SSB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	35 studies	34% ± 13%	Explore
fibroblast	34 studies	34% ± 13%	Explore
B cell	32 studies	27% ± 7%	Explore
natural killer cell	31 studies	27% ± 7%	Explore
pericyte	30 studies	33% ± 11%	Explore
macrophage	29 studies	30% ± 11%	Explore
CD4-positive, alpha-beta T cell	28 studies	30% ± 9%	Explore
CD8-positive, alpha-beta T cell	28 studies	28% ± 8%	Explore
conventional dendritic cell	26 studies	32% ± 14%	Explore
T cell	24 studies	27% ± 10%	Explore
smooth muscle cell	24 studies	36% ± 9%	Explore
non-classical monocyte	22 studies	29% ± 13%	Explore
regulatory T cell	21 studies	29% ± 5%	Explore
basal cell	20 studies	32% ± 16%	Explore
classical monocyte	20 studies	25% ± 11%	Explore
memory B cell	19 studies	27% ± 8%	Explore
epithelial cell	18 studies	36% ± 21%	Explore
naive B cell	18 studies	23% ± 5%	Explore
ciliated cell	17 studies	58% ± 17%	Explore
gamma-delta T cell	17 studies	30% ± 13%	Explore
monocyte	16 studies	25% ± 7%	Explore
mast cell	15 studies	29% ± 9%	Explore
endothelial cell of lymphatic vessel	15 studies	41% ± 13%	Explore
mature NK T cell	15 studies	27% ± 7%	Explore
plasmacytoid dendritic cell	14 studies	30% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	30% ± 7%	Explore
connective tissue cell	14 studies	40% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	30% ± 8%	Explore
myofibroblast cell	13 studies	36% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	29% ± 6%	Explore
capillary endothelial cell	12 studies	28% ± 9%	Explore
mucosal invariant T cell	12 studies	27% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	29% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	31% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	28% ± 6%	Explore
vein endothelial cell	11 studies	29% ± 7%	Explore
endothelial cell of vascular tree	11 studies	31% ± 10%	Explore
dendritic cell	10 studies	36% ± 21%	Explore
endothelial cell of artery	10 studies	27% ± 5%	Explore
secretory cell	9 studies	33% ± 16%	Explore
abnormal cell	9 studies	35% ± 11%	Explore
myeloid cell	9 studies	34% ± 14%	Explore
plasma cell	8 studies	31% ± 13%	Explore
plasmablast	8 studies	42% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	32% ± 8%	Explore
neuron	8 studies	38% ± 14%	Explore
mesothelial cell	8 studies	39% ± 18%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	31% ± 9%	Explore
progenitor cell	7 studies	47% ± 10%	Explore
precursor B cell	7 studies	36% ± 13%	Explore
astrocyte	7 studies	27% ± 12%	Explore
alveolar macrophage	6 studies	33% ± 8%	Explore
leukocyte	6 studies	30% ± 6%	Explore
kidney loop of Henle epithelial cell	6 studies	27% ± 7%	Explore
epithelial cell of proximal tubule	6 studies	24% ± 12%	Explore
goblet cell	6 studies	28% ± 11%	Explore
erythroblast	6 studies	46% ± 27%	Explore
innate lymphoid cell	6 studies	27% ± 3%	Explore
erythrocyte	6 studies	38% ± 24%	Explore
T follicular helper cell	6 studies	28% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	34% ± 9%	Explore
type I pneumocyte	5 studies	34% ± 10%	Explore
hematopoietic precursor cell	5 studies	53% ± 21%	Explore
hematopoietic stem cell	5 studies	49% ± 12%	Explore
pro-B cell	5 studies	35% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	32% ± 8%	Explore
adipocyte	5 studies	20% ± 4%	Explore
granulocyte	5 studies	29% ± 9%	Explore
GABAergic neuron	5 studies	33% ± 10%	Explore
deuterosomal cell	4 studies	42% ± 4%	Explore
ionocyte	4 studies	36% ± 9%	Explore
pancreatic A cell	4 studies	46% ± 13%	Explore
mononuclear phagocyte	4 studies	35% ± 16%	Explore
exhausted T cell	4 studies	29% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	45% ± 16%	Explore
enteroendocrine cell	4 studies	38% ± 14%	Explore
retinal ganglion cell	4 studies	50% ± 26%	Explore
club cell	4 studies	37% ± 8%	Explore
immature B cell	4 studies	30% ± 8%	Explore
retina horizontal cell	4 studies	35% ± 14%	Explore
retinal rod cell	4 studies	27% ± 11%	Explore
microglial cell	4 studies	27% ± 8%	Explore
adventitial cell	4 studies	26% ± 8%	Explore
muscle cell	4 studies	33% ± 18%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	34% ± 9%	Explore
glutamatergic neuron	4 studies	44% ± 12%	Explore
oligodendrocyte precursor cell	4 studies	38% ± 8%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	67% ± 16%	Explore
T-helper 17 cell	4 studies	34% ± 15%	Explore
interneuron	4 studies	33% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	28% ± 7%	Explore
duct epithelial cell	3 studies	16% ± 0%	Explore
precursor cell	3 studies	50% ± 17%	Explore
respiratory goblet cell	3 studies	32% ± 22%	Explore
pancreatic D cell	3 studies	43% ± 20%	Explore
type B pancreatic cell	3 studies	54% ± 12%	Explore
glomerular endothelial cell	3 studies	25% ± 5%	Explore
podocyte	3 studies	53% ± 10%	Explore
renal alpha-intercalated cell	3 studies	36% ± 12%	Explore
intestinal crypt stem cell	3 studies	27% ± 4%	Explore
neural crest cell	3 studies	49% ± 5%	Explore
retinal bipolar neuron	3 studies	39% ± 12%	Explore
extravillous trophoblast	3 studies	33% ± 4%	Explore
placental villous trophoblast	3 studies	50% ± 8%	Explore
common myeloid progenitor	3 studies	38% ± 25%	Explore
lymphocyte	3 studies	40% ± 11%	Explore
megakaryocyte	3 studies	33% ± 13%	Explore
neuroendocrine cell	3 studies	35% ± 13%	Explore
type II pneumocyte	3 studies	40% ± 12%	Explore
amacrine cell	3 studies	37% ± 10%	Explore
retinal cone cell	3 studies	39% ± 11%	Explore
serous secreting cell	3 studies	19% ± 0%	Explore
Mueller cell	3 studies	31% ± 5%	Explore
rod bipolar cell	3 studies	32% ± 11%	Explore
acinar cell	3 studies	31% ± 12%	Explore
germinal center B cell	3 studies	28% ± 6%	Explore
intermediate monocyte	3 studies	38% ± 17%	Explore
CD4-positive helper T cell	3 studies	32% ± 11%	Explore
myoepithelial cell	3 studies	35% ± 2%	Explore
pancreatic ductal cell	3 studies	58% ± 12%	Explore
granulocyte monocyte progenitor cell	3 studies	40% ± 18%	Explore
glial cell	3 studies	38% ± 22%	Explore
group 3 innate lymphoid cell	3 studies	39% ± 13%	Explore
T-helper 1 cell	3 studies	35% ± 4%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	33% ± 5%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	29% ± 6%	Explore
double negative thymocyte	3 studies	45% ± 18%	Explore
progenitor cell of mammary luminal epithelium	3 studies	24% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	30% ± 9%	Explore
lung	16 studies	35% ± 13%	Explore
brain	10 studies	28% ± 9%	Explore
intestine	9 studies	29% ± 13%	Explore
eye	9 studies	26% ± 11%	Explore
kidney	8 studies	28% ± 9%	Explore
liver	6 studies	34% ± 20%	Explore
bone marrow	5 studies	28% ± 9%	Explore
lymph node	5 studies	32% ± 10%	Explore
pancreas	4 studies	43% ± 16%	Explore
uterus	4 studies	44% ± 14%	Explore
breast	4 studies	29% ± 3%	Explore
placenta	3 studies	39% ± 5%	Explore
skin	3 studies	17% ± 1%	Explore
thymus	3 studies	45% ± 20%	Explore
prostate	3 studies	24% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	4773.49	459 / 459	100%	57.83	1118 / 1118
esophagus	100%	3174.74	1443 / 1445	100%	37.58	183 / 183
brain	100%	3365.15	2638 / 2642	100%	51.25	705 / 705
ovary	100%	3958.04	180 / 180	100%	44.02	429 / 430
lung	100%	3071.51	576 / 578	100%	50.37	1155 / 1155
uterus	100%	3774.55	170 / 170	100%	55.51	457 / 459
thymus	100%	3772.50	653 / 653	100%	53.17	602 / 605
prostate	100%	3361.22	245 / 245	99%	50.08	499 / 502
bladder	100%	3491.05	21 / 21	99%	50.96	499 / 504
stomach	100%	2476.65	359 / 359	98%	46.98	281 / 286
intestine	100%	3397.55	966 / 966	98%	52.80	516 / 527
adrenal gland	100%	3896.67	258 / 258	97%	36.32	224 / 230
kidney	100%	2871.99	89 / 89	97%	31.51	872 / 901
pancreas	97%	1376.05	318 / 328	99%	40.97	176 / 178
liver	99%	1689.32	223 / 226	97%	24.69	393 / 406
skin	100%	4434.50	1804 / 1809	95%	46.86	450 / 472
blood vessel	100%	4679.58	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	48.61	29 / 29
spleen	100%	3163.00	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	38.15	45 / 45
ureter	0%	0	0 / 0	100%	30.12	1 / 1
adipose	100%	5393.09	1203 / 1204	0%	0	0 / 0
muscle	100%	2268.26	801 / 803	0%	0	0 / 0
heart	97%	2318.51	831 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	79%	19.30	63 / 80
peripheral blood	45%	1678.41	416 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1903608	Biological process	protein localization to cytoplasmic stress granule
GO_0042780	Biological process	tRNA 3'-end processing
GO_0008334	Biological process	histone mRNA metabolic process
GO_0006409	Biological process	tRNA export from nucleus
GO_0001682	Biological process	tRNA 5'-leader removal
GO_0006400	Biological process	tRNA modification
GO_0008033	Biological process	tRNA processing
GO_0045727	Biological process	positive regulation of translation
GO_0075522	Biological process	IRES-dependent viral translational initiation
GO_0071045	Biological process	nuclear histone mRNA catabolic process
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0000781	Cellular component	chromosome, telomeric region
GO_1990904	Cellular component	ribonucleoprotein complex
GO_0010494	Cellular component	cytoplasmic stress granule
GO_0005634	Cellular component	nucleus
GO_1990825	Molecular function	sequence-specific mRNA binding
GO_0003729	Molecular function	mRNA binding
GO_0008266	Molecular function	poly(U) RNA binding
GO_0003723	Molecular function	RNA binding
GO_0000049	Molecular function	tRNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SSB
Protein name	Small RNA binding exonuclease protection factor La Autoantigen La Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B)
Synonyms
Description	FUNCTION: Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation . In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation . .
Accessions	ENST00000409333.1 E9PFL9 E7ERC4 ENST00000417292.5 B5BUB5 ENST00000422006.5 ENST00000413002.5 E9PGX9 P05455 ENST00000260956.9

SSB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review