ZNF207 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	45 studies	34% ± 12%	Explore
fibroblast	40 studies	29% ± 11%	Explore
B cell	37 studies	30% ± 10%	Explore
natural killer cell	37 studies	32% ± 10%	Explore
macrophage	32 studies	29% ± 10%	Explore
CD8-positive, alpha-beta T cell	32 studies	27% ± 9%	Explore
CD4-positive, alpha-beta T cell	31 studies	27% ± 9%	Explore
T cell	30 studies	29% ± 7%	Explore
pericyte	30 studies	28% ± 9%	Explore
smooth muscle cell	28 studies	26% ± 7%	Explore
conventional dendritic cell	25 studies	30% ± 16%	Explore
classical monocyte	24 studies	33% ± 15%	Explore
regulatory T cell	22 studies	28% ± 6%	Explore
mast cell	20 studies	24% ± 9%	Explore
memory B cell	20 studies	27% ± 6%	Explore
monocyte	19 studies	33% ± 10%	Explore
epithelial cell	19 studies	35% ± 22%	Explore
naive B cell	19 studies	26% ± 6%	Explore
non-classical monocyte	19 studies	31% ± 16%	Explore
plasmacytoid dendritic cell	18 studies	35% ± 12%	Explore
basal cell	17 studies	33% ± 15%	Explore
endothelial cell of lymphatic vessel	16 studies	29% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	25% ± 9%	Explore
mature NK T cell	16 studies	28% ± 7%	Explore
gamma-delta T cell	16 studies	32% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	34% ± 10%	Explore
ciliated cell	15 studies	32% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	33% ± 9%	Explore
connective tissue cell	15 studies	28% ± 8%	Explore
dendritic cell	14 studies	34% ± 19%	Explore
astrocyte	14 studies	36% ± 17%	Explore
mucosal invariant T cell	14 studies	26% ± 6%	Explore
endothelial cell of vascular tree	14 studies	26% ± 9%	Explore
myeloid cell	14 studies	31% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	27% ± 10%	Explore
capillary endothelial cell	13 studies	26% ± 6%	Explore
myofibroblast cell	13 studies	28% ± 7%	Explore
microglial cell	13 studies	34% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	30% ± 8%	Explore
oligodendrocyte precursor cell	12 studies	42% ± 20%	Explore
vein endothelial cell	12 studies	28% ± 10%	Explore
plasma cell	11 studies	30% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	27% ± 6%	Explore
endothelial cell of artery	11 studies	24% ± 5%	Explore
type I pneumocyte	10 studies	32% ± 7%	Explore
glutamatergic neuron	10 studies	42% ± 26%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	31% ± 10%	Explore
club cell	10 studies	28% ± 10%	Explore
oligodendrocyte	10 studies	40% ± 14%	Explore
type II pneumocyte	9 studies	29% ± 9%	Explore
plasmablast	9 studies	39% ± 24%	Explore
secretory cell	9 studies	29% ± 7%	Explore
GABAergic neuron	9 studies	43% ± 24%	Explore
abnormal cell	9 studies	28% ± 12%	Explore
adipocyte	9 studies	34% ± 10%	Explore
leukocyte	8 studies	30% ± 7%	Explore
progenitor cell	8 studies	33% ± 11%	Explore
goblet cell	8 studies	32% ± 17%	Explore
mesothelial cell	8 studies	30% ± 11%	Explore
amacrine cell	8 studies	27% ± 8%	Explore
retinal rod cell	8 studies	21% ± 5%	Explore
neuron	8 studies	41% ± 17%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	26% ± 3%	Explore
mononuclear phagocyte	7 studies	29% ± 12%	Explore
precursor B cell	7 studies	45% ± 15%	Explore
innate lymphoid cell	7 studies	29% ± 5%	Explore
alveolar macrophage	7 studies	28% ± 12%	Explore
T follicular helper cell	7 studies	27% ± 3%	Explore
respiratory goblet cell	6 studies	31% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	23% ± 6%	Explore
interneuron	6 studies	43% ± 20%	Explore
hematopoietic stem cell	6 studies	30% ± 7%	Explore
lymphocyte	6 studies	39% ± 11%	Explore
retina horizontal cell	6 studies	32% ± 10%	Explore
retinal cone cell	6 studies	30% ± 11%	Explore
Mueller cell	6 studies	24% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	31% ± 13%	Explore
hematopoietic precursor cell	5 studies	52% ± 14%	Explore
transit amplifying cell	5 studies	32% ± 26%	Explore
retinal bipolar neuron	5 studies	29% ± 7%	Explore
pro-B cell	5 studies	47% ± 8%	Explore
brush cell	5 studies	30% ± 10%	Explore
cardiac muscle cell	5 studies	26% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	25% ± 4%	Explore
ionocyte	4 studies	29% ± 10%	Explore
squamous epithelial cell	4 studies	41% ± 20%	Explore
pancreatic A cell	4 studies	36% ± 7%	Explore
exhausted T cell	4 studies	37% ± 16%	Explore
glial cell	4 studies	33% ± 16%	Explore
granule cell	4 studies	25% ± 8%	Explore
erythroblast	4 studies	46% ± 23%	Explore
immature B cell	4 studies	33% ± 5%	Explore
retinal pigment epithelial cell	4 studies	38% ± 21%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	30% ± 4%	Explore
hepatocyte	4 studies	51% ± 18%	Explore
muscle cell	4 studies	37% ± 18%	Explore
neutrophil	4 studies	22% ± 6%	Explore
enteroendocrine cell	4 studies	32% ± 10%	Explore
erythrocyte	4 studies	30% ± 19%	Explore
T-helper 17 cell	4 studies	25% ± 5%	Explore
double negative thymocyte	4 studies	42% ± 18%	Explore
precursor cell	3 studies	26% ± 4%	Explore
type B pancreatic cell	3 studies	31% ± 9%	Explore
glomerular endothelial cell	3 studies	27% ± 3%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	33% ± 9%	Explore
neural crest cell	3 studies	38% ± 4%	Explore
GABAergic interneuron	3 studies	27% ± 2%	Explore
kidney loop of Henle epithelial cell	3 studies	17% ± 1%	Explore
extravillous trophoblast	3 studies	21% ± 1%	Explore
placental villous trophoblast	3 studies	24% ± 3%	Explore
enterocyte	3 studies	19% ± 3%	Explore
tissue-resident macrophage	3 studies	30% ± 6%	Explore
OFF-bipolar cell	3 studies	27% ± 8%	Explore
ON-bipolar cell	3 studies	29% ± 9%	Explore
glycinergic amacrine cell	3 studies	27% ± 6%	Explore
rod bipolar cell	3 studies	34% ± 7%	Explore
germinal center B cell	3 studies	33% ± 2%	Explore
intermediate monocyte	3 studies	44% ± 28%	Explore
CD4-positive helper T cell	3 studies	26% ± 7%	Explore
pancreatic ductal cell	3 studies	50% ± 15%	Explore
ependymal cell	3 studies	33% ± 15%	Explore
granulocyte	3 studies	24% ± 8%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	59% ± 18%	Explore
adventitial cell	3 studies	24% ± 1%	Explore
chondrocyte	3 studies	34% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	41% ± 10%	Explore
keratinocyte	3 studies	28% ± 3%	Explore
T-helper 1 cell	3 studies	28% ± 4%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	22% ± 3%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	20% ± 0%	Explore
myoepithelial cell	3 studies	31% ± 7%	Explore
luminal cell of prostate epithelium	3 studies	25% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	29% ± 10%	Explore
peripheral blood	16 studies	33% ± 14%	Explore
brain	15 studies	38% ± 21%	Explore
eye	10 studies	29% ± 13%	Explore
intestine	8 studies	26% ± 12%	Explore
kidney	7 studies	24% ± 6%	Explore
bone marrow	5 studies	27% ± 9%	Explore
heart	5 studies	26% ± 3%	Explore
lymph node	5 studies	24% ± 5%	Explore
breast	5 studies	23% ± 6%	Explore
liver	5 studies	41% ± 17%	Explore
pancreas	4 studies	32% ± 12%	Explore
placenta	4 studies	23% ± 4%	Explore
uterus	4 studies	31% ± 14%	Explore
prostate	4 studies	25% ± 7%	Explore
adipose	4 studies	35% ± 10%	Explore
skin	3 studies	22% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	11227.06	459 / 459	100%	31.54	1118 / 1118
esophagus	100%	10958.59	1445 / 1445	100%	37.69	183 / 183
intestine	100%	10404.42	966 / 966	100%	30.22	527 / 527
lung	100%	12125.23	578 / 578	100%	31.78	1155 / 1155
ovary	100%	13171.34	180 / 180	100%	24.88	430 / 430
prostate	100%	10967.65	245 / 245	100%	24.46	502 / 502
stomach	100%	8333.53	359 / 359	100%	29.94	286 / 286
uterus	100%	13062.18	170 / 170	100%	30.49	459 / 459
bladder	100%	10584.95	21 / 21	100%	31.82	503 / 504
skin	100%	11389.15	1809 / 1809	100%	27.56	471 / 472
pancreas	100%	5868.14	327 / 328	100%	25.16	178 / 178
thymus	100%	11662.56	653 / 653	100%	24.85	603 / 605
kidney	100%	7759.02	89 / 89	100%	21.04	898 / 901
liver	100%	4960.79	226 / 226	99%	14.06	403 / 406
brain	99%	6419.32	2619 / 2642	100%	26.22	705 / 705
adrenal gland	100%	9288.45	258 / 258	98%	16.87	226 / 230
adipose	100%	10197.65	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	34.66	29 / 29
spleen	100%	12672.78	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	30.32	45 / 45
ureter	0%	0	0 / 0	100%	11.10	1 / 1
blood vessel	100%	10617.36	1334 / 1335	0%	0	0 / 0
muscle	100%	6104.14	802 / 803	0%	0	0 / 0
heart	99%	5851.19	851 / 861	0%	0	0 / 0
peripheral blood	98%	9003.75	908 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	98%	19.53	78 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0008608	Biological process	attachment of spindle microtubules to kinetochore
GO_0000070	Biological process	mitotic sister chromatid segregation
GO_0051301	Biological process	cell division
GO_0090307	Biological process	mitotic spindle assembly
GO_0046785	Biological process	microtubule polymerization
GO_0051983	Biological process	regulation of chromosome segregation
GO_0050821	Biological process	protein stabilization
GO_0007094	Biological process	mitotic spindle assembly checkpoint signaling
GO_0001578	Biological process	microtubule bundle formation
GO_0005730	Cellular component	nucleolus
GO_0005874	Cellular component	microtubule
GO_0000776	Cellular component	kinetochore
GO_1990047	Cellular component	spindle matrix
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0005819	Cellular component	spindle
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0008201	Molecular function	heparin binding
GO_0008017	Molecular function	microtubule binding
GO_0046872	Molecular function	metal ion binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ZNF207
Protein name	BUB3-interacting and GLEBS motif-containing protein ZNF207 (BuGZ) (hBuGZ) (Zinc finger protein 207) Zinc finger protein 207
Synonyms	BUGZ
Description	FUNCTION: Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly . ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks . Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 . Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 . According to another report, the stabilization is independent of the proteasome . .
Accessions	O43670 ENST00000578918.1 X6R4W8 J3KTL1 ENST00000577908.5 J3KS31 ENST00000394673.6 [O43670-2] J3KRW6 ENST00000582165.1 J3KRB6 ENST00000342555.10 ENST00000321233.10 [O43670-1] J3QRS9 ENST00000581531.5 H0Y3M2 J3QS27 ENST00000394679.9 ENST00000579634.5 ENST00000394670.9 [O43670-4] ENST00000580759.5

ZNF207 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review