NOP10 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	35 studies	37% ± 11%	Explore
B cell	34 studies	34% ± 13%	Explore
macrophage	34 studies	54% ± 18%	Explore
CD8-positive, alpha-beta T cell	33 studies	36% ± 16%	Explore
endothelial cell	32 studies	47% ± 18%	Explore
CD4-positive, alpha-beta T cell	30 studies	37% ± 17%	Explore
fibroblast	30 studies	33% ± 13%	Explore
T cell	28 studies	37% ± 12%	Explore
conventional dendritic cell	26 studies	44% ± 16%	Explore
classical monocyte	25 studies	54% ± 13%	Explore
smooth muscle cell	24 studies	29% ± 12%	Explore
non-classical monocyte	23 studies	58% ± 14%	Explore
pericyte	23 studies	32% ± 15%	Explore
regulatory T cell	23 studies	45% ± 16%	Explore
epithelial cell	21 studies	48% ± 20%	Explore
monocyte	19 studies	57% ± 15%	Explore
memory B cell	19 studies	30% ± 12%	Explore
plasmacytoid dendritic cell	18 studies	41% ± 13%	Explore
mast cell	17 studies	34% ± 16%	Explore
endothelial cell of lymphatic vessel	17 studies	55% ± 15%	Explore
basal cell	17 studies	41% ± 20%	Explore
dendritic cell	16 studies	42% ± 22%	Explore
naive B cell	16 studies	31% ± 11%	Explore
mature NK T cell	16 studies	33% ± 10%	Explore
connective tissue cell	16 studies	37% ± 12%	Explore
gamma-delta T cell	16 studies	36% ± 17%	Explore
plasma cell	15 studies	46% ± 16%	Explore
ciliated cell	15 studies	45% ± 22%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	33% ± 10%	Explore
myeloid cell	14 studies	52% ± 18%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	27% ± 7%	Explore
neutrophil	12 studies	48% ± 18%	Explore
capillary endothelial cell	12 studies	40% ± 13%	Explore
vein endothelial cell	12 studies	49% ± 15%	Explore
plasmablast	11 studies	52% ± 21%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	34% ± 14%	Explore
myofibroblast cell	11 studies	33% ± 11%	Explore
endothelial cell of artery	11 studies	47% ± 13%	Explore
goblet cell	11 studies	37% ± 17%	Explore
mucosal invariant T cell	11 studies	25% ± 6%	Explore
endothelial cell of vascular tree	11 studies	48% ± 16%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	35% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	37% ± 17%	Explore
secretory cell	10 studies	41% ± 21%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	34% ± 11%	Explore
progenitor cell	10 studies	46% ± 14%	Explore
abnormal cell	10 studies	35% ± 15%	Explore
type I pneumocyte	8 studies	37% ± 14%	Explore
leukocyte	8 studies	38% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	30% ± 10%	Explore
innate lymphoid cell	8 studies	40% ± 13%	Explore
T follicular helper cell	8 studies	35% ± 11%	Explore
club cell	7 studies	38% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	45% ± 21%	Explore
epithelial cell of proximal tubule	7 studies	44% ± 15%	Explore
alveolar macrophage	6 studies	70% ± 23%	Explore
hematopoietic precursor cell	6 studies	43% ± 22%	Explore
mononuclear phagocyte	6 studies	43% ± 19%	Explore
kidney loop of Henle epithelial cell	6 studies	33% ± 4%	Explore
renal alpha-intercalated cell	6 studies	50% ± 8%	Explore
enterocyte	6 studies	39% ± 10%	Explore
mesothelial cell	6 studies	43% ± 16%	Explore
type II pneumocyte	6 studies	48% ± 20%	Explore
exhausted T cell	5 studies	49% ± 17%	Explore
respiratory goblet cell	5 studies	31% ± 17%	Explore
enteroendocrine cell	5 studies	51% ± 21%	Explore
transit amplifying cell	5 studies	30% ± 12%	Explore
erythroblast	5 studies	57% ± 16%	Explore
hematopoietic stem cell	5 studies	40% ± 15%	Explore
precursor B cell	5 studies	49% ± 16%	Explore
neuron	5 studies	51% ± 17%	Explore
erythrocyte	5 studies	47% ± 27%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	48% ± 16%	Explore
intermediate monocyte	5 studies	67% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	40% ± 20%	Explore
pancreatic A cell	4 studies	50% ± 19%	Explore
type B pancreatic cell	4 studies	46% ± 17%	Explore
glomerular endothelial cell	4 studies	34% ± 10%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	52% ± 14%	Explore
intestinal crypt stem cell	4 studies	31% ± 13%	Explore
IgG plasma cell	4 studies	28% ± 10%	Explore
pro-B cell	4 studies	36% ± 12%	Explore
immature B cell	4 studies	44% ± 13%	Explore
adventitial cell	4 studies	26% ± 5%	Explore
CD4-positive helper T cell	4 studies	26% ± 10%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	39% ± 9%	Explore
granulocyte	4 studies	44% ± 19%	Explore
T-helper 17 cell	4 studies	47% ± 19%	Explore
T-helper 1 cell	4 studies	52% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	27% ± 7%	Explore
deuterosomal cell	3 studies	30% ± 3%	Explore
duct epithelial cell	3 studies	20% ± 2%	Explore
ionocyte	3 studies	32% ± 10%	Explore
precursor cell	3 studies	48% ± 12%	Explore
squamous epithelial cell	3 studies	49% ± 26%	Explore
neural crest cell	3 studies	47% ± 7%	Explore
IgA plasma cell	3 studies	28% ± 11%	Explore
retinal ganglion cell	3 studies	51% ± 29%	Explore
extravillous trophoblast	3 studies	61% ± 12%	Explore
placental villous trophoblast	3 studies	46% ± 4%	Explore
lymphocyte	3 studies	50% ± 10%	Explore
brush cell	3 studies	36% ± 15%	Explore
neuroendocrine cell	3 studies	56% ± 20%	Explore
microglial cell	3 studies	36% ± 13%	Explore
serous secreting cell	3 studies	35% ± 10%	Explore
intraepithelial lymphocyte	3 studies	49% ± 14%	Explore
acinar cell	3 studies	25% ± 6%	Explore
endothelial cell of sinusoid	3 studies	27% ± 6%	Explore
muscle cell	3 studies	35% ± 19%	Explore
germinal center B cell	3 studies	48% ± 4%	Explore
myoepithelial cell	3 studies	27% ± 12%	Explore
inflammatory macrophage	3 studies	46% ± 12%	Explore
luminal cell of prostate epithelium	3 studies	34% ± 9%	Explore
IgM plasma cell	3 studies	33% ± 9%	Explore
pancreatic ductal cell	3 studies	65% ± 9%	Explore
oligodendrocyte precursor cell	3 studies	33% ± 11%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	57% ± 28%	Explore
glial cell	3 studies	40% ± 21%	Explore
hepatocyte	3 studies	51% ± 32%	Explore
group 3 innate lymphoid cell	3 studies	43% ± 17%	Explore
keratinocyte	3 studies	36% ± 10%	Explore
double negative thymocyte	3 studies	47% ± 26%	Explore
progenitor cell of mammary luminal epithelium	3 studies	23% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	46% ± 15%	Explore
peripheral blood	18 studies	37% ± 10%	Explore
intestine	11 studies	34% ± 15%	Explore
kidney	8 studies	40% ± 6%	Explore
bone marrow	6 studies	30% ± 13%	Explore
lymph node	6 studies	33% ± 10%	Explore
liver	6 studies	41% ± 21%	Explore
pancreas	5 studies	44% ± 19%	Explore
uterus	5 studies	39% ± 22%	Explore
placenta	4 studies	47% ± 15%	Explore
eye	4 studies	28% ± 11%	Explore
brain	4 studies	33% ± 9%	Explore
prostate	4 studies	31% ± 8%	Explore
breast	4 studies	32% ± 5%	Explore
adrenal gland	3 studies	32% ± 3%	Explore
esophagus	3 studies	50% ± 25%	Explore
skin	3 studies	29% ± 7%	Explore
thymus	3 studies	57% ± 18%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2100.07	1445 / 1445	100%	313.46	183 / 183
intestine	100%	1977.55	966 / 966	100%	401.87	527 / 527
ovary	100%	1067.61	180 / 180	100%	419.35	430 / 430
stomach	100%	1659.29	359 / 359	100%	367.08	286 / 286
uterus	100%	1535.72	170 / 170	100%	500.65	459 / 459
lung	100%	2733.40	578 / 578	100%	412.37	1154 / 1155
thymus	100%	1774.78	653 / 653	100%	338.13	604 / 605
prostate	100%	1774.01	245 / 245	100%	410.79	501 / 502
skin	100%	2701.95	1809 / 1809	100%	378.66	471 / 472
kidney	100%	2633.37	89 / 89	100%	302.35	899 / 901
bladder	100%	1951.24	21 / 21	100%	480.77	502 / 504
liver	100%	1686.38	225 / 226	100%	331.92	406 / 406
breast	100%	2148.27	459 / 459	100%	339.20	1113 / 1118
adrenal gland	100%	2536.45	258 / 258	99%	271.48	228 / 230
brain	99%	1167.59	2614 / 2642	100%	288.13	704 / 705
pancreas	98%	890.67	321 / 328	99%	403.43	177 / 178
adipose	100%	2372.43	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	260.01	80 / 80
lymph node	0%	0	0 / 0	100%	643.01	29 / 29
spleen	100%	2935.44	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	402.26	45 / 45
ureter	0%	0	0 / 0	100%	1052.64	1 / 1
peripheral blood	100%	5095.02	928 / 929	0%	0	0 / 0
muscle	100%	1918.32	801 / 803	0%	0	0 / 0
blood vessel	99%	1971.56	1328 / 1335	0%	0	0 / 0
heart	98%	1811.09	847 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1904874	Biological process	positive regulation of telomerase RNA localization to Cajal body
GO_0031118	Biological process	rRNA pseudouridine synthesis
GO_0001522	Biological process	pseudouridine synthesis
GO_0031120	Biological process	snRNA pseudouridine synthesis
GO_0007004	Biological process	telomere maintenance via telomerase
GO_0005732	Cellular component	sno(s)RNA-containing ribonucleoprotein complex
GO_0016604	Cellular component	nuclear body
GO_0005654	Cellular component	nucleoplasm
GO_0031429	Cellular component	box H/ACA snoRNP complex
GO_0072589	Cellular component	box H/ACA scaRNP complex
GO_0090661	Cellular component	box H/ACA telomerase RNP complex
GO_0005697	Cellular component	telomerase holoenzyme complex
GO_0070034	Molecular function	telomerase RNA binding
GO_0005515	Molecular function	protein binding
GO_0034513	Molecular function	box H/ACA snoRNA binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	NOP10
Protein name	H/ACA ribonucleoprotein complex subunit 3 (Nucleolar protein 10) (Nucleolar protein family A member 3) (snoRNP protein NOP10) NOP10 ribonucleoprotein Nucleolar protein 10
Synonyms	NOLA3
Description	FUNCTION: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA . This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. .
Accessions	ENST00000699936.1 ENST00000328848.6 ENST00000699926.1 ENST00000699937.1 A0A8V8TQT0 A0A8V8TPD4 A0A8V8TQE9 Q9NPE3 A0A8V8TQE5 ENST00000557912.2 ENST00000699935.1 ENST00000699938.1 A0A8V8TP28 A0A8V8TPK8 ENST00000699934.1 ENST00000709520.1 H0YM60

NOP10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review