CD63 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035646Biological processendosome to melanosome transport
GO_1901379Biological processregulation of potassium ion transmembrane transport
GO_0007160Biological processcell-matrix adhesion
GO_1900746Biological processregulation of vascular endothelial growth factor signaling pathway
GO_2001046Biological processpositive regulation of integrin-mediated signaling pathway
GO_0002092Biological processpositive regulation of receptor internalization
GO_0048757Biological processpigment granule maturation
GO_0015031Biological processprotein transport
GO_0016477Biological processcell migration
GO_0005615Cellular componentextracellular space
GO_0031902Cellular componentlate endosome membrane
GO_0005886Cellular componentplasma membrane
GO_0031088Cellular componentplatelet dense granule membrane
GO_0035577Cellular componentazurophil granule membrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0097487Cellular componentmultivesicular body, internal vesicle
GO_0009986Cellular componentcell surface
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0010008Cellular componentendosome membrane
GO_0005765Cellular componentlysosomal membrane
GO_0032585Cellular componentmultivesicular body membrane
GO_0042470Cellular componentmelanosome
GO_0031904Cellular componentendosome lumen
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCD63
Protein nameCD63 molecule
Tetraspanin
CD63 antigen (Granulophysin) (Lysosomal-associated membrane protein 3) (LAMP-3) (Lysosome integral membrane protein 1) (Limp1) (Melanoma-associated antigen ME491) (OMA81H) (Ocular melanoma-associated antigen) (Tetraspanin-30) (Tspan-30) (CD antigen CD63)
SynonymsMLA1
TSPAN30
DescriptionFUNCTION: Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. .

FUNCTION: Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. .

FUNCTION: Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. .

FUNCTION: Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. .

AccessionsP08962
ENST00000546457.1
ENST00000551173.5
ENST00000548898.5
ENST00000549117.5 [P08962-1]
ENST00000552754.5 [P08962-2]
ENST00000420846.7 [P08962-1]
ENST00000550050.5
ENST00000552164.5
F8VX62
ENST00000257857.9 [P08962-1]
F8VNT9
W6A4U0
F8W022
ENST00000552067.5
ENST00000548160.5
F8VV56
F8VWK8
ENST00000552692.5 [P08962-1]
ENST00000546939.5 [P08962-3]
ENST00000550776.5 [P08962-3]