VAMP8 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	42 studies	65% ± 23%	Explore
natural killer cell	38 studies	46% ± 13%	Explore
B cell	35 studies	33% ± 11%	Explore
CD8-positive, alpha-beta T cell	32 studies	40% ± 12%	Explore
T cell	30 studies	36% ± 12%	Explore
CD4-positive, alpha-beta T cell	29 studies	39% ± 11%	Explore
conventional dendritic cell	28 studies	78% ± 12%	Explore
classical monocyte	26 studies	62% ± 18%	Explore
regulatory T cell	26 studies	42% ± 16%	Explore
dendritic cell	25 studies	59% ± 24%	Explore
plasmacytoid dendritic cell	24 studies	79% ± 16%	Explore
non-classical monocyte	23 studies	65% ± 14%	Explore
epithelial cell	22 studies	58% ± 22%	Explore
mast cell	21 studies	42% ± 16%	Explore
monocyte	21 studies	61% ± 20%	Explore
mature NK T cell	20 studies	42% ± 12%	Explore
memory B cell	19 studies	29% ± 8%	Explore
basal cell	19 studies	50% ± 19%	Explore
naive B cell	18 studies	28% ± 7%	Explore
ciliated cell	17 studies	69% ± 18%	Explore
gamma-delta T cell	17 studies	43% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	49% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	32% ± 10%	Explore
myeloid cell	15 studies	60% ± 24%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	40% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	41% ± 13%	Explore
mucosal invariant T cell	13 studies	34% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	39% ± 16%	Explore
endothelial cell	11 studies	24% ± 8%	Explore
plasma cell	11 studies	40% ± 12%	Explore
secretory cell	11 studies	65% ± 14%	Explore
innate lymphoid cell	10 studies	44% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	43% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	41% ± 12%	Explore
goblet cell	10 studies	44% ± 15%	Explore
type I pneumocyte	9 studies	63% ± 18%	Explore
type II pneumocyte	9 studies	57% ± 21%	Explore
plasmablast	9 studies	39% ± 26%	Explore
hematopoietic stem cell	9 studies	62% ± 23%	Explore
club cell	8 studies	71% ± 20%	Explore
platelet	8 studies	27% ± 10%	Explore
leukocyte	8 studies	50% ± 18%	Explore
neutrophil	8 studies	43% ± 19%	Explore
enterocyte	8 studies	53% ± 23%	Explore
T follicular helper cell	8 studies	39% ± 10%	Explore
alveolar macrophage	7 studies	66% ± 27%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	45% ± 16%	Explore
mononuclear phagocyte	7 studies	61% ± 23%	Explore
epithelial cell of proximal tubule	7 studies	46% ± 13%	Explore
precursor B cell	7 studies	50% ± 17%	Explore
progenitor cell	7 studies	54% ± 22%	Explore
hematopoietic precursor cell	6 studies	71% ± 19%	Explore
ionocyte	6 studies	52% ± 7%	Explore
respiratory goblet cell	6 studies	69% ± 16%	Explore
kidney loop of Henle epithelial cell	6 studies	51% ± 8%	Explore
abnormal cell	6 studies	38% ± 19%	Explore
microglial cell	6 studies	52% ± 19%	Explore
intermediate monocyte	6 studies	70% ± 24%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	47% ± 18%	Explore
CD4-positive helper T cell	5 studies	28% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	37% ± 12%	Explore
exhausted T cell	5 studies	54% ± 14%	Explore
renal alpha-intercalated cell	5 studies	70% ± 6%	Explore
capillary endothelial cell	5 studies	23% ± 3%	Explore
transit amplifying cell	5 studies	30% ± 12%	Explore
erythroblast	5 studies	36% ± 15%	Explore
brush cell	5 studies	33% ± 17%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	56% ± 19%	Explore
granulocyte	5 studies	45% ± 23%	Explore
deuterosomal cell	4 studies	56% ± 12%	Explore
duct epithelial cell	4 studies	84% ± 2%	Explore
squamous epithelial cell	4 studies	54% ± 20%	Explore
pancreatic A cell	4 studies	43% ± 24%	Explore
pro-B cell	4 studies	57% ± 3%	Explore
immature B cell	4 studies	48% ± 18%	Explore
endothelial cell of artery	4 studies	25% ± 7%	Explore
mucus secreting cell	4 studies	64% ± 23%	Explore
acinar cell	4 studies	36% ± 19%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	67% ± 5%	Explore
group 3 innate lymphoid cell	4 studies	56% ± 11%	Explore
T-helper 17 cell	4 studies	47% ± 11%	Explore
double negative thymocyte	4 studies	48% ± 15%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	45% ± 21%	Explore
monocyte-derived dendritic cell	3 studies	63% ± 33%	Explore
podocyte	3 studies	33% ± 5%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	44% ± 14%	Explore
intestinal crypt stem cell	3 studies	35% ± 10%	Explore
IgG plasma cell	3 studies	17% ± 0%	Explore
renal principal cell	3 studies	51% ± 1%	Explore
extravillous trophoblast	3 studies	67% ± 14%	Explore
placental villous trophoblast	3 studies	82% ± 19%	Explore
common myeloid progenitor	3 studies	75% ± 15%	Explore
megakaryocyte	3 studies	43% ± 10%	Explore
neuroendocrine cell	3 studies	37% ± 14%	Explore
serous secreting cell	3 studies	70% ± 10%	Explore
mesothelial cell	3 studies	18% ± 1%	Explore
tissue-resident macrophage	3 studies	57% ± 24%	Explore
intraepithelial lymphocyte	3 studies	48% ± 8%	Explore
germinal center B cell	3 studies	42% ± 1%	Explore
inflammatory macrophage	3 studies	66% ± 18%	Explore
luminal cell of prostate epithelium	3 studies	48% ± 12%	Explore
pancreatic ductal cell	3 studies	74% ± 3%	Explore
granulocyte monocyte progenitor cell	3 studies	85% ± 12%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	70% ± 19%	Explore
hepatocyte	3 studies	47% ± 21%	Explore
erythrocyte	3 studies	35% ± 8%	Explore
keratinocyte	3 studies	47% ± 5%	Explore
T-helper 1 cell	3 studies	51% ± 7%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	42% ± 9%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	36% ± 13%	Explore
progenitor cell of mammary luminal epithelium	3 studies	41% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	47% ± 14%	Explore
lung	17 studies	44% ± 18%	Explore
intestine	13 studies	28% ± 15%	Explore
kidney	9 studies	40% ± 13%	Explore
liver	6 studies	35% ± 12%	Explore
pancreas	5 studies	39% ± 18%	Explore
bone marrow	5 studies	36% ± 12%	Explore
placenta	4 studies	56% ± 26%	Explore
prostate	4 studies	31% ± 11%	Explore
lymph node	4 studies	45% ± 25%	Explore
breast	4 studies	34% ± 8%	Explore
uterus	3 studies	44% ± 10%	Explore
thymus	3 studies	52% ± 29%	Explore
brain	3 studies	39% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	3762.43	653 / 653	100%	588.90	604 / 605
kidney	100%	6492.73	89 / 89	100%	433.02	897 / 901
lung	100%	5957.38	577 / 578	99%	553.79	1145 / 1155
pancreas	100%	3079.41	328 / 328	98%	479.88	175 / 178
liver	100%	2765.53	226 / 226	97%	295.59	392 / 406
prostate	97%	3146.18	237 / 245	99%	351.70	495 / 502
breast	95%	2370.32	438 / 459	99%	528.65	1109 / 1118
stomach	87%	3034.01	311 / 359	98%	302.81	281 / 286
bladder	76%	1774.62	16 / 21	98%	556.18	493 / 504
intestine	68%	2594.59	658 / 966	99%	366.11	522 / 527
esophagus	60%	3171.83	869 / 1445	100%	264.94	183 / 183
skin	72%	3976.49	1305 / 1809	73%	178.53	345 / 472
uterus	21%	260.58	36 / 170	93%	512.07	425 / 459
ovary	8%	74.74	15 / 180	100%	410.98	428 / 430
lymph node	0%	0	0 / 0	100%	822.15	29 / 29
spleen	100%	5200.29	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	454.50	45 / 45
ureter	0%	0	0 / 0	100%	394.00	1 / 1
peripheral blood	98%	2979.58	910 / 929	0%	0	0 / 0
adipose	92%	1562.66	1108 / 1204	0%	0	0 / 0
adrenal gland	76%	859.01	196 / 258	9%	21.11	21 / 230
brain	10%	100.05	272 / 2642	39%	67.91	277 / 705
eye	0%	0	0 / 0	41%	76.49	33 / 80
blood vessel	37%	492.89	492 / 1335	0%	0	0 / 0
heart	19%	191.69	166 / 861	0%	0	0 / 0
muscle	7%	54.08	55 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043308	Biological process	eosinophil degranulation
GO_0051607	Biological process	defense response to virus
GO_1903531	Biological process	negative regulation of secretion by cell
GO_0035493	Biological process	SNARE complex assembly
GO_0016240	Biological process	autophagosome membrane docking
GO_1903595	Biological process	positive regulation of histamine secretion by mast cell
GO_0046718	Biological process	symbiont entry into host cell
GO_0043312	Biological process	neutrophil degranulation
GO_0015031	Biological process	protein transport
GO_0006906	Biological process	vesicle fusion
GO_1903076	Biological process	regulation of protein localization to plasma membrane
GO_0070254	Biological process	mucus secretion
GO_0097352	Biological process	autophagosome maturation
GO_0030667	Cellular component	secretory granule membrane
GO_0031902	Cellular component	late endosome membrane
GO_0035579	Cellular component	specific granule membrane
GO_0005886	Cellular component	plasma membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0055037	Cellular component	recycling endosome
GO_0005769	Cellular component	early endosome
GO_0031901	Cellular component	early endosome membrane
GO_0035577	Cellular component	azurophil granule membrane
GO_0070062	Cellular component	extracellular exosome
GO_0055038	Cellular component	recycling endosome membrane
GO_0030669	Cellular component	clathrin-coated endocytic vesicle membrane
GO_0005829	Cellular component	cytosol
GO_0070821	Cellular component	tertiary granule membrane
GO_0098594	Cellular component	mucin granule
GO_0042589	Cellular component	zymogen granule membrane
GO_0005737	Cellular component	cytoplasm
GO_0030670	Cellular component	phagocytic vesicle membrane
GO_0031982	Cellular component	vesicle
GO_0031201	Cellular component	SNARE complex
GO_0005765	Cellular component	lysosomal membrane
GO_0019905	Molecular function	syntaxin binding
GO_0005484	Molecular function	SNAP receptor activity
GO_0005515	Molecular function	protein binding
GO_0019869	Molecular function	chloride channel inhibitor activity

IV. Literature review

[source]

Gene name	VAMP8
Protein name	Vesicle-associated membrane protein 8 (Endobrevin) Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB)
Synonyms
Description	FUNCTION: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex . Also required for dense-granule secretion in platelets . Also plays a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes (By similarity). Participates also in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism . .
Accessions	Q9BV40 ENST00000432071.1 ENST00000409760.1 B8ZZT4 ENST00000263864.10 C9JXZ5

VAMP8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review