FIS1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	34 studies	35% ± 15%	Explore
fibroblast	33 studies	39% ± 17%	Explore
endothelial cell	32 studies	46% ± 19%	Explore
CD8-positive, alpha-beta T cell	29 studies	32% ± 13%	Explore
macrophage	28 studies	35% ± 16%	Explore
pericyte	28 studies	44% ± 17%	Explore
CD4-positive, alpha-beta T cell	28 studies	30% ± 10%	Explore
B cell	27 studies	32% ± 17%	Explore
conventional dendritic cell	27 studies	35% ± 20%	Explore
smooth muscle cell	24 studies	44% ± 18%	Explore
non-classical monocyte	23 studies	37% ± 15%	Explore
classical monocyte	23 studies	34% ± 12%	Explore
regulatory T cell	22 studies	39% ± 16%	Explore
T cell	21 studies	30% ± 7%	Explore
epithelial cell	19 studies	45% ± 21%	Explore
monocyte	18 studies	33% ± 18%	Explore
basal cell	18 studies	41% ± 23%	Explore
naive B cell	18 studies	26% ± 7%	Explore
mast cell	17 studies	38% ± 18%	Explore
endothelial cell of lymphatic vessel	17 studies	50% ± 15%	Explore
plasmacytoid dendritic cell	17 studies	31% ± 10%	Explore
mature NK T cell	16 studies	31% ± 9%	Explore
memory B cell	16 studies	27% ± 7%	Explore
ciliated cell	16 studies	54% ± 19%	Explore
gamma-delta T cell	16 studies	33% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	36% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	29% ± 10%	Explore
connective tissue cell	15 studies	39% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	34% ± 11%	Explore
plasma cell	14 studies	51% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	36% ± 12%	Explore
myofibroblast cell	13 studies	40% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	37% ± 20%	Explore
dendritic cell	12 studies	39% ± 24%	Explore
capillary endothelial cell	12 studies	40% ± 13%	Explore
endothelial cell of artery	12 studies	47% ± 17%	Explore
plasmablast	11 studies	38% ± 22%	Explore
oligodendrocyte	11 studies	31% ± 14%	Explore
vein endothelial cell	11 studies	48% ± 14%	Explore
mucosal invariant T cell	11 studies	30% ± 8%	Explore
endothelial cell of vascular tree	11 studies	47% ± 18%	Explore
myeloid cell	11 studies	34% ± 11%	Explore
secretory cell	10 studies	40% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	32% ± 12%	Explore
abnormal cell	10 studies	37% ± 15%	Explore
mesothelial cell	10 studies	62% ± 20%	Explore
erythrocyte	10 studies	45% ± 21%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	35% ± 10%	Explore
progenitor cell	9 studies	37% ± 14%	Explore
type I pneumocyte	8 studies	42% ± 13%	Explore
type II pneumocyte	8 studies	45% ± 19%	Explore
club cell	7 studies	38% ± 11%	Explore
leukocyte	7 studies	28% ± 6%	Explore
epithelial cell of proximal tubule	7 studies	49% ± 17%	Explore
goblet cell	7 studies	39% ± 14%	Explore
T follicular helper cell	7 studies	28% ± 7%	Explore
respiratory goblet cell	6 studies	33% ± 18%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	37% ± 9%	Explore
kidney loop of Henle epithelial cell	6 studies	44% ± 14%	Explore
renal alpha-intercalated cell	6 studies	60% ± 7%	Explore
neuron	6 studies	55% ± 22%	Explore
enterocyte	6 studies	42% ± 16%	Explore
erythroblast	6 studies	47% ± 28%	Explore
hematopoietic stem cell	6 studies	46% ± 16%	Explore
innate lymphoid cell	6 studies	42% ± 26%	Explore
alveolar macrophage	5 studies	32% ± 6%	Explore
exhausted T cell	5 studies	42% ± 9%	Explore
ionocyte	5 studies	39% ± 12%	Explore
mononuclear phagocyte	5 studies	33% ± 16%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	51% ± 8%	Explore
enteroendocrine cell	5 studies	46% ± 19%	Explore
IgG plasma cell	5 studies	24% ± 7%	Explore
transit amplifying cell	5 studies	25% ± 9%	Explore
precursor B cell	5 studies	36% ± 7%	Explore
astrocyte	5 studies	36% ± 18%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	37% ± 14%	Explore
hematopoietic precursor cell	4 studies	63% ± 12%	Explore
glomerular endothelial cell	4 studies	43% ± 12%	Explore
IgA plasma cell	4 studies	24% ± 6%	Explore
retinal ganglion cell	4 studies	69% ± 23%	Explore
pro-B cell	4 studies	26% ± 4%	Explore
brush cell	4 studies	33% ± 13%	Explore
immature B cell	4 studies	33% ± 7%	Explore
microglial cell	4 studies	26% ± 12%	Explore
adventitial cell	4 studies	30% ± 1%	Explore
keratinocyte	4 studies	45% ± 32%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	47% ± 3%	Explore
intermediate monocyte	4 studies	48% ± 17%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	47% ± 9%	Explore
oligodendrocyte precursor cell	4 studies	33% ± 10%	Explore
hepatocyte	4 studies	45% ± 31%	Explore
T-helper 17 cell	4 studies	26% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	32% ± 9%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	28% ± 11%	Explore
deuterosomal cell	3 studies	31% ± 11%	Explore
duct epithelial cell	3 studies	39% ± 12%	Explore
platelet	3 studies	19% ± 2%	Explore
pancreatic A cell	3 studies	58% ± 17%	Explore
type B pancreatic cell	3 studies	57% ± 17%	Explore
podocyte	3 studies	58% ± 4%	Explore
intestinal crypt stem cell	3 studies	39% ± 7%	Explore
neural crest cell	3 studies	34% ± 2%	Explore
renal principal cell	3 studies	53% ± 6%	Explore
extravillous trophoblast	3 studies	44% ± 13%	Explore
placental villous trophoblast	3 studies	48% ± 23%	Explore
lymphocyte	3 studies	39% ± 9%	Explore
neuroendocrine cell	3 studies	45% ± 17%	Explore
Schwann cell	3 studies	61% ± 17%	Explore
retinal cone cell	3 studies	31% ± 6%	Explore
retinal rod cell	3 studies	22% ± 2%	Explore
mucus secreting cell	3 studies	39% ± 17%	Explore
serous secreting cell	3 studies	37% ± 5%	Explore
intraepithelial lymphocyte	3 studies	32% ± 14%	Explore
Mueller cell	3 studies	40% ± 9%	Explore
CD4-positive helper T cell	3 studies	48% ± 36%	Explore
melanocyte	3 studies	55% ± 30%	Explore
germinal center B cell	3 studies	23% ± 2%	Explore
myoepithelial cell	3 studies	46% ± 23%	Explore
luminal cell of prostate epithelium	3 studies	36% ± 9%	Explore
glutamatergic neuron	3 studies	34% ± 12%	Explore
granulocyte	3 studies	30% ± 8%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	63% ± 21%	Explore
glial cell	3 studies	43% ± 20%	Explore
group 3 innate lymphoid cell	3 studies	40% ± 15%	Explore
T-helper 1 cell	3 studies	36% ± 7%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	33% ± 11%	Explore
double negative thymocyte	3 studies	48% ± 13%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	39% ± 5%	Explore
progenitor cell of mammary luminal epithelium	3 studies	37% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	36% ± 11%	Explore
lung	16 studies	39% ± 14%	Explore
intestine	11 studies	32% ± 15%	Explore
kidney	9 studies	38% ± 12%	Explore
brain	8 studies	27% ± 8%	Explore
eye	7 studies	26% ± 9%	Explore
liver	6 studies	35% ± 24%	Explore
lymph node	5 studies	33% ± 14%	Explore
bone marrow	4 studies	31% ± 9%	Explore
uterus	4 studies	48% ± 14%	Explore
breast	4 studies	37% ± 7%	Explore
pancreas	3 studies	54% ± 21%	Explore
placenta	3 studies	42% ± 15%	Explore
skin	3 studies	54% ± 30%	Explore
adrenal gland	3 studies	26% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5015.47	1445 / 1445	100%	83.54	183 / 183
liver	100%	4382.37	226 / 226	100%	203.43	406 / 406
ovary	100%	4275.04	180 / 180	100%	156.88	430 / 430
pancreas	100%	3269.65	328 / 328	100%	170.84	178 / 178
skin	100%	4545.55	1809 / 1809	100%	209.74	472 / 472
thymus	100%	5577.78	653 / 653	100%	276.52	605 / 605
brain	100%	6180.12	2641 / 2642	100%	268.97	705 / 705
kidney	100%	6229.00	89 / 89	100%	159.03	898 / 901
prostate	100%	4852.38	245 / 245	100%	222.93	500 / 502
uterus	100%	5168.70	170 / 170	100%	140.99	457 / 459
intestine	100%	5079.04	966 / 966	99%	168.09	524 / 527
adrenal gland	100%	6160.39	258 / 258	99%	203.14	228 / 230
stomach	100%	4379.59	359 / 359	99%	130.33	283 / 286
breast	100%	5751.97	459 / 459	99%	156.46	1106 / 1118
lung	100%	4236.81	576 / 578	99%	141.20	1145 / 1155
bladder	100%	4789.29	21 / 21	98%	157.30	495 / 504
adipose	100%	5837.77	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	333.05	80 / 80
lymph node	0%	0	0 / 0	100%	184.75	29 / 29
muscle	100%	7648.94	803 / 803	0%	0	0 / 0
spleen	100%	4840.59	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	116.21	45 / 45
ureter	0%	0	0 / 0	100%	95.54	1 / 1
blood vessel	100%	5650.32	1334 / 1335	0%	0	0 / 0
heart	100%	6049.51	859 / 861	0%	0	0 / 0
peripheral blood	99%	3138.84	921 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000266	Biological process	mitochondrial fission
GO_0010821	Biological process	regulation of mitochondrion organization
GO_0090141	Biological process	positive regulation of mitochondrial fission
GO_2001244	Biological process	positive regulation of intrinsic apoptotic signaling pathway
GO_2000192	Biological process	negative regulation of fatty acid transport
GO_0008053	Biological process	mitochondrial fusion
GO_0043653	Biological process	mitochondrial fragmentation involved in apoptotic process
GO_0007005	Biological process	mitochondrion organization
GO_1903579	Biological process	negative regulation of ATP metabolic process
GO_0016559	Biological process	peroxisome fission
GO_0090314	Biological process	positive regulation of protein targeting to membrane
GO_0001836	Biological process	release of cytochrome c from mitochondria
GO_0000422	Biological process	autophagy of mitochondrion
GO_0006626	Biological process	protein targeting to mitochondrion
GO_0005778	Cellular component	peroxisomal membrane
GO_0016020	Cellular component	membrane
GO_0005739	Cellular component	mitochondrion
GO_0032991	Cellular component	protein-containing complex
GO_0005777	Cellular component	peroxisome
GO_0005829	Cellular component	cytosol
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0008289	Molecular function	lipid binding
GO_0060090	Molecular function	molecular adaptor activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	FIS1
Protein name	Fission, mitochondrial 1 Mitochondrial fission 1 protein (FIS1 homolog) (hFis1) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11)
Synonyms	TTC11 CGI-135
Description	FUNCTION: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering . Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission . May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event . Also mediates peroxisomal fission . May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis . Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis . .
Accessions	ENST00000223136.5 Q9Y3D6 F5H509 F5H8A8 ENST00000474120.5 F8WBT1 ENST00000442303.1 ENST00000473527.5 ENST00000435848.1 F8WD11 ENST00000449367.5 C9JXH1

FIS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review