PAPOLA | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	45 studies	34% ± 13%	Explore
fibroblast	39 studies	29% ± 10%	Explore
B cell	37 studies	36% ± 11%	Explore
natural killer cell	36 studies	32% ± 11%	Explore
CD8-positive, alpha-beta T cell	34 studies	31% ± 10%	Explore
macrophage	33 studies	31% ± 9%	Explore
pericyte	32 studies	28% ± 8%	Explore
T cell	31 studies	29% ± 10%	Explore
CD4-positive, alpha-beta T cell	30 studies	31% ± 9%	Explore
smooth muscle cell	27 studies	28% ± 7%	Explore
conventional dendritic cell	26 studies	33% ± 14%	Explore
epithelial cell	23 studies	40% ± 22%	Explore
classical monocyte	23 studies	34% ± 12%	Explore
non-classical monocyte	22 studies	35% ± 15%	Explore
regulatory T cell	22 studies	33% ± 8%	Explore
mast cell	20 studies	31% ± 12%	Explore
monocyte	20 studies	32% ± 9%	Explore
endothelial cell of lymphatic vessel	20 studies	33% ± 10%	Explore
memory B cell	20 studies	35% ± 9%	Explore
basal cell	19 studies	36% ± 16%	Explore
ciliated cell	19 studies	51% ± 19%	Explore
naive B cell	19 studies	38% ± 8%	Explore
mature NK T cell	17 studies	30% ± 6%	Explore
dendritic cell	16 studies	37% ± 21%	Explore
plasmacytoid dendritic cell	16 studies	30% ± 11%	Explore
gamma-delta T cell	16 studies	37% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	27% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	32% ± 11%	Explore
connective tissue cell	15 studies	32% ± 9%	Explore
capillary endothelial cell	14 studies	27% ± 8%	Explore
plasma cell	13 studies	37% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	34% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	32% ± 10%	Explore
vein endothelial cell	13 studies	30% ± 10%	Explore
astrocyte	13 studies	32% ± 14%	Explore
mucosal invariant T cell	13 studies	30% ± 9%	Explore
endothelial cell of vascular tree	13 studies	36% ± 12%	Explore
myeloid cell	13 studies	31% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	36% ± 11%	Explore
microglial cell	12 studies	29% ± 12%	Explore
oligodendrocyte precursor cell	12 studies	35% ± 17%	Explore
plasmablast	11 studies	45% ± 22%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	31% ± 9%	Explore
secretory cell	11 studies	37% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	31% ± 13%	Explore
myofibroblast cell	11 studies	31% ± 9%	Explore
endothelial cell of artery	11 studies	29% ± 7%	Explore
oligodendrocyte	11 studies	34% ± 14%	Explore
leukocyte	10 studies	34% ± 8%	Explore
type II pneumocyte	9 studies	26% ± 12%	Explore
abnormal cell	9 studies	34% ± 9%	Explore
neuron	9 studies	35% ± 18%	Explore
goblet cell	9 studies	35% ± 18%	Explore
glutamatergic neuron	9 studies	44% ± 26%	Explore
type I pneumocyte	8 studies	27% ± 7%	Explore
club cell	8 studies	28% ± 13%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	28% ± 8%	Explore
GABAergic neuron	8 studies	45% ± 23%	Explore
progenitor cell	8 studies	30% ± 8%	Explore
mesothelial cell	8 studies	29% ± 12%	Explore
alveolar macrophage	7 studies	25% ± 5%	Explore
kidney loop of Henle epithelial cell	7 studies	23% ± 4%	Explore
precursor B cell	7 studies	48% ± 14%	Explore
innate lymphoid cell	7 studies	35% ± 8%	Explore
retinal rod cell	7 studies	25% ± 7%	Explore
T follicular helper cell	7 studies	32% ± 7%	Explore
mononuclear phagocyte	6 studies	37% ± 11%	Explore
IgA plasma cell	6 studies	22% ± 5%	Explore
IgG plasma cell	6 studies	21% ± 4%	Explore
transit amplifying cell	6 studies	28% ± 13%	Explore
interneuron	6 studies	46% ± 23%	Explore
lymphocyte	6 studies	34% ± 13%	Explore
amacrine cell	6 studies	29% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	34% ± 12%	Explore
hematopoietic precursor cell	5 studies	46% ± 16%	Explore
respiratory goblet cell	5 studies	29% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	30% ± 6%	Explore
renal alpha-intercalated cell	5 studies	34% ± 7%	Explore
enteroendocrine cell	5 studies	36% ± 12%	Explore
intestinal crypt stem cell	5 studies	27% ± 9%	Explore
pro-B cell	5 studies	40% ± 8%	Explore
brush cell	5 studies	27% ± 14%	Explore
immature B cell	5 studies	44% ± 4%	Explore
retina horizontal cell	5 studies	29% ± 8%	Explore
adipocyte	5 studies	21% ± 3%	Explore
cardiac muscle cell	5 studies	22% ± 1%	Explore
Mueller cell	5 studies	27% ± 6%	Explore
neutrophil	5 studies	21% ± 4%	Explore
erythrocyte	5 studies	33% ± 19%	Explore
deuterosomal cell	4 studies	28% ± 4%	Explore
duct epithelial cell	4 studies	20% ± 6%	Explore
ionocyte	4 studies	33% ± 12%	Explore
squamous epithelial cell	4 studies	35% ± 25%	Explore
platelet	4 studies	18% ± 1%	Explore
pancreatic A cell	4 studies	58% ± 15%	Explore
type B pancreatic cell	4 studies	54% ± 22%	Explore
exhausted T cell	4 studies	40% ± 11%	Explore
enterocyte	4 studies	26% ± 5%	Explore
retinal bipolar neuron	4 studies	27% ± 10%	Explore
glial cell	4 studies	32% ± 15%	Explore
granule cell	4 studies	21% ± 5%	Explore
erythroblast	4 studies	43% ± 21%	Explore
hematopoietic stem cell	4 studies	37% ± 5%	Explore
retinal cone cell	4 studies	42% ± 11%	Explore
acinar cell	4 studies	39% ± 23%	Explore
intermediate monocyte	4 studies	43% ± 21%	Explore
CD4-positive helper T cell	4 studies	30% ± 14%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	39% ± 2%	Explore
hepatocyte	4 studies	44% ± 22%	Explore
granulocyte	4 studies	38% ± 9%	Explore
luminal cell of prostate epithelium	4 studies	39% ± 15%	Explore
T-helper 17 cell	4 studies	34% ± 10%	Explore
pancreatic D cell	3 studies	55% ± 25%	Explore
monocyte-derived dendritic cell	3 studies	37% ± 13%	Explore
glomerular endothelial cell	3 studies	25% ± 3%	Explore
podocyte	3 studies	33% ± 13%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	38% ± 8%	Explore
epithelial cell of proximal tubule	3 studies	26% ± 7%	Explore
neural crest cell	3 studies	34% ± 8%	Explore
GABAergic interneuron	3 studies	31% ± 2%	Explore
retinal ganglion cell	3 studies	47% ± 18%	Explore
extravillous trophoblast	3 studies	69% ± 13%	Explore
placental villous trophoblast	3 studies	81% ± 5%	Explore
neuroendocrine cell	3 studies	35% ± 15%	Explore
retinal pigment epithelial cell	3 studies	40% ± 16%	Explore
mucus secreting cell	3 studies	23% ± 0%	Explore
serous secreting cell	3 studies	26% ± 5%	Explore
tissue-resident macrophage	3 studies	29% ± 0%	Explore
GABAergic amacrine cell	3 studies	24% ± 6%	Explore
OFF-bipolar cell	3 studies	23% ± 4%	Explore
ON-bipolar cell	3 studies	26% ± 6%	Explore
glycinergic amacrine cell	3 studies	22% ± 3%	Explore
rod bipolar cell	3 studies	31% ± 5%	Explore
germinal center B cell	3 studies	40% ± 2%	Explore
muscle cell	3 studies	40% ± 16%	Explore
pancreatic ductal cell	3 studies	62% ± 12%	Explore
ependymal cell	3 studies	37% ± 15%	Explore
adventitial cell	3 studies	24% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	47% ± 12%	Explore
melanocyte	3 studies	32% ± 9%	Explore
keratinocyte	3 studies	28% ± 9%	Explore
T-helper 1 cell	3 studies	37% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	27% ± 3%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	20% ± 3%	Explore
double negative thymocyte	3 studies	44% ± 21%	Explore
myoepithelial cell	3 studies	26% ± 4%	Explore
progenitor cell of mammary luminal epithelium	3 studies	20% ± 0%	Explore
mural cell	3 studies	32% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	33% ± 12%	Explore
peripheral blood	17 studies	35% ± 13%	Explore
brain	17 studies	34% ± 19%	Explore
intestine	11 studies	28% ± 12%	Explore
eye	11 studies	27% ± 10%	Explore
kidney	8 studies	28% ± 5%	Explore
liver	6 studies	35% ± 20%	Explore
lymph node	5 studies	31% ± 6%	Explore
pancreas	4 studies	56% ± 18%	Explore
bone marrow	4 studies	31% ± 9%	Explore
heart	4 studies	21% ± 2%	Explore
uterus	4 studies	40% ± 16%	Explore
breast	4 studies	29% ± 4%	Explore
prostate	4 studies	40% ± 17%	Explore
placenta	3 studies	58% ± 7%	Explore
skin	3 studies	23% ± 7%	Explore
adipose	3 studies	25% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	9112.84	1445 / 1445	100%	64.52	183 / 183
lung	100%	9063.33	578 / 578	100%	52.42	1155 / 1155
ovary	100%	11388.41	180 / 180	100%	41.31	430 / 430
prostate	100%	9257.18	245 / 245	100%	45.74	502 / 502
breast	100%	9065.46	459 / 459	100%	57.79	1117 / 1118
brain	100%	6530.61	2638 / 2642	100%	37.69	705 / 705
intestine	100%	10007.26	966 / 966	100%	47.80	526 / 527
bladder	100%	9738.00	21 / 21	100%	44.34	503 / 504
uterus	100%	10973.21	170 / 170	100%	46.42	457 / 459
thymus	100%	9666.05	653 / 653	100%	37.70	602 / 605
pancreas	100%	7000.02	328 / 328	99%	39.49	177 / 178
stomach	100%	7580.15	359 / 359	99%	51.57	284 / 286
kidney	100%	7530.20	89 / 89	99%	35.54	892 / 901
adrenal gland	100%	10382.16	258 / 258	98%	35.56	226 / 230
liver	100%	5415.61	226 / 226	98%	25.58	398 / 406
skin	100%	8957.14	1808 / 1809	97%	42.74	456 / 472
adipose	100%	9235.00	1204 / 1204	0%	0	0 / 0
blood vessel	100%	8075.70	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	40.92	29 / 29
spleen	100%	10382.28	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	44.09	45 / 45
ureter	0%	0	0 / 0	100%	16.17	1 / 1
muscle	100%	5165.05	802 / 803	0%	0	0 / 0
heart	99%	6774.34	853 / 861	0%	0	0 / 0
peripheral blood	96%	7183.76	892 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	94%	25.60	75 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	PAPOLA
Protein name	polynucleotide adenylyltransferase (EC 2.7.7.19) Poly(A) polymerase alpha Poly(A) polymerase (EC 2.7.7.19) Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) Alternative protein PAPOLA
Synonyms	hCG_24516 PAP
Description	FUNCTION: Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. . FUNCTION: Polymerase that creates the 3'-poly(A) tail of mRNA's. .
Accessions	A0A0C4DGK1 ENST00000557320.5 [P51003-2] G3V457 ENST00000556619.5 ENST00000553689.5 G3V3I9 H0YJL4 ENST00000556459.1 P51003 ENST00000216277.13 [P51003-1] ENST00000392990.6 ENST00000557471.5 H0YJ00 ENST00000553461.1 L8ECL5 G3XAH6

GO_0031124	Biological process	mRNA 3'-end processing
GO_0180010	Biological process	co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway
GO_0180011	Biological process	cytosolic mRNA polyadenylation
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0030145	Molecular function	manganese ion binding
GO_1990817	Molecular function	poly(A) RNA polymerase activity
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding
GO_0000287	Molecular function	magnesium ion binding
GO_0003723	Molecular function	RNA binding

PAPOLA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review