COX6B1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	44 studies	52% ± 19%	Explore
macrophage	40 studies	64% ± 22%	Explore
natural killer cell	38 studies	59% ± 15%	Explore
endothelial cell	37 studies	49% ± 21%	Explore
fibroblast	36 studies	55% ± 19%	Explore
CD8-positive, alpha-beta T cell	35 studies	59% ± 20%	Explore
T cell	34 studies	56% ± 20%	Explore
CD4-positive, alpha-beta T cell	32 studies	61% ± 19%	Explore
pericyte	30 studies	60% ± 18%	Explore
conventional dendritic cell	29 studies	79% ± 13%	Explore
classical monocyte	28 studies	71% ± 19%	Explore
regulatory T cell	27 studies	64% ± 16%	Explore
dendritic cell	26 studies	64% ± 26%	Explore
smooth muscle cell	26 studies	58% ± 19%	Explore
plasmacytoid dendritic cell	25 studies	71% ± 16%	Explore
non-classical monocyte	24 studies	81% ± 16%	Explore
epithelial cell	24 studies	73% ± 18%	Explore
monocyte	23 studies	66% ± 23%	Explore
plasma cell	23 studies	61% ± 23%	Explore
basal cell	21 studies	63% ± 21%	Explore
mast cell	20 studies	52% ± 17%	Explore
mature NK T cell	20 studies	54% ± 15%	Explore
memory B cell	20 studies	58% ± 12%	Explore
endothelial cell of lymphatic vessel	19 studies	68% ± 14%	Explore
gamma-delta T cell	19 studies	56% ± 18%	Explore
naive B cell	19 studies	47% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	52% ± 16%	Explore
connective tissue cell	18 studies	61% ± 20%	Explore
mucosal invariant T cell	16 studies	49% ± 15%	Explore
ciliated cell	16 studies	74% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	61% ± 14%	Explore
myeloid cell	15 studies	64% ± 25%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	53% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	62% ± 15%	Explore
myofibroblast cell	13 studies	63% ± 18%	Explore
plasmablast	12 studies	74% ± 17%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	59% ± 19%	Explore
secretory cell	12 studies	71% ± 17%	Explore
capillary endothelial cell	12 studies	46% ± 16%	Explore
endothelial cell of artery	12 studies	51% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	53% ± 18%	Explore
innate lymphoid cell	11 studies	51% ± 19%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	60% ± 19%	Explore
neutrophil	11 studies	53% ± 25%	Explore
vein endothelial cell	11 studies	52% ± 18%	Explore
endothelial cell of vascular tree	11 studies	50% ± 12%	Explore
progenitor cell	10 studies	82% ± 15%	Explore
goblet cell	10 studies	73% ± 21%	Explore
mesothelial cell	10 studies	73% ± 20%	Explore
erythrocyte	10 studies	51% ± 25%	Explore
type I pneumocyte	9 studies	51% ± 21%	Explore
type II pneumocyte	9 studies	57% ± 26%	Explore
platelet	9 studies	43% ± 13%	Explore
leukocyte	9 studies	58% ± 19%	Explore
abnormal cell	9 studies	67% ± 21%	Explore
T follicular helper cell	9 studies	60% ± 15%	Explore
club cell	8 studies	69% ± 20%	Explore
astrocyte	8 studies	37% ± 21%	Explore
neuron	8 studies	58% ± 25%	Explore
IgG plasma cell	8 studies	40% ± 18%	Explore
hematopoietic stem cell	8 studies	73% ± 19%	Explore
ionocyte	7 studies	69% ± 15%	Explore
respiratory goblet cell	7 studies	67% ± 19%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	68% ± 22%	Explore
mononuclear phagocyte	7 studies	63% ± 27%	Explore
epithelial cell of proximal tubule	7 studies	72% ± 15%	Explore
enterocyte	7 studies	80% ± 18%	Explore
IgA plasma cell	7 studies	39% ± 18%	Explore
glutamatergic neuron	7 studies	28% ± 12%	Explore
hematopoietic precursor cell	6 studies	70% ± 23%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	69% ± 24%	Explore
kidney loop of Henle epithelial cell	6 studies	78% ± 10%	Explore
renal alpha-intercalated cell	6 studies	90% ± 4%	Explore
retinal rod cell	6 studies	47% ± 21%	Explore
microglial cell	6 studies	48% ± 20%	Explore
retinal cone cell	6 studies	62% ± 31%	Explore
precursor B cell	6 studies	69% ± 12%	Explore
brush cell	6 studies	68% ± 17%	Explore
intermediate monocyte	6 studies	77% ± 25%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	65% ± 20%	Explore
alveolar macrophage	5 studies	79% ± 11%	Explore
CD4-positive helper T cell	5 studies	42% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	52% ± 15%	Explore
exhausted T cell	5 studies	78% ± 11%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	88% ± 4%	Explore
megakaryocyte	5 studies	75% ± 12%	Explore
oligodendrocyte	5 studies	30% ± 8%	Explore
enteroendocrine cell	5 studies	87% ± 11%	Explore
erythroblast	5 studies	71% ± 23%	Explore
transit amplifying cell	5 studies	73% ± 30%	Explore
retinal ganglion cell	5 studies	75% ± 29%	Explore
neuroendocrine cell	5 studies	75% ± 18%	Explore
T-helper 17 cell	5 studies	69% ± 17%	Explore
immature B cell	5 studies	68% ± 12%	Explore
amacrine cell	5 studies	54% ± 20%	Explore
double negative thymocyte	5 studies	73% ± 13%	Explore
hepatocyte	5 studies	51% ± 34%	Explore
granulocyte	5 studies	59% ± 22%	Explore
GABAergic neuron	5 studies	24% ± 8%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	53% ± 17%	Explore
deuterosomal cell	4 studies	62% ± 22%	Explore
duct epithelial cell	4 studies	79% ± 5%	Explore
squamous epithelial cell	4 studies	47% ± 27%	Explore
pancreatic A cell	4 studies	76% ± 16%	Explore
type B pancreatic cell	4 studies	68% ± 16%	Explore
glomerular endothelial cell	4 studies	45% ± 16%	Explore
kidney connecting tubule epithelial cell	4 studies	87% ± 6%	Explore
podocyte	4 studies	76% ± 11%	Explore
intestinal crypt stem cell	4 studies	90% ± 7%	Explore
OFF-bipolar cell	4 studies	52% ± 31%	Explore
ON-bipolar cell	4 studies	55% ± 30%	Explore
pro-B cell	4 studies	73% ± 3%	Explore
retina horizontal cell	4 studies	52% ± 21%	Explore
adventitial cell	4 studies	49% ± 5%	Explore
mucus secreting cell	4 studies	69% ± 18%	Explore
cardiac muscle cell	4 studies	36% ± 16%	Explore
acinar cell	4 studies	51% ± 9%	Explore
muscle cell	4 studies	46% ± 21%	Explore
germinal center B cell	4 studies	64% ± 21%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	74% ± 8%	Explore
oligodendrocyte precursor cell	4 studies	51% ± 16%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	73% ± 32%	Explore
group 3 innate lymphoid cell	4 studies	61% ± 15%	Explore
interneuron	4 studies	42% ± 23%	Explore
T-helper 1 cell	4 studies	74% ± 12%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	69% ± 24%	Explore
precursor cell	3 studies	82% ± 8%	Explore
monocyte-derived dendritic cell	3 studies	71% ± 30%	Explore
renal beta-intercalated cell	3 studies	89% ± 5%	Explore
neural crest cell	3 studies	73% ± 10%	Explore
retinal bipolar neuron	3 studies	64% ± 29%	Explore
GABAergic amacrine cell	3 studies	36% ± 11%	Explore
glycinergic amacrine cell	3 studies	33% ± 10%	Explore
renal principal cell	3 studies	82% ± 6%	Explore
thymocyte	3 studies	50% ± 29%	Explore
extravillous trophoblast	3 studies	85% ± 8%	Explore
placental villous trophoblast	3 studies	88% ± 9%	Explore
lymphocyte	3 studies	72% ± 13%	Explore
retinal pigment epithelial cell	3 studies	57% ± 29%	Explore
serous secreting cell	3 studies	73% ± 6%	Explore
tissue-resident macrophage	3 studies	50% ± 25%	Explore
intraepithelial lymphocyte	3 studies	63% ± 14%	Explore
Mueller cell	3 studies	57% ± 13%	Explore
rod bipolar cell	3 studies	60% ± 21%	Explore
myoepithelial cell	3 studies	51% ± 15%	Explore
inflammatory macrophage	3 studies	60% ± 13%	Explore
luminal cell of prostate epithelium	3 studies	71% ± 10%	Explore
IgM plasma cell	3 studies	57% ± 14%	Explore
pancreatic ductal cell	3 studies	79% ± 8%	Explore
glial cell	3 studies	62% ± 23%	Explore
keratinocyte	3 studies	69% ± 5%	Explore
melanocyte	3 studies	59% ± 18%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	66% ± 7%	Explore
progenitor cell of mammary luminal epithelium	3 studies	68% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	63% ± 14%	Explore
lung	18 studies	64% ± 15%	Explore
intestine	13 studies	57% ± 25%	Explore
brain	11 studies	36% ± 14%	Explore
kidney	9 studies	65% ± 14%	Explore
eye	9 studies	47% ± 20%	Explore
liver	7 studies	53% ± 27%	Explore
bone marrow	6 studies	49% ± 18%	Explore
lymph node	6 studies	64% ± 16%	Explore
pancreas	5 studies	63% ± 20%	Explore
uterus	5 studies	63% ± 24%	Explore
placenta	4 studies	70% ± 19%	Explore
prostate	4 studies	52% ± 14%	Explore
breast	4 studies	60% ± 11%	Explore
heart	3 studies	34% ± 14%	Explore
adrenal gland	3 studies	57% ± 12%	Explore
esophagus	3 studies	67% ± 26%	Explore
skin	3 studies	50% ± 18%	Explore
thymus	3 studies	71% ± 24%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	4521.53	258 / 258	100%	373.27	230 / 230
esophagus	100%	5895.21	1445 / 1445	100%	316.00	183 / 183
ovary	100%	3425.34	180 / 180	100%	693.46	430 / 430
skin	100%	4985.18	1809 / 1809	100%	420.96	472 / 472
thymus	100%	4376.55	653 / 653	100%	389.17	605 / 605
uterus	100%	3680.31	170 / 170	100%	573.02	459 / 459
brain	100%	5838.53	2639 / 2642	100%	324.51	704 / 705
kidney	100%	7319.98	89 / 89	100%	358.47	898 / 901
stomach	100%	5098.15	359 / 359	100%	447.13	285 / 286
intestine	100%	6347.16	966 / 966	100%	481.58	525 / 527
liver	100%	4303.05	225 / 226	100%	489.88	406 / 406
prostate	100%	4763.96	245 / 245	99%	403.84	499 / 502
breast	100%	4445.76	459 / 459	99%	400.62	1110 / 1118
bladder	100%	4786.43	21 / 21	99%	518.48	500 / 504
pancreas	99%	2759.16	325 / 328	100%	388.81	178 / 178
lung	100%	3864.63	576 / 578	99%	394.82	1145 / 1155
adipose	100%	4658.03	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	526.28	80 / 80
lymph node	0%	0	0 / 0	100%	625.64	29 / 29
muscle	100%	10161.97	803 / 803	0%	0	0 / 0
spleen	100%	4300.35	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	431.98	45 / 45
ureter	0%	0	0 / 0	100%	597.96	1 / 1
blood vessel	100%	4527.21	1331 / 1335	0%	0	0 / 0
peripheral blood	100%	5570.49	926 / 929	0%	0	0 / 0
heart	100%	13309.04	858 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	COX6B1
Protein name	Cytochrome c oxidase subunit 6B1 (Cytochrome c oxidase subunit VIb isoform 1) (COX VIb-1) Cytochrome c oxidase subunit 6B1 (Cytochrome c oxidase subunit VIb isoform 1)
Synonyms	COX6B
Description	FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. .
Accessions	A0A494C160 ENST00000652250.1 P14854 ENST00000649813.2 K7EQD3 ENST00000392201.1 ENST00000590618.1 ENST00000592141.6

GO_1902600	Biological process	proton transmembrane transport
GO_0045333	Biological process	cellular respiration
GO_0021762	Biological process	substantia nigra development
GO_0006123	Biological process	mitochondrial electron transport, cytochrome c to oxygen
GO_0031966	Cellular component	mitochondrial membrane
GO_0045277	Cellular component	respiratory chain complex IV
GO_0005751	Cellular component	mitochondrial respiratory chain complex IV
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0004129	Molecular function	cytochrome-c oxidase activity

COX6B1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review