MBNL1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	49 studies	49% ± 18%	Explore
B cell	46 studies	44% ± 18%	Explore
natural killer cell	45 studies	49% ± 18%	Explore
macrophage	42 studies	46% ± 18%	Explore
CD8-positive, alpha-beta T cell	37 studies	50% ± 16%	Explore
T cell	35 studies	51% ± 21%	Explore
fibroblast	35 studies	42% ± 19%	Explore
CD4-positive, alpha-beta T cell	35 studies	50% ± 17%	Explore
smooth muscle cell	31 studies	39% ± 19%	Explore
pericyte	29 studies	38% ± 18%	Explore
conventional dendritic cell	28 studies	46% ± 17%	Explore
regulatory T cell	28 studies	58% ± 14%	Explore
dendritic cell	24 studies	53% ± 23%	Explore
classical monocyte	24 studies	46% ± 15%	Explore
non-classical monocyte	24 studies	48% ± 15%	Explore
mast cell	23 studies	43% ± 22%	Explore
monocyte	22 studies	50% ± 21%	Explore
mature NK T cell	22 studies	48% ± 15%	Explore
endothelial cell of lymphatic vessel	20 studies	47% ± 22%	Explore
memory B cell	20 studies	47% ± 10%	Explore
naive B cell	20 studies	49% ± 12%	Explore
gamma-delta T cell	19 studies	53% ± 15%	Explore
astrocyte	19 studies	47% ± 19%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	60% ± 15%	Explore
plasmacytoid dendritic cell	18 studies	40% ± 12%	Explore
microglial cell	18 studies	65% ± 19%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	58% ± 16%	Explore
mucosal invariant T cell	16 studies	56% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	59% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	58% ± 13%	Explore
oligodendrocyte	15 studies	53% ± 14%	Explore
capillary endothelial cell	15 studies	34% ± 16%	Explore
myeloid cell	15 studies	49% ± 18%	Explore
ciliated cell	15 studies	34% ± 16%	Explore
endothelial cell of vascular tree	14 studies	38% ± 19%	Explore
vein endothelial cell	14 studies	46% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	58% ± 15%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	58% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	59% ± 12%	Explore
oligodendrocyte precursor cell	13 studies	47% ± 16%	Explore
endothelial cell of artery	13 studies	39% ± 16%	Explore
epithelial cell	13 studies	40% ± 16%	Explore
type I pneumocyte	12 studies	57% ± 23%	Explore
type II pneumocyte	12 studies	57% ± 25%	Explore
basal cell	12 studies	40% ± 20%	Explore
plasma cell	11 studies	36% ± 16%	Explore
platelet	11 studies	47% ± 13%	Explore
leukocyte	11 studies	61% ± 24%	Explore
glutamatergic neuron	11 studies	59% ± 24%	Explore
myofibroblast cell	11 studies	31% ± 18%	Explore
GABAergic neuron	10 studies	52% ± 20%	Explore
adipocyte	10 studies	70% ± 18%	Explore
innate lymphoid cell	9 studies	50% ± 17%	Explore
plasmablast	9 studies	45% ± 23%	Explore
mesothelial cell	9 studies	45% ± 23%	Explore
alveolar macrophage	8 studies	56% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	50% ± 11%	Explore
erythrocyte	8 studies	46% ± 18%	Explore
hematopoietic stem cell	8 studies	58% ± 15%	Explore
club cell	8 studies	52% ± 21%	Explore
mononuclear phagocyte	7 studies	49% ± 15%	Explore
precursor B cell	7 studies	52% ± 12%	Explore
retinal rod cell	7 studies	39% ± 23%	Explore
T follicular helper cell	7 studies	55% ± 15%	Explore
connective tissue cell	7 studies	35% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	54% ± 17%	Explore
hematopoietic precursor cell	6 studies	57% ± 28%	Explore
neutrophil	6 studies	41% ± 20%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	51% ± 13%	Explore
neuron	6 studies	48% ± 21%	Explore
interneuron	6 studies	51% ± 25%	Explore
lymphocyte	6 studies	67% ± 17%	Explore
immature B cell	6 studies	52% ± 7%	Explore
cardiac muscle cell	6 studies	65% ± 25%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	56% ± 9%	Explore
CD4-positive helper T cell	5 studies	45% ± 19%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	54% ± 12%	Explore
exhausted T cell	5 studies	57% ± 10%	Explore
hepatocyte	5 studies	60% ± 26%	Explore
glial cell	5 studies	33% ± 11%	Explore
progenitor cell	5 studies	39% ± 10%	Explore
pro-B cell	5 studies	50% ± 12%	Explore
adventitial cell	5 studies	34% ± 20%	Explore
secretory cell	5 studies	23% ± 5%	Explore
double negative thymocyte	5 studies	63% ± 10%	Explore
abnormal cell	5 studies	48% ± 15%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	44% ± 11%	Explore
cholangiocyte	4 studies	59% ± 18%	Explore
granule cell	4 studies	40% ± 13%	Explore
retinal ganglion cell	4 studies	31% ± 12%	Explore
retinal cone cell	4 studies	28% ± 13%	Explore
respiratory goblet cell	4 studies	42% ± 22%	Explore
intermediate monocyte	4 studies	53% ± 21%	Explore
muscle cell	4 studies	59% ± 17%	Explore
brush cell	4 studies	26% ± 5%	Explore
T-helper 17 cell	4 studies	45% ± 7%	Explore
T-helper 1 cell	4 studies	55% ± 9%	Explore
hepatic stellate cell	3 studies	56% ± 17%	Explore
glomerular endothelial cell	3 studies	32% ± 4%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	52% ± 9%	Explore
GABAergic interneuron	3 studies	40% ± 5%	Explore
erythroblast	3 studies	50% ± 17%	Explore
megakaryocyte	3 studies	64% ± 13%	Explore
retinal pigment epithelial cell	3 studies	34% ± 22%	Explore
endocardial cell	3 studies	57% ± 21%	Explore
tissue-resident macrophage	3 studies	54% ± 16%	Explore
amacrine cell	3 studies	30% ± 13%	Explore
glycinergic amacrine cell	3 studies	29% ± 8%	Explore
germinal center B cell	3 studies	44% ± 14%	Explore
ependymal cell	3 studies	48% ± 25%	Explore
granulocyte	3 studies	49% ± 25%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	78% ± 8%	Explore
enterocyte	3 studies	18% ± 3%	Explore
enteroendocrine cell	3 studies	22% ± 2%	Explore
goblet cell	3 studies	36% ± 19%	Explore
chondrocyte	3 studies	48% ± 25%	Explore
group 3 innate lymphoid cell	3 studies	54% ± 12%	Explore
Schwann cell	3 studies	39% ± 15%	Explore
melanocyte	3 studies	50% ± 17%	Explore
transit amplifying cell	3 studies	40% ± 33%	Explore
keratinocyte	3 studies	37% ± 13%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	64% ± 8%	Explore
double-positive, alpha-beta thymocyte	3 studies	71% ± 12%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	40% ± 15%	Explore
kidney loop of Henle epithelial cell	3 studies	40% ± 17%	Explore
renal alpha-intercalated cell	3 studies	41% ± 19%	Explore
renal principal cell	3 studies	30% ± 11%	Explore
mural cell	3 studies	70% ± 11%	Explore
mucus secreting cell	3 studies	42% ± 5%	Explore
myoepithelial cell	3 studies	53% ± 28%	Explore
IgA plasma cell	3 studies	30% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	20 studies	48% ± 21%	Explore
lung	19 studies	38% ± 21%	Explore
peripheral blood	19 studies	53% ± 14%	Explore
intestine	9 studies	22% ± 4%	Explore
liver	7 studies	41% ± 18%	Explore
eye	7 studies	34% ± 16%	Explore
heart	6 studies	55% ± 21%	Explore
kidney	6 studies	41% ± 9%	Explore
bone marrow	4 studies	52% ± 20%	Explore
uterus	4 studies	32% ± 6%	Explore
lymph node	4 studies	43% ± 10%	Explore
breast	4 studies	33% ± 8%	Explore
adipose	4 studies	56% ± 19%	Explore
skin	3 studies	35% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	12054.23	459 / 459	100%	48.06	1118 / 1118
lung	100%	12798.90	578 / 578	100%	61.53	1155 / 1155
esophagus	100%	11693.67	1444 / 1445	100%	75.34	183 / 183
uterus	100%	13271.24	170 / 170	100%	49.45	457 / 459
ovary	99%	6581.88	179 / 180	100%	26.72	430 / 430
intestine	100%	15237.70	966 / 966	99%	39.06	524 / 527
bladder	100%	13881.10	21 / 21	99%	37.78	501 / 504
prostate	100%	8311.67	244 / 245	100%	40.19	501 / 502
thymus	100%	7341.87	650 / 653	100%	41.31	603 / 605
adrenal gland	99%	5699.32	256 / 258	98%	25.05	225 / 230
skin	100%	10483.26	1804 / 1809	93%	40.77	437 / 472
stomach	89%	6775.19	321 / 359	99%	47.37	282 / 286
kidney	88%	3607.74	78 / 89	99%	48.16	893 / 901
brain	82%	3223.09	2163 / 2642	100%	30.83	703 / 705
liver	87%	3107.98	196 / 226	94%	21.35	382 / 406
pancreas	58%	1926.21	189 / 328	99%	44.06	176 / 178
adipose	100%	15345.46	1204 / 1204	0%	0	0 / 0
blood vessel	100%	29131.09	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	81.99	29 / 29
spleen	100%	9986.99	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	69.17	45 / 45
ureter	0%	0	0 / 0	100%	12.01	1 / 1
muscle	100%	18880.86	802 / 803	0%	0	0 / 0
heart	94%	6587.38	808 / 861	0%	0	0 / 0
peripheral blood	85%	10778.87	792 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	59%	10.88	47 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043484	Biological process	regulation of RNA splicing
GO_0045445	Biological process	myoblast differentiation
GO_0008380	Biological process	RNA splicing
GO_0006397	Biological process	mRNA processing
GO_0030326	Biological process	embryonic limb morphogenesis
GO_0001701	Biological process	in utero embryonic development
GO_0007399	Biological process	nervous system development
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0010494	Cellular component	cytoplasmic stress granule
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0001069	Molecular function	regulatory region RNA binding
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding
GO_0003725	Molecular function	double-stranded RNA binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	MBNL1
Protein name	Muscleblind-like protein 1 (Triplet-expansion RNA-binding protein) MBNL1 protein (Muscleblind like splicing regulator 1) (Muscleblind-like (Drosophila), isoform CRA_f) Muscleblind like splicing regulator 1
Synonyms	MBNL KIAA0428 EXP hCG_28028
Description	FUNCTION: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues. Together with RNA binding proteins RBPMS and RBFOX2, activates vascular smooth muscle cells alternative splicing events . Regulates NCOR2 alternative splicing (By similarity). .
Accessions	C9J7P7 ENST00000282486.10 [Q9NR56-1] C9JP00 ENST00000498502.5 ENST00000464596.5 ENST00000465907.6 [Q9NR56-4] ENST00000460591.5 C9JCX1 ENST00000478535.1 ENST00000357472.7 [Q9NR56-6] ENST00000495875.6 ENST00000485910.5 [Q9NR56-3] Q86VM6 ENST00000492948.5 [Q9NR56-6] ENST00000493459.5 A0A0A0MQX8 ENST00000355460.6 [Q9NR56-2] ENST00000463374.5 [Q9NR56-1] ENST00000545754.5 [Q9NR56-4] ENST00000459747.1 ENST00000282488.11 H7C4T5 Q9NR56 ENST00000324196.9 [Q9NR56-7] ENST00000324210.10 [Q9NR56-5] C9J4T8 H7C4Y1 ENST00000485509.5 [Q9NR56-7]

MBNL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review