DAZAP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034063Biological processstress granule assembly
GO_0031648Biological processprotein destabilization
GO_1905636Biological processpositive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
GO_0016607Cellular componentnuclear speck
GO_0032991Cellular componentprotein-containing complex
GO_0016604Cellular componentnuclear body
GO_0005737Cellular componentcytoplasm
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0031435Molecular functionmitogen-activated protein kinase kinase kinase binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0042802Molecular functionidentical protein binding
GO_0050699Molecular functionWW domain binding
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0120283Molecular functionprotein serine/threonine kinase binding
GO_0002039Molecular functionp53 binding
GO_0005515Molecular functionprotein binding
GO_0030971Molecular functionreceptor tyrosine kinase binding

IV. Literature review

[source]
Gene nameDAZAP2
Protein nameDAZ-associated protein 2 (Deleted in azoospermia-associated protein 2) (Proline-rich transcript in brain protein)
SynonymsKIAA0058
PRTB
DescriptionFUNCTION: In unstressed cells, promotes SIAH1-mediated polyubiquitination and degradation of the serine/threonine-protein kinase HIPK2, probably by acting as a loading factor that potentiates complex formation between HIPK2 and ubiquitin ligase SIAH1 . In response to DNA damage, localizes to the nucleus following phosphorylation by HIPK2 and modulates the expression of a subset of TP53/p53 target genes by binding to TP53 at target gene promoters . This limits the expression of a number of cell death-mediating TP53 target genes, reducing DNA damage-induced cell death . Enhances the binding of transcription factor TCF7L2/TCF4, a Wnt signaling pathway effector, to the promoters of target genes (By similarity). Plays a role in stress granule formation . .

AccessionsF8VUW5
ENST00000551313.1
E9PE89
ENST00000412716.8 [Q15038-1]
ENST00000436900.2
ENST00000449723.7 [Q15038-6]
ENST00000549555.5 [Q15038-5]
Q15038
S4R3Q0
ENST00000425012.6 [Q15038-2]
ENST00000604900.5
ENST00000549732.6 [Q15038-3]
ENST00000439799.6 [Q15038-4]