4427.22	801 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0039702	Biological process	viral budding via host ESCRT complex
GO_0036258	Biological process	multivesicular body assembly
GO_0016236	Biological process	macroautophagy
GO_0043162	Biological process	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO_0090148	Biological process	membrane fission
GO_0045732	Biological process	positive regulation of protein catabolic process
GO_2000397	Biological process	positive regulation of ubiquitin-dependent endocytosis
GO_0043328	Biological process	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO_0031397	Biological process	negative regulation of protein ubiquitination
GO_0031902	Cellular component	late endosome membrane
GO_0005886	Cellular component	plasma membrane
GO_0005769	Cellular component	early endosome
GO_0070062	Cellular component	extracellular exosome
GO_0000813	Cellular component	ESCRT I complex
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0010008	Cellular component	endosome membrane
GO_0005768	Cellular component	endosome
GO_0044877	Molecular function	protein-containing complex binding
GO_0005515	Molecular function	protein binding
GO_0043130	Molecular function	ubiquitin binding

IV. Literature review

[source]

Gene name	VPS28
Protein name	Vacuolar protein sorting-associated protein 28 homolog Vacuolar protein sorting-associated protein 28 homolog (H-Vps28) (ESCRT-I complex subunit VPS28) VPS28 subunit of ESCRT-I
Synonyms	hCG_24005
Description	FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. . FUNCTION: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. .
Accessions	ENST00000530790.5 E9PQR7 ENST00000529182.5 [Q9UK41-2] ENST00000643186.2 [Q9UK41-1] ENST00000646588.1 [Q9UK41-2] E9PM90 E9PLM9 A0A0S2Z5H5 ENST00000530836.5 ENST00000526054.5 [Q9UK41-1] ENST00000377348.6 [Q9UK41-2] ENST00000292510.6 [Q9UK41-1] ENST00000642202.1 [Q9UK41-2] Q9UK41 ENST00000531032.5 ENST00000642867.1 [Q9UK41-1] E9PR04 Q548N1 ENST00000526204.5 ENST00000533806.5

VPS28 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review