SMDT1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	39 studies	48% ± 16%	Explore
natural killer cell	33 studies	32% ± 10%	Explore
CD8-positive, alpha-beta T cell	31 studies	37% ± 12%	Explore
CD4-positive, alpha-beta T cell	30 studies	42% ± 13%	Explore
fibroblast	29 studies	30% ± 13%	Explore
macrophage	28 studies	32% ± 10%	Explore
conventional dendritic cell	28 studies	49% ± 15%	Explore
T cell	25 studies	36% ± 11%	Explore
endothelial cell	25 studies	33% ± 15%	Explore
classical monocyte	25 studies	36% ± 14%	Explore
regulatory T cell	25 studies	36% ± 11%	Explore
smooth muscle cell	23 studies	34% ± 10%	Explore
plasma cell	22 studies	45% ± 21%	Explore
non-classical monocyte	22 studies	39% ± 16%	Explore
pericyte	22 studies	34% ± 12%	Explore
memory B cell	20 studies	51% ± 11%	Explore
naive B cell	20 studies	43% ± 11%	Explore
plasmacytoid dendritic cell	20 studies	42% ± 14%	Explore
monocyte	17 studies	37% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	42% ± 13%	Explore
epithelial cell	17 studies	48% ± 20%	Explore
gamma-delta T cell	17 studies	36% ± 15%	Explore
endothelial cell of lymphatic vessel	16 studies	37% ± 9%	Explore
basal cell	16 studies	40% ± 18%	Explore
ciliated cell	16 studies	59% ± 17%	Explore
mature NK T cell	16 studies	32% ± 10%	Explore
dendritic cell	15 studies	49% ± 24%	Explore
mast cell	15 studies	30% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	31% ± 10%	Explore
mucosal invariant T cell	14 studies	34% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	47% ± 12%	Explore
connective tissue cell	14 studies	35% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	36% ± 11%	Explore
plasmablast	12 studies	47% ± 22%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	39% ± 14%	Explore
myofibroblast cell	12 studies	32% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	41% ± 15%	Explore
vein endothelial cell	11 studies	28% ± 9%	Explore
myeloid cell	11 studies	35% ± 14%	Explore
secretory cell	10 studies	39% ± 14%	Explore
endothelial cell of artery	10 studies	23% ± 7%	Explore
platelet	9 studies	23% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	36% ± 16%	Explore
progenitor cell	9 studies	43% ± 13%	Explore
capillary endothelial cell	9 studies	25% ± 9%	Explore
endothelial cell of vascular tree	9 studies	33% ± 6%	Explore
innate lymphoid cell	8 studies	34% ± 7%	Explore
leukocyte	8 studies	37% ± 10%	Explore
goblet cell	8 studies	40% ± 21%	Explore
T follicular helper cell	8 studies	44% ± 9%	Explore
type I pneumocyte	7 studies	30% ± 15%	Explore
type II pneumocyte	7 studies	49% ± 19%	Explore
club cell	7 studies	43% ± 8%	Explore
abnormal cell	7 studies	42% ± 17%	Explore
IgA plasma cell	7 studies	33% ± 14%	Explore
IgG plasma cell	7 studies	32% ± 13%	Explore
hematopoietic stem cell	7 studies	38% ± 15%	Explore
hematopoietic precursor cell	6 studies	46% ± 23%	Explore
ionocyte	6 studies	38% ± 12%	Explore
respiratory goblet cell	6 studies	38% ± 16%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	38% ± 20%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	32% ± 9%	Explore
epithelial cell of proximal tubule	6 studies	40% ± 9%	Explore
kidney loop of Henle epithelial cell	6 studies	44% ± 12%	Explore
renal alpha-intercalated cell	6 studies	64% ± 12%	Explore
precursor B cell	6 studies	44% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	49% ± 16%	Explore
alveolar macrophage	5 studies	28% ± 8%	Explore
CD4-positive helper T cell	5 studies	30% ± 7%	Explore
exhausted T cell	5 studies	42% ± 12%	Explore
mononuclear phagocyte	5 studies	43% ± 19%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	50% ± 6%	Explore
enterocyte	5 studies	43% ± 6%	Explore
enteroendocrine cell	5 studies	51% ± 23%	Explore
intestinal crypt stem cell	5 studies	38% ± 14%	Explore
mesothelial cell	5 studies	44% ± 17%	Explore
retinal ganglion cell	5 studies	58% ± 31%	Explore
retinal rod cell	5 studies	34% ± 16%	Explore
pro-B cell	5 studies	44% ± 7%	Explore
immature B cell	5 studies	50% ± 19%	Explore
neuron	5 studies	55% ± 25%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	31% ± 12%	Explore
transit amplifying cell	4 studies	38% ± 14%	Explore
retinal cone cell	4 studies	64% ± 25%	Explore
brush cell	4 studies	34% ± 14%	Explore
amacrine cell	4 studies	40% ± 15%	Explore
astrocyte	4 studies	31% ± 15%	Explore
adventitial cell	4 studies	21% ± 6%	Explore
germinal center B cell	4 studies	50% ± 17%	Explore
intermediate monocyte	4 studies	50% ± 18%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	53% ± 14%	Explore
granulocyte	4 studies	33% ± 9%	Explore
T-helper 17 cell	4 studies	35% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	26% ± 10%	Explore
double negative thymocyte	4 studies	46% ± 22%	Explore
erythrocyte	4 studies	36% ± 18%	Explore
deuterosomal cell	3 studies	46% ± 3%	Explore
duct epithelial cell	3 studies	46% ± 9%	Explore
squamous epithelial cell	3 studies	35% ± 25%	Explore
neural crest cell	3 studies	36% ± 7%	Explore
retinal bipolar neuron	3 studies	48% ± 23%	Explore
OFF-bipolar cell	3 studies	49% ± 30%	Explore
ON-bipolar cell	3 studies	50% ± 31%	Explore
renal principal cell	3 studies	50% ± 7%	Explore
erythroblast	3 studies	37% ± 22%	Explore
lymphocyte	3 studies	43% ± 11%	Explore
megakaryocyte	3 studies	28% ± 5%	Explore
retina horizontal cell	3 studies	45% ± 15%	Explore
microglial cell	3 studies	32% ± 12%	Explore
mucus secreting cell	3 studies	49% ± 19%	Explore
serous secreting cell	3 studies	56% ± 16%	Explore
intraepithelial lymphocyte	3 studies	40% ± 12%	Explore
Mueller cell	3 studies	36% ± 9%	Explore
luminal cell of prostate epithelium	3 studies	49% ± 11%	Explore
IgM plasma cell	3 studies	40% ± 15%	Explore
hepatocyte	3 studies	52% ± 30%	Explore
group 3 innate lymphoid cell	3 studies	52% ± 13%	Explore
keratinocyte	3 studies	32% ± 9%	Explore
T-helper 1 cell	3 studies	47% ± 12%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	44% ± 14%	Explore
progenitor cell of mammary luminal epithelium	3 studies	53% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	41% ± 13%	Explore
lung	16 studies	39% ± 13%	Explore
intestine	11 studies	36% ± 15%	Explore
kidney	8 studies	34% ± 8%	Explore
eye	7 studies	35% ± 16%	Explore
lymph node	6 studies	39% ± 11%	Explore
bone marrow	4 studies	30% ± 10%	Explore
uterus	4 studies	46% ± 13%	Explore
breast	4 studies	37% ± 10%	Explore
liver	4 studies	42% ± 17%	Explore
placenta	3 studies	34% ± 16%	Explore
adrenal gland	3 studies	30% ± 8%	Explore
prostate	3 studies	26% ± 7%	Explore
thymus	3 studies	51% ± 25%	Explore
brain	3 studies	29% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	2866.65	2642 / 2642	100%	107.26	705 / 705
esophagus	100%	2519.65	1445 / 1445	100%	46.55	183 / 183
liver	100%	1731.39	226 / 226	100%	67.58	406 / 406
ovary	100%	3537.43	180 / 180	100%	66.40	430 / 430
pancreas	100%	2004.53	328 / 328	100%	70.27	178 / 178
prostate	100%	3136.79	245 / 245	100%	176.22	502 / 502
stomach	100%	2578.70	359 / 359	100%	63.04	286 / 286
thymus	100%	3021.76	653 / 653	100%	132.63	605 / 605
kidney	100%	3070.62	89 / 89	100%	67.38	900 / 901
uterus	100%	2671.98	170 / 170	100%	72.15	458 / 459
skin	100%	1956.58	1802 / 1809	100%	77.79	472 / 472
bladder	100%	2384.57	21 / 21	100%	70.84	502 / 504
intestine	100%	2561.55	966 / 966	99%	69.13	524 / 527
lung	99%	1947.92	575 / 578	100%	63.31	1151 / 1155
breast	100%	2509.80	459 / 459	99%	70.86	1105 / 1118
adrenal gland	100%	2678.66	258 / 258	99%	89.57	227 / 230
adipose	100%	2136.39	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	99.69	80 / 80
lymph node	0%	0	0 / 0	100%	169.38	29 / 29
muscle	100%	3765.21	803 / 803	0%	0	0 / 0
spleen	100%	2344.40	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	67.14	45 / 45
ureter	0%	0	0 / 0	100%	61.07	1 / 1
blood vessel	100%	2314.30	1333 / 1335	0%	0	0 / 0
heart	99%	2356.08	851 / 861	0%	0	0 / 0
peripheral blood	95%	1431.66	881 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006851	Biological process	mitochondrial calcium ion transmembrane transport
GO_0036444	Biological process	calcium import into the mitochondrion
GO_0051560	Biological process	mitochondrial calcium ion homeostasis
GO_0005654	Cellular component	nucleoplasm
GO_0005759	Cellular component	mitochondrial matrix
GO_1990246	Cellular component	uniplex complex
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0099103	Molecular function	channel activator activity
GO_0030674	Molecular function	protein-macromolecule adaptor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SMDT1
Protein name	Essential MCU regulator, mitochondrial (Single-pass membrane protein with aspartate-rich tail 1, mitochondrial) Essential MCU regulator, mitochondrial (Single-pass membrane protein with aspartate rich tail 1)
Synonyms	EMRE C22orf32
Description	FUNCTION: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria . Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU . Plays a central role in regulating the uniplex complex response to intracellular calcium signaling . Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling . .
Accessions	F8WDX6 ENST00000331479.4 ENST00000608773.1 Q9H4I9 ENST00000625945.1 ENST00000630819.1 ENST00000615504.2 ENST00000422252.1 ENST00000607293.3 ENST00000571525.3

SMDT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review