TMED10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902003Biological processregulation of amyloid-beta formation
GO_0035459Biological processvesicle cargo loading
GO_0006890Biological processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO_0006886Biological processintracellular protein transport
GO_0035964Biological processCOPI-coated vesicle budding
GO_0032732Biological processpositive regulation of interleukin-1 production
GO_0048199Biological processvesicle targeting, to, from or within Golgi
GO_0106272Biological processprotein localization to ERGIC
GO_0045055Biological processregulated exocytosis
GO_0050714Biological processpositive regulation of protein secretion
GO_0007030Biological processGolgi organization
GO_0106273Biological processcytosol to ERGIC protein transport
GO_0006888Biological processendoplasmic reticulum to Golgi vesicle-mediated transport
GO_0048205Biological processCOPI coating of Golgi vesicle
GO_0048208Biological processCOPII vesicle coating
GO_0071806Biological processprotein transmembrane transport
GO_0005801Cellular componentcis-Golgi network
GO_0030667Cellular componentsecretory granule membrane
GO_0070765Cellular componentgamma-secretase complex
GO_0005886Cellular componentplasma membrane
GO_0030137Cellular componentCOPI-coated vesicle
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005794Cellular componentGolgi apparatus
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0042589Cellular componentzymogen granule membrane
GO_0030140Cellular componenttrans-Golgi network transport vesicle
GO_0005793Cellular componentendoplasmic reticulum-Golgi intermediate compartment
GO_0030134Cellular componentCOPII-coated ER to Golgi transport vesicle
GO_0030133Cellular componenttransport vesicle
GO_0012507Cellular componentER to Golgi transport vesicle membrane
GO_0042470Cellular componentmelanosome
GO_0019905Molecular functionsyntaxin binding
GO_0038024Molecular functioncargo receptor activity
GO_0008320Molecular functionprotein transmembrane transporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTMED10
Protein nameTransmembrane emp24 domain-containing protein 10 (Protein TMED10) (21 kDa transmembrane-trafficking protein) (S31I125) (S31III125) (Tmp-21-I) (Transmembrane protein Tmp21) (p23) (p24 family protein delta-1) (p24delta1) (p24delta)
Transmembrane p24 trafficking protein 10
SynonymsTMP21
DescriptionFUNCTION: Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi . The p24 protein family is a group of transmembrane proteins that bind coat protein complex I/COPI and coat protein complex II/COPII involved in vesicular trafficking between the membranes . Acts at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and involved in vesicle coat formation at the cytoplasmic side . Mainly functions in the early secretory pathway and cycles between the ER, ER-Golgi intermediate compartment (ERGIC) and Golgi, mediating cargo transport through COPI and COPII-coated vesicles . In COPII vesicle-mediated anterograde transport, involved in the transport of GPI-anchored proteins by acting together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER . Recognizes GPI anchors structural remodeled in the ER by the GPI inositol-deacylase/PGAP1 and the metallophosphoesterase MPPE1/PGAP5 (By similarity). In COPI vesicle-mediated retrograde transport, involved in the biogenesis of COPI vesicles and vesicle coat recruitment . Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent from the modulation of gamma-secretase activity) . Involved in the KDELR2-mediated retrograde transport of the toxin A subunit (CTX-A-K63)together with COPI and the COOH terminus of KDELR2 (By similarity). On Golgi membranes, acts as a primary receptor for ARF1-GDP, a GTP-binding protein involved in COPI-vesicle formation . Increases coatomer-dependent GTPase-activating activity of ARFGAP2 which mediates the hydrolysis of ARF1-bound GTP and therefore modulates protein trafficking from the Golgi apparatus . Involved in the exocytic trafficking of G protein-coupled receptors F2LR1/PAR2 (trypsin and tryspin-like enzyme receptor), OPRM1 (opioid receptor) and P2RY4 (UTD and UDP receptor) from the Golgi to the plasma membrane, thus contributing to receptor resensitization . In addition to its cargo receptor activity, may also act as a protein channel after oligomerization, facilitating the post-translational entry of leaderless cytoplasmic cargo into the ERGIC . Involved in the translocation into ERGIC, the vesicle entry and the secretion of leaderless cargos (lacking the secretion signal sequence), including the mature form of interleukin 1/IL-1 family members, the alpha-crystallin B chain HSPB5, the carbohydrate-binding proteins galectin-1/LGALS1 and galectin-3/LGALS3, the microtubule-associated protein Tau/MAPT, and the annexin A1/ANXA1; the translocation process is dependent on cargo protein unfolding and enhanced by chaperones HSP90AB1 and HSP90B1/GRP9 . Could also associates with the presenilin-dependent gamma-secretase complex in order to regulate gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40/Abeta40 . .

AccessionsENST00000303575.9
ENST00000555873.1
P49755
G3V2K7