ATP5F1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071549Biological processcellular response to dexamethasone stimulus
GO_0043536Biological processpositive regulation of blood vessel endothelial cell migration
GO_0015986Biological processproton motive force-driven ATP synthesis
GO_0006754Biological processATP biosynthetic process
GO_0045471Biological processresponse to ethanol
GO_0042776Biological processproton motive force-driven mitochondrial ATP synthesis
GO_0071732Biological processcellular response to nitric oxide
GO_0014850Biological processresponse to muscle activity
GO_0001937Biological processnegative regulation of endothelial cell proliferation
GO_0006629Biological processlipid metabolic process
GO_1902600Biological processproton transmembrane transport
GO_0045261Cellular componentproton-transporting ATP synthase complex, catalytic core F(1)
GO_0005754Cellular componentmitochondrial proton-transporting ATP synthase, catalytic core
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0070062Cellular componentextracellular exosome
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005753Cellular componentmitochondrial proton-transporting ATP synthase complex
GO_0009986Cellular componentcell surface
GO_0005759Cellular componentmitochondrial matrix
GO_0008180Cellular componentCOP9 signalosome
GO_0045259Cellular componentproton-transporting ATP synthase complex
GO_0043531Molecular functionADP binding
GO_0046933Molecular functionproton-transporting ATP synthase activity, rotational mechanism
GO_0002020Molecular functionprotease binding
GO_0042288Molecular functionMHC class I protein binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0043532Molecular functionangiostatin binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameATP5F1A
Protein nameATP synthase subunit alpha, mitochondrial
ATP synthase F1 subunit alpha
ATP synthase subunit alpha, mitochondrial (ATP synthase F1 subunit alpha)
SynonymsATP5A
ATPM
ATP5AL2
ATP5A1
DescriptionFUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions . .

AccessionsK7EJP1
ENST00000586592.5
ENST00000593152.6 [P25705-2]
K7ERX7
ENST00000591981.5
ENST00000398752.11 [P25705-1]
ENST00000590406.5
ENST00000592364.5
ENST00000590324.5
K7ESA0
ENST00000585650.1
ENST00000590665.5 [P25705-3]
K7EQU6
K7EM08
ENST00000589252.5
K7EKV9
K7EK77
P25705
ENST00000592989.1
ENST00000589869.5
K7EQH4
K7ENJ4
A0A0A0MTS3
ENST00000282050.6 [P25705-1]
ENST00000590156.5