TRMT112 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	41 studies	44% ± 14%	Explore
natural killer cell	36 studies	44% ± 12%	Explore
fibroblast	35 studies	49% ± 18%	Explore
CD8-positive, alpha-beta T cell	35 studies	47% ± 17%	Explore
endothelial cell	34 studies	46% ± 20%	Explore
macrophage	31 studies	43% ± 15%	Explore
CD4-positive, alpha-beta T cell	31 studies	45% ± 15%	Explore
T cell	30 studies	44% ± 14%	Explore
pericyte	29 studies	50% ± 17%	Explore
conventional dendritic cell	28 studies	48% ± 14%	Explore
smooth muscle cell	25 studies	51% ± 17%	Explore
regulatory T cell	25 studies	46% ± 14%	Explore
classical monocyte	24 studies	36% ± 14%	Explore
plasma cell	22 studies	51% ± 20%	Explore
non-classical monocyte	21 studies	37% ± 13%	Explore
plasmacytoid dendritic cell	21 studies	48% ± 15%	Explore
epithelial cell	21 studies	52% ± 23%	Explore
dendritic cell	20 studies	43% ± 23%	Explore
memory B cell	20 studies	45% ± 12%	Explore
naive B cell	20 studies	37% ± 12%	Explore
monocyte	19 studies	36% ± 12%	Explore
mature NK T cell	19 studies	43% ± 11%	Explore
basal cell	19 studies	51% ± 17%	Explore
mast cell	18 studies	46% ± 14%	Explore
connective tissue cell	18 studies	51% ± 20%	Explore
endothelial cell of lymphatic vessel	17 studies	57% ± 14%	Explore
ciliated cell	17 studies	56% ± 20%	Explore
gamma-delta T cell	17 studies	48% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	34% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	36% ± 15%	Explore
mucosal invariant T cell	15 studies	36% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	41% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	42% ± 11%	Explore
myofibroblast cell	13 studies	56% ± 17%	Explore
myeloid cell	13 studies	45% ± 17%	Explore
plasmablast	12 studies	55% ± 20%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	47% ± 14%	Explore
capillary endothelial cell	12 studies	41% ± 15%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	42% ± 16%	Explore
endothelial cell of artery	11 studies	46% ± 14%	Explore
vein endothelial cell	11 studies	49% ± 15%	Explore
endothelial cell of vascular tree	11 studies	52% ± 9%	Explore
innate lymphoid cell	10 studies	46% ± 14%	Explore
secretory cell	10 studies	46% ± 18%	Explore
abnormal cell	10 studies	56% ± 18%	Explore
mesothelial cell	10 studies	64% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	44% ± 11%	Explore
type I pneumocyte	8 studies	47% ± 19%	Explore
type II pneumocyte	8 studies	50% ± 25%	Explore
leukocyte	8 studies	42% ± 11%	Explore
progenitor cell	8 studies	54% ± 20%	Explore
goblet cell	8 studies	29% ± 15%	Explore
IgG plasma cell	8 studies	31% ± 11%	Explore
T follicular helper cell	8 studies	47% ± 7%	Explore
club cell	7 studies	41% ± 18%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	55% ± 12%	Explore
epithelial cell of proximal tubule	7 studies	47% ± 16%	Explore
neuron	7 studies	46% ± 24%	Explore
precursor B cell	7 studies	46% ± 18%	Explore
hematopoietic precursor cell	6 studies	47% ± 27%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	52% ± 14%	Explore
kidney loop of Henle epithelial cell	6 studies	42% ± 6%	Explore
renal alpha-intercalated cell	6 studies	62% ± 10%	Explore
IgA plasma cell	6 studies	36% ± 11%	Explore
erythrocyte	6 studies	48% ± 24%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	45% ± 12%	Explore
alveolar macrophage	5 studies	47% ± 11%	Explore
CD4-positive helper T cell	5 studies	33% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	38% ± 11%	Explore
exhausted T cell	5 studies	56% ± 4%	Explore
mononuclear phagocyte	5 studies	46% ± 17%	Explore
retinal rod cell	5 studies	33% ± 18%	Explore
erythroblast	5 studies	58% ± 23%	Explore
hematopoietic stem cell	5 studies	49% ± 11%	Explore
pro-B cell	5 studies	46% ± 13%	Explore
granulocyte	5 studies	43% ± 18%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	37% ± 15%	Explore
pancreatic A cell	4 studies	72% ± 17%	Explore
type B pancreatic cell	4 studies	70% ± 19%	Explore
glomerular endothelial cell	4 studies	38% ± 13%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	68% ± 16%	Explore
enterocyte	4 studies	28% ± 11%	Explore
enteroendocrine cell	4 studies	54% ± 17%	Explore
intestinal crypt stem cell	4 studies	31% ± 7%	Explore
transit amplifying cell	4 studies	25% ± 3%	Explore
retinal ganglion cell	4 studies	62% ± 28%	Explore
retinal cone cell	4 studies	53% ± 26%	Explore
immature B cell	4 studies	59% ± 13%	Explore
amacrine cell	4 studies	37% ± 17%	Explore
adventitial cell	4 studies	42% ± 6%	Explore
neutrophil	4 studies	20% ± 2%	Explore
double negative thymocyte	4 studies	60% ± 15%	Explore
intermediate monocyte	4 studies	50% ± 16%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	54% ± 9%	Explore
group 3 innate lymphoid cell	4 studies	58% ± 13%	Explore
T-helper 17 cell	4 studies	51% ± 16%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	48% ± 22%	Explore
deuterosomal cell	3 studies	40% ± 2%	Explore
duct epithelial cell	3 studies	24% ± 2%	Explore
ionocyte	3 studies	37% ± 3%	Explore
precursor cell	3 studies	71% ± 13%	Explore
respiratory goblet cell	3 studies	35% ± 19%	Explore
pancreatic D cell	3 studies	72% ± 21%	Explore
podocyte	3 studies	69% ± 14%	Explore
neural crest cell	3 studies	67% ± 8%	Explore
retinal bipolar neuron	3 studies	50% ± 22%	Explore
OFF-bipolar cell	3 studies	45% ± 23%	Explore
ON-bipolar cell	3 studies	46% ± 22%	Explore
renal principal cell	3 studies	53% ± 4%	Explore
thymocyte	3 studies	43% ± 30%	Explore
extravillous trophoblast	3 studies	60% ± 18%	Explore
placental villous trophoblast	3 studies	62% ± 23%	Explore
lymphocyte	3 studies	56% ± 12%	Explore
neuroendocrine cell	3 studies	41% ± 8%	Explore
astrocyte	3 studies	30% ± 15%	Explore
retina horizontal cell	3 studies	40% ± 15%	Explore
microglial cell	3 studies	39% ± 11%	Explore
serous secreting cell	3 studies	33% ± 0%	Explore
intraepithelial lymphocyte	3 studies	51% ± 10%	Explore
Mueller cell	3 studies	37% ± 8%	Explore
rod bipolar cell	3 studies	39% ± 14%	Explore
acinar cell	3 studies	39% ± 19%	Explore
endothelial cell of sinusoid	3 studies	24% ± 6%	Explore
muscle cell	3 studies	46% ± 22%	Explore
oligodendrocyte	3 studies	20% ± 1%	Explore
germinal center B cell	3 studies	59% ± 4%	Explore
myoepithelial cell	3 studies	57% ± 10%	Explore
luminal cell of prostate epithelium	3 studies	34% ± 10%	Explore
IgM plasma cell	3 studies	43% ± 16%	Explore
pancreatic ductal cell	3 studies	52% ± 13%	Explore
oligodendrocyte precursor cell	3 studies	37% ± 20%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	51% ± 29%	Explore
glial cell	3 studies	48% ± 23%	Explore
hepatocyte	3 studies	50% ± 33%	Explore
keratinocyte	3 studies	49% ± 7%	Explore
T-helper 1 cell	3 studies	59% ± 9%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	41% ± 11%	Explore
progenitor cell of mammary luminal epithelium	3 studies	38% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	37% ± 13%	Explore
lung	18 studies	48% ± 17%	Explore
intestine	12 studies	37% ± 18%	Explore
kidney	9 studies	48% ± 15%	Explore
eye	8 studies	36% ± 15%	Explore
brain	7 studies	29% ± 10%	Explore
liver	7 studies	38% ± 24%	Explore
bone marrow	6 studies	28% ± 10%	Explore
lymph node	6 studies	51% ± 16%	Explore
uterus	6 studies	49% ± 22%	Explore
pancreas	5 studies	55% ± 27%	Explore
placenta	4 studies	49% ± 25%	Explore
prostate	4 studies	40% ± 12%	Explore
breast	4 studies	45% ± 7%	Explore
adrenal gland	3 studies	43% ± 7%	Explore
esophagus	3 studies	52% ± 27%	Explore
skin	3 studies	37% ± 12%	Explore
thymus	3 studies	63% ± 24%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	6755.63	258 / 258	100%	479.25	230 / 230
ovary	100%	5938.17	180 / 180	100%	367.06	430 / 430
skin	100%	4002.71	1809 / 1809	100%	408.60	472 / 472
thymus	100%	4201.04	653 / 653	100%	453.91	605 / 605
uterus	100%	5056.82	170 / 170	100%	439.37	459 / 459
kidney	100%	3907.34	89 / 89	100%	280.80	898 / 901
brain	100%	2893.42	2632 / 2642	100%	245.34	705 / 705
prostate	100%	3896.56	245 / 245	100%	354.48	500 / 502
liver	100%	2299.54	225 / 226	100%	252.51	406 / 406
intestine	100%	3343.89	965 / 966	99%	281.64	524 / 527
bladder	100%	4061.10	21 / 21	99%	374.89	500 / 504
lung	100%	3585.34	577 / 578	99%	338.93	1146 / 1155
breast	100%	4043.24	459 / 459	99%	332.91	1106 / 1118
esophagus	100%	3692.62	1445 / 1445	99%	179.83	181 / 183
pancreas	99%	1910.05	326 / 328	99%	282.57	176 / 178
stomach	100%	2687.64	359 / 359	98%	227.25	280 / 286
adipose	100%	3908.03	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4279.07	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	485.20	80 / 80
lymph node	0%	0	0 / 0	100%	483.13	29 / 29
spleen	100%	4191.99	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	334.94	45 / 45
ureter	0%	0	0 / 0	100%	578.12	1 / 1
muscle	99%	2284.40	794 / 803	0%	0	0 / 0
heart	99%	2085.72	851 / 861	0%	0	0 / 0
peripheral blood	96%	2721.21	896 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_2000234	Biological process	positive regulation of rRNA processing
GO_0018364	Biological process	peptidyl-glutamine methylation
GO_0070476	Biological process	rRNA (guanine-N7)-methylation
GO_0030488	Biological process	tRNA methylation
GO_0045815	Biological process	transcription initiation-coupled chromatin remodeling
GO_0031167	Biological process	rRNA methylation
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0008276	Molecular function	protein methyltransferase activity
GO_0046982	Molecular function	protein heterodimerization activity
GO_0141106	Molecular function	tRNA methyltransferase activator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TRMT112
Protein name	Multifunctional methyltransferase subunit TRM112-like protein (tRNA methyltransferase 112 homolog)
Synonyms	HSPC170 AD-001 HSPC152
Description	FUNCTION: Acts as an activator of both rRNA/tRNA and protein methyltransferases . Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA . The heterodimer with N6AMT1/HEMK2 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor . The heterodimer with N6AMT1/HEMK2 also monomethylates 'Lys-12' of histone H4 (H4K12me1) . The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species . Together with methyltransferase THUMPD3, catalyzes the formation of N(2)-methylguanosine at position 6 in a broad range of tRNA substrates and at position 7 of tRNA(Trp) . Involved in the pre-rRNA processing steps leading to small-subunit rRNA production . Together with methyltransferase METTL5, specifically methylates the 6th position of adenine in position 1832 of 18S rRNA . .
Accessions	ENST00000308774.6 [Q9UI30-2] Q9UI30 ENST00000544844.6 [Q9UI30-1]

TRMT112 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review