HERPUD1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	46 studies	47% ± 23%	Explore
B cell	44 studies	59% ± 17%	Explore
endothelial cell	43 studies	44% ± 19%	Explore
fibroblast	35 studies	38% ± 16%	Explore
natural killer cell	34 studies	33% ± 11%	Explore
plasma cell	32 studies	76% ± 21%	Explore
CD8-positive, alpha-beta T cell	32 studies	36% ± 14%	Explore
conventional dendritic cell	31 studies	58% ± 14%	Explore
pericyte	30 studies	35% ± 16%	Explore
CD4-positive, alpha-beta T cell	30 studies	30% ± 10%	Explore
T cell	29 studies	35% ± 13%	Explore
dendritic cell	27 studies	51% ± 23%	Explore
plasmacytoid dendritic cell	27 studies	85% ± 14%	Explore
classical monocyte	26 studies	41% ± 13%	Explore
non-classical monocyte	24 studies	47% ± 15%	Explore
regulatory T cell	24 studies	40% ± 14%	Explore
smooth muscle cell	23 studies	31% ± 11%	Explore
monocyte	21 studies	38% ± 17%	Explore
endothelial cell of lymphatic vessel	20 studies	37% ± 11%	Explore
memory B cell	20 studies	60% ± 15%	Explore
naive B cell	20 studies	48% ± 15%	Explore
basal cell	20 studies	37% ± 13%	Explore
gamma-delta T cell	18 studies	35% ± 13%	Explore
mast cell	17 studies	28% ± 11%	Explore
epithelial cell	17 studies	44% ± 20%	Explore
microglial cell	17 studies	36% ± 18%	Explore
connective tissue cell	15 studies	39% ± 12%	Explore
mature NK T cell	15 studies	37% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	30% ± 8%	Explore
capillary endothelial cell	14 studies	43% ± 17%	Explore
endothelial cell of vascular tree	14 studies	39% ± 11%	Explore
myeloid cell	14 studies	45% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	33% ± 10%	Explore
endothelial cell of artery	13 studies	46% ± 17%	Explore
ciliated cell	13 studies	33% ± 15%	Explore
plasmablast	12 studies	64% ± 22%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	41% ± 14%	Explore
myofibroblast cell	12 studies	36% ± 14%	Explore
mucosal invariant T cell	12 studies	36% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	29% ± 11%	Explore
secretory cell	11 studies	37% ± 9%	Explore
goblet cell	11 studies	44% ± 13%	Explore
vein endothelial cell	11 studies	33% ± 10%	Explore
club cell	10 studies	31% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	23% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	29% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	41% ± 15%	Explore
type I pneumocyte	9 studies	34% ± 12%	Explore
type II pneumocyte	9 studies	35% ± 16%	Explore
innate lymphoid cell	9 studies	39% ± 15%	Explore
leukocyte	9 studies	49% ± 13%	Explore
IgA plasma cell	9 studies	79% ± 23%	Explore
IgG plasma cell	9 studies	77% ± 15%	Explore
abnormal cell	9 studies	37% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	31% ± 9%	Explore
mononuclear phagocyte	7 studies	51% ± 23%	Explore
epithelial cell of proximal tubule	7 studies	35% ± 7%	Explore
progenitor cell	7 studies	25% ± 10%	Explore
precursor B cell	7 studies	51% ± 10%	Explore
alveolar macrophage	6 studies	22% ± 3%	Explore
ionocyte	6 studies	46% ± 9%	Explore
respiratory goblet cell	6 studies	31% ± 14%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	32% ± 9%	Explore
kidney loop of Henle epithelial cell	6 studies	41% ± 9%	Explore
renal alpha-intercalated cell	6 studies	63% ± 16%	Explore
immature B cell	6 studies	62% ± 10%	Explore
T follicular helper cell	6 studies	33% ± 9%	Explore
astrocyte	5 studies	22% ± 7%	Explore
mucus secreting cell	5 studies	43% ± 22%	Explore
mesothelial cell	5 studies	35% ± 18%	Explore
inflammatory macrophage	5 studies	32% ± 10%	Explore
CD4-positive helper T cell	5 studies	39% ± 17%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	38% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	31% ± 11%	Explore
duct epithelial cell	4 studies	42% ± 13%	Explore
pancreatic A cell	4 studies	46% ± 4%	Explore
type B pancreatic cell	4 studies	58% ± 12%	Explore
exhausted T cell	4 studies	36% ± 13%	Explore
hematopoietic precursor cell	4 studies	27% ± 8%	Explore
glomerular endothelial cell	4 studies	52% ± 12%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	33% ± 8%	Explore
neuron	4 studies	31% ± 13%	Explore
retinal ganglion cell	4 studies	48% ± 25%	Explore
lymphocyte	4 studies	37% ± 13%	Explore
enterocyte	4 studies	25% ± 4%	Explore
retinal pigment epithelial cell	4 studies	37% ± 21%	Explore
adventitial cell	4 studies	34% ± 12%	Explore
germinal center B cell	4 studies	56% ± 15%	Explore
intermediate monocyte	4 studies	55% ± 22%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	49% ± 9%	Explore
granulocyte	4 studies	25% ± 5%	Explore
luminal cell of prostate epithelium	4 studies	50% ± 5%	Explore
IgM plasma cell	4 studies	73% ± 14%	Explore
glutamatergic neuron	4 studies	35% ± 16%	Explore
glial cell	4 studies	29% ± 8%	Explore
squamous epithelial cell	3 studies	37% ± 22%	Explore
pancreatic D cell	3 studies	54% ± 7%	Explore
monocyte-derived dendritic cell	3 studies	66% ± 17%	Explore
podocyte	3 studies	48% ± 5%	Explore
transit amplifying cell	3 studies	25% ± 8%	Explore
amacrine cell	3 studies	41% ± 13%	Explore
retinal bipolar neuron	3 studies	36% ± 9%	Explore
ON-bipolar cell	3 studies	26% ± 7%	Explore
renal principal cell	3 studies	39% ± 16%	Explore
extravillous trophoblast	3 studies	43% ± 11%	Explore
placental villous trophoblast	3 studies	42% ± 12%	Explore
retina horizontal cell	3 studies	35% ± 10%	Explore
serous secreting cell	3 studies	59% ± 22%	Explore
tissue-resident macrophage	3 studies	57% ± 23%	Explore
intraepithelial lymphocyte	3 studies	26% ± 9%	Explore
Mueller cell	3 studies	31% ± 2%	Explore
muscle cell	3 studies	29% ± 16%	Explore
GABAergic neuron	3 studies	32% ± 9%	Explore
acinar cell	3 studies	53% ± 15%	Explore
pancreatic ductal cell	3 studies	56% ± 9%	Explore
enteroendocrine cell	3 studies	46% ± 13%	Explore
intestinal crypt stem cell	3 studies	24% ± 7%	Explore
group 3 innate lymphoid cell	3 studies	49% ± 16%	Explore
brush cell	3 studies	26% ± 7%	Explore
melanocyte	3 studies	40% ± 12%	Explore
T-helper 17 cell	3 studies	39% ± 19%	Explore
neutrophil	3 studies	28% ± 5%	Explore
T-helper 1 cell	3 studies	42% ± 16%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	31% ± 7%	Explore
double negative thymocyte	3 studies	48% ± 11%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	28% ± 3%	Explore
progenitor cell of mammary luminal epithelium	3 studies	47% ± 7%	Explore
hepatocyte	3 studies	36% ± 18%	Explore
erythrocyte	3 studies	27% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	36% ± 11%	Explore
peripheral blood	18 studies	35% ± 11%	Explore
intestine	13 studies	37% ± 19%	Explore
kidney	9 studies	39% ± 14%	Explore
eye	8 studies	32% ± 18%	Explore
brain	7 studies	34% ± 14%	Explore
bone marrow	5 studies	25% ± 11%	Explore
uterus	5 studies	42% ± 13%	Explore
prostate	5 studies	35% ± 5%	Explore
lymph node	5 studies	45% ± 20%	Explore
liver	5 studies	30% ± 7%	Explore
pancreas	4 studies	51% ± 7%	Explore
skin	4 studies	32% ± 8%	Explore
breast	4 studies	46% ± 6%	Explore
placenta	3 studies	36% ± 10%	Explore
adrenal gland	3 studies	41% ± 20%	Explore
thymus	3 studies	29% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	100%	17744.14	328 / 328	100%	92.39	178 / 178
prostate	100%	15735.38	245 / 245	100%	291.50	502 / 502
kidney	100%	9164.47	89 / 89	100%	149.67	900 / 901
lung	100%	10334.05	577 / 578	100%	92.58	1154 / 1155
thymus	100%	12751.39	653 / 653	100%	107.74	602 / 605
intestine	100%	7175.06	966 / 966	99%	71.78	524 / 527
esophagus	100%	4035.44	1444 / 1445	99%	66.49	182 / 183
stomach	100%	9609.59	359 / 359	99%	71.64	284 / 286
breast	100%	7964.67	459 / 459	99%	90.20	1109 / 1118
liver	100%	9498.15	226 / 226	99%	68.09	402 / 406
skin	100%	6648.13	1807 / 1809	99%	78.17	465 / 472
adrenal gland	100%	10561.79	258 / 258	98%	86.96	226 / 230
ovary	100%	12770.49	180 / 180	98%	58.38	422 / 430
bladder	100%	5851.62	21 / 21	97%	64.13	491 / 504
brain	97%	3779.74	2569 / 2642	100%	66.17	704 / 705
uterus	100%	5137.48	170 / 170	97%	52.34	444 / 459
adipose	100%	7461.85	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	154.97	29 / 29
spleen	100%	11718.02	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	19.97	1 / 1
blood vessel	100%	7035.27	1332 / 1335	0%	0	0 / 0
muscle	100%	6117.78	801 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	61.94	44 / 45
heart	97%	5364.30	836 / 861	0%	0	0 / 0
peripheral blood	95%	6300.17	886 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	88%	31.88	70 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006986	Biological process	response to unfolded protein
GO_0030970	Biological process	retrograde protein transport, ER to cytosol
GO_1902236	Biological process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO_1904292	Biological process	regulation of ERAD pathway
GO_0034976	Biological process	response to endoplasmic reticulum stress
GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0031396	Biological process	regulation of protein ubiquitination
GO_0030968	Biological process	endoplasmic reticulum unfolded protein response
GO_0045047	Biological process	protein targeting to ER
GO_2000060	Biological process	positive regulation of ubiquitin-dependent protein catabolic process
GO_1904294	Biological process	positive regulation of ERAD pathway
GO_2001243	Biological process	negative regulation of intrinsic apoptotic signaling pathway
GO_0036503	Biological process	ERAD pathway
GO_0032469	Biological process	endoplasmic reticulum calcium ion homeostasis
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0044322	Cellular component	endoplasmic reticulum quality control compartment
GO_1990037	Cellular component	Lewy body core
GO_0005783	Cellular component	endoplasmic reticulum
GO_1990756	Molecular function	ubiquitin-like ligase-substrate adaptor activity
GO_0044325	Molecular function	transmembrane transporter binding
GO_0005515	Molecular function	protein binding
GO_0003674	Molecular function	molecular_function

IV. Literature review

[source]

Gene name	HERPUD1
Protein name	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (Methyl methanesulfonate (MMF)-inducible fragment protein 1) Homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1 isoform 1 Homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1 protein Homocysteine inducible ER protein with ubiquitin like domain 1
Synonyms	HERP MIF1 KIAA0025
Description	FUNCTION: Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins . Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway . .
Accessions	ENST00000344114.8 [Q15011-3] ENST00000568358.1 H3BTA8 ENST00000569429.5 A4UAE9 ENST00000563911.5 ENST00000565966.5 ENST00000439977.7 [Q15011-1] ENST00000300302.9 [Q15011-2] H3BP08 A0A2Z2EHH6 H3BQM2 ENST00000568651.1 Q15011 ENST00000563343.5 ENST00000379792.6 [Q15011-4] H3BTT7 H3BV54 H3BRS4

HERPUD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review