GABARAPL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032781Biological processpositive regulation of ATP-dependent activity
GO_0000045Biological processautophagosome assembly
GO_1901799Biological processnegative regulation of proteasomal protein catabolic process
GO_0070972Biological processprotein localization to endoplasmic reticulum
GO_0006891Biological processintra-Golgi vesicle-mediated transport
GO_0000422Biological processautophagy of mitochondrion
GO_0015031Biological processprotein transport
GO_0006914Biological processautophagy
GO_0097352Biological processautophagosome maturation
GO_0006995Biological processcellular response to nitrogen starvation
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0000421Cellular componentautophagosome membrane
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0005776Cellular componentautophagosome
GO_0005737Cellular componentcytoplasm
GO_0048487Molecular functionbeta-tubulin binding
GO_0050811Molecular functionGABA receptor binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0000149Molecular functionSNARE binding
GO_0008017Molecular functionmicrotubule binding
GO_0051117Molecular functionATPase binding
GO_0008429Molecular functionphosphatidylethanolamine binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGABARAPL2
Protein nameGamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein)
GABA type A receptor associated protein like 2 (GABA(A) receptor-associated protein-like 2, isoform CRA_a)
GABA type A receptor associated protein like 2
SynonymsGEF2
hCG_21766
FLC3A
DescriptionFUNCTION: Ubiquitin-like modifier involved in intra-Golgi traffic (By similarity). Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation (By similarity). It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy . Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production . Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation . .

AccessionsENST00000565057.5
P60520
H3BU36
H3BQ50
ENST00000037243.7
ENST00000568455.1
H3BSM5
ENST00000563744.1