TECR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042761Biological processvery long-chain fatty acid biosynthetic process
GO_0030497Biological processfatty acid elongation
GO_0035338Biological processlong-chain fatty-acyl-CoA biosynthetic process
GO_0006665Biological processsphingolipid metabolic process
GO_0005783Cellular componentendoplasmic reticulum
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005634Cellular componentnucleus
GO_0017099Molecular functionvery-long-chain fatty acyl-CoA dehydrogenase activity
GO_0016491Molecular functionoxidoreductase activity
GO_0005515Molecular functionprotein binding
GO_0102758Molecular functionvery-long-chain enoyl-CoA reductase activity

IV. Literature review

[source]
Gene nameTECR
Protein namevery-long-chain enoyl-CoA reductase (EC 1.3.1.93)
Very-long-chain enoyl-CoA reductase (EC 1.3.1.93) (Synaptic glycoprotein SC2) (Trans-2,3-enoyl-CoA reductase) (TER)
Trans-2,3-enoyl-CoA reductase
SynonymsSC2
GPSN2
DescriptionFUNCTION: Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway . Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle . This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle . This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation . Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators . Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA . .

AccessionsENST00000598333.5
ENST00000215567.10 [Q9NZ01-1]
M0R329
ENST00000598987.5
M0R2N5
ENST00000596073.6
ENST00000601187.1
Q9NZ01
M0R2E5
M0R3C3