PRMT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0001701Biological processin utero embryonic development
GO_0031175Biological processneuron projection development
GO_0030510Biological processregulation of BMP signaling pathway
GO_0006974Biological processDNA damage response
GO_0045652Biological processregulation of megakaryocyte differentiation
GO_1900745Biological processpositive regulation of p38MAPK cascade
GO_0006338Biological processchromatin remodeling
GO_0061431Biological processcellular response to methionine
GO_0006479Biological processprotein methylation
GO_0018216Biological processpeptidyl-arginine methylation
GO_0019919Biological processpeptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO_0008380Biological processRNA splicing
GO_0046329Biological processnegative regulation of JNK cascade
GO_0019082Biological processviral protein processing
GO_0045648Biological processpositive regulation of erythrocyte differentiation
GO_1905168Biological processpositive regulation of double-strand break repair via homologous recombination
GO_0045727Biological processpositive regulation of translation
GO_0045653Biological processnegative regulation of megakaryocyte differentiation
GO_0048738Biological processcardiac muscle tissue development
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0046985Biological processpositive regulation of hemoglobin biosynthetic process
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005654Cellular componentnucleoplasm
GO_0034709Cellular componentmethylosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005765Cellular componentlysosomal membrane
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0048273Molecular functionmitogen-activated protein kinase p38 binding
GO_1904047Molecular functionS-adenosyl-L-methionine binding
GO_0042802Molecular functionidentical protein binding
GO_0035241Molecular functionprotein-arginine omega-N monomethyltransferase activity
GO_0042054Molecular functionhistone methyltransferase activity
GO_0008327Molecular functionmethyl-CpG binding
GO_0008168Molecular functionmethyltransferase activity
GO_0003723Molecular functionRNA binding
GO_0008276Molecular functionprotein methyltransferase activity
GO_0016274Molecular functionprotein-arginine N-methyltransferase activity
GO_0008170Molecular functionN-methyltransferase activity
GO_0106080Molecular functionGATOR1 complex binding
GO_0035242Molecular functionprotein-arginine omega-N asymmetric methyltransferase activity
GO_0044020Molecular functionhistone H4R3 methyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRMT1
Protein nameProtein arginine N-methyltransferase 1 transcript variant 46
Protein arginine N-methyltransferase 1 transcript variant 23
type I protein arginine methyltransferase (EC 2.1.1.319)
Protein arginine N-methyltransferase 1 transcript variant 24
Protein arginine N-methyltransferase 1 transcript variant 30
Protein arginine N-methyltransferase 1 transcript variant 38
Protein arginine N-methyltransferase 1 transcript variant 48
Protein arginine N-methyltransferase 1 transcript variant 45
Protein arginine N-methyltransferase 1 transcript variant 12
Protein arginine methyltransferase 1
Protein arginine N-methyltransferase 1 transcript variant 35
Protein arginine N-methyltransferase 1 transcript variant 29
Protein arginine N-methyltransferase 1 transcript variant 18
Protein arginine N-methyltransferase 1 transcript variant 20
Protein arginine N-methyltransferase 1 transcript variant 16
Protein arginine N-methyltransferase 1 transcript variant 10
Protein arginine N-methyltransferase 1 transcript variant 25
Protein arginine N-methyltransferase 1 transcript variant 13
Protein arginine N-methyltransferase 1 transcript variant 49
Protein arginine N-methyltransferase 1 transcript variant 8
Protein arginine N-methyltransferase 1 transcript variant 27
Protein arginine N-methyltransferase 1 transcript variant 21
Protein arginine N-methyltransferase 1 transcript variant 19
Protein arginine N-methyltransferase 1 transcript variant 36
Protein arginine N-methyltransferase 1 transcript variant 42
Protein arginine N-methyltransferase 1 transcript variant 47
Protein arginine N-methyltransferase 1 transcript variant 34
Protein arginine N-methyltransferase 1 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT1) (Interferon receptor 1-bound protein 4)
Protein arginine N-methyltransferase 1 transcript variant 32
Protein arginine N-methyltransferase 1 transcript variant 7
Protein arginine N-methyltransferase 1 transcript variant 15
Protein arginine N-methyltransferase 1 transcript variant 6
Protein arginine N-methyltransferase 1 transcript variant 44
Protein arginine N-methyltransferase 1 transcript variant 26
Protein arginine N-methyltransferase 1 transcript variant 9
Protein arginine N-methyltransferase 1 transcript variant 41
Protein arginine N-methyltransferase 1 transcript variant 33
Protein arginine N-methyltransferase 1 transcript variant 37
Protein arginine N-methyltransferase 1 transcript variant 17
SynonymsIR1B4
HCP1
HRMT1L2
HMT2
ANM1
DescriptionFUNCTION: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, FMR1, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4, SERBP1, RBM15, FOXO1, CHTOP, MAP3K5/ASK1 and NPRL2 . Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates RBM15, promoting ubiquitination and degradation of RBM15 . Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity . Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity . Methylates MAP3K5/ASK1 at 'Arg-78' and 'Arg-80' which promotes association of MAP3K5 with thioredoxin and negatively regulates MAP3K5 association with TRAF2, inhibiting MAP3K5 stimulation and MAP3K5-induced activation of JNK . Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner . Plays a role in regulating alternative splicing in the heart (By similarity). Methylates NPRL2 at 'Arg-78' leading to inhibition of its GTPase activator activity and then the GATOR1 complex and consequently inducing timely mTORC1 activation under methionine-sufficient conditions . .

AccessionsA0A3S6H7Z6
E9PIX6
A0A3Q8AM27
ENST00000529284.5
A0A3S6H8B5
A0A3S6H8V5
ENST00000528623.5
A0A3Q8AIS8
A0A3S6H7E4
ENST00000391851.8 [Q99873-3]
E9PMZ2
A0A3S6H950
ENST00000526224.5
ENST00000610806.4 [Q99873-5]
A0A3S6H7K8
A0A3S6H7W7
A0A3Q8B9M7
ENST00000529836.5
A0A3S6H812
A0A3Q8B027
A0A3Q8BCJ2
E9PIE2
A0A3Q8B032
A0A3S6H7G3
A0A3S6H7X4
A0A3Q8AIR8
A0A3Q8APX7
A0A3S6H758
E9PKG1
ENST00000524771.5
A0A3S6H824
A0A3S6H7Y8
A0A3S6H7Y4
E9PMW9
A0A3Q8B9M1
A0A3Q8B4N0
A0A3Q8ATG4
A0A3Q8APW9
A0A3S6H942
A0A3S6H7E9
A0A3S6H960
A0A3S6H8W3
ENST00000532489.5
E9PNR9
H0YDE4
A0A3Q8BCI7
A0A3S6H767
A0A3S6H7X9
ENST00000454376.7 [Q99873-1]
A0A3Q8AIS5
A0A3S6H8A6
Q99873
A0A3Q8AX95
A0A3Q8B022
E9PQ98
A0A3Q8ATF5
A0A3Q8AX88
ENST00000534465.6
A0A3S6H765
A0A3Q8APY3
A0A3Q8B4M4
ENST00000534280.5
A0A3S6H761
A0A3Q8AIS2
ENST00000527382.5
A0A3Q8AM22