TPM3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	43 studies	60% ± 20%	Explore
endothelial cell	43 studies	52% ± 22%	Explore
natural killer cell	42 studies	62% ± 19%	Explore
B cell	41 studies	57% ± 17%	Explore
T cell	37 studies	50% ± 21%	Explore
CD8-positive, alpha-beta T cell	37 studies	59% ± 20%	Explore
CD4-positive, alpha-beta T cell	32 studies	60% ± 20%	Explore
dendritic cell	29 studies	66% ± 25%	Explore
classical monocyte	29 studies	73% ± 19%	Explore
conventional dendritic cell	29 studies	79% ± 16%	Explore
regulatory T cell	26 studies	66% ± 17%	Explore
monocyte	25 studies	62% ± 24%	Explore
fibroblast	25 studies	29% ± 11%	Explore
non-classical monocyte	25 studies	84% ± 15%	Explore
endothelial cell of lymphatic vessel	23 studies	52% ± 20%	Explore
plasmacytoid dendritic cell	22 studies	68% ± 17%	Explore
epithelial cell	22 studies	44% ± 20%	Explore
mast cell	21 studies	46% ± 20%	Explore
mature NK T cell	20 studies	61% ± 17%	Explore
memory B cell	20 studies	67% ± 13%	Explore
gamma-delta T cell	19 studies	65% ± 18%	Explore
naive B cell	19 studies	55% ± 13%	Explore
basal cell	19 studies	36% ± 16%	Explore
pericyte	18 studies	26% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	57% ± 14%	Explore
myeloid cell	17 studies	63% ± 26%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	64% ± 19%	Explore
mucosal invariant T cell	16 studies	62% ± 20%	Explore
neutrophil	16 studies	46% ± 14%	Explore
plasma cell	15 studies	39% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	65% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	74% ± 16%	Explore
ciliated cell	14 studies	44% ± 18%	Explore
capillary endothelial cell	14 studies	47% ± 18%	Explore
vein endothelial cell	14 studies	57% ± 20%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	65% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	66% ± 17%	Explore
endothelial cell of vascular tree	13 studies	58% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	64% ± 22%	Explore
endothelial cell of artery	12 studies	55% ± 15%	Explore
smooth muscle cell	11 studies	20% ± 4%	Explore
platelet	11 studies	67% ± 15%	Explore
secretory cell	11 studies	41% ± 19%	Explore
connective tissue cell	11 studies	32% ± 16%	Explore
microglial cell	11 studies	33% ± 16%	Explore
type I pneumocyte	10 studies	43% ± 16%	Explore
plasmablast	10 studies	64% ± 23%	Explore
innate lymphoid cell	9 studies	59% ± 16%	Explore
leukocyte	9 studies	54% ± 19%	Explore
progenitor cell	9 studies	48% ± 21%	Explore
abnormal cell	9 studies	48% ± 18%	Explore
type II pneumocyte	8 studies	30% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	74% ± 19%	Explore
mesothelial cell	8 studies	30% ± 13%	Explore
T follicular helper cell	8 studies	56% ± 11%	Explore
glutamatergic neuron	8 studies	38% ± 24%	Explore
hematopoietic stem cell	8 studies	83% ± 10%	Explore
alveolar macrophage	7 studies	59% ± 17%	Explore
club cell	7 studies	30% ± 13%	Explore
neuron	7 studies	36% ± 14%	Explore
hematopoietic precursor cell	6 studies	79% ± 19%	Explore
ionocyte	6 studies	28% ± 9%	Explore
respiratory goblet cell	6 studies	32% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	76% ± 18%	Explore
mononuclear phagocyte	6 studies	64% ± 13%	Explore
megakaryocyte	6 studies	81% ± 16%	Explore
enterocyte	6 studies	35% ± 10%	Explore
goblet cell	6 studies	38% ± 12%	Explore
transit amplifying cell	6 studies	40% ± 16%	Explore
lymphocyte	6 studies	47% ± 29%	Explore
precursor B cell	6 studies	63% ± 17%	Explore
immature B cell	6 studies	68% ± 6%	Explore
retina horizontal cell	6 studies	75% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	76% ± 11%	Explore
erythrocyte	6 studies	48% ± 23%	Explore
CD4-positive helper T cell	5 studies	53% ± 16%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	68% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	68% ± 11%	Explore
exhausted T cell	5 studies	73% ± 12%	Explore
kidney loop of Henle epithelial cell	5 studies	19% ± 5%	Explore
myofibroblast cell	5 studies	22% ± 5%	Explore
brush cell	5 studies	32% ± 14%	Explore
T-helper 17 cell	5 studies	67% ± 19%	Explore
group 3 innate lymphoid cell	5 studies	68% ± 10%	Explore
double negative thymocyte	5 studies	76% ± 8%	Explore
intermediate monocyte	5 studies	86% ± 8%	Explore
granulocyte	5 studies	57% ± 14%	Explore
interneuron	5 studies	30% ± 19%	Explore
deuterosomal cell	4 studies	26% ± 8%	Explore
pancreatic A cell	4 studies	70% ± 9%	Explore
type B pancreatic cell	4 studies	65% ± 18%	Explore
glomerular endothelial cell	4 studies	48% ± 8%	Explore
epithelial cell of proximal tubule	4 studies	23% ± 3%	Explore
enteroendocrine cell	4 studies	47% ± 8%	Explore
retinal ganglion cell	4 studies	54% ± 26%	Explore
erythroblast	4 studies	57% ± 28%	Explore
pro-B cell	4 studies	65% ± 16%	Explore
amacrine cell	4 studies	35% ± 13%	Explore
adventitial cell	4 studies	22% ± 5%	Explore
inflammatory macrophage	4 studies	48% ± 17%	Explore
germinal center B cell	4 studies	52% ± 23%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	44% ± 5%	Explore
GABAergic neuron	4 studies	43% ± 16%	Explore
oligodendrocyte	4 studies	20% ± 2%	Explore
T-helper 1 cell	4 studies	70% ± 19%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	74% ± 13%	Explore
squamous epithelial cell	3 studies	49% ± 22%	Explore
pancreatic D cell	3 studies	49% ± 19%	Explore
monocyte-derived dendritic cell	3 studies	73% ± 26%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	29% ± 8%	Explore
intestinal crypt stem cell	3 studies	35% ± 12%	Explore
neural crest cell	3 studies	30% ± 2%	Explore
retinal bipolar neuron	3 studies	37% ± 14%	Explore
extravillous trophoblast	3 studies	61% ± 2%	Explore
placental villous trophoblast	3 studies	41% ± 11%	Explore
common myeloid progenitor	3 studies	59% ± 32%	Explore
neuroendocrine cell	3 studies	47% ± 14%	Explore
retinal rod cell	3 studies	20% ± 4%	Explore
tissue-resident macrophage	3 studies	62% ± 16%	Explore
intraepithelial lymphocyte	3 studies	56% ± 15%	Explore
IgA plasma cell	3 studies	28% ± 14%	Explore
myoepithelial cell	3 studies	27% ± 7%	Explore
muscle cell	3 studies	34% ± 6%	Explore
pancreatic ductal cell	3 studies	74% ± 15%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	95% ± 4%	Explore
hepatocyte	3 studies	42% ± 22%	Explore
keratinocyte	3 studies	24% ± 4%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	75% ± 6%	Explore
double-positive, alpha-beta thymocyte	3 studies	79% ± 10%	Explore
astrocyte	3 studies	20% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	69% ± 15%	Explore
lung	19 studies	44% ± 16%	Explore
brain	12 studies	32% ± 16%	Explore
intestine	11 studies	33% ± 9%	Explore
kidney	8 studies	37% ± 18%	Explore
eye	7 studies	25% ± 6%	Explore
liver	6 studies	41% ± 17%	Explore
bone marrow	5 studies	54% ± 27%	Explore
lymph node	5 studies	56% ± 13%	Explore
pancreas	4 studies	62% ± 18%	Explore
placenta	4 studies	45% ± 19%	Explore
uterus	4 studies	50% ± 14%	Explore
breast	4 studies	43% ± 8%	Explore
prostate	3 studies	33% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	13599.69	459 / 459	100%	125.34	1118 / 1118
bladder	100%	9134.57	21 / 21	100%	89.56	503 / 504
lung	100%	20531.57	577 / 578	100%	94.60	1154 / 1155
skin	100%	16485.38	1808 / 1809	100%	113.84	471 / 472
stomach	100%	8944.83	358 / 359	100%	88.86	286 / 286
uterus	100%	7704.59	170 / 170	99%	90.09	456 / 459
thymus	100%	10331.38	652 / 653	99%	57.45	600 / 605
prostate	100%	8492.81	244 / 245	99%	40.44	497 / 502
brain	98%	9759.66	2599 / 2642	100%	45.25	704 / 705
esophagus	98%	9365.25	1416 / 1445	100%	85.68	183 / 183
intestine	97%	11169.94	935 / 966	100%	93.63	527 / 527
kidney	100%	11004.40	89 / 89	97%	54.81	871 / 901
ovary	96%	5350.49	173 / 180	100%	85.30	430 / 430
adrenal gland	100%	12991.16	258 / 258	93%	39.76	213 / 230
pancreas	93%	5658.75	305 / 328	99%	83.92	176 / 178
liver	82%	4781.98	185 / 226	97%	46.65	393 / 406
adipose	100%	15847.15	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	116.83	29 / 29
spleen	100%	20935.87	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	82.52	45 / 45
ureter	0%	0	0 / 0	100%	41.75	1 / 1
muscle	100%	217522.43	802 / 803	0%	0	0 / 0
peripheral blood	100%	31139.06	925 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	98%	57.41	78 / 80
blood vessel	94%	6847.64	1260 / 1335	0%	0	0 / 0
heart	90%	13489.96	777 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	TPM3
Protein name	Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5) Tropomyosin 3 isoform 1 Tropomyosin 3 Tropomyosin 3 isoform 2 (Tropomyosin 3, isoform CRA_h) TPM3 protein (cDNA FLJ32435 fis, clone SKMUS2001287, highly similar to Tropomyosin alpha-3 chain) Tropomyosin 3 isoform 3
Synonyms	hCG_1997142 TPM3nu
Description	FUNCTION: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. .
Accessions	ENST00000368531.6 [P06753-3] A0A2R2Y2Q3 ENST00000651644.1 ENST00000515609.1 ENST00000328159.9 [P06753-6] ENST00000341485.10 [P06753-4] ENST00000368533.8 [P06753-2] Q5VU62 A0A494C0G0 A0A0S2Z4G4 A0A0S2Z4I4 ENST00000611659.5 ENST00000651873.1 ENST00000509409.5 ENST00000323144.12 [P06753-4] P06753 D6R904 ENST00000330188.13 [P06753-5] ENST00000651731.1 ENST00000271850.11 A0A0S2Z4G8 ENST00000302206.9 [P06753-7] A0A087WWU8 ENST00000368530.7 ENST00000341372.8 A0A494C0P6 Q5VU61 A0A494C034 D6RGJ6 ENST00000509601.1 J3KN67 ENST00000651641.1 [P06753-1]

GO_0006936	Biological process	muscle contraction
GO_0007015	Biological process	actin filament organization
GO_0005862	Cellular component	muscle thin filament tropomyosin
GO_0001725	Cellular component	stress fiber
GO_0015629	Cellular component	actin cytoskeleton
GO_0070062	Cellular component	extracellular exosome
GO_0005856	Cellular component	cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0005884	Cellular component	actin filament
GO_0051015	Molecular function	actin filament binding
GO_0005515	Molecular function	protein binding
GO_0003674	Molecular function	molecular_function

TPM3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review