EWSR1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	37 studies	31% ± 12%	Explore
B cell	33 studies	29% ± 9%	Explore
fibroblast	33 studies	26% ± 10%	Explore
natural killer cell	31 studies	34% ± 13%	Explore
macrophage	28 studies	26% ± 8%	Explore
CD8-positive, alpha-beta T cell	28 studies	36% ± 13%	Explore
CD4-positive, alpha-beta T cell	27 studies	33% ± 13%	Explore
T cell	26 studies	31% ± 12%	Explore
smooth muscle cell	23 studies	23% ± 8%	Explore
pericyte	23 studies	24% ± 8%	Explore
conventional dendritic cell	22 studies	32% ± 17%	Explore
regulatory T cell	21 studies	37% ± 10%	Explore
non-classical monocyte	20 studies	32% ± 12%	Explore
classical monocyte	20 studies	29% ± 12%	Explore
memory B cell	19 studies	34% ± 10%	Explore
naive B cell	18 studies	31% ± 9%	Explore
monocyte	17 studies	26% ± 8%	Explore
ciliated cell	17 studies	34% ± 15%	Explore
endothelial cell of lymphatic vessel	16 studies	27% ± 9%	Explore
mature NK T cell	16 studies	29% ± 10%	Explore
plasmacytoid dendritic cell	16 studies	38% ± 14%	Explore
basal cell	15 studies	31% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	36% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	39% ± 10%	Explore
epithelial cell	14 studies	38% ± 22%	Explore
myofibroblast cell	14 studies	29% ± 10%	Explore
plasma cell	13 studies	34% ± 14%	Explore
capillary endothelial cell	13 studies	25% ± 9%	Explore
gamma-delta T cell	13 studies	38% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	37% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	30% ± 7%	Explore
vein endothelial cell	12 studies	25% ± 9%	Explore
astrocyte	12 studies	29% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	35% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	34% ± 6%	Explore
connective tissue cell	11 studies	30% ± 12%	Explore
mucosal invariant T cell	11 studies	37% ± 10%	Explore
myeloid cell	11 studies	30% ± 13%	Explore
mast cell	11 studies	21% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	33% ± 11%	Explore
endothelial cell of artery	10 studies	25% ± 5%	Explore
microglial cell	10 studies	28% ± 9%	Explore
oligodendrocyte precursor cell	10 studies	32% ± 14%	Explore
dendritic cell	10 studies	41% ± 17%	Explore
endothelial cell of vascular tree	10 studies	25% ± 8%	Explore
plasmablast	9 studies	53% ± 23%	Explore
abnormal cell	9 studies	29% ± 10%	Explore
type I pneumocyte	8 studies	28% ± 10%	Explore
glutamatergic neuron	8 studies	37% ± 24%	Explore
adipocyte	8 studies	23% ± 6%	Explore
oligodendrocyte	8 studies	28% ± 8%	Explore
progenitor cell	7 studies	32% ± 9%	Explore
interneuron	7 studies	32% ± 19%	Explore
neuron	7 studies	37% ± 16%	Explore
precursor B cell	7 studies	53% ± 15%	Explore
type II pneumocyte	7 studies	27% ± 10%	Explore
GABAergic neuron	7 studies	35% ± 19%	Explore
goblet cell	7 studies	35% ± 16%	Explore
club cell	6 studies	30% ± 9%	Explore
secretory cell	6 studies	29% ± 7%	Explore
leukocyte	6 studies	25% ± 7%	Explore
hematopoietic stem cell	6 studies	48% ± 12%	Explore
lymphocyte	6 studies	33% ± 10%	Explore
innate lymphoid cell	6 studies	28% ± 8%	Explore
mesothelial cell	6 studies	30% ± 11%	Explore
T follicular helper cell	6 studies	33% ± 4%	Explore
hematopoietic precursor cell	5 studies	51% ± 14%	Explore
exhausted T cell	5 studies	42% ± 7%	Explore
respiratory goblet cell	5 studies	30% ± 10%	Explore
transit amplifying cell	5 studies	31% ± 20%	Explore
pro-B cell	5 studies	57% ± 13%	Explore
brush cell	5 studies	27% ± 6%	Explore
immature B cell	5 studies	40% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	45% ± 18%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	36% ± 10%	Explore
erythrocyte	5 studies	36% ± 19%	Explore
deuterosomal cell	4 studies	36% ± 9%	Explore
pancreatic A cell	4 studies	47% ± 11%	Explore
mononuclear phagocyte	4 studies	31% ± 12%	Explore
erythroblast	4 studies	50% ± 25%	Explore
amacrine cell	4 studies	32% ± 10%	Explore
retina horizontal cell	4 studies	36% ± 9%	Explore
retinal rod cell	4 studies	29% ± 14%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	48% ± 10%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	25% ± 6%	Explore
hepatocyte	4 studies	42% ± 18%	Explore
enteroendocrine cell	4 studies	31% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	35% ± 9%	Explore
ionocyte	3 studies	30% ± 6%	Explore
precursor cell	3 studies	56% ± 18%	Explore
squamous epithelial cell	3 studies	36% ± 24%	Explore
pancreatic D cell	3 studies	36% ± 17%	Explore
type B pancreatic cell	3 studies	50% ± 7%	Explore
glomerular endothelial cell	3 studies	25% ± 3%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	29% ± 9%	Explore
enterocyte	3 studies	18% ± 1%	Explore
intestinal crypt stem cell	3 studies	24% ± 6%	Explore
neural crest cell	3 studies	37% ± 11%	Explore
retinal bipolar neuron	3 studies	33% ± 13%	Explore
glial cell	3 studies	36% ± 16%	Explore
kidney loop of Henle epithelial cell	3 studies	17% ± 1%	Explore
megakaryocyte	3 studies	18% ± 1%	Explore
tissue-resident macrophage	3 studies	26% ± 4%	Explore
intraepithelial lymphocyte	3 studies	32% ± 20%	Explore
Mueller cell	3 studies	20% ± 3%	Explore
rod bipolar cell	3 studies	24% ± 1%	Explore
germinal center B cell	3 studies	46% ± 14%	Explore
intermediate monocyte	3 studies	44% ± 22%	Explore
muscle cell	3 studies	35% ± 12%	Explore
pancreatic ductal cell	3 studies	55% ± 19%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	59% ± 30%	Explore
alveolar macrophage	3 studies	26% ± 7%	Explore
group 3 innate lymphoid cell	3 studies	42% ± 12%	Explore
T-helper 17 cell	3 studies	36% ± 18%	Explore
T-helper 1 cell	3 studies	40% ± 10%	Explore
double negative thymocyte	3 studies	55% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	17 studies	26% ± 9%	Explore
peripheral blood	16 studies	34% ± 10%	Explore
brain	12 studies	33% ± 16%	Explore
intestine	8 studies	24% ± 10%	Explore
kidney	7 studies	24% ± 8%	Explore
eye	6 studies	31% ± 13%	Explore
pancreas	4 studies	41% ± 16%	Explore
bone marrow	4 studies	30% ± 14%	Explore
lymph node	4 studies	30% ± 3%	Explore
breast	4 studies	20% ± 3%	Explore
liver	4 studies	38% ± 17%	Explore
adipose	4 studies	24% ± 4%	Explore
uterus	3 studies	29% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	12099.14	21 / 21	100%	86.29	504 / 504
esophagus	100%	11908.75	1445 / 1445	100%	75.31	183 / 183
intestine	100%	13592.10	966 / 966	100%	76.33	527 / 527
pancreas	100%	7785.57	328 / 328	100%	67.47	178 / 178
prostate	100%	14592.76	245 / 245	100%	79.69	502 / 502
skin	100%	13273.53	1809 / 1809	100%	85.10	472 / 472
stomach	100%	9964.45	359 / 359	100%	72.16	286 / 286
uterus	100%	14609.76	170 / 170	100%	97.76	459 / 459
lung	100%	12803.63	578 / 578	100%	76.11	1154 / 1155
breast	100%	12811.42	459 / 459	100%	76.71	1117 / 1118
thymus	100%	14733.30	653 / 653	100%	77.93	604 / 605
liver	100%	8015.22	226 / 226	100%	46.26	405 / 406
kidney	100%	10468.75	89 / 89	100%	52.04	898 / 901
brain	100%	10108.16	2633 / 2642	100%	87.00	705 / 705
ovary	100%	13632.77	180 / 180	100%	49.35	428 / 430
adrenal gland	100%	15842.69	258 / 258	99%	55.60	228 / 230
adipose	100%	12279.73	1204 / 1204	0%	0	0 / 0
blood vessel	100%	11441.15	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	55.52	80 / 80
lymph node	0%	0	0 / 0	100%	115.64	29 / 29
muscle	100%	9266.91	803 / 803	0%	0	0 / 0
spleen	100%	19452.42	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	93.07	45 / 45
ureter	0%	0	0 / 0	100%	44.58	1 / 1
heart	99%	8289.72	852 / 861	0%	0	0 / 0
peripheral blood	99%	11245.13	917 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0015030	Cellular component	Cajal body
GO_0005730	Cellular component	nucleolus
GO_0005654	Cellular component	nucleoplasm
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0005516	Molecular function	calmodulin binding
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0003712	Molecular function	transcription coregulator activity
GO_0046872	Molecular function	metal ion binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	EWSR1
Protein name	EWS RNA binding protein 1 (EWS RNA-binding protein variant 6) RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein) EWS RNA binding protein 1
Synonyms	EWS
Description	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.
Accessions	ENST00000629659.2 B0QYJ3 A0A0D9SFL3 H7BY36 B0QYJ7 ENST00000455726.5 ENST00000447973.5 ENST00000415761.5 Q01844 F8WC90 ENST00000333395.11 [Q01844-4] ENST00000332050.10 B0QYJ4 B0QYJ6 ENST00000331029.11 ENST00000437155.6 ENST00000436425.5 ENST00000397938.7 [Q01844-1] C9JGE3 B0QYK0 ENST00000406548.5 [Q01844-3] ENST00000360091.3 B0QYJ5 ENST00000414183.6 [Q01844-5] ENST00000332035.10 [Q01844-6] ENST00000444626.5

EWSR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review