NHP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1904874Biological processpositive regulation of telomerase RNA localization to Cajal body
GO_0031118Biological processrRNA pseudouridine synthesis
GO_0031120Biological processsnRNA pseudouridine synthesis
GO_0007004Biological processtelomere maintenance via telomerase
GO_0005732Cellular componentsno(s)RNA-containing ribonucleoprotein complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0005654Cellular componentnucleoplasm
GO_0031429Cellular componentbox H/ACA snoRNP complex
GO_0072589Cellular componentbox H/ACA scaRNP complex
GO_0090661Cellular componentbox H/ACA telomerase RNP complex
GO_0005697Cellular componenttelomerase holoenzyme complex
GO_0070034Molecular functiontelomerase RNA binding
GO_0005515Molecular functionprotein binding
GO_0034513Molecular functionbox H/ACA snoRNA binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameNHP2
Protein nameH/ACA ribonucleoprotein complex subunit 2
H/ACA ribonucleoprotein complex subunit 2 (Nucleolar protein family A member 2) (snoRNP protein NHP2)
SynonymsNOLA2
HSPC286
DescriptionFUNCTION: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. .

FUNCTION: Common component of the spliceosome and rRNA processing machinery. .; FUNCTION: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. .

FUNCTION: Common component of the spliceosome and rRNA processing machinery. .; FUNCTION: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. .

FUNCTION: Common component of the spliceosome and rRNA processing machinery. .; FUNCTION: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. .

AccessionsENST00000314397.9
ENST00000511078.1
Q9NX24
D6RCB9
ENST00000514354.5
D6RC52
ENST00000274606.8
J3QSY4