SERF2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	50 studies	78% ± 21%	Explore
endothelial cell	48 studies	70% ± 27%	Explore
macrophage	47 studies	78% ± 25%	Explore
natural killer cell	47 studies	82% ± 21%	Explore
fibroblast	45 studies	74% ± 27%	Explore
T cell	43 studies	70% ± 28%	Explore
CD8-positive, alpha-beta T cell	39 studies	80% ± 21%	Explore
pericyte	38 studies	74% ± 27%	Explore
CD4-positive, alpha-beta T cell	35 studies	80% ± 21%	Explore
conventional dendritic cell	31 studies	93% ± 11%	Explore
dendritic cell	29 studies	82% ± 22%	Explore
smooth muscle cell	29 studies	76% ± 26%	Explore
classical monocyte	29 studies	89% ± 18%	Explore
plasmacytoid dendritic cell	29 studies	93% ± 6%	Explore
monocyte	27 studies	82% ± 22%	Explore
plasma cell	27 studies	83% ± 19%	Explore
regulatory T cell	27 studies	88% ± 12%	Explore
endothelial cell of lymphatic vessel	26 studies	78% ± 26%	Explore
non-classical monocyte	26 studies	92% ± 15%	Explore
epithelial cell	26 studies	84% ± 22%	Explore
mast cell	23 studies	74% ± 21%	Explore
mature NK T cell	22 studies	82% ± 17%	Explore
basal cell	21 studies	84% ± 19%	Explore
connective tissue cell	21 studies	80% ± 22%	Explore
gamma-delta T cell	20 studies	84% ± 18%	Explore
memory B cell	20 studies	86% ± 10%	Explore
naive B cell	19 studies	83% ± 12%	Explore
ciliated cell	18 studies	86% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	80% ± 15%	Explore
capillary endothelial cell	17 studies	71% ± 20%	Explore
mucosal invariant T cell	16 studies	83% ± 15%	Explore
endothelial cell of artery	16 studies	75% ± 22%	Explore
myeloid cell	16 studies	76% ± 29%	Explore
erythrocyte	15 studies	70% ± 27%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	84% ± 21%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	88% ± 11%	Explore
neutrophil	15 studies	66% ± 25%	Explore
myofibroblast cell	15 studies	84% ± 19%	Explore
vein endothelial cell	15 studies	75% ± 26%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	84% ± 17%	Explore
astrocyte	14 studies	35% ± 20%	Explore
goblet cell	14 studies	78% ± 26%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	77% ± 22%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	80% ± 22%	Explore
endothelial cell of vascular tree	13 studies	79% ± 26%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	77% ± 20%	Explore
innate lymphoid cell	12 studies	86% ± 12%	Explore
plasmablast	12 studies	92% ± 5%	Explore
secretory cell	12 studies	92% ± 9%	Explore
microglial cell	12 studies	54% ± 29%	Explore
type I pneumocyte	11 studies	72% ± 24%	Explore
platelet	11 studies	83% ± 19%	Explore
club cell	11 studies	77% ± 30%	Explore
leukocyte	11 studies	79% ± 23%	Explore
mesothelial cell	11 studies	76% ± 29%	Explore
type II pneumocyte	10 studies	77% ± 27%	Explore
T follicular helper cell	10 studies	90% ± 8%	Explore
progenitor cell	10 studies	92% ± 12%	Explore
IgG plasma cell	10 studies	73% ± 25%	Explore
abnormal cell	9 studies	87% ± 14%	Explore
neuron	9 studies	59% ± 24%	Explore
IgA plasma cell	9 studies	70% ± 29%	Explore
hematopoietic stem cell	9 studies	91% ± 10%	Explore
alveolar macrophage	8 studies	71% ± 33%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	84% ± 22%	Explore
mononuclear phagocyte	8 studies	75% ± 30%	Explore
oligodendrocyte	8 studies	34% ± 17%	Explore
enterocyte	8 studies	82% ± 20%	Explore
ionocyte	7 studies	90% ± 10%	Explore
respiratory goblet cell	7 studies	85% ± 13%	Explore
effector CD4-positive, alpha-beta T cell	7 studies	81% ± 26%	Explore
epithelial cell of proximal tubule	7 studies	83% ± 17%	Explore
enteroendocrine cell	7 studies	83% ± 24%	Explore
brush cell	7 studies	75% ± 26%	Explore
hematopoietic precursor cell	6 studies	79% ± 21%	Explore
kidney loop of Henle epithelial cell	6 studies	87% ± 13%	Explore
renal alpha-intercalated cell	6 studies	95% ± 4%	Explore
erythroblast	6 studies	77% ± 20%	Explore
transit amplifying cell	6 studies	77% ± 24%	Explore
retinal cone cell	6 studies	57% ± 31%	Explore
precursor B cell	6 studies	91% ± 7%	Explore
glial cell	6 studies	65% ± 22%	Explore
immature B cell	6 studies	88% ± 15%	Explore
intermediate monocyte	6 studies	92% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	87% ± 8%	Explore
CD4-positive helper T cell	5 studies	80% ± 10%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	80% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	86% ± 8%	Explore
duct epithelial cell	5 studies	82% ± 29%	Explore
exhausted T cell	5 studies	95% ± 3%	Explore
endothelial cell of sinusoid	5 studies	49% ± 28%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	97% ± 1%	Explore
megakaryocyte	5 studies	95% ± 2%	Explore
retinal ganglion cell	5 studies	67% ± 31%	Explore
retinal rod cell	5 studies	40% ± 17%	Explore
lymphocyte	5 studies	79% ± 30%	Explore
neuroendocrine cell	5 studies	94% ± 10%	Explore
T-helper 17 cell	5 studies	95% ± 6%	Explore
group 3 innate lymphoid cell	5 studies	92% ± 4%	Explore
mucus secreting cell	5 studies	77% ± 28%	Explore
adipocyte	5 studies	28% ± 10%	Explore
double negative thymocyte	5 studies	94% ± 3%	Explore
hepatocyte	5 studies	67% ± 26%	Explore
granulocyte	5 studies	86% ± 12%	Explore
melanocyte	5 studies	70% ± 28%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	79% ± 24%	Explore
deuterosomal cell	4 studies	87% ± 15%	Explore
squamous epithelial cell	4 studies	60% ± 26%	Explore
glomerular endothelial cell	4 studies	84% ± 11%	Explore
kidney connecting tubule epithelial cell	4 studies	95% ± 4%	Explore
podocyte	4 studies	93% ± 5%	Explore
intestinal crypt stem cell	4 studies	96% ± 5%	Explore
glutamatergic neuron	4 studies	34% ± 17%	Explore
pro-B cell	4 studies	91% ± 6%	Explore
amacrine cell	4 studies	39% ± 15%	Explore
retinal pigment epithelial cell	4 studies	65% ± 27%	Explore
adventitial cell	4 studies	82% ± 12%	Explore
cardiac muscle cell	4 studies	33% ± 15%	Explore
inflammatory macrophage	4 studies	81% ± 16%	Explore
muscle cell	4 studies	50% ± 19%	Explore
germinal center B cell	4 studies	97% ± 2%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	95% ± 7%	Explore
luminal cell of prostate epithelium	4 studies	86% ± 24%	Explore
IgM plasma cell	4 studies	75% ± 20%	Explore
oligodendrocyte precursor cell	4 studies	52% ± 26%	Explore
T-helper 1 cell	4 studies	96% ± 2%	Explore
hillock cell	3 studies	72% ± 30%	Explore
precursor cell	3 studies	93% ± 5%	Explore
pancreatic A cell	3 studies	92% ± 9%	Explore
type B pancreatic cell	3 studies	91% ± 7%	Explore
monocyte-derived dendritic cell	3 studies	97% ± 3%	Explore
renal beta-intercalated cell	3 studies	97% ± 2%	Explore
neural crest cell	3 studies	93% ± 3%	Explore
paneth cell	3 studies	88% ± 11%	Explore
GABAergic neuron	3 studies	28% ± 14%	Explore
renal principal cell	3 studies	94% ± 4%	Explore
thymocyte	3 studies	85% ± 10%	Explore
extravillous trophoblast	3 studies	99% ± 0%	Explore
placental villous trophoblast	3 studies	100% ± 0%	Explore
Schwann cell	3 studies	67% ± 33%	Explore
retina horizontal cell	3 studies	38% ± 20%	Explore
serous secreting cell	3 studies	87% ± 9%	Explore
tissue-resident macrophage	3 studies	73% ± 27%	Explore
follicular B cell	3 studies	79% ± 10%	Explore
intraepithelial lymphocyte	3 studies	92% ± 4%	Explore
Mueller cell	3 studies	64% ± 9%	Explore
acinar cell	3 studies	74% ± 14%	Explore
chondrocyte	3 studies	55% ± 21%	Explore
myoepithelial cell	3 studies	84% ± 11%	Explore
cholangiocyte	3 studies	49% ± 31%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	96% ± 5%	Explore
keratinocyte	3 studies	90% ± 6%	Explore
interneuron	3 studies	50% ± 29%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	94% ± 0%	Explore
double-positive, alpha-beta thymocyte	3 studies	95% ± 2%	Explore
progenitor cell of mammary luminal epithelium	3 studies	97% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	21 studies	85% ± 15%	Explore
lung	20 studies	79% ± 20%	Explore
intestine	13 studies	81% ± 19%	Explore
brain	11 studies	45% ± 25%	Explore
kidney	9 studies	82% ± 17%	Explore
eye	9 studies	50% ± 21%	Explore
liver	8 studies	67% ± 26%	Explore
bone marrow	6 studies	77% ± 14%	Explore
lymph node	6 studies	89% ± 6%	Explore
heart	5 studies	37% ± 18%	Explore
uterus	5 studies	84% ± 20%	Explore
prostate	5 studies	72% ± 29%	Explore
pancreas	4 studies	79% ± 19%	Explore
placenta	4 studies	87% ± 21%	Explore
adipose	4 studies	54% ± 25%	Explore
esophagus	4 studies	66% ± 28%	Explore
breast	4 studies	90% ± 6%	Explore
adrenal gland	3 studies	79% ± 15%	Explore
skin	3 studies	77% ± 19%	Explore
stomach	3 studies	55% ± 21%	Explore
thymus	3 studies	84% ± 19%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	16034.08	258 / 258	100%	78.15	230 / 230
liver	100%	10494.55	226 / 226	100%	77.10	406 / 406
ovary	100%	7655.95	180 / 180	100%	77.51	430 / 430
thymus	100%	12497.30	653 / 653	100%	80.45	605 / 605
uterus	100%	8878.95	170 / 170	100%	94.78	459 / 459
skin	100%	11297.94	1808 / 1809	100%	80.87	472 / 472
prostate	100%	13456.51	245 / 245	100%	119.43	500 / 502
esophagus	100%	10383.99	1445 / 1445	99%	38.61	182 / 183
brain	100%	6075.71	2635 / 2642	100%	46.93	703 / 705
kidney	100%	13827.11	89 / 89	99%	60.25	896 / 901
pancreas	100%	7127.35	328 / 328	99%	78.59	177 / 178
intestine	100%	10801.05	966 / 966	99%	82.67	524 / 527
lung	100%	11627.26	578 / 578	99%	69.63	1145 / 1155
bladder	100%	9943.81	21 / 21	99%	87.50	499 / 504
breast	100%	10173.07	459 / 459	99%	85.26	1103 / 1118
stomach	100%	9709.64	359 / 359	99%	63.39	282 / 286
adipose	100%	10397.09	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	112.29	80 / 80
lymph node	0%	0	0 / 0	100%	143.46	29 / 29
peripheral blood	100%	12763.70	929 / 929	0%	0	0 / 0
spleen	100%	11723.26	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	61.55	45 / 45
ureter	0%	0	0 / 0	100%	183.90	1 / 1
heart	100%	10996.33	860 / 861	0%	0	0 / 0
blood vessel	100%	12103.17	1332 / 1335	0%	0	0 / 0
muscle	99%	6107.35	793 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	SERF2
Protein name	Small EDRK-rich factor 2 Small EDRK-rich factor 2 (Gastric cancer-related protein VRG107) (Protein 4F5-related) (4F5rel) (h4F5rel)
Synonyms	FAM2C
Description	FUNCTION: Positive regulator of amyloid protein aggregation and proteotoxicity . Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formation of aggregates . .
Accessions	ENST00000409614.1 [P84101-4] ENST00000339624.9 [P84101-3] F8WBN3 ENST00000430901.1 C9JQZ0 ENST00000409617.6 ENST00000630046.2 ENST00000409646.5 B8ZZY7 P84101 ENST00000402131.5 [P84101-4] ENST00000403425.5 [P84101-4] ENST00000409291.5 B9A031 ENST00000381359.5 [P84101-1] ENST00000448830.2 F8WBV6 ENST00000445816.5 [P84101-1] ENST00000409960.6 [P84101-2] ENST00000249786.9 [P84101-1]

GO_0031648	Biological process	protein destabilization
GO_0005829	Cellular component	cytosol
GO_0005634	Cellular component	nucleus
GO_0003674	Molecular function	molecular_function

SERF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review