CCT4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	35 studies	32% ± 15%	Explore
B cell	34 studies	31% ± 10%	Explore
fibroblast	32 studies	31% ± 12%	Explore
natural killer cell	31 studies	32% ± 13%	Explore
CD8-positive, alpha-beta T cell	31 studies	33% ± 15%	Explore
CD4-positive, alpha-beta T cell	28 studies	37% ± 15%	Explore
T cell	27 studies	32% ± 12%	Explore
conventional dendritic cell	24 studies	32% ± 13%	Explore
macrophage	24 studies	27% ± 10%	Explore
pericyte	24 studies	31% ± 12%	Explore
smooth muscle cell	23 studies	35% ± 12%	Explore
regulatory T cell	22 studies	36% ± 12%	Explore
basal cell	21 studies	34% ± 14%	Explore
memory B cell	18 studies	30% ± 10%	Explore
classical monocyte	18 studies	22% ± 8%	Explore
naive B cell	18 studies	28% ± 8%	Explore
non-classical monocyte	18 studies	26% ± 10%	Explore
epithelial cell	17 studies	37% ± 20%	Explore
mast cell	16 studies	28% ± 14%	Explore
endothelial cell of lymphatic vessel	16 studies	32% ± 12%	Explore
mature NK T cell	16 studies	28% ± 9%	Explore
gamma-delta T cell	16 studies	34% ± 16%	Explore
plasmacytoid dendritic cell	15 studies	30% ± 11%	Explore
ciliated cell	15 studies	37% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	30% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	28% ± 8%	Explore
connective tissue cell	14 studies	41% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	33% ± 9%	Explore
myofibroblast cell	13 studies	37% ± 15%	Explore
monocyte	13 studies	26% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	31% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	34% ± 8%	Explore
capillary endothelial cell	12 studies	25% ± 13%	Explore
vein endothelial cell	12 studies	31% ± 13%	Explore
endothelial cell of vascular tree	12 studies	34% ± 9%	Explore
mucosal invariant T cell	11 studies	32% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	34% ± 10%	Explore
plasma cell	9 studies	37% ± 17%	Explore
plasmablast	9 studies	44% ± 21%	Explore
secretory cell	9 studies	28% ± 12%	Explore
abnormal cell	9 studies	36% ± 9%	Explore
dendritic cell	9 studies	36% ± 21%	Explore
leukocyte	8 studies	32% ± 10%	Explore
neuron	8 studies	39% ± 20%	Explore
endothelial cell of artery	8 studies	24% ± 6%	Explore
myeloid cell	8 studies	26% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	39% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	35% ± 6%	Explore
epithelial cell of proximal tubule	7 studies	24% ± 13%	Explore
progenitor cell	7 studies	47% ± 15%	Explore
mesothelial cell	7 studies	47% ± 20%	Explore
hematopoietic stem cell	7 studies	56% ± 14%	Explore
innate lymphoid cell	7 studies	33% ± 8%	Explore
oligodendrocyte	7 studies	23% ± 9%	Explore
T follicular helper cell	7 studies	30% ± 7%	Explore
goblet cell	6 studies	25% ± 9%	Explore
precursor B cell	6 studies	42% ± 15%	Explore
astrocyte	6 studies	27% ± 8%	Explore
erythrocyte	6 studies	38% ± 24%	Explore
oligodendrocyte precursor cell	6 studies	33% ± 13%	Explore
hematopoietic precursor cell	5 studies	57% ± 22%	Explore
kidney loop of Henle epithelial cell	5 studies	19% ± 2%	Explore
transit amplifying cell	5 studies	23% ± 4%	Explore
pro-B cell	5 studies	44% ± 7%	Explore
immature B cell	5 studies	43% ± 12%	Explore
microglial cell	5 studies	25% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	45% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	39% ± 8%	Explore
granulocyte	5 studies	26% ± 8%	Explore
glutamatergic neuron	5 studies	40% ± 17%	Explore
deuterosomal cell	4 studies	21% ± 3%	Explore
pancreatic A cell	4 studies	41% ± 15%	Explore
type B pancreatic cell	4 studies	47% ± 23%	Explore
mononuclear phagocyte	4 studies	33% ± 16%	Explore
exhausted T cell	4 studies	39% ± 7%	Explore
renal alpha-intercalated cell	4 studies	40% ± 13%	Explore
enteroendocrine cell	4 studies	41% ± 12%	Explore
intestinal crypt stem cell	4 studies	27% ± 7%	Explore
retinal ganglion cell	4 studies	50% ± 28%	Explore
erythroblast	4 studies	56% ± 17%	Explore
lymphocyte	4 studies	34% ± 13%	Explore
retinal rod cell	4 studies	28% ± 10%	Explore
alveolar macrophage	4 studies	19% ± 2%	Explore
muscle cell	4 studies	28% ± 14%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	34% ± 2%	Explore
GABAergic neuron	4 studies	36% ± 13%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	59% ± 21%	Explore
T-helper 17 cell	4 studies	38% ± 23%	Explore
interneuron	4 studies	30% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	28% ± 7%	Explore
precursor cell	3 studies	60% ± 20%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	54% ± 20%	Explore
enterocyte	3 studies	20% ± 5%	Explore
neural crest cell	3 studies	50% ± 11%	Explore
extravillous trophoblast	3 studies	38% ± 9%	Explore
placental villous trophoblast	3 studies	46% ± 13%	Explore
common myeloid progenitor	3 studies	43% ± 30%	Explore
club cell	3 studies	31% ± 6%	Explore
type I pneumocyte	3 studies	35% ± 8%	Explore
type II pneumocyte	3 studies	35% ± 12%	Explore
retina horizontal cell	3 studies	27% ± 10%	Explore
retinal cone cell	3 studies	41% ± 10%	Explore
intraepithelial lymphocyte	3 studies	35% ± 18%	Explore
Mueller cell	3 studies	22% ± 1%	Explore
rod bipolar cell	3 studies	28% ± 9%	Explore
acinar cell	3 studies	38% ± 18%	Explore
germinal center B cell	3 studies	40% ± 8%	Explore
intermediate monocyte	3 studies	37% ± 16%	Explore
luminal cell of prostate epithelium	3 studies	21% ± 3%	Explore
pancreatic ductal cell	3 studies	49% ± 15%	Explore
group 3 innate lymphoid cell	3 studies	49% ± 14%	Explore
keratinocyte	3 studies	27% ± 6%	Explore
T-helper 1 cell	3 studies	44% ± 8%	Explore
double negative thymocyte	3 studies	50% ± 21%	Explore
progenitor cell of mammary luminal epithelium	3 studies	35% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	31% ± 13%	Explore
peripheral blood	15 studies	31% ± 9%	Explore
kidney	8 studies	30% ± 11%	Explore
brain	8 studies	30% ± 11%	Explore
intestine	7 studies	33% ± 13%	Explore
eye	7 studies	26% ± 9%	Explore
bone marrow	5 studies	25% ± 6%	Explore
liver	5 studies	36% ± 20%	Explore
lymph node	5 studies	35% ± 6%	Explore
pancreas	4 studies	43% ± 17%	Explore
uterus	4 studies	38% ± 13%	Explore
breast	4 studies	31% ± 2%	Explore
placenta	3 studies	37% ± 10%	Explore
adrenal gland	3 studies	28% ± 8%	Explore
prostate	3 studies	35% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6751.58	1445 / 1445	100%	168.98	183 / 183
ovary	100%	9509.84	180 / 180	100%	171.54	430 / 430
stomach	100%	5603.68	359 / 359	100%	164.95	286 / 286
pancreas	100%	5770.20	327 / 328	100%	112.43	178 / 178
breast	100%	7138.91	459 / 459	100%	184.15	1114 / 1118
intestine	100%	6379.05	966 / 966	100%	188.09	525 / 527
lung	100%	5710.43	576 / 578	100%	190.90	1154 / 1155
uterus	100%	7773.78	170 / 170	100%	188.12	457 / 459
thymus	100%	5602.39	653 / 653	99%	136.83	600 / 605
bladder	100%	7185.76	21 / 21	99%	183.76	499 / 504
brain	99%	4919.52	2617 / 2642	100%	141.14	704 / 705
prostate	100%	5277.55	245 / 245	99%	142.19	496 / 502
skin	100%	9196.12	1809 / 1809	99%	170.97	466 / 472
kidney	100%	5192.72	89 / 89	97%	107.09	870 / 901
liver	99%	3161.42	224 / 226	97%	89.16	395 / 406
adrenal gland	100%	7206.72	258 / 258	90%	106.69	208 / 230
adipose	100%	7062.33	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	266.95	29 / 29
muscle	100%	6307.31	803 / 803	0%	0	0 / 0
spleen	100%	5938.85	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	172.96	45 / 45
ureter	0%	0	0 / 0	100%	48.56	1 / 1
blood vessel	100%	6404.52	1334 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	98%	149.23	78 / 80
heart	96%	4703.89	828 / 861	0%	0	0 / 0
peripheral blood	89%	5540.20	828 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007339	Biological process	binding of sperm to zona pellucida
GO_1904871	Biological process	positive regulation of protein localization to Cajal body
GO_0061077	Biological process	chaperone-mediated protein folding
GO_1904874	Biological process	positive regulation of telomerase RNA localization to Cajal body
GO_1904851	Biological process	positive regulation of establishment of protein localization to telomere
GO_0006457	Biological process	protein folding
GO_0050821	Biological process	protein stabilization
GO_0090666	Biological process	scaRNA localization to Cajal body
GO_0051973	Biological process	positive regulation of telomerase activity
GO_0032212	Biological process	positive regulation of telomere maintenance via telomerase
GO_0005874	Cellular component	microtubule
GO_0005832	Cellular component	chaperonin-containing T-complex
GO_0002199	Cellular component	zona pellucida receptor complex
GO_0005813	Cellular component	centrosome
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0042995	Cellular component	cell projection
GO_0044297	Cellular component	cell body
GO_0042470	Cellular component	melanosome
GO_0044183	Molecular function	protein folding chaperone
GO_0051082	Molecular function	unfolded protein binding
GO_0140662	Molecular function	ATP-dependent protein folding chaperone
GO_0005524	Molecular function	ATP binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	CCT4
Protein name	T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) (Stimulator of TAR RNA-binding)
Synonyms	SRB CCTD
Description	FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis . The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance . As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia . The TRiC complex plays a role in the folding of actin and tubulin (Probable). .
Accessions	ENST00000544079.2 [P50991-2] ENST00000394440.8 [P50991-1] P50991

CCT4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review