SSBP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	36 studies	32% ± 13%	Explore
natural killer cell	35 studies	32% ± 10%	Explore
B cell	34 studies	30% ± 9%	Explore
fibroblast	34 studies	31% ± 13%	Explore
CD8-positive, alpha-beta T cell	30 studies	35% ± 14%	Explore
macrophage	28 studies	30% ± 11%	Explore
CD4-positive, alpha-beta T cell	28 studies	37% ± 15%	Explore
T cell	27 studies	32% ± 11%	Explore
conventional dendritic cell	26 studies	37% ± 16%	Explore
pericyte	24 studies	32% ± 10%	Explore
smooth muscle cell	22 studies	36% ± 10%	Explore
classical monocyte	22 studies	29% ± 13%	Explore
non-classical monocyte	21 studies	30% ± 15%	Explore
regulatory T cell	21 studies	37% ± 12%	Explore
basal cell	20 studies	37% ± 16%	Explore
epithelial cell	20 studies	43% ± 20%	Explore
memory B cell	19 studies	28% ± 10%	Explore
naive B cell	19 studies	26% ± 6%	Explore
mast cell	17 studies	35% ± 12%	Explore
endothelial cell of lymphatic vessel	17 studies	35% ± 12%	Explore
plasmacytoid dendritic cell	17 studies	31% ± 11%	Explore
gamma-delta T cell	17 studies	33% ± 14%	Explore
monocyte	16 studies	30% ± 10%	Explore
ciliated cell	16 studies	39% ± 17%	Explore
mature NK T cell	16 studies	32% ± 9%	Explore
dendritic cell	15 studies	37% ± 24%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	33% ± 9%	Explore
connective tissue cell	15 studies	36% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	32% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	38% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	33% ± 11%	Explore
myofibroblast cell	13 studies	34% ± 8%	Explore
plasma cell	12 studies	38% ± 14%	Explore
capillary endothelial cell	12 studies	26% ± 8%	Explore
vein endothelial cell	12 studies	29% ± 6%	Explore
endothelial cell of vascular tree	12 studies	30% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	34% ± 12%	Explore
mucosal invariant T cell	11 studies	31% ± 6%	Explore
plasmablast	10 studies	47% ± 23%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	36% ± 12%	Explore
secretory cell	10 studies	36% ± 17%	Explore
progenitor cell	10 studies	40% ± 14%	Explore
abnormal cell	10 studies	44% ± 17%	Explore
endothelial cell of artery	10 studies	28% ± 7%	Explore
myeloid cell	10 studies	37% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	33% ± 11%	Explore
mesothelial cell	9 studies	34% ± 17%	Explore
leukocyte	8 studies	31% ± 8%	Explore
type I pneumocyte	7 studies	31% ± 13%	Explore
epithelial cell of proximal tubule	7 studies	34% ± 8%	Explore
goblet cell	7 studies	31% ± 13%	Explore
precursor B cell	7 studies	38% ± 16%	Explore
club cell	7 studies	33% ± 13%	Explore
T follicular helper cell	7 studies	31% ± 6%	Explore
type II pneumocyte	6 studies	37% ± 18%	Explore
hematopoietic precursor cell	6 studies	52% ± 25%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	45% ± 12%	Explore
kidney loop of Henle epithelial cell	6 studies	30% ± 5%	Explore
renal alpha-intercalated cell	6 studies	37% ± 5%	Explore
transit amplifying cell	6 studies	28% ± 7%	Explore
microglial cell	6 studies	28% ± 10%	Explore
innate lymphoid cell	6 studies	31% ± 3%	Explore
neuron	6 studies	41% ± 15%	Explore
astrocyte	6 studies	32% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	40% ± 15%	Explore
oligodendrocyte	6 studies	25% ± 7%	Explore
alveolar macrophage	5 studies	28% ± 6%	Explore
ionocyte	5 studies	26% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	47% ± 11%	Explore
mononuclear phagocyte	5 studies	35% ± 15%	Explore
enterocyte	5 studies	26% ± 7%	Explore
intestinal crypt stem cell	5 studies	30% ± 12%	Explore
erythroblast	5 studies	56% ± 22%	Explore
hematopoietic stem cell	5 studies	48% ± 9%	Explore
lymphocyte	5 studies	35% ± 16%	Explore
pro-B cell	5 studies	40% ± 12%	Explore
erythrocyte	5 studies	40% ± 21%	Explore
deuterosomal cell	4 studies	31% ± 2%	Explore
pancreatic A cell	4 studies	51% ± 18%	Explore
exhausted T cell	4 studies	43% ± 10%	Explore
enteroendocrine cell	4 studies	43% ± 11%	Explore
glial cell	4 studies	31% ± 21%	Explore
retinal ganglion cell	4 studies	47% ± 28%	Explore
immature B cell	4 studies	43% ± 16%	Explore
amacrine cell	4 studies	30% ± 14%	Explore
retina horizontal cell	4 studies	26% ± 14%	Explore
adventitial cell	4 studies	24% ± 7%	Explore
Mueller cell	4 studies	28% ± 8%	Explore
muscle cell	4 studies	32% ± 17%	Explore
neutrophil	4 studies	19% ± 2%	Explore
CD4-positive helper T cell	4 studies	26% ± 7%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	35% ± 6%	Explore
granulocyte	4 studies	34% ± 11%	Explore
oligodendrocyte precursor cell	4 studies	34% ± 10%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	60% ± 20%	Explore
hepatocyte	4 studies	37% ± 25%	Explore
T-helper 17 cell	4 studies	40% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	33% ± 7%	Explore
double negative thymocyte	4 studies	44% ± 20%	Explore
duct epithelial cell	3 studies	25% ± 0%	Explore
precursor cell	3 studies	51% ± 10%	Explore
respiratory goblet cell	3 studies	21% ± 3%	Explore
type B pancreatic cell	3 studies	51% ± 13%	Explore
glomerular endothelial cell	3 studies	19% ± 1%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	46% ± 9%	Explore
neural crest cell	3 studies	48% ± 5%	Explore
extravillous trophoblast	3 studies	40% ± 11%	Explore
placental villous trophoblast	3 studies	60% ± 14%	Explore
common myeloid progenitor	3 studies	43% ± 23%	Explore
brush cell	3 studies	38% ± 23%	Explore
neuroendocrine cell	3 studies	39% ± 12%	Explore
retinal cone cell	3 studies	44% ± 15%	Explore
retinal rod cell	3 studies	30% ± 11%	Explore
serous secreting cell	3 studies	28% ± 5%	Explore
intraepithelial lymphocyte	3 studies	35% ± 12%	Explore
ON-bipolar cell	3 studies	25% ± 7%	Explore
rod bipolar cell	3 studies	25% ± 3%	Explore
germinal center B cell	3 studies	35% ± 3%	Explore
intermediate monocyte	3 studies	44% ± 17%	Explore
myoepithelial cell	3 studies	36% ± 8%	Explore
pancreatic ductal cell	3 studies	55% ± 10%	Explore
granulocyte monocyte progenitor cell	3 studies	50% ± 21%	Explore
group 3 innate lymphoid cell	3 studies	37% ± 15%	Explore
melanocyte	3 studies	21% ± 2%	Explore
keratinocyte	3 studies	27% ± 6%	Explore
glutamatergic neuron	3 studies	29% ± 14%	Explore
interneuron	3 studies	41% ± 21%	Explore
T-helper 1 cell	3 studies	44% ± 11%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	37% ± 6%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	35% ± 8%	Explore
progenitor cell of mammary luminal epithelium	3 studies	33% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	34% ± 14%	Explore
peripheral blood	18 studies	35% ± 12%	Explore
intestine	11 studies	27% ± 12%	Explore
kidney	9 studies	32% ± 8%	Explore
brain	8 studies	29% ± 10%	Explore
eye	7 studies	29% ± 11%	Explore
liver	6 studies	36% ± 17%	Explore
pancreas	5 studies	42% ± 20%	Explore
bone marrow	5 studies	33% ± 7%	Explore
lymph node	5 studies	39% ± 11%	Explore
placenta	4 studies	39% ± 18%	Explore
uterus	4 studies	45% ± 15%	Explore
breast	4 studies	32% ± 1%	Explore
adrenal gland	3 studies	30% ± 6%	Explore
esophagus	3 studies	42% ± 25%	Explore
prostate	3 studies	23% ± 7%	Explore
thymus	3 studies	57% ± 22%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2406.64	1445 / 1445	100%	35.00	183 / 183
kidney	100%	2098.56	89 / 89	100%	37.01	901 / 901
ovary	100%	2097.08	180 / 180	100%	50.29	430 / 430
prostate	100%	1647.62	245 / 245	100%	37.07	502 / 502
skin	100%	2781.08	1809 / 1809	100%	53.57	472 / 472
stomach	100%	1871.94	359 / 359	100%	46.81	286 / 286
uterus	100%	2054.52	170 / 170	100%	50.21	459 / 459
thymus	100%	1875.78	653 / 653	100%	42.33	604 / 605
breast	100%	2239.88	459 / 459	100%	48.75	1116 / 1118
intestine	100%	2228.87	966 / 966	100%	54.05	526 / 527
bladder	100%	2073.57	21 / 21	100%	51.00	503 / 504
brain	100%	1544.62	2634 / 2642	100%	43.84	705 / 705
lung	100%	1754.47	576 / 578	100%	44.80	1155 / 1155
liver	100%	1526.37	225 / 226	100%	31.02	406 / 406
pancreas	100%	1248.54	327 / 328	99%	35.83	177 / 178
adrenal gland	100%	2564.86	258 / 258	99%	36.76	228 / 230
adipose	100%	2170.76	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	66.49	29 / 29
spleen	100%	2019.23	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	40.64	45 / 45
ureter	0%	0	0 / 0	100%	30.42	1 / 1
blood vessel	100%	2380.11	1334 / 1335	0%	0	0 / 0
muscle	100%	2028.22	802 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	99%	32.43	79 / 80
heart	98%	2077.62	846 / 861	0%	0	0 / 0
peripheral blood	89%	1808.76	824 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0051096	Biological process	positive regulation of helicase activity
GO_0006264	Biological process	mitochondrial DNA replication
GO_0051289	Biological process	protein homotetramerization
GO_0090297	Biological process	positive regulation of mitochondrial DNA replication
GO_0006268	Biological process	DNA unwinding involved in DNA replication
GO_0070062	Cellular component	extracellular exosome
GO_0005759	Cellular component	mitochondrial matrix
GO_0042645	Cellular component	mitochondrial nucleoid
GO_0005739	Cellular component	mitochondrion
GO_0005634	Cellular component	nucleus
GO_0003723	Molecular function	RNA binding
GO_0042803	Molecular function	protein homodimerization activity
GO_0042802	Molecular function	identical protein binding
GO_0003697	Molecular function	single-stranded DNA binding
GO_0005515	Molecular function	protein binding
GO_0003682	Molecular function	chromatin binding

IV. Literature review

[source]

Gene name	SSBP1
Protein name	Uncharacterized protein SSBP1 SSBP1 protein Single-stranded DNA-binding protein, mitochondrial Single stranded DNA binding protein 1 (Single-stranded DNA-binding protein, mitochondrial) Single-stranded DNA-binding protein, mitochondrial (Mt-SSB) (MtSSB) (PWP1-interacting protein 17) Single-stranded DNA-binding protein
Synonyms	hCG_2014251 SSBP tcag7.401
Description	FUNCTION: Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) . In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork . Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity . In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK . May also function in mtDNA repair . .
Accessions	Q04837 A4D1U3 C9K0U8 ENST00000481508.1 ENST00000473783.5 A0A0G2JLD8 ENST00000467681.5 ENST00000574199.5 Q567R6 ENST00000571709.5 E7EUY5 Q75MV9 Q96QL6 ENST00000576834.2 ENST00000498107.5 ENST00000575059.5 ENST00000463093.5 ENST00000576311.5 ENST00000465582.5 ENST00000571430.5 C9J8J0 ENST00000570667.5 ENST00000612337.4 ENST00000484178.5 ENST00000265304.11 ENST00000573322.5 B7Z268

SSBP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review