LDHA | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	41 studies	55% ± 22%	Explore
natural killer cell	40 studies	53% ± 17%	Explore
fibroblast	39 studies	61% ± 21%	Explore
CD8-positive, alpha-beta T cell	38 studies	53% ± 21%	Explore
T cell	35 studies	54% ± 20%	Explore
B cell	34 studies	36% ± 12%	Explore
macrophage	33 studies	52% ± 17%	Explore
pericyte	33 studies	62% ± 25%	Explore
CD4-positive, alpha-beta T cell	32 studies	57% ± 19%	Explore
conventional dendritic cell	30 studies	65% ± 16%	Explore
classical monocyte	29 studies	46% ± 16%	Explore
regulatory T cell	28 studies	55% ± 18%	Explore
smooth muscle cell	27 studies	61% ± 22%	Explore
dendritic cell	26 studies	59% ± 22%	Explore
non-classical monocyte	24 studies	56% ± 13%	Explore
plasma cell	22 studies	39% ± 19%	Explore
epithelial cell	22 studies	59% ± 23%	Explore
plasmacytoid dendritic cell	21 studies	40% ± 12%	Explore
basal cell	21 studies	63% ± 17%	Explore
monocyte	20 studies	53% ± 17%	Explore
mature NK T cell	20 studies	48% ± 14%	Explore
memory B cell	20 studies	32% ± 12%	Explore
mast cell	19 studies	41% ± 17%	Explore
endothelial cell of lymphatic vessel	19 studies	55% ± 14%	Explore
connective tissue cell	19 studies	61% ± 16%	Explore
gamma-delta T cell	18 studies	55% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	44% ± 14%	Explore
naive B cell	18 studies	28% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	48% ± 18%	Explore
mucosal invariant T cell	16 studies	48% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	50% ± 12%	Explore
myeloid cell	15 studies	55% ± 20%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	51% ± 19%	Explore
vein endothelial cell	14 studies	56% ± 21%	Explore
capillary endothelial cell	13 studies	46% ± 16%	Explore
myofibroblast cell	13 studies	64% ± 17%	Explore
endothelial cell of vascular tree	13 studies	72% ± 21%	Explore
innate lymphoid cell	12 studies	56% ± 19%	Explore
plasmablast	12 studies	58% ± 24%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	57% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	58% ± 16%	Explore
secretory cell	12 studies	47% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	48% ± 16%	Explore
endothelial cell of artery	11 studies	52% ± 10%	Explore
mesothelial cell	11 studies	63% ± 21%	Explore
progenitor cell	10 studies	66% ± 16%	Explore
abnormal cell	10 studies	58% ± 28%	Explore
type II pneumocyte	9 studies	52% ± 20%	Explore
effector CD8-positive, alpha-beta T cell	9 studies	66% ± 18%	Explore
T follicular helper cell	9 studies	51% ± 18%	Explore
microglial cell	9 studies	53% ± 22%	Explore
type I pneumocyte	8 studies	41% ± 12%	Explore
neutrophil	8 studies	41% ± 12%	Explore
leukocyte	8 studies	58% ± 13%	Explore
neuron	8 studies	42% ± 19%	Explore
enterocyte	8 studies	63% ± 23%	Explore
goblet cell	8 studies	44% ± 15%	Explore
retinal rod cell	8 studies	55% ± 22%	Explore
ciliated cell	8 studies	42% ± 14%	Explore
club cell	7 studies	47% ± 18%	Explore
ionocyte	7 studies	61% ± 15%	Explore
epithelial cell of proximal tubule	7 studies	45% ± 18%	Explore
astrocyte	7 studies	47% ± 21%	Explore
hematopoietic stem cell	7 studies	71% ± 14%	Explore
precursor B cell	7 studies	48% ± 23%	Explore
alveolar macrophage	6 studies	48% ± 14%	Explore
CD4-positive helper T cell	6 studies	51% ± 17%	Explore
respiratory goblet cell	6 studies	40% ± 22%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	72% ± 17%	Explore
mononuclear phagocyte	6 studies	51% ± 17%	Explore
kidney loop of Henle epithelial cell	6 studies	50% ± 12%	Explore
renal alpha-intercalated cell	6 studies	75% ± 8%	Explore
transit amplifying cell	6 studies	44% ± 18%	Explore
amacrine cell	6 studies	54% ± 12%	Explore
retina horizontal cell	6 studies	64% ± 18%	Explore
retinal ganglion cell	6 studies	85% ± 17%	Explore
retinal cone cell	6 studies	67% ± 20%	Explore
adipocyte	6 studies	33% ± 17%	Explore
erythrocyte	6 studies	39% ± 18%	Explore
IgA plasma cell	6 studies	25% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	63% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	46% ± 14%	Explore
hematopoietic precursor cell	5 studies	71% ± 19%	Explore
exhausted T cell	5 studies	55% ± 19%	Explore
monocyte-derived dendritic cell	5 studies	74% ± 12%	Explore
intestinal crypt stem cell	5 studies	40% ± 20%	Explore
erythroblast	5 studies	52% ± 21%	Explore
pro-B cell	5 studies	50% ± 19%	Explore
T-helper 17 cell	5 studies	68% ± 22%	Explore
group 3 innate lymphoid cell	5 studies	69% ± 12%	Explore
intermediate monocyte	5 studies	59% ± 19%	Explore
hepatocyte	5 studies	54% ± 24%	Explore
granulocyte	5 studies	54% ± 19%	Explore
melanocyte	5 studies	54% ± 24%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	57% ± 24%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	45% ± 19%	Explore
duct epithelial cell	4 studies	49% ± 13%	Explore
platelet	4 studies	26% ± 8%	Explore
pancreatic A cell	4 studies	53% ± 19%	Explore
glomerular endothelial cell	4 studies	42% ± 11%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	57% ± 8%	Explore
enteroendocrine cell	4 studies	53% ± 14%	Explore
retinal bipolar neuron	4 studies	53% ± 23%	Explore
OFF-bipolar cell	4 studies	76% ± 20%	Explore
ON-bipolar cell	4 studies	66% ± 22%	Explore
Schwann cell	4 studies	56% ± 25%	Explore
immature B cell	4 studies	51% ± 15%	Explore
adventitial cell	4 studies	76% ± 13%	Explore
mucus secreting cell	4 studies	44% ± 14%	Explore
Mueller cell	4 studies	52% ± 12%	Explore
acinar cell	4 studies	53% ± 27%	Explore
muscle cell	4 studies	50% ± 18%	Explore
germinal center B cell	4 studies	40% ± 15%	Explore
IgG plasma cell	4 studies	32% ± 10%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	68% ± 10%	Explore
inflammatory macrophage	4 studies	39% ± 17%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	77% ± 27%	Explore
keratinocyte	4 studies	84% ± 11%	Explore
GABAergic neuron	4 studies	29% ± 9%	Explore
glutamatergic neuron	4 studies	34% ± 15%	Explore
T-helper 1 cell	4 studies	69% ± 17%	Explore
Langerhans cell	3 studies	74% ± 16%	Explore
precursor cell	3 studies	77% ± 3%	Explore
squamous epithelial cell	3 studies	38% ± 22%	Explore
neural crest cell	3 studies	68% ± 13%	Explore
GABAergic amacrine cell	3 studies	68% ± 15%	Explore
glycinergic amacrine cell	3 studies	62% ± 22%	Explore
renal principal cell	3 studies	64% ± 9%	Explore
thymocyte	3 studies	58% ± 23%	Explore
extravillous trophoblast	3 studies	91% ± 5%	Explore
placental villous trophoblast	3 studies	65% ± 15%	Explore
lymphocyte	3 studies	66% ± 13%	Explore
megakaryocyte	3 studies	46% ± 14%	Explore
retinal pigment epithelial cell	3 studies	38% ± 14%	Explore
serous secreting cell	3 studies	46% ± 9%	Explore
tissue-resident macrophage	3 studies	38% ± 23%	Explore
intraepithelial lymphocyte	3 studies	55% ± 11%	Explore
rod bipolar cell	3 studies	75% ± 4%	Explore
chondrocyte	3 studies	47% ± 13%	Explore
endothelial cell of sinusoid	3 studies	27% ± 9%	Explore
myoepithelial cell	3 studies	73% ± 7%	Explore
luminal cell of prostate epithelium	3 studies	31% ± 11%	Explore
pancreatic ductal cell	3 studies	62% ± 15%	Explore
oligodendrocyte precursor cell	3 studies	33% ± 16%	Explore
glial cell	3 studies	47% ± 22%	Explore
interneuron	3 studies	29% ± 10%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	55% ± 17%	Explore
double negative thymocyte	3 studies	69% ± 11%	Explore
double-positive, alpha-beta thymocyte	3 studies	70% ± 3%	Explore
progenitor cell of mammary luminal epithelium	3 studies	58% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	48% ± 14%	Explore
lung	18 studies	51% ± 12%	Explore
intestine	14 studies	44% ± 19%	Explore
eye	11 studies	53% ± 19%	Explore
kidney	9 studies	52% ± 15%	Explore
liver	9 studies	40% ± 16%	Explore
bone marrow	7 studies	40% ± 17%	Explore
lymph node	7 studies	54% ± 16%	Explore
brain	7 studies	32% ± 11%	Explore
uterus	6 studies	62% ± 16%	Explore
pancreas	5 studies	41% ± 11%	Explore
placenta	4 studies	68% ± 22%	Explore
prostate	4 studies	54% ± 6%	Explore
skin	4 studies	70% ± 16%	Explore
breast	4 studies	64% ± 5%	Explore
ovary	3 studies	41% ± 2%	Explore
heart	3 studies	33% ± 11%	Explore
adipose	3 studies	41% ± 16%	Explore
adrenal gland	3 studies	53% ± 9%	Explore
esophagus	3 studies	68% ± 14%	Explore
thymus	3 studies	68% ± 24%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	29740.17	1443 / 1445	100%	555.36	183 / 183
intestine	100%	24838.71	966 / 966	99%	483.86	524 / 527
breast	100%	30457.19	459 / 459	99%	391.93	1110 / 1118
lung	99%	22656.07	575 / 578	100%	506.73	1152 / 1155
skin	100%	60471.22	1808 / 1809	99%	534.17	467 / 472
kidney	99%	28248.84	88 / 89	96%	698.30	869 / 901
bladder	100%	24586.00	21 / 21	94%	388.97	475 / 504
uterus	95%	13837.19	161 / 170	99%	467.85	455 / 459
thymus	99%	17606.75	647 / 653	94%	186.39	566 / 605
liver	97%	35462.76	219 / 226	94%	242.42	382 / 406
prostate	91%	15355.96	223 / 245	94%	176.85	471 / 502
ovary	84%	12313.22	151 / 180	100%	503.83	429 / 430
stomach	74%	13163.55	266 / 359	100%	454.26	286 / 286
adrenal gland	100%	31023.19	258 / 258	66%	200.60	151 / 230
pancreas	62%	7798.62	203 / 328	93%	346.40	165 / 178
brain	82%	11296.74	2166 / 2642	53%	139.79	371 / 705
adipose	100%	37451.95	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	436.53	29 / 29
tonsil	0%	0	0 / 0	100%	519.90	45 / 45
ureter	0%	0	0 / 0	100%	95.47	1 / 1
blood vessel	100%	41577.95	1333 / 1335	0%	0	0 / 0
muscle	99%	46903.04	795 / 803	0%	0	0 / 0
spleen	99%	16186.85	238 / 241	0%	0	0 / 0
peripheral blood	98%	50005.36	908 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	98%	311.04	78 / 80
heart	90%	20524.50	778 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	LDHA
Protein name	L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) L-lactate dehydrogenase A chain (LDH muscle subunit) Lactate dehydrogenase A
Synonyms	PIG19
Description	FUNCTION: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). .
Accessions	ENST00000539814.5 F5GYU2 ENST00000541097.5 F5H6W8 ENST00000673007.1 [P00338-3] ENST00000673083.1 [P00338-2] F5GXH2 ENST00000543695.5 ENST00000430553.6 [P00338-4] ENST00000542179.1 [P00338-1] ENST00000545467.5 ENST00000536528.5 ENST00000227157.8 [P00338-5] ENST00000673204.1 [P00338-1] F5H5J4 F5H8H6 ENST00000478970.6 F5GXC7 ENST00000379412.9 [P00338-3] ENST00000543445.5 ENST00000495052.5 ENST00000486690.6 F5GXY2 F5GWW2 F5GZQ4 ENST00000672405.1 [P00338-1] F5GXU1 ENST00000672078.1 [P00338-5] ENST00000535451.5 ENST00000396222.6 [P00338-2] ENST00000422447.8 [P00338-1] ENST00000545215.5 P00338 ENST00000671981.1 [P00338-1] ENST00000672996.1 [P00338-4]

GO_0006089	Biological process	lactate metabolic process
GO_0006096	Biological process	glycolytic process
GO_0006090	Biological process	pyruvate metabolic process
GO_1990204	Cellular component	oxidoreductase complex
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0016020	Cellular component	membrane
GO_0005739	Cellular component	mitochondrion
GO_0005634	Cellular component	nucleus
GO_0045296	Molecular function	cadherin binding
GO_0004459	Molecular function	L-lactate dehydrogenase activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding

LDHA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review