ENY2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0006282Biological processregulation of DNA repair
GO_0006368Biological processtranscription elongation by RNA polymerase II
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0043484Biological processregulation of RNA splicing
GO_0015031Biological processprotein transport
GO_0061179Biological processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
GO_0016973Biological processpoly(A)+ mRNA export from nucleus
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0070390Cellular componenttranscription export complex 2
GO_0033276Cellular componenttranscription factor TFTC complex
GO_0044615Cellular componentnuclear pore nuclear basket
GO_0071819Cellular componentDUBm complex
GO_0000124Cellular componentSAGA complex
GO_0003682Molecular functionchromatin binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0030374Molecular functionnuclear receptor coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameENY2
Protein nameTranscription and mRNA export factor ENY2 (Enhancer of yellow 2 transcription factor homolog)
ENY2 transcription and export complex 2 subunit
SynonymsDC6
DescriptionFUNCTION: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation . As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores . .

FUNCTION: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. .

AccessionsENST00000517311.5
E5RI00
Q9NPA8
E5RHT9
E5RHX8
ENST00000521688.6 [Q9NPA8-1]
J3KNT2
ENST00000521662.5 [Q9NPA8-2]
ENST00000522766.5
ENST00000523335.1
E5RJ84
ENST00000520147.5
ENST00000339942.11