CCT3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	33 studies	32% ± 8%	Explore
natural killer cell	32 studies	29% ± 12%	Explore
fibroblast	30 studies	29% ± 11%	Explore
endothelial cell	29 studies	33% ± 13%	Explore
CD8-positive, alpha-beta T cell	29 studies	33% ± 16%	Explore
CD4-positive, alpha-beta T cell	29 studies	33% ± 16%	Explore
smooth muscle cell	24 studies	36% ± 14%	Explore
T cell	23 studies	32% ± 12%	Explore
pericyte	23 studies	32% ± 10%	Explore
conventional dendritic cell	23 studies	30% ± 15%	Explore
regulatory T cell	22 studies	34% ± 12%	Explore
basal cell	20 studies	33% ± 14%	Explore
macrophage	19 studies	25% ± 10%	Explore
memory B cell	18 studies	29% ± 11%	Explore
plasmacytoid dendritic cell	18 studies	29% ± 11%	Explore
epithelial cell	18 studies	38% ± 21%	Explore
naive B cell	17 studies	26% ± 7%	Explore
gamma-delta T cell	17 studies	29% ± 15%	Explore
ciliated cell	16 studies	38% ± 15%	Explore
mature NK T cell	15 studies	26% ± 8%	Explore
endothelial cell of lymphatic vessel	14 studies	36% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	28% ± 8%	Explore
connective tissue cell	14 studies	37% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	32% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	26% ± 7%	Explore
mast cell	12 studies	25% ± 9%	Explore
non-classical monocyte	12 studies	28% ± 13%	Explore
myofibroblast cell	12 studies	38% ± 14%	Explore
plasma cell	11 studies	34% ± 18%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	29% ± 9%	Explore
vein endothelial cell	11 studies	28% ± 12%	Explore
endothelial cell of vascular tree	11 studies	31% ± 8%	Explore
monocyte	10 studies	22% ± 6%	Explore
capillary endothelial cell	10 studies	26% ± 13%	Explore
abnormal cell	10 studies	41% ± 16%	Explore
mucosal invariant T cell	10 studies	25% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	31% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	32% ± 11%	Explore
myeloid cell	9 studies	25% ± 13%	Explore
astrocyte	9 studies	28% ± 10%	Explore
plasmablast	8 studies	48% ± 22%	Explore
secretory cell	8 studies	31% ± 11%	Explore
classical monocyte	8 studies	26% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	37% ± 17%	Explore
leukocyte	8 studies	27% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	29% ± 7%	Explore
neuron	8 studies	50% ± 25%	Explore
endothelial cell of artery	8 studies	25% ± 7%	Explore
retinal rod cell	8 studies	33% ± 16%	Explore
dendritic cell	8 studies	35% ± 23%	Explore
oligodendrocyte precursor cell	8 studies	33% ± 15%	Explore
progenitor cell	7 studies	45% ± 13%	Explore
T follicular helper cell	7 studies	26% ± 5%	Explore
oligodendrocyte	7 studies	25% ± 10%	Explore
epithelial cell of proximal tubule	6 studies	26% ± 12%	Explore
goblet cell	6 studies	27% ± 10%	Explore
retinal cone cell	6 studies	42% ± 25%	Explore
precursor B cell	6 studies	38% ± 13%	Explore
innate lymphoid cell	6 studies	28% ± 6%	Explore
erythrocyte	6 studies	38% ± 25%	Explore
type I pneumocyte	5 studies	32% ± 12%	Explore
club cell	5 studies	31% ± 10%	Explore
enteroendocrine cell	5 studies	44% ± 15%	Explore
mesothelial cell	5 studies	51% ± 14%	Explore
transit amplifying cell	5 studies	23% ± 6%	Explore
retinal ganglion cell	5 studies	50% ± 27%	Explore
erythroblast	5 studies	41% ± 18%	Explore
pro-B cell	5 studies	32% ± 7%	Explore
immature B cell	5 studies	45% ± 16%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	40% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	37% ± 10%	Explore
glutamatergic neuron	5 studies	43% ± 18%	Explore
deuterosomal cell	4 studies	34% ± 4%	Explore
pancreatic A cell	4 studies	47% ± 15%	Explore
exhausted T cell	4 studies	37% ± 9%	Explore
kidney loop of Henle epithelial cell	4 studies	24% ± 2%	Explore
enterocyte	4 studies	24% ± 9%	Explore
intestinal crypt stem cell	4 studies	32% ± 8%	Explore
hematopoietic stem cell	4 studies	50% ± 11%	Explore
brush cell	4 studies	34% ± 20%	Explore
amacrine cell	4 studies	35% ± 13%	Explore
retina horizontal cell	4 studies	34% ± 14%	Explore
microglial cell	4 studies	26% ± 7%	Explore
adventitial cell	4 studies	22% ± 9%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	38% ± 8%	Explore
GABAergic neuron	4 studies	40% ± 12%	Explore
interneuron	4 studies	33% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	25% ± 6%	Explore
hematopoietic precursor cell	3 studies	67% ± 14%	Explore
precursor cell	3 studies	59% ± 16%	Explore
respiratory goblet cell	3 studies	35% ± 21%	Explore
type B pancreatic cell	3 studies	47% ± 8%	Explore
mononuclear phagocyte	3 studies	32% ± 16%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	55% ± 21%	Explore
neural crest cell	3 studies	60% ± 7%	Explore
retinal bipolar neuron	3 studies	40% ± 12%	Explore
extravillous trophoblast	3 studies	25% ± 4%	Explore
placental villous trophoblast	3 studies	50% ± 8%	Explore
common myeloid progenitor	3 studies	34% ± 26%	Explore
lymphocyte	3 studies	40% ± 9%	Explore
neuroendocrine cell	3 studies	49% ± 17%	Explore
type II pneumocyte	3 studies	41% ± 12%	Explore
Mueller cell	3 studies	26% ± 3%	Explore
rod bipolar cell	3 studies	38% ± 14%	Explore
germinal center B cell	3 studies	39% ± 5%	Explore
myoepithelial cell	3 studies	37% ± 7%	Explore
muscle cell	3 studies	30% ± 16%	Explore
pancreatic ductal cell	3 studies	45% ± 13%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	55% ± 19%	Explore
group 3 innate lymphoid cell	3 studies	34% ± 18%	Explore
keratinocyte	3 studies	27% ± 1%	Explore
T-helper 17 cell	3 studies	40% ± 22%	Explore
T-helper 1 cell	3 studies	39% ± 15%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	28% ± 10%	Explore
double negative thymocyte	3 studies	46% ± 26%	Explore
progenitor cell of mammary luminal epithelium	3 studies	41% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	15 studies	33% ± 13%	Explore
peripheral blood	14 studies	30% ± 10%	Explore
brain	9 studies	31% ± 10%	Explore
intestine	8 studies	31% ± 14%	Explore
eye	8 studies	32% ± 15%	Explore
kidney	7 studies	28% ± 8%	Explore
liver	6 studies	36% ± 20%	Explore
lymph node	5 studies	37% ± 13%	Explore
pancreas	4 studies	43% ± 16%	Explore
bone marrow	4 studies	22% ± 6%	Explore
uterus	4 studies	38% ± 17%	Explore
breast	4 studies	33% ± 6%	Explore
placenta	3 studies	34% ± 7%	Explore
adrenal gland	3 studies	30% ± 11%	Explore
prostate	3 studies	28% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	9714.70	1445 / 1445	100%	221.15	183 / 183
liver	100%	6067.20	226 / 226	100%	272.48	406 / 406
ovary	100%	8983.22	180 / 180	100%	244.53	430 / 430
skin	100%	11308.23	1809 / 1809	100%	418.04	472 / 472
stomach	100%	7424.28	359 / 359	100%	263.57	286 / 286
breast	100%	8005.00	459 / 459	100%	427.29	1117 / 1118
prostate	100%	7718.08	245 / 245	100%	297.71	501 / 502
uterus	100%	9342.40	170 / 170	100%	351.10	458 / 459
lung	100%	6941.57	577 / 578	100%	289.68	1153 / 1155
brain	100%	6893.48	2630 / 2642	100%	262.91	705 / 705
intestine	100%	9177.94	966 / 966	99%	300.39	524 / 527
thymus	100%	7083.14	653 / 653	99%	200.38	601 / 605
bladder	100%	10199.48	21 / 21	99%	322.62	500 / 504
pancreas	100%	5692.65	327 / 328	99%	214.09	177 / 178
adrenal gland	100%	13501.76	258 / 258	97%	237.59	224 / 230
kidney	100%	7699.99	89 / 89	97%	159.60	877 / 901
adipose	100%	8037.26	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	594.12	80 / 80
lymph node	0%	0	0 / 0	100%	434.60	29 / 29
muscle	100%	8731.72	803 / 803	0%	0	0 / 0
spleen	100%	7923.41	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	257.07	45 / 45
ureter	0%	0	0 / 0	100%	156.32	1 / 1
blood vessel	100%	8039.39	1334 / 1335	0%	0	0 / 0
heart	97%	6406.34	832 / 861	0%	0	0 / 0
peripheral blood	91%	7073.42	848 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007339	Biological process	binding of sperm to zona pellucida
GO_1904871	Biological process	positive regulation of protein localization to Cajal body
GO_0061077	Biological process	chaperone-mediated protein folding
GO_1904874	Biological process	positive regulation of telomerase RNA localization to Cajal body
GO_1904851	Biological process	positive regulation of establishment of protein localization to telomere
GO_0006457	Biological process	protein folding
GO_0050821	Biological process	protein stabilization
GO_0032212	Biological process	positive regulation of telomere maintenance via telomerase
GO_0005856	Cellular component	cytoskeleton
GO_0005874	Cellular component	microtubule
GO_0005832	Cellular component	chaperonin-containing T-complex
GO_0002199	Cellular component	zona pellucida receptor complex
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0044297	Cellular component	cell body
GO_0044183	Molecular function	protein folding chaperone
GO_0051082	Molecular function	unfolded protein binding
GO_0140662	Molecular function	ATP-dependent protein folding chaperone
GO_0005524	Molecular function	ATP binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	CCT3
Protein name	T-complex protein 1 subunit gamma (CCT-gamma) T-complex protein 1 subunit gamma Chaperonin containing TCP1 subunit 3 T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) (hTRiC5)
Synonyms	CCTG TRIC5
Description	FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis . The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance . As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia . The TRiC complex plays a role in the folding of actin and tubulin (Probable). .
Accessions	ENST00000295688.8 [P49368-1] ENST00000478640.6 P49368 ENST00000446905.5 E9PRM9 ENST00000496684.6 ENST00000415548.1 ENST00000472765.6 E9PRN0 Q5SZW8 ENST00000413555.5 ENST00000533194.5 E9PRC8 Q5SZX6 Q5SZX9 E9PM09 ENST00000368259.6 [P49368-2] ENST00000368258.7 ENST00000368262.7 E9PQ35 B4DUR8

CCT3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review