ENSA | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	40 studies	32% ± 13%	Explore
natural killer cell	38 studies	35% ± 11%	Explore
B cell	37 studies	31% ± 10%	Explore
fibroblast	34 studies	26% ± 11%	Explore
macrophage	33 studies	26% ± 10%	Explore
CD8-positive, alpha-beta T cell	33 studies	32% ± 12%	Explore
T cell	32 studies	30% ± 8%	Explore
CD4-positive, alpha-beta T cell	29 studies	30% ± 9%	Explore
conventional dendritic cell	28 studies	37% ± 16%	Explore
smooth muscle cell	27 studies	25% ± 8%	Explore
pericyte	25 studies	26% ± 7%	Explore
basal cell	22 studies	39% ± 18%	Explore
dendritic cell	21 studies	37% ± 21%	Explore
epithelial cell	21 studies	40% ± 18%	Explore
regulatory T cell	21 studies	31% ± 6%	Explore
mast cell	20 studies	35% ± 13%	Explore
classical monocyte	20 studies	28% ± 12%	Explore
endothelial cell of lymphatic vessel	19 studies	33% ± 9%	Explore
memory B cell	19 studies	30% ± 8%	Explore
ciliated cell	19 studies	40% ± 17%	Explore
naive B cell	19 studies	29% ± 7%	Explore
non-classical monocyte	18 studies	30% ± 13%	Explore
monocyte	17 studies	29% ± 11%	Explore
plasmacytoid dendritic cell	17 studies	33% ± 11%	Explore
mature NK T cell	17 studies	31% ± 7%	Explore
gamma-delta T cell	17 studies	36% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	25% ± 7%	Explore
astrocyte	15 studies	34% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	36% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	33% ± 11%	Explore
myofibroblast cell	14 studies	27% ± 7%	Explore
capillary endothelial cell	13 studies	23% ± 5%	Explore
connective tissue cell	13 studies	26% ± 10%	Explore
type II pneumocyte	12 studies	38% ± 19%	Explore
plasma cell	12 studies	31% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	34% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	32% ± 7%	Explore
vein endothelial cell	12 studies	30% ± 7%	Explore
endothelial cell of vascular tree	12 studies	30% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	29% ± 9%	Explore
club cell	11 studies	30% ± 11%	Explore
glutamatergic neuron	11 studies	44% ± 21%	Explore
mucosal invariant T cell	11 studies	29% ± 7%	Explore
myeloid cell	11 studies	30% ± 12%	Explore
secretory cell	10 studies	31% ± 18%	Explore
endothelial cell of artery	10 studies	25% ± 4%	Explore
type I pneumocyte	9 studies	31% ± 14%	Explore
leukocyte	9 studies	30% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	33% ± 12%	Explore
goblet cell	9 studies	29% ± 14%	Explore
microglial cell	9 studies	25% ± 10%	Explore
abnormal cell	9 studies	37% ± 13%	Explore
oligodendrocyte precursor cell	9 studies	32% ± 14%	Explore
plasmablast	8 studies	41% ± 22%	Explore
progenitor cell	8 studies	27% ± 6%	Explore
GABAergic neuron	8 studies	42% ± 19%	Explore
alveolar macrophage	7 studies	21% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	37% ± 12%	Explore
interneuron	7 studies	41% ± 25%	Explore
neuron	7 studies	35% ± 18%	Explore
precursor B cell	7 studies	38% ± 12%	Explore
innate lymphoid cell	7 studies	31% ± 5%	Explore
T follicular helper cell	7 studies	28% ± 4%	Explore
hematopoietic precursor cell	6 studies	48% ± 21%	Explore
ionocyte	6 studies	33% ± 7%	Explore
epithelial cell of proximal tubule	6 studies	21% ± 5%	Explore
kidney loop of Henle epithelial cell	6 studies	26% ± 7%	Explore
enterocyte	6 studies	19% ± 3%	Explore
transit amplifying cell	6 studies	29% ± 15%	Explore
hematopoietic stem cell	6 studies	44% ± 6%	Explore
amacrine cell	6 studies	32% ± 12%	Explore
retina horizontal cell	6 studies	29% ± 10%	Explore
oligodendrocyte	6 studies	22% ± 6%	Explore
respiratory goblet cell	5 studies	33% ± 16%	Explore
mononuclear phagocyte	5 studies	32% ± 14%	Explore
enteroendocrine cell	5 studies	34% ± 16%	Explore
mesothelial cell	5 studies	30% ± 17%	Explore
erythroblast	5 studies	42% ± 22%	Explore
lymphocyte	5 studies	36% ± 10%	Explore
pro-B cell	5 studies	37% ± 6%	Explore
immature B cell	5 studies	38% ± 15%	Explore
retinal rod cell	5 studies	21% ± 4%	Explore
Mueller cell	5 studies	26% ± 5%	Explore
CD4-positive helper T cell	5 studies	25% ± 13%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	39% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	37% ± 12%	Explore
granulocyte	5 studies	35% ± 13%	Explore
duct epithelial cell	4 studies	17% ± 2%	Explore
squamous epithelial cell	4 studies	34% ± 22%	Explore
pancreatic A cell	4 studies	60% ± 16%	Explore
type B pancreatic cell	4 studies	49% ± 22%	Explore
platelet	4 studies	21% ± 5%	Explore
exhausted T cell	4 studies	43% ± 6%	Explore
retinal ganglion cell	4 studies	45% ± 23%	Explore
megakaryocyte	4 studies	35% ± 12%	Explore
brush cell	4 studies	30% ± 10%	Explore
retinal bipolar neuron	4 studies	33% ± 5%	Explore
retinal cone cell	4 studies	32% ± 13%	Explore
OFF-bipolar cell	4 studies	25% ± 2%	Explore
ON-bipolar cell	4 studies	24% ± 2%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	45% ± 4%	Explore
adipocyte	4 studies	20% ± 4%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	59% ± 23%	Explore
hepatocyte	4 studies	39% ± 25%	Explore
erythrocyte	4 studies	34% ± 19%	Explore
keratinocyte	4 studies	41% ± 13%	Explore
T-helper 17 cell	4 studies	35% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	31% ± 6%	Explore
hillock cell	3 studies	31% ± 7%	Explore
pancreatic D cell	3 studies	54% ± 23%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	37% ± 6%	Explore
intestinal crypt stem cell	3 studies	25% ± 7%	Explore
neural crest cell	3 studies	28% ± 4%	Explore
GABAergic interneuron	3 studies	32% ± 8%	Explore
glial cell	3 studies	31% ± 18%	Explore
placental villous trophoblast	3 studies	43% ± 20%	Explore
neuroendocrine cell	3 studies	45% ± 10%	Explore
retinal pigment epithelial cell	3 studies	41% ± 14%	Explore
serous secreting cell	3 studies	30% ± 14%	Explore
intraepithelial lymphocyte	3 studies	37% ± 12%	Explore
GABAergic amacrine cell	3 studies	25% ± 8%	Explore
glycinergic amacrine cell	3 studies	29% ± 6%	Explore
rod bipolar cell	3 studies	34% ± 8%	Explore
germinal center B cell	3 studies	32% ± 4%	Explore
intermediate monocyte	3 studies	42% ± 23%	Explore
pancreatic ductal cell	3 studies	57% ± 14%	Explore
ependymal cell	3 studies	46% ± 15%	Explore
group 3 innate lymphoid cell	3 studies	47% ± 11%	Explore
T-helper 1 cell	3 studies	39% ± 3%	Explore
double negative thymocyte	3 studies	48% ± 14%	Explore
progenitor cell of mammary luminal epithelium	3 studies	30% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	17 studies	36% ± 13%	Explore
peripheral blood	16 studies	32% ± 11%	Explore
brain	16 studies	33% ± 14%	Explore
intestine	11 studies	25% ± 10%	Explore
kidney	8 studies	27% ± 5%	Explore
eye	8 studies	28% ± 9%	Explore
bone marrow	5 studies	26% ± 8%	Explore
liver	5 studies	38% ± 20%	Explore
lymph node	5 studies	34% ± 9%	Explore
pancreas	4 studies	52% ± 21%	Explore
placenta	4 studies	26% ± 15%	Explore
uterus	4 studies	34% ± 13%	Explore
breast	4 studies	31% ± 4%	Explore
esophagus	3 studies	50% ± 25%	Explore
adipose	3 studies	23% ± 3%	Explore
skin	3 studies	31% ± 12%	Explore
prostate	3 studies	24% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	9053.86	21 / 21	100%	154.58	504 / 504
breast	100%	9943.10	459 / 459	100%	227.27	1118 / 1118
esophagus	100%	12148.54	1445 / 1445	100%	94.67	183 / 183
liver	100%	4895.35	226 / 226	100%	108.28	406 / 406
lung	100%	9531.60	578 / 578	100%	146.40	1155 / 1155
ovary	100%	8521.85	180 / 180	100%	101.97	430 / 430
pancreas	100%	4332.77	328 / 328	100%	111.95	178 / 178
prostate	100%	8723.78	245 / 245	100%	135.73	502 / 502
stomach	100%	7272.37	359 / 359	100%	90.28	286 / 286
thymus	100%	10024.09	653 / 653	100%	145.26	605 / 605
uterus	100%	10093.99	170 / 170	100%	180.50	459 / 459
brain	100%	10870.31	2640 / 2642	100%	109.35	705 / 705
kidney	100%	8072.96	89 / 89	100%	86.87	900 / 901
intestine	100%	8919.24	966 / 966	100%	99.00	526 / 527
skin	100%	11749.63	1809 / 1809	100%	123.19	471 / 472
adrenal gland	100%	7748.04	258 / 258	99%	121.72	227 / 230
adipose	100%	8702.32	1204 / 1204	0%	0	0 / 0
blood vessel	100%	10233.11	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	186.24	29 / 29
muscle	100%	12107.09	803 / 803	0%	0	0 / 0
spleen	100%	7133.38	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	159.24	45 / 45
ureter	0%	0	0 / 0	100%	88.43	1 / 1
eye	0%	0	0 / 0	99%	87.60	79 / 80
heart	98%	6764.59	846 / 861	0%	0	0 / 0
peripheral blood	98%	6650.90	909 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007584	Biological process	response to nutrient
GO_0000086	Biological process	G2/M transition of mitotic cell cycle
GO_0050796	Biological process	regulation of insulin secretion
GO_0051301	Biological process	cell division
GO_0000278	Biological process	mitotic cell cycle
GO_0035308	Biological process	negative regulation of protein dephosphorylation
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0004864	Molecular function	protein phosphatase inhibitor activity
GO_0051721	Molecular function	protein phosphatase 2A binding
GO_0019888	Molecular function	protein phosphatase regulator activity
GO_0019870	Molecular function	potassium channel inhibitor activity
GO_0005102	Molecular function	signaling receptor binding
GO_0005515	Molecular function	protein binding
GO_0008200	Molecular function	ion channel inhibitor activity
GO_0019212	Molecular function	phosphatase inhibitor activity

IV. Literature review

[source]

Gene name	ENSA
Protein name	Endosulfine alpha Alpha-endosulfine (ARPP-19e) Alpha-endosulfine
Synonyms
Description	FUNCTION: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. . FUNCTION: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. . FUNCTION: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. .
Accessions	Q5T5H1 ENST00000638926.1 ENST00000362052.7 [O43768-8] ENST00000513281.5 [O43768-6] ENST00000369016.8 O43768 ENST00000509582.5 [O43768-8] ENST00000361532.9 [O43768-5] ENST00000503345.1 [O43768-8] A6NMQ3 ENST00000503241.1 [O43768-9] ENST00000356527.9 ENST00000361631.9 [O43768-7] ENST00000271690.12 [O43768-2] ENST00000369014.10 [O43768-1] ENST00000339643.9 [O43768-3] A0A1W2PRU0

ENSA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review