SPCS1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	40 studies	42% ± 15%	Explore
natural killer cell	35 studies	41% ± 12%	Explore
fibroblast	34 studies	42% ± 14%	Explore
CD8-positive, alpha-beta T cell	34 studies	45% ± 16%	Explore
endothelial cell	31 studies	39% ± 16%	Explore
macrophage	30 studies	37% ± 13%	Explore
CD4-positive, alpha-beta T cell	30 studies	46% ± 15%	Explore
T cell	29 studies	41% ± 12%	Explore
conventional dendritic cell	28 studies	47% ± 15%	Explore
pericyte	27 studies	42% ± 11%	Explore
plasma cell	26 studies	74% ± 18%	Explore
plasmacytoid dendritic cell	26 studies	83% ± 14%	Explore
regulatory T cell	26 studies	47% ± 15%	Explore
classical monocyte	25 studies	37% ± 14%	Explore
smooth muscle cell	22 studies	41% ± 11%	Explore
non-classical monocyte	22 studies	45% ± 16%	Explore
dendritic cell	20 studies	46% ± 21%	Explore
memory B cell	20 studies	42% ± 10%	Explore
epithelial cell	20 studies	48% ± 20%	Explore
mast cell	19 studies	45% ± 14%	Explore
monocyte	19 studies	36% ± 13%	Explore
basal cell	19 studies	45% ± 18%	Explore
naive B cell	19 studies	34% ± 9%	Explore
mature NK T cell	18 studies	41% ± 12%	Explore
connective tissue cell	18 studies	40% ± 13%	Explore
endothelial cell of lymphatic vessel	17 studies	46% ± 11%	Explore
gamma-delta T cell	17 studies	46% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	42% ± 13%	Explore
ciliated cell	16 studies	65% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	43% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	39% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	49% ± 13%	Explore
mucosal invariant T cell	13 studies	43% ± 13%	Explore
myofibroblast cell	13 studies	44% ± 10%	Explore
plasmablast	12 studies	76% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	45% ± 15%	Explore
secretory cell	12 studies	46% ± 16%	Explore
capillary endothelial cell	12 studies	32% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	47% ± 15%	Explore
vein endothelial cell	11 studies	34% ± 8%	Explore
myeloid cell	11 studies	42% ± 14%	Explore
progenitor cell	10 studies	43% ± 14%	Explore
abnormal cell	10 studies	44% ± 14%	Explore
endothelial cell of artery	10 studies	34% ± 8%	Explore
mesothelial cell	10 studies	44% ± 16%	Explore
endothelial cell of vascular tree	10 studies	36% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	48% ± 15%	Explore
goblet cell	9 studies	38% ± 15%	Explore
IgG plasma cell	9 studies	60% ± 22%	Explore
type I pneumocyte	8 studies	38% ± 13%	Explore
leukocyte	8 studies	40% ± 9%	Explore
neuron	8 studies	37% ± 16%	Explore
IgA plasma cell	8 studies	66% ± 24%	Explore
T follicular helper cell	8 studies	51% ± 7%	Explore
type II pneumocyte	7 studies	46% ± 18%	Explore
innate lymphoid cell	7 studies	37% ± 9%	Explore
club cell	7 studies	53% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	51% ± 17%	Explore
epithelial cell of proximal tubule	7 studies	43% ± 14%	Explore
enterocyte	7 studies	37% ± 14%	Explore
retinal rod cell	7 studies	40% ± 22%	Explore
astrocyte	7 studies	32% ± 21%	Explore
hematopoietic precursor cell	6 studies	48% ± 23%	Explore
respiratory goblet cell	6 studies	47% ± 22%	Explore
platelet	6 studies	23% ± 3%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	57% ± 22%	Explore
kidney loop of Henle epithelial cell	6 studies	48% ± 12%	Explore
renal alpha-intercalated cell	6 studies	63% ± 8%	Explore
retinal cone cell	6 studies	55% ± 28%	Explore
hematopoietic stem cell	6 studies	42% ± 12%	Explore
erythrocyte	6 studies	36% ± 17%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	52% ± 19%	Explore
alveolar macrophage	5 studies	43% ± 10%	Explore
CD4-positive helper T cell	5 studies	33% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	42% ± 15%	Explore
exhausted T cell	5 studies	59% ± 7%	Explore
ionocyte	5 studies	41% ± 11%	Explore
mononuclear phagocyte	5 studies	47% ± 18%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	58% ± 8%	Explore
enteroendocrine cell	5 studies	46% ± 18%	Explore
intestinal crypt stem cell	5 studies	35% ± 12%	Explore
transit amplifying cell	5 studies	33% ± 14%	Explore
retinal ganglion cell	5 studies	55% ± 27%	Explore
ON-bipolar cell	5 studies	48% ± 16%	Explore
precursor B cell	5 studies	44% ± 11%	Explore
pro-B cell	5 studies	38% ± 9%	Explore
oligodendrocyte	5 studies	25% ± 12%	Explore
granulocyte	5 studies	43% ± 15%	Explore
GABAergic neuron	5 studies	28% ± 10%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	42% ± 17%	Explore
deuterosomal cell	4 studies	54% ± 14%	Explore
pancreatic A cell	4 studies	81% ± 10%	Explore
type B pancreatic cell	4 studies	79% ± 9%	Explore
glomerular endothelial cell	4 studies	34% ± 10%	Explore
retinal bipolar neuron	4 studies	65% ± 29%	Explore
OFF-bipolar cell	4 studies	50% ± 10%	Explore
erythroblast	4 studies	48% ± 17%	Explore
immature B cell	4 studies	48% ± 11%	Explore
amacrine cell	4 studies	41% ± 20%	Explore
retina horizontal cell	4 studies	38% ± 18%	Explore
microglial cell	4 studies	37% ± 18%	Explore
adventitial cell	4 studies	38% ± 9%	Explore
mucus secreting cell	4 studies	45% ± 16%	Explore
acinar cell	4 studies	45% ± 19%	Explore
neutrophil	4 studies	22% ± 3%	Explore
intermediate monocyte	4 studies	52% ± 20%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	68% ± 10%	Explore
IgM plasma cell	4 studies	55% ± 19%	Explore
glutamatergic neuron	4 studies	37% ± 10%	Explore
oligodendrocyte precursor cell	4 studies	31% ± 12%	Explore
group 3 innate lymphoid cell	4 studies	51% ± 13%	Explore
T-helper 17 cell	4 studies	52% ± 18%	Explore
double negative thymocyte	4 studies	54% ± 13%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	52% ± 21%	Explore
duct epithelial cell	3 studies	58% ± 6%	Explore
squamous epithelial cell	3 studies	42% ± 23%	Explore
pancreatic D cell	3 studies	79% ± 10%	Explore
podocyte	3 studies	54% ± 4%	Explore
neural crest cell	3 studies	44% ± 4%	Explore
renal principal cell	3 studies	62% ± 10%	Explore
extravillous trophoblast	3 studies	59% ± 13%	Explore
placental villous trophoblast	3 studies	74% ± 15%	Explore
common myeloid progenitor	3 studies	43% ± 25%	Explore
lymphocyte	3 studies	49% ± 13%	Explore
megakaryocyte	3 studies	31% ± 3%	Explore
brush cell	3 studies	36% ± 19%	Explore
neuroendocrine cell	3 studies	57% ± 23%	Explore
serous secreting cell	3 studies	61% ± 18%	Explore
intraepithelial lymphocyte	3 studies	47% ± 12%	Explore
Mueller cell	3 studies	48% ± 13%	Explore
rod bipolar cell	3 studies	70% ± 12%	Explore
muscle cell	3 studies	34% ± 20%	Explore
germinal center B cell	3 studies	35% ± 5%	Explore
myoepithelial cell	3 studies	45% ± 11%	Explore
luminal cell of prostate epithelium	3 studies	42% ± 10%	Explore
pancreatic ductal cell	3 studies	68% ± 4%	Explore
granulocyte monocyte progenitor cell	3 studies	51% ± 32%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	47% ± 32%	Explore
glial cell	3 studies	43% ± 20%	Explore
hepatocyte	3 studies	48% ± 29%	Explore
keratinocyte	3 studies	35% ± 5%	Explore
interneuron	3 studies	28% ± 11%	Explore
T-helper 1 cell	3 studies	61% ± 12%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	52% ± 13%	Explore
progenitor cell of mammary luminal epithelium	3 studies	47% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	45% ± 14%	Explore
lung	18 studies	44% ± 15%	Explore
intestine	12 studies	41% ± 16%	Explore
brain	10 studies	29% ± 11%	Explore
kidney	9 studies	42% ± 10%	Explore
eye	9 studies	41% ± 20%	Explore
bone marrow	6 studies	34% ± 9%	Explore
liver	6 studies	40% ± 18%	Explore
pancreas	5 studies	63% ± 25%	Explore
lymph node	5 studies	44% ± 8%	Explore
placenta	4 studies	46% ± 24%	Explore
uterus	4 studies	54% ± 15%	Explore
prostate	4 studies	29% ± 9%	Explore
breast	4 studies	46% ± 8%	Explore
adrenal gland	3 studies	35% ± 8%	Explore
thymus	3 studies	51% ± 21%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3141.35	1445 / 1445	100%	40.62	183 / 183
ovary	100%	3026.16	180 / 180	100%	71.20	430 / 430
pancreas	100%	4162.77	328 / 328	100%	56.96	178 / 178
prostate	100%	3448.91	245 / 245	100%	80.56	502 / 502
stomach	100%	3824.89	359 / 359	100%	60.15	286 / 286
brain	100%	3192.23	2638 / 2642	100%	63.41	705 / 705
thymus	100%	4202.55	653 / 653	100%	74.69	604 / 605
lung	100%	3133.22	577 / 578	100%	53.33	1155 / 1155
intestine	100%	3449.14	966 / 966	100%	62.85	526 / 527
skin	100%	4017.11	1809 / 1809	100%	81.70	471 / 472
uterus	100%	3284.36	170 / 170	100%	56.37	458 / 459
liver	100%	3122.58	226 / 226	100%	63.86	405 / 406
bladder	100%	3499.86	21 / 21	100%	75.68	502 / 504
breast	100%	3519.93	459 / 459	100%	75.64	1113 / 1118
kidney	100%	4165.54	89 / 89	99%	41.48	892 / 901
adrenal gland	100%	5083.52	258 / 258	98%	62.75	226 / 230
adipose	100%	3151.94	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	45.46	80 / 80
lymph node	0%	0	0 / 0	100%	64.36	29 / 29
spleen	100%	3556.61	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	46.49	45 / 45
ureter	0%	0	0 / 0	100%	59.23	1 / 1
blood vessel	100%	3897.42	1334 / 1335	0%	0	0 / 0
muscle	100%	2769.10	801 / 803	0%	0	0 / 0
peripheral blood	98%	3532.28	908 / 929	0%	0	0 / 0
heart	97%	2600.94	839 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	SPCS1
Protein name	Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit)
Synonyms	SPC12 HSPC033
Description	FUNCTION: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum . Dispensable for SPC enzymatic activity (By similarity). .; FUNCTION: (Microbial infection) Required for the post-translational processing of proteins involved in virion assembly and secretion from flaviviruses such as West Nile virus (WNV), Japanese encephalitis virus (JEV), Dengue virus type 2 (DENV-2), Yellow Fever virus (YFV), Zika virus (ZIKV) and hepatitis C virus (HCV) . Plays a key role in the post-translational processing of flaviviral structural proteins prM, E, and NS1 . In HCV, it is involved in virion assembly where it promotes the interaction between HCV virus proteins NS2 and E2 . .
Accessions	Q9Y6A9 ENST00000233025.11 C9JBL1 ENST00000423431.5 ENST00000619898.5 A0A5F9YFS9

GO_0006465	Biological process	signal peptide processing
GO_0045047	Biological process	protein targeting to ER
GO_0019082	Biological process	viral protein processing
GO_0006508	Biological process	proteolysis
GO_0019068	Biological process	virion assembly
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005787	Cellular component	signal peptidase complex
GO_0005515	Molecular function	protein binding
GO_0003674	Molecular function	molecular_function

SPCS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review