UBE2N report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_1902523Biological processpositive regulation of protein K63-linked ubiquitination
GO_0045739Biological processpositive regulation of DNA repair
GO_0006282Biological processregulation of DNA repair
GO_1902533Biological processpositive regulation of intracellular signal transduction
GO_0006301Biological processpostreplication repair
GO_0050852Biological processT cell receptor signaling pathway
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0000729Biological processDNA double-strand break processing
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0070534Biological processprotein K63-linked ubiquitination
GO_2000781Biological processpositive regulation of double-strand break repair
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0140374Biological processantiviral innate immune response
GO_0000151Cellular componentubiquitin ligase complex
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0031371Cellular componentubiquitin conjugating enzyme complex
GO_0005737Cellular componentcytoplasm
GO_0031372Cellular componentUBC13-MMS2 complex
GO_0005634Cellular componentnucleus
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0061631Molecular functionubiquitin conjugating enzyme activity
GO_0097027Molecular functionubiquitin-protein transferase activator activity
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameUBE2N
Protein nameUbiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)
E2 ubiquitin-conjugating enzyme (EC 2.3.2.23)
Ubiquitin conjugating enzyme E2 N
SynonymshCG_38950
BLU
HEL-S-71
DescriptionFUNCTION: The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production . UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway. .

AccessionsF8VV71
P61088
ENST00000552442.1
ENST00000549833.1
V9HW41
F8VZ29
F8VQQ8
F8VSD4
ENST00000549490.1
ENST00000550657.1
ENST00000318066.7