CYCS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097194Biological processexecution phase of apoptosis
GO_0097193Biological processintrinsic apoptotic signaling pathway
GO_0006122Biological processmitochondrial electron transport, ubiquinol to cytochrome c
GO_0045333Biological processcellular respiration
GO_0043280Biological processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0006123Biological processmitochondrial electron transport, cytochrome c to oxygen
GO_0070469Cellular componentrespirasome
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0005829Cellular componentcytosol
GO_0043293Cellular componentapoptosome
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0020037Molecular functionheme binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0009055Molecular functionelectron transfer activity

IV. Literature review

[source]
Gene nameCYCS
Protein nameCytochrome c
SynonymsCYC
DescriptionFUNCTION: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.; FUNCTION: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

FUNCTION: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. .; FUNCTION: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. .

FUNCTION: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. .; FUNCTION: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. .

AccessionsP99999
ENST00000409764.5
G4XXL9
ENST00000305786.7
ENST00000409409.5
ENST00000413447.1
C9JFR7