LSM5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD4-positive, alpha-beta T cell	26 studies	32% ± 16%	Explore
B cell	25 studies	29% ± 12%	Explore
natural killer cell	25 studies	24% ± 10%	Explore
T cell	24 studies	30% ± 12%	Explore
CD8-positive, alpha-beta T cell	23 studies	30% ± 15%	Explore
fibroblast	22 studies	28% ± 10%	Explore
conventional dendritic cell	19 studies	33% ± 14%	Explore
pericyte	17 studies	27% ± 10%	Explore
smooth muscle cell	17 studies	29% ± 9%	Explore
plasmacytoid dendritic cell	17 studies	33% ± 12%	Explore
regulatory T cell	17 studies	25% ± 8%	Explore
basal cell	16 studies	29% ± 16%	Explore
endothelial cell	16 studies	28% ± 13%	Explore
epithelial cell	16 studies	38% ± 21%	Explore
ciliated cell	15 studies	35% ± 18%	Explore
macrophage	15 studies	25% ± 12%	Explore
memory B cell	15 studies	24% ± 8%	Explore
plasma cell	14 studies	35% ± 12%	Explore
naive B cell	14 studies	23% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	28% ± 8%	Explore
connective tissue cell	14 studies	30% ± 12%	Explore
monocyte	13 studies	27% ± 9%	Explore
gamma-delta T cell	13 studies	28% ± 17%	Explore
mast cell	12 studies	21% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	29% ± 9%	Explore
classical monocyte	11 studies	23% ± 9%	Explore
mature NK T cell	11 studies	21% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	23% ± 8%	Explore
non-classical monocyte	10 studies	25% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	23% ± 5%	Explore
mucosal invariant T cell	10 studies	21% ± 4%	Explore
plasmablast	9 studies	46% ± 22%	Explore
myofibroblast cell	9 studies	30% ± 10%	Explore
progenitor cell	9 studies	44% ± 13%	Explore
abnormal cell	9 studies	32% ± 11%	Explore
dendritic cell	9 studies	38% ± 25%	Explore
endothelial cell of lymphatic vessel	9 studies	25% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	26% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	19% ± 3%	Explore
T follicular helper cell	8 studies	27% ± 8%	Explore
epithelial cell of proximal tubule	7 studies	26% ± 7%	Explore
vein endothelial cell	7 studies	22% ± 7%	Explore
hematopoietic precursor cell	6 studies	42% ± 23%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	33% ± 14%	Explore
kidney loop of Henle epithelial cell	6 studies	21% ± 2%	Explore
goblet cell	6 studies	31% ± 12%	Explore
mesothelial cell	6 studies	36% ± 17%	Explore
innate lymphoid cell	6 studies	21% ± 3%	Explore
myeloid cell	6 studies	26% ± 11%	Explore
club cell	6 studies	25% ± 8%	Explore
erythrocyte	6 studies	36% ± 21%	Explore
neuron	6 studies	32% ± 15%	Explore
endothelial cell of vascular tree	6 studies	22% ± 3%	Explore
leukocyte	5 studies	30% ± 12%	Explore
mononuclear phagocyte	5 studies	29% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	26% ± 6%	Explore
endothelial cell of artery	5 studies	21% ± 4%	Explore
enterocyte	5 studies	23% ± 9%	Explore
intestinal crypt stem cell	5 studies	34% ± 13%	Explore
transit amplifying cell	5 studies	44% ± 21%	Explore
erythroblast	5 studies	49% ± 20%	Explore
hematopoietic stem cell	5 studies	32% ± 11%	Explore
pro-B cell	5 studies	33% ± 4%	Explore
type II pneumocyte	5 studies	33% ± 19%	Explore
pancreatic A cell	4 studies	28% ± 9%	Explore
type B pancreatic cell	4 studies	31% ± 12%	Explore
exhausted T cell	4 studies	26% ± 8%	Explore
capillary endothelial cell	4 studies	20% ± 3%	Explore
enteroendocrine cell	4 studies	35% ± 10%	Explore
immature B cell	4 studies	34% ± 19%	Explore
precursor B cell	4 studies	33% ± 14%	Explore
germinal center B cell	4 studies	29% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	29% ± 9%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	33% ± 9%	Explore
GABAergic neuron	4 studies	24% ± 7%	Explore
glutamatergic neuron	4 studies	29% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	31% ± 9%	Explore
secretory cell	4 studies	33% ± 17%	Explore
T-helper 17 cell	4 studies	36% ± 22%	Explore
deuterosomal cell	3 studies	42% ± 4%	Explore
precursor cell	3 studies	39% ± 12%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	43% ± 12%	Explore
neural crest cell	3 studies	57% ± 12%	Explore
IgG plasma cell	3 studies	19% ± 2%	Explore
common myeloid progenitor	3 studies	39% ± 21%	Explore
lymphocyte	3 studies	37% ± 15%	Explore
type I pneumocyte	3 studies	30% ± 15%	Explore
amacrine cell	3 studies	35% ± 9%	Explore
astrocyte	3 studies	24% ± 11%	Explore
Mueller cell	3 studies	21% ± 8%	Explore
intermediate monocyte	3 studies	33% ± 15%	Explore
CD4-positive helper T cell	3 studies	18% ± 3%	Explore
myoepithelial cell	3 studies	25% ± 9%	Explore
granulocyte monocyte progenitor cell	3 studies	49% ± 24%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	50% ± 23%	Explore
group 3 innate lymphoid cell	3 studies	32% ± 16%	Explore
keratinocyte	3 studies	28% ± 1%	Explore
T-helper 1 cell	3 studies	29% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	20% ± 4%	Explore
double negative thymocyte	3 studies	41% ± 26%	Explore
progenitor cell of mammary luminal epithelium	3 studies	25% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	14 studies	29% ± 14%	Explore
peripheral blood	14 studies	27% ± 7%	Explore
intestine	9 studies	29% ± 12%	Explore
kidney	8 studies	24% ± 6%	Explore
brain	7 studies	21% ± 8%	Explore
liver	6 studies	32% ± 24%	Explore
pancreas	5 studies	27% ± 10%	Explore
bone marrow	5 studies	23% ± 6%	Explore
lymph node	5 studies	26% ± 5%	Explore
uterus	4 studies	29% ± 17%	Explore
eye	3 studies	33% ± 9%	Explore
adrenal gland	3 studies	17% ± 1%	Explore
thymus	3 studies	53% ± 25%	Explore
breast	3 studies	26% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1012.44	1445 / 1445	100%	26.57	183 / 183
ovary	100%	1140.35	180 / 180	100%	25.11	430 / 430
stomach	100%	1045.46	359 / 359	100%	28.17	286 / 286
uterus	100%	1095.61	170 / 170	100%	35.88	459 / 459
brain	100%	891.01	2640 / 2642	100%	29.53	704 / 705
thymus	100%	1132.22	653 / 653	100%	23.13	603 / 605
lung	100%	894.56	576 / 578	100%	28.39	1155 / 1155
bladder	100%	1043.24	21 / 21	100%	29.48	502 / 504
breast	100%	1172.26	459 / 459	100%	29.39	1113 / 1118
kidney	100%	1095.78	89 / 89	99%	18.66	896 / 901
pancreas	100%	869.66	328 / 328	99%	19.67	177 / 178
prostate	100%	1094.57	245 / 245	99%	24.34	499 / 502
skin	100%	1148.02	1808 / 1809	99%	24.46	469 / 472
intestine	100%	1163.24	966 / 966	99%	32.15	522 / 527
adrenal gland	100%	1256.98	258 / 258	99%	21.02	227 / 230
liver	100%	852.55	226 / 226	98%	15.41	396 / 406
blood vessel	100%	1061.14	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	36.24	29 / 29
spleen	100%	1144.44	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	28.44	45 / 45
ureter	0%	0	0 / 0	100%	19.22	1 / 1
adipose	100%	1018.45	1203 / 1204	0%	0	0 / 0
muscle	100%	985.52	801 / 803	0%	0	0 / 0
heart	99%	919.44	851 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	91%	9.59	73 / 80
peripheral blood	61%	809.33	566 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0009617	Biological process	response to bacterium
GO_0006397	Biological process	mRNA processing
GO_0006402	Biological process	mRNA catabolic process
GO_0046540	Cellular component	U4/U6 x U5 tri-snRNP complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0120115	Cellular component	Lsm2-8 complex
GO_0005688	Cellular component	U6 snRNP
GO_1990726	Cellular component	Lsm1-7-Pat1 complex
GO_0071005	Cellular component	U2-type precatalytic spliceosome
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0046982	Molecular function	protein heterodimerization activity
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	LSM5
Protein name	U6 snRNA-associated Sm-like protein LSm5 LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
Synonyms	tcag7.675 hCG_37327
Description	FUNCTION: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) . The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA . . FUNCTION: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. .
Accessions	ENST00000409952.3 [Q9Y4Y9-2] ENST00000409987.5 ENST00000409782.5 [Q9Y4Y9-2] F8W8Y8 B8ZZF8 ENST00000409292.5 [Q9Y4Y9-2] A0A090N8Y5 ENST00000410044.5 [Q9Y4Y9-2] ENST00000409909.7 [Q9Y4Y9-2] ENST00000450169.7 [Q9Y4Y9-1] Q9Y4Y9 ENST00000223084.7

LSM5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review