SEM1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	40 studies	47% ± 19%	Explore
fibroblast	40 studies	48% ± 18%	Explore
pericyte	37 studies	48% ± 20%	Explore
macrophage	34 studies	40% ± 14%	Explore
natural killer cell	33 studies	34% ± 12%	Explore
B cell	32 studies	30% ± 12%	Explore
CD8-positive, alpha-beta T cell	32 studies	38% ± 18%	Explore
smooth muscle cell	28 studies	47% ± 18%	Explore
conventional dendritic cell	27 studies	48% ± 13%	Explore
CD4-positive, alpha-beta T cell	27 studies	37% ± 17%	Explore
T cell	26 studies	40% ± 15%	Explore
classical monocyte	23 studies	40% ± 13%	Explore
endothelial cell of lymphatic vessel	22 studies	54% ± 21%	Explore
non-classical monocyte	22 studies	43% ± 13%	Explore
epithelial cell	22 studies	57% ± 20%	Explore
regulatory T cell	21 studies	44% ± 12%	Explore
dendritic cell	20 studies	42% ± 22%	Explore
monocyte	19 studies	39% ± 14%	Explore
plasmacytoid dendritic cell	19 studies	38% ± 13%	Explore
basal cell	19 studies	56% ± 17%	Explore
connective tissue cell	19 studies	53% ± 20%	Explore
mast cell	17 studies	34% ± 13%	Explore
ciliated cell	16 studies	69% ± 21%	Explore
mature NK T cell	16 studies	33% ± 7%	Explore
memory B cell	15 studies	29% ± 11%	Explore
plasma cell	15 studies	42% ± 13%	Explore
naive B cell	15 studies	24% ± 7%	Explore
gamma-delta T cell	15 studies	36% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	26% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	31% ± 10%	Explore
myofibroblast cell	13 studies	53% ± 19%	Explore
myeloid cell	13 studies	45% ± 17%	Explore
secretory cell	12 studies	56% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	29% ± 9%	Explore
astrocyte	12 studies	35% ± 18%	Explore
goblet cell	12 studies	44% ± 18%	Explore
endothelial cell of vascular tree	12 studies	47% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	39% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	33% ± 10%	Explore
capillary endothelial cell	11 studies	44% ± 15%	Explore
progenitor cell	11 studies	57% ± 18%	Explore
mesothelial cell	11 studies	56% ± 25%	Explore
vein endothelial cell	11 studies	50% ± 18%	Explore
mucosal invariant T cell	11 studies	30% ± 7%	Explore
plasmablast	10 studies	46% ± 21%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	37% ± 17%	Explore
abnormal cell	10 studies	56% ± 21%	Explore
endothelial cell of artery	10 studies	50% ± 16%	Explore
leukocyte	9 studies	32% ± 12%	Explore
neuron	9 studies	43% ± 20%	Explore
oligodendrocyte	9 studies	34% ± 13%	Explore
type I pneumocyte	8 studies	43% ± 20%	Explore
type II pneumocyte	8 studies	47% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	32% ± 12%	Explore
club cell	7 studies	64% ± 9%	Explore
epithelial cell of proximal tubule	7 studies	45% ± 11%	Explore
enterocyte	7 studies	41% ± 13%	Explore
T follicular helper cell	7 studies	41% ± 9%	Explore
glutamatergic neuron	7 studies	38% ± 19%	Explore
adipocyte	7 studies	25% ± 7%	Explore
GABAergic neuron	7 studies	39% ± 17%	Explore
oligodendrocyte precursor cell	7 studies	44% ± 16%	Explore
hematopoietic precursor cell	6 studies	49% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	52% ± 20%	Explore
mononuclear phagocyte	6 studies	42% ± 15%	Explore
kidney loop of Henle epithelial cell	6 studies	44% ± 4%	Explore
renal alpha-intercalated cell	6 studies	62% ± 8%	Explore
transit amplifying cell	6 studies	41% ± 20%	Explore
hematopoietic stem cell	6 studies	51% ± 13%	Explore
precursor B cell	6 studies	36% ± 14%	Explore
retina horizontal cell	6 studies	40% ± 17%	Explore
microglial cell	6 studies	30% ± 10%	Explore
cardiac muscle cell	6 studies	23% ± 8%	Explore
alveolar macrophage	5 studies	39% ± 14%	Explore
exhausted T cell	5 studies	56% ± 9%	Explore
ionocyte	5 studies	47% ± 11%	Explore
respiratory goblet cell	5 studies	54% ± 22%	Explore
enteroendocrine cell	5 studies	57% ± 21%	Explore
retinal bipolar neuron	5 studies	37% ± 22%	Explore
retinal ganglion cell	5 studies	51% ± 29%	Explore
pro-B cell	5 studies	45% ± 9%	Explore
innate lymphoid cell	5 studies	33% ± 4%	Explore
brush cell	5 studies	34% ± 23%	Explore
amacrine cell	5 studies	38% ± 14%	Explore
retinal cone cell	5 studies	40% ± 22%	Explore
retinal rod cell	5 studies	27% ± 11%	Explore
erythrocyte	5 studies	41% ± 18%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	41% ± 19%	Explore
hepatocyte	5 studies	50% ± 30%	Explore
interneuron	5 studies	51% ± 21%	Explore
deuterosomal cell	4 studies	62% ± 22%	Explore
glomerular endothelial cell	4 studies	35% ± 10%	Explore
podocyte	4 studies	47% ± 20%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	64% ± 10%	Explore
intestinal crypt stem cell	4 studies	49% ± 16%	Explore
erythroblast	4 studies	50% ± 17%	Explore
lymphocyte	4 studies	52% ± 19%	Explore
immature B cell	4 studies	41% ± 21%	Explore
mucus secreting cell	4 studies	46% ± 19%	Explore
glial cell	4 studies	44% ± 26%	Explore
Mueller cell	4 studies	36% ± 9%	Explore
OFF-bipolar cell	4 studies	36% ± 14%	Explore
ON-bipolar cell	4 studies	39% ± 11%	Explore
neutrophil	4 studies	23% ± 5%	Explore
double negative thymocyte	4 studies	54% ± 21%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	56% ± 9%	Explore
intermediate monocyte	4 studies	61% ± 8%	Explore
CD4-positive helper T cell	4 studies	25% ± 6%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	52% ± 3%	Explore
luminal cell of prostate epithelium	4 studies	42% ± 17%	Explore
group 3 innate lymphoid cell	4 studies	46% ± 15%	Explore
duct epithelial cell	3 studies	54% ± 10%	Explore
precursor cell	3 studies	75% ± 16%	Explore
pancreatic A cell	3 studies	78% ± 5%	Explore
type B pancreatic cell	3 studies	68% ± 11%	Explore
neural crest cell	3 studies	69% ± 16%	Explore
IgA plasma cell	3 studies	22% ± 5%	Explore
IgG plasma cell	3 studies	21% ± 5%	Explore
renal principal cell	3 studies	49% ± 6%	Explore
extravillous trophoblast	3 studies	90% ± 5%	Explore
placental villous trophoblast	3 studies	92% ± 3%	Explore
common myeloid progenitor	3 studies	50% ± 26%	Explore
megakaryocyte	3 studies	31% ± 8%	Explore
neuroendocrine cell	3 studies	73% ± 21%	Explore
Schwann cell	3 studies	50% ± 25%	Explore
retinal pigment epithelial cell	3 studies	42% ± 26%	Explore
adventitial cell	3 studies	38% ± 7%	Explore
intraepithelial lymphocyte	3 studies	41% ± 15%	Explore
GABAergic amacrine cell	3 studies	24% ± 4%	Explore
glycinergic amacrine cell	3 studies	28% ± 2%	Explore
rod bipolar cell	3 studies	45% ± 7%	Explore
acinar cell	3 studies	32% ± 11%	Explore
endothelial cell of sinusoid	3 studies	29% ± 3%	Explore
muscle cell	3 studies	51% ± 13%	Explore
germinal center B cell	3 studies	52% ± 4%	Explore
myoepithelial cell	3 studies	50% ± 8%	Explore
granulocyte	3 studies	42% ± 4%	Explore
granulocyte monocyte progenitor cell	3 studies	52% ± 24%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	56% ± 31%	Explore
melanocyte	3 studies	30% ± 8%	Explore
keratinocyte	3 studies	53% ± 6%	Explore
T-helper 17 cell	3 studies	49% ± 24%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	34% ± 6%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	29% ± 10%	Explore
progenitor cell of mammary luminal epithelium	3 studies	40% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	34% ± 10%	Explore
lung	16 studies	53% ± 16%	Explore
brain	15 studies	33% ± 14%	Explore
intestine	12 studies	38% ± 19%	Explore
eye	10 studies	33% ± 12%	Explore
kidney	9 studies	47% ± 12%	Explore
liver	6 studies	45% ± 17%	Explore
bone marrow	5 studies	32% ± 9%	Explore
heart	5 studies	25% ± 9%	Explore
uterus	5 studies	57% ± 20%	Explore
adipose	5 studies	23% ± 7%	Explore
pancreas	4 studies	56% ± 20%	Explore
placenta	4 studies	65% ± 25%	Explore
prostate	4 studies	41% ± 10%	Explore
lymph node	4 studies	50% ± 16%	Explore
breast	4 studies	45% ± 3%	Explore
adrenal gland	3 studies	46% ± 9%	Explore
esophagus	3 studies	57% ± 24%	Explore
skin	3 studies	44% ± 8%	Explore
thymus	3 studies	59% ± 19%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	3687.99	258 / 258	100%	24.49	230 / 230
esophagus	100%	3049.95	1445 / 1445	100%	36.06	183 / 183
liver	100%	2675.93	226 / 226	100%	31.80	406 / 406
ovary	100%	3557.82	180 / 180	100%	21.38	430 / 430
skin	100%	3594.25	1809 / 1809	100%	31.59	472 / 472
stomach	100%	2247.86	359 / 359	100%	25.88	286 / 286
thymus	100%	2653.28	653 / 653	100%	23.93	605 / 605
uterus	100%	3080.14	170 / 170	100%	43.59	459 / 459
brain	100%	2149.58	2640 / 2642	100%	20.27	705 / 705
intestine	100%	2880.13	966 / 966	100%	27.94	526 / 527
kidney	100%	2601.27	89 / 89	100%	19.43	898 / 901
prostate	100%	3062.92	245 / 245	100%	28.47	500 / 502
lung	100%	2396.40	576 / 578	100%	32.30	1154 / 1155
bladder	100%	2838.67	21 / 21	99%	37.44	501 / 504
breast	100%	3033.22	459 / 459	99%	25.75	1108 / 1118
pancreas	99%	1359.16	326 / 328	99%	27.03	177 / 178
adipose	100%	3004.75	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2985.00	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	19.50	80 / 80
lymph node	0%	0	0 / 0	100%	38.60	29 / 29
muscle	100%	3213.17	803 / 803	0%	0	0 / 0
spleen	100%	2295.91	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	34.76	45 / 45
ureter	0%	0	0 / 0	100%	52.52	1 / 1
heart	99%	2812.54	853 / 861	0%	0	0 / 0
peripheral blood	28%	1181.12	262 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	SEM1
Protein name	Putative protein SEM1, isoform 2 SEM1 26S proteasome subunit FLJ42280 protein (SEM1 26S proteasome subunit) 26S proteasome complex subunit SEM1 (26S proteasome complex subunit DSS1) (Deleted in split hand/split foot protein 1) (Split hand/foot deleted protein 1) (Split hand/foot malformation type 1 protein) 26S proteasome complex subunit SEM1 (26S proteasome complex subunit DSS1)
Synonyms	hCG_2023166 C7orf76 tcag7.1219 DSS1 SHFDG1 FLJ42280 SHFM1
Description	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair . Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 . The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells. . FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. . FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. . FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. . FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. . FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. . FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. . FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. . FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. . FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. . FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. .
Accessions	ENST00000449279.5 ENST00000417009.5 A0A087WUG5 ENST00000248566.4 [P60896-1] A0A087WYU0 P60896 B7ZVW6 Q6IBB7 A0A096LP28 Q6ZVN7 A0A087X261 A0A087X1V0 F2Z309 ENST00000444799.5 ENST00000618105.4 A0A096LP17 ENST00000613919.4 ENST00000466986.5 ENST00000619259.4 ENST00000488005.5 ENST00000356686.2 [Q6ZVN7-1] ENST00000617133.4 F2Z2L7 ENST00000623693.3 F2Z2N6 ENST00000615352.4 ENST00000623498.3 A0A087WXB9 ENST00000413065.5

GO_0000724	Biological process	double-strand break repair via homologous recombination
GO_0006406	Biological process	mRNA export from nucleus
GO_0043248	Biological process	proteasome assembly
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000502	Cellular component	proteasome complex
GO_0032039	Cellular component	integrator complex
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0008541	Cellular component	proteasome regulatory particle, lid subcomplex
GO_0005515	Molecular function	protein binding

SEM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review