JMJD1C | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	52 studies	55% ± 21%	Explore
fibroblast	42 studies	43% ± 19%	Explore
B cell	41 studies	36% ± 13%	Explore
macrophage	36 studies	45% ± 21%	Explore
pericyte	34 studies	41% ± 21%	Explore
smooth muscle cell	31 studies	41% ± 20%	Explore
natural killer cell	27 studies	24% ± 9%	Explore
T cell	26 studies	31% ± 15%	Explore
conventional dendritic cell	25 studies	36% ± 16%	Explore
classical monocyte	24 studies	36% ± 13%	Explore
CD4-positive, alpha-beta T cell	24 studies	31% ± 9%	Explore
CD8-positive, alpha-beta T cell	23 studies	26% ± 8%	Explore
endothelial cell of lymphatic vessel	21 studies	53% ± 23%	Explore
monocyte	20 studies	42% ± 22%	Explore
memory B cell	20 studies	34% ± 8%	Explore
plasmacytoid dendritic cell	20 studies	36% ± 12%	Explore
astrocyte	20 studies	57% ± 17%	Explore
dendritic cell	19 studies	49% ± 21%	Explore
naive B cell	19 studies	34% ± 9%	Explore
regulatory T cell	19 studies	29% ± 8%	Explore
basal cell	18 studies	39% ± 19%	Explore
non-classical monocyte	18 studies	34% ± 14%	Explore
microglial cell	18 studies	63% ± 19%	Explore
ciliated cell	16 studies	38% ± 18%	Explore
oligodendrocyte precursor cell	16 studies	70% ± 19%	Explore
oligodendrocyte	15 studies	63% ± 13%	Explore
capillary endothelial cell	15 studies	40% ± 16%	Explore
vein endothelial cell	15 studies	41% ± 20%	Explore
gamma-delta T cell	15 studies	27% ± 12%	Explore
epithelial cell	15 studies	48% ± 23%	Explore
myofibroblast cell	14 studies	35% ± 17%	Explore
connective tissue cell	14 studies	36% ± 17%	Explore
endothelial cell of vascular tree	14 studies	44% ± 17%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	26% ± 8%	Explore
mature NK T cell	13 studies	24% ± 11%	Explore
endothelial cell of artery	13 studies	42% ± 15%	Explore
myeloid cell	13 studies	47% ± 20%	Explore
mast cell	12 studies	31% ± 16%	Explore
leukocyte	12 studies	43% ± 19%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	30% ± 12%	Explore
glutamatergic neuron	12 studies	86% ± 13%	Explore
mucosal invariant T cell	12 studies	29% ± 10%	Explore
neutrophil	11 studies	32% ± 9%	Explore
GABAergic neuron	11 studies	76% ± 19%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	25% ± 8%	Explore
adipocyte	11 studies	65% ± 23%	Explore
type I pneumocyte	10 studies	47% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	30% ± 10%	Explore
type II pneumocyte	9 studies	47% ± 22%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	30% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	27% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	34% ± 12%	Explore
neuron	9 studies	54% ± 25%	Explore
alveolar macrophage	8 studies	48% ± 26%	Explore
club cell	8 studies	46% ± 22%	Explore
secretory cell	8 studies	32% ± 8%	Explore
amacrine cell	8 studies	61% ± 25%	Explore
retinal rod cell	8 studies	55% ± 23%	Explore
innate lymphoid cell	8 studies	27% ± 9%	Explore
mesothelial cell	8 studies	52% ± 16%	Explore
plasma cell	7 studies	33% ± 13%	Explore
mononuclear phagocyte	7 studies	43% ± 15%	Explore
progenitor cell	7 studies	40% ± 24%	Explore
abnormal cell	7 studies	34% ± 19%	Explore
retinal ganglion cell	7 studies	63% ± 29%	Explore
retinal cone cell	7 studies	69% ± 20%	Explore
goblet cell	7 studies	33% ± 27%	Explore
respiratory goblet cell	6 studies	46% ± 24%	Explore
interneuron	6 studies	81% ± 13%	Explore
precursor B cell	6 studies	44% ± 10%	Explore
retina horizontal cell	6 studies	64% ± 19%	Explore
Mueller cell	6 studies	56% ± 20%	Explore
T follicular helper cell	6 studies	32% ± 13%	Explore
plasmablast	5 studies	35% ± 25%	Explore
hepatocyte	5 studies	60% ± 27%	Explore
retinal bipolar neuron	5 studies	45% ± 19%	Explore
glial cell	5 studies	48% ± 13%	Explore
kidney loop of Henle epithelial cell	5 studies	35% ± 23%	Explore
pro-B cell	5 studies	38% ± 10%	Explore
cardiac muscle cell	5 studies	66% ± 14%	Explore
lymphocyte	5 studies	48% ± 15%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	28% ± 11%	Explore
ionocyte	4 studies	24% ± 6%	Explore
squamous epithelial cell	4 studies	42% ± 21%	Explore
pancreatic A cell	4 studies	38% ± 15%	Explore
cholangiocyte	4 studies	58% ± 21%	Explore
granule cell	4 studies	83% ± 9%	Explore
hematopoietic stem cell	4 studies	30% ± 22%	Explore
immature B cell	4 studies	43% ± 6%	Explore
retinal pigment epithelial cell	4 studies	58% ± 21%	Explore
OFF-bipolar cell	4 studies	61% ± 20%	Explore
ON-bipolar cell	4 studies	64% ± 18%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	32% ± 8%	Explore
luminal cell of prostate epithelium	4 studies	34% ± 13%	Explore
muscle cell	4 studies	46% ± 21%	Explore
brush cell	4 studies	27% ± 7%	Explore
enteroendocrine cell	4 studies	32% ± 7%	Explore
myoepithelial cell	4 studies	45% ± 20%	Explore
erythrocyte	4 studies	34% ± 17%	Explore
hematopoietic precursor cell	3 studies	54% ± 21%	Explore
pancreatic D cell	3 studies	40% ± 21%	Explore
type B pancreatic cell	3 studies	48% ± 16%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	34% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	28% ± 7%	Explore
endothelial cell of sinusoid	3 studies	40% ± 11%	Explore
hepatic stellate cell	3 studies	55% ± 21%	Explore
exhausted T cell	3 studies	24% ± 12%	Explore
glomerular endothelial cell	3 studies	27% ± 3%	Explore
epithelial cell of proximal tubule	3 studies	39% ± 18%	Explore
podocyte	3 studies	40% ± 19%	Explore
renal alpha-intercalated cell	3 studies	56% ± 28%	Explore
renal beta-intercalated cell	3 studies	56% ± 24%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	76% ± 6%	Explore
interstitial cell of Cajal	3 studies	39% ± 9%	Explore
neural crest cell	3 studies	26% ± 1%	Explore
GABAergic interneuron	3 studies	82% ± 3%	Explore
endocardial cell	3 studies	54% ± 15%	Explore
tissue-resident macrophage	3 studies	49% ± 14%	Explore
GABAergic amacrine cell	3 studies	78% ± 7%	Explore
glycinergic amacrine cell	3 studies	82% ± 3%	Explore
rod bipolar cell	3 studies	48% ± 15%	Explore
germinal center B cell	3 studies	32% ± 7%	Explore
intermediate monocyte	3 studies	53% ± 13%	Explore
CD4-positive helper T cell	3 studies	40% ± 14%	Explore
granulocyte	3 studies	29% ± 10%	Explore
pancreatic ductal cell	3 studies	43% ± 19%	Explore
ependymal cell	3 studies	71% ± 7%	Explore
enterocyte	3 studies	20% ± 2%	Explore
adventitial cell	3 studies	48% ± 9%	Explore
chondrocyte	3 studies	53% ± 22%	Explore
group 3 innate lymphoid cell	3 studies	42% ± 9%	Explore
Schwann cell	3 studies	43% ± 14%	Explore
transit amplifying cell	3 studies	43% ± 37%	Explore
T-helper 17 cell	3 studies	31% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	29% ± 12%	Explore
progenitor cell of mammary luminal epithelium	3 studies	33% ± 7%	Explore
renal principal cell	3 studies	52% ± 26%	Explore
mucus secreting cell	3 studies	62% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	35% ± 18%	Explore
brain	19 studies	68% ± 20%	Explore
peripheral blood	14 studies	32% ± 15%	Explore
intestine	10 studies	24% ± 9%	Explore
eye	10 studies	53% ± 23%	Explore
kidney	8 studies	34% ± 19%	Explore
liver	6 studies	38% ± 21%	Explore
heart	6 studies	53% ± 20%	Explore
uterus	5 studies	31% ± 11%	Explore
lymph node	5 studies	25% ± 6%	Explore
breast	5 studies	35% ± 12%	Explore
bone marrow	4 studies	33% ± 21%	Explore
prostate	4 studies	41% ± 10%	Explore
adipose	4 studies	58% ± 26%	Explore
pancreas	3 studies	45% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4145.82	1444 / 1445	100%	29.07	183 / 183
lung	100%	6600.86	578 / 578	99%	18.88	1147 / 1155
brain	99%	4250.85	2612 / 2642	100%	27.91	702 / 705
breast	100%	6472.79	459 / 459	98%	24.86	1099 / 1118
prostate	100%	4077.13	245 / 245	98%	21.50	490 / 502
stomach	100%	3816.40	359 / 359	98%	19.74	279 / 286
thymus	100%	5841.19	653 / 653	97%	19.76	585 / 605
intestine	100%	5016.96	966 / 966	97%	17.38	509 / 527
pancreas	98%	2470.82	323 / 328	98%	21.18	174 / 178
kidney	100%	3037.06	89 / 89	96%	20.77	862 / 901
ovary	100%	6070.08	180 / 180	96%	11.62	411 / 430
uterus	100%	6226.49	170 / 170	95%	15.76	436 / 459
bladder	100%	3968.14	21 / 21	93%	13.53	471 / 504
adrenal gland	100%	3598.17	258 / 258	92%	13.18	212 / 230
skin	100%	4784.10	1807 / 1809	86%	13.44	404 / 472
liver	100%	2380.97	226 / 226	81%	9.38	329 / 406
adipose	100%	6306.40	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4892.25	1335 / 1335	0%	0	0 / 0
spleen	100%	5113.06	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	4.53	1 / 1
muscle	100%	2786.74	802 / 803	0%	0	0 / 0
heart	97%	2711.55	834 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	12.29	42 / 45
peripheral blood	91%	4067.96	845 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	12.97	26 / 29
eye	0%	0	0 / 0	53%	5.76	42 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007596	Biological process	blood coagulation
GO_0006338	Biological process	chromatin remodeling
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0000118	Cellular component	histone deacetylase complex
GO_0005654	Cellular component	nucleoplasm
GO_0000785	Cellular component	chromatin
GO_0046966	Molecular function	nuclear thyroid hormone receptor binding
GO_0031490	Molecular function	chromatin DNA binding
GO_0032454	Molecular function	histone H3K9 demethylase activity
GO_0051213	Molecular function	dioxygenase activity
GO_0005515	Molecular function	protein binding
GO_0003712	Molecular function	transcription coregulator activity
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	JMJD1C
Protein name	Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TR-interacting protein 8) (TRIP-8) Lysine-specific demethylase (EC 1.14.11.65) Jumonji domain containing 1C JMJD1C protein
Synonyms	KIAA1380 JHDM2C TRIP8
Description	FUNCTION: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). . FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. .
Accessions	H7BXU7 ENST00000399262.7 [Q15652-1] B7ZLC8 Q15652 A0PJE4 ENST00000542921.5 [Q15652-3] ENST00000327520.7

JMJD1C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review