NSD3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	38 studies	33% ± 11%	Explore
endothelial cell	35 studies	30% ± 13%	Explore
fibroblast	33 studies	28% ± 11%	Explore
natural killer cell	32 studies	26% ± 10%	Explore
CD4-positive, alpha-beta T cell	30 studies	32% ± 11%	Explore
CD8-positive, alpha-beta T cell	28 studies	27% ± 9%	Explore
T cell	27 studies	29% ± 9%	Explore
pericyte	27 studies	26% ± 8%	Explore
regulatory T cell	24 studies	40% ± 13%	Explore
smooth muscle cell	21 studies	26% ± 5%	Explore
naive B cell	19 studies	39% ± 12%	Explore
ciliated cell	18 studies	38% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	36% ± 12%	Explore
astrocyte	17 studies	39% ± 18%	Explore
memory B cell	16 studies	33% ± 10%	Explore
basal cell	14 studies	35% ± 16%	Explore
oligodendrocyte	14 studies	41% ± 18%	Explore
endothelial cell of lymphatic vessel	13 studies	28% ± 9%	Explore
epithelial cell	13 studies	37% ± 19%	Explore
oligodendrocyte precursor cell	13 studies	45% ± 20%	Explore
mature NK T cell	13 studies	27% ± 6%	Explore
gamma-delta T cell	13 studies	36% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	30% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	31% ± 11%	Explore
glutamatergic neuron	12 studies	61% ± 24%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	27% ± 8%	Explore
mucosal invariant T cell	12 studies	27% ± 6%	Explore
macrophage	12 studies	27% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	35% ± 10%	Explore
classical monocyte	11 studies	24% ± 11%	Explore
GABAergic neuron	11 studies	56% ± 24%	Explore
connective tissue cell	11 studies	28% ± 8%	Explore
microglial cell	11 studies	33% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	38% ± 11%	Explore
myofibroblast cell	10 studies	28% ± 8%	Explore
adipocyte	10 studies	32% ± 9%	Explore
mast cell	9 studies	21% ± 5%	Explore
type I pneumocyte	9 studies	25% ± 6%	Explore
plasma cell	9 studies	32% ± 11%	Explore
plasmablast	9 studies	35% ± 19%	Explore
plasmacytoid dendritic cell	9 studies	23% ± 8%	Explore
neuron	9 studies	58% ± 17%	Explore
endothelial cell of artery	9 studies	19% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	37% ± 11%	Explore
capillary endothelial cell	8 studies	22% ± 4%	Explore
abnormal cell	8 studies	36% ± 14%	Explore
amacrine cell	8 studies	47% ± 12%	Explore
myeloid cell	8 studies	27% ± 7%	Explore
monocyte	8 studies	25% ± 7%	Explore
secretory cell	7 studies	28% ± 14%	Explore
mesothelial cell	7 studies	29% ± 10%	Explore
retinal ganglion cell	7 studies	44% ± 17%	Explore
retinal cone cell	7 studies	31% ± 9%	Explore
retinal rod cell	7 studies	21% ± 3%	Explore
dendritic cell	7 studies	31% ± 17%	Explore
endothelial cell of vascular tree	7 studies	24% ± 12%	Explore
club cell	6 studies	34% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	30% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	26% ± 6%	Explore
leukocyte	6 studies	32% ± 3%	Explore
non-classical monocyte	6 studies	28% ± 10%	Explore
conventional dendritic cell	6 studies	30% ± 15%	Explore
vein endothelial cell	6 studies	25% ± 13%	Explore
lymphocyte	6 studies	35% ± 13%	Explore
type II pneumocyte	6 studies	24% ± 6%	Explore
retina horizontal cell	6 studies	57% ± 11%	Explore
Mueller cell	6 studies	27% ± 5%	Explore
T follicular helper cell	6 studies	32% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	44% ± 14%	Explore
hematopoietic precursor cell	5 studies	40% ± 17%	Explore
respiratory goblet cell	5 studies	38% ± 11%	Explore
progenitor cell	5 studies	28% ± 6%	Explore
retinal bipolar neuron	5 studies	40% ± 4%	Explore
precursor B cell	5 studies	31% ± 7%	Explore
pro-B cell	5 studies	32% ± 5%	Explore
brush cell	5 studies	27% ± 10%	Explore
cardiac muscle cell	5 studies	23% ± 4%	Explore
goblet cell	5 studies	40% ± 25%	Explore
interneuron	5 studies	75% ± 15%	Explore
CD4-positive helper T cell	4 studies	32% ± 8%	Explore
deuterosomal cell	4 studies	26% ± 11%	Explore
exhausted T cell	4 studies	36% ± 14%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	18% ± 2%	Explore
hematopoietic stem cell	4 studies	27% ± 7%	Explore
immature B cell	4 studies	31% ± 10%	Explore
retinal pigment epithelial cell	4 studies	45% ± 17%	Explore
OFF-bipolar cell	4 studies	35% ± 9%	Explore
ON-bipolar cell	4 studies	34% ± 10%	Explore
innate lymphoid cell	4 studies	27% ± 7%	Explore
enteroendocrine cell	4 studies	28% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	21% ± 6%	Explore
double negative thymocyte	4 studies	41% ± 15%	Explore
pancreatic A cell	3 studies	23% ± 7%	Explore
neural crest cell	3 studies	28% ± 7%	Explore
extravillous trophoblast	3 studies	34% ± 8%	Explore
placental villous trophoblast	3 studies	28% ± 7%	Explore
squamous epithelial cell	3 studies	38% ± 24%	Explore
glial cell	3 studies	30% ± 14%	Explore
GABAergic amacrine cell	3 studies	49% ± 9%	Explore
glycinergic amacrine cell	3 studies	42% ± 2%	Explore
rod bipolar cell	3 studies	47% ± 6%	Explore
erythroblast	3 studies	36% ± 15%	Explore
germinal center B cell	3 studies	27% ± 2%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	23% ± 3%	Explore
ependymal cell	3 studies	56% ± 16%	Explore
intestinal crypt stem cell	3 studies	22% ± 5%	Explore
alveolar macrophage	3 studies	31% ± 10%	Explore
mucus secreting cell	3 studies	24% ± 4%	Explore
group 3 innate lymphoid cell	3 studies	35% ± 11%	Explore
transit amplifying cell	3 studies	40% ± 26%	Explore
T-helper 17 cell	3 studies	24% ± 4%	Explore
granule cell	3 studies	47% ± 4%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	38% ± 10%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	25% ± 10%	Explore
mural cell	3 studies	42% ± 12%	Explore
kidney loop of Henle epithelial cell	3 studies	16% ± 0%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	29% ± 11%	Explore
peripheral blood	16 studies	31% ± 11%	Explore
brain	16 studies	50% ± 23%	Explore
eye	10 studies	32% ± 12%	Explore
intestine	7 studies	25% ± 10%	Explore
kidney	5 studies	24% ± 4%	Explore
heart	5 studies	22% ± 4%	Explore
bone marrow	4 studies	30% ± 10%	Explore
lymph node	4 studies	28% ± 11%	Explore
breast	4 studies	20% ± 3%	Explore
liver	4 studies	38% ± 11%	Explore
adipose	4 studies	35% ± 10%	Explore
placenta	3 studies	25% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5139.73	1445 / 1445	100%	22.63	183 / 183
lung	100%	5989.64	578 / 578	100%	23.42	1153 / 1155
brain	100%	5641.84	2639 / 2642	100%	22.88	704 / 705
breast	100%	6004.30	459 / 459	100%	35.41	1114 / 1118
uterus	100%	6132.49	170 / 170	100%	19.17	457 / 459
pancreas	100%	3056.56	327 / 328	99%	16.80	177 / 178
thymus	100%	5751.04	653 / 653	99%	16.04	598 / 605
bladder	100%	6014.57	21 / 21	99%	17.76	498 / 504
prostate	100%	6143.84	245 / 245	99%	15.07	495 / 502
intestine	100%	5960.20	966 / 966	98%	15.38	516 / 527
ovary	100%	8248.71	180 / 180	98%	12.47	420 / 430
stomach	100%	4376.77	359 / 359	98%	17.51	279 / 286
skin	100%	5371.09	1808 / 1809	96%	15.20	452 / 472
kidney	100%	3526.09	89 / 89	95%	11.99	856 / 901
adrenal gland	100%	3375.52	258 / 258	93%	11.69	213 / 230
liver	99%	1715.02	223 / 226	49%	4.39	200 / 406
adipose	100%	5602.95	1204 / 1204	0%	0	0 / 0
blood vessel	100%	6024.73	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	13.34	29 / 29
spleen	100%	5447.84	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	19.62	45 / 45
ureter	0%	0	0 / 0	100%	13.44	1 / 1
muscle	99%	2434.09	798 / 803	0%	0	0 / 0
heart	97%	2525.98	837 / 861	0%	0	0 / 0
peripheral blood	97%	4094.01	901 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	93%	13.46	74 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0032259	Biological process	methylation
GO_0006338	Biological process	chromatin remodeling
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0005654	Cellular component	nucleoplasm
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0140951	Molecular function	histone H3K27 trimethyltransferase activity
GO_0140938	Molecular function	histone H3 methyltransferase activity
GO_0046975	Molecular function	histone H3K36 methyltransferase activity
GO_0005515	Molecular function	protein binding
GO_0140537	Molecular function	transcription regulator activator activity
GO_0046872	Molecular function	metal ion binding
GO_0140946	Molecular function	histone H3K4 dimethyltransferase activity
GO_0140952	Molecular function	histone H3K27 dimethyltransferase activity

IV. Literature review

[source]

Gene name	NSD3
Protein name	Nuclear receptor binding SET domain protein 3 Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)
Synonyms	DC28 WHSC1L1
Description	FUNCTION: Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. .
Accessions	E9PKL3 ENST00000534539.1 ENST00000534155.1 H0YE68 ENST00000433384.6 [Q9BZ95-2] E9PQ95 ENST00000528627.1 ENST00000317025.13 [Q9BZ95-1] ENST00000529223.1 ENST00000316985.7 [Q9BZ95-3] ENST00000527502.5 [Q9BZ95-5] E9PKA2 Q9BZ95

NSD3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review