SNX3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051224Biological processnegative regulation of protein transport
GO_0042177Biological processnegative regulation of protein catabolic process
GO_0010976Biological processpositive regulation of neuron projection development
GO_0009617Biological processresponse to bacterium
GO_0010324Biological processmembrane invagination
GO_0046597Biological processnegative regulation of viral entry into host cell
GO_0032456Biological processendocytic recycling
GO_0034499Biological processlate endosome to Golgi transport
GO_2000642Biological processnegative regulation of early endosome to late endosome transport
GO_0050765Biological processnegative regulation of phagocytosis
GO_0022615Biological processprotein to membrane docking
GO_0015031Biological processprotein transport
GO_0030111Biological processregulation of Wnt signaling pathway
GO_0070676Biological processintralumenal vesicle formation
GO_0032009Cellular componentearly phagosome
GO_0005769Cellular componentearly endosome
GO_0031901Cellular componentearly endosome membrane
GO_0070062Cellular componentextracellular exosome
GO_0030136Cellular componentclathrin-coated vesicle
GO_0030904Cellular componentretromer complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_1905394Molecular functionretromer complex binding
GO_0070273Molecular functionphosphatidylinositol-4-phosphate binding
GO_0019903Molecular functionprotein phosphatase binding
GO_0032266Molecular functionphosphatidylinositol-3-phosphate binding
GO_0080025Molecular functionphosphatidylinositol-3,5-bisphosphate binding
GO_0005515Molecular functionprotein binding
GO_0010314Molecular functionphosphatidylinositol-5-phosphate binding

IV. Literature review

[source]
Gene nameSNX3
Protein nameSorting nexin-3 (Protein SDP3)
Synonyms
DescriptionFUNCTION: Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Can also bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway . Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes . Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (By similarity). In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs . .

AccessionsENST00000349379.5 [O60493-4]
ENST00000230085.13 [O60493-1]
O60493
ENST00000368979.6 [O60493-3]
ENST00000426155.6 [O60493-2]