ATP5IF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0006091Biological processgeneration of precursor metabolites and energy
GO_1901030Biological processpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO_1903214Biological processregulation of protein targeting to mitochondrion
GO_1904925Biological processpositive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
GO_0006783Biological processheme biosynthetic process
GO_1903052Biological processpositive regulation of proteolysis involved in protein catabolic process
GO_0032780Biological processnegative regulation of ATP-dependent activity
GO_0072593Biological processreactive oxygen species metabolic process
GO_1903578Biological processregulation of ATP metabolic process
GO_0030218Biological processerythrocyte differentiation
GO_0001937Biological processnegative regulation of endothelial cell proliferation
GO_0051882Biological processmitochondrial depolarization
GO_0051346Biological processnegative regulation of hydrolase activity
GO_0005739Cellular componentmitochondrion
GO_0032991Cellular componentprotein-containing complex
GO_0009986Cellular componentcell surface
GO_0019899Molecular functionenzyme binding
GO_0140260Molecular functionmitochondrial proton-transporting ATP synthase complex binding
GO_0004857Molecular functionenzyme inhibitor activity
GO_0042802Molecular functionidentical protein binding
GO_0042030Molecular functionATPase inhibitor activity
GO_0051117Molecular functionATPase binding
GO_0005516Molecular functioncalmodulin binding
GO_0043532Molecular functionangiostatin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATP5IF1
Protein nameATPase inhibitor, mitochondrial (ATP synthase F1 subunit epsilon) (Inhibitor of F(1)F(o)-ATPase) (IF(1)) (IF1)
ATPase inhibitor, mitochondrial (ATP synthase F1 subunit epsilon)
SynonymsATPIF1
ATPI
DescriptionFUNCTION: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. .

FUNCTION: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. .; FUNCTION: Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme. .

AccessionsA0A0B4J230
ENST00000468425.2
ENST00000647074.2 [Q9UII2-1]
ENST00000647380.1 [Q9UII2-3]
ENST00000497986.5 [Q9UII2-2]
ENST00000646781.1
ENST00000465645.1 [Q9UII2-3]
ENST00000642464.1 [Q9UII2-2]
ENST00000335514.10 [Q9UII2-1]
Q9UII2